Consulta: subjectFacets:"Hyperglycemia"
Registros recuperados: 19
Data/hora: 16/06/2024 01:03:57

Diabetic nephropathy in dogs: literature review
Provedor de dados: 195
Autores: Martorelli, Cínthia Ribas; Kogika, Márcia Mery; Caragelasco, Douglas Segalla.
Diabetes mellitus caused by insulin deficiency and chronic hyperglycemia usually presents complications including cataract, retinopathy, recurrent infections and ketoacidosis. Chronic hyperglycemia can cause long-term complications such as diabetic nephropathy. In humans, diabetic nephropathy is characterized mainly by glomerular injury and usually it is associated with systemic hypertension. The mechanisms proposed for the pathogenesis of diabetic nephropathy could be glomerular injury, as well as renal tubular damage. However, there are few studies analyzing the relationship between diabetes mellitus and kidney damage in dogs. The objective of this review is to clarify the pathophysiological mechanisms of diabetic nephropathy and to analyze the available...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Canine; Kidney; Hyperglycemia; Diabetes mellitus canino; Rim; Hiperglicemia; Diabetes mellitus.
Ano: 2018
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/37712

Effect of dietary Acrocomia aculeata kernel oil rich in medium chain fatty acids on type 2 diabetic rats.
Provedor de dados: 119
Autores: NUNES, A. A.; BUCCINI, D. F.; JAQUES, J. A. dos S.; PORTUGAL, L. C.; GUIMARÃES, R. C. A. da; FAVARO, S. P.; CALDAS, R. de A.; CARVALHO, C. M. E.
This study evaluated the effects of dietaries formulated with kernel oil of Acrocomia aculeata (AKO), rich in medium chain fatty acids (MCFA), as partial substitute of carbohydrate calories upon blood glucose, lipid profile, insulin secretion and insulin sensitivity in diabetic rats. Overall, the dietary with any AKO dose reduced hyperglycemia, ameliorated insulin secretion, lowered insulin resistance by model HOMA-IR and HOMA-Beta and augmented pancreatic beta cells functionality, restored the number of pancreatic Beta-cell in the diabetic rats and increased it in the non-diabetic rats. In addition, AKO fed rats showed reducing triglycerides, lower density lipoprotein-cholesterol and increasing high density lipoprotein-cholesterol levels, and improved...
Tipo: Artigo de periódico
Palavras-chave: Diabetes tipo 2; Hiperglicemia; Nutracêuticos; Resistência à insulina; Ácido láurico; Diabete; Insulina; Macaúba; Colesterol; Ácido Lático; Insulin resistance; Diabetes mellitus; Hyperglycemia; Cholesterol.
Ano: 2020
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1127820

Glucose tolerance in six fi sh species reared in Brazil: differences between carnivorous and omnivorous.
Provedor de dados: 119
Autores: SOUZA, A. M. de; COPATTI, C. E.; CAMPECHE, D. F. B.; MELO, F. V. S. T. de; MELO, J. F. B.
The objective of this study was to evaluate the effect of pure glucose, glucose plus fructose, and fructose on the blood glucose of omnivorous fish tambaqui (Colossoma macropomum), Nile tilapia (Oreochromis niloticus), piau (Leporinus elongatus), and carnivorous fish hybrid Amazon catfish (Pseudoplatystoma fasciatum × Leiarius marmoratus), pacamã (Lophiosilurus alexandri), and traíra (Hoplias malabaricus). In each species, the dose 1 mL per fish with 1,000 mg kg of body weight-1 of glucose, fructose or glucose plus fructose were tested intraperitoneally. Blood glucose was measured at times 0 (control), 0.5, 1, 2, 4, 8, 16, and 24 h. The administration of 1,000 mg of glucose or glucose plus fructose per kg of live weight causes hyperglycemia in the...
Tipo: Artigo de periódico
Palavras-chave: Nile tilapia; Peixes onívoros; Peixes carnívoros; Hiperglicemia; Intraperitoneal; Tambaqui; Peixe; Piscicultura; Frutose; Fructose; Hyperglycemia; Intraperitoneal injection.
Ano: 2021
URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1161546

Resveratrol and resveratrol-hydroxypropyl-β-cyclodextrin complex recovered the changes of creatine kinase and Na+, K+-ATPase activities found in the spleen from streptozotocin-induced diabetic rats
Provedor de dados: 42
Autores: KOLLING,JENIFER; KOLLING,JANAÍNA; FRANCESCHI,ITIANE D. DE; NISHIHIRA,VIVIAN S.K.; BALDISSERA,MATHEUS D.; PINTO,CLÁUDIA G.; MEZZOMO,NATHANA J.; CARMO,GUILHERME M. DO; FEKSA,LUCIANE R.; FERNANDES,LIANA S.; ORENGO,GILBERTO; VAUCHER,RODRIGO A.; GIONGO,JANICE L.; WYSE,ANGELA T.S.; WANNMACHER,CLOVIS M.D.; RECH,VIRGINIA C.
Abstract: Type 1 diabetes (T1D) is the result of the selective destruction of the pancreatic β-cells by T cells of the immune system. Although spleen is a secondary lymphoid organ, it is also involved in the T1D pathogenesis. However, the alterations in a variety of cellular processes of this disease need to be further understood. We aimed to analyze the benefits of resveratrol, and its complexed form on diabetic complications in the spleen of rats. To this end, we investigated important enzymes of phosphoryl transfer network, and Na+, K+-ATPase activity. Wistar rats were divided into non-diabetic groups: Control, Ethanol, Resveratrol, Hydroxypropyl-β-cyclodextrin, Resveratrol-hydroxypropyl-β-cyclodextrin, and diabetic groups with the same treatments....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Energy metabolism; Hydroxypropyl-β-cyclodextrin; Hyperglycemia; Nanotecnology.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500701

Investigation of risk factors to coronary heart disease in two countryside villages
Provedor de dados: 52
Autores: Silva,Gisleine Elisa Cavalcante da; Bazotte,Roberto Barbosa; Curi,Rui; Silva,Maria Angélica Rafaini Covas Pereira da.
The aim of this study was to investigate risk factors to coronary heart disease in two countryside villages in the State of Paraná, southern Brazil, typical in terms of the poverty and lack of access to public health care. All population was invited to participate in the study. The 462 volunteers (61.3% female, mean age = 42 years) showed high prevalence of hypercholesterolemia (7.0%), hypertriglyceridemia (19.0%), hyperglycemia (11.0%), hypertension (30.0%) and obesity (16.0%). The majority of the individuals, during the interview did not report the diseases detected by the testes. The results revealed that the high prevalence of hypercholesterolemia, hypertriglyceridemia, obesity, hypertension and diabetes mellitus could be consequence of the delayed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hyperlipidemia; Hyperglycemia; Hypertension; Obesity; Coronary heart disease - Paraná State - Brazil.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132004000300008

Neonatally induced diabetes: liver glycogen storage in pregnant rats
Provedor de dados: 52
Autores: Iessi,Isabela Lovizutto; Bueno,Aline; Sinzato,Yuri Karen; Spada,Ana Paula Machado; Rudge,Marilza Vieira Cunha; Heubel,Maricê Thereza Correa Domingues; Damasceno,Débora Cristina.
The aim of this sstudy was to evaluate the liver glycogen storage in pregnant rats presenting neonatal streptozotocin-induced diabetes and to establish a relation with glycemia and insulin levels. Wistar rats were divided in to two groups: 1) Mild Diabetes (STZ) - received streptozotocin (glycemia from 120 to 300 mg/dL), 2) Control - received vehicle (glycemia below 120 mg/dL). At days 0, 7, 14 and 21 of the pregnancy, body weight and glycemia were evaluated. At day 21 of the pregnancy, the rats were anesthetized for blood and liver collection so as to determine insulin and liver glycogen, which showed no changes in the STZ group as compared to the controls. In the STZ group, maternal weight gain were lower as compared to those in the control group....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pregnancy; Rat; Hyperglycemia; Glycogen storage liver; Mild diabetes; Hyperglycemia.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000200010

Infliximab treatment prevents hyperglycemia and the intensification of hepatic gluconeogenesis in an animal model of high fat diet-induced liver glucose overproduction
Provedor de dados: 52
Autores: Haida,Karissa Satomi; Bertachini,Gabriela; Tavoni,Thauany; Guilhermetti,Márcio; Loures,Marco Rocha; Bazotte,Roberto Barbosa.
The effect of infliximab on gluconeogenesis in an animal model of diet-induced liver glucose overproduction was investigated. The mice were treated with standard diet (SD group) or high fat diet (HFD group). HFD group were randomly divided and treated either with saline (100 µl/dose, ip, twice a day) or infliximab (10 µg in 100 µl saline per dose, ip, twice a day, i.e., 0.5 mg/kg per day). SD group also received saline. The treatment with infliximab or saline started on the first day of the introduction of the HFD and was maintained during two weeks. After this period, the mice were fasted (15 h) and anesthetized. After laparotomy, blood was collected for glucose determination followed by liver perfusion in which L-alanine (5 mM) was used as gluconeogenic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Infliximab; Hyperglycemia; TNF-alpha; Liver gluconeogenesis; Type 2 diabetes; Mouse.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000300009

Lack of antidiabetic effect of a Eugenia jambolana leaf decoction on rat streptozotocin diabetes
Provedor de dados: 56
Autores: Pepato,M.T.; Folgado,V.B.B.; Kettelhut,I.C.; Brunetti,I.L.
Streptozotocin-diabetic rats were treated for 17 days with a decoction of Eugenia jambolana (Myrtaceae) leaves (15%, w/v) as a substitute for water. Body weight, food and fluid intake, urine volume, glycemia, urinary glucose and urea were evaluated every 5 days. The animals were sacrificed by decapitation and blood samples collected for the determination of glycemia, serum cholesterol, HDL-cholesterol, triglycerides and angiotensin-converting enzyme. The weight of adipose and muscle tissues was also determined. There were no statistically significant differences between treated and untreated rats for any of the biochemical or physiological parameters. We conclude that, at least in this experimental model, Eugenia jambolana leaf decoction has no...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antidiabetic plant; Hyperglycemia; Diabetic rats; Eugenia jambolana.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300014

Does acute hyperglycemia alter rat aortic depressor nerve function?
Provedor de dados: 56
Autores: Huber,D.A.; Carmo,J.M. do; Castania,J.A.; Fazan Jr,R.; Salgado,H.C.
Because it is not known where in the reflex arch, i.e., afference, central nervous system or efferences, hyperglycemia affects baroreflex function, the present study examined the effect of short-term (30 min) hyperglycemia on aortic depressor nerve function measured by a mean arterial pressure vs aortic depressor nerve activity curve, fitted by sigmoidal regression, or by cross-spectral analysis between mean arterial pressure and aortic depressor nerve activity. Anesthetized male Wistar rats received an intravenous bolus (0.25 mL) injection, followed by 30 min of infusion (1 mL/h) of 30% glucose (N = 14). Control groups received a bolus injection and infusion of 0.9% saline (N = 14), or 30% mannitol (N = 14). Glucose significantly increased both blood...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pressoreceptors; Hyperglycemia; Arterial pressure; Spectral analysis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100017

Cardiovascular, respiratory and metabolic responses to temperature and hypoxia of the winter frog Rana catesbeiana
Provedor de dados: 56
The objective of the present study was to determine the effects of hypoxia and temperature on the cardiovascular and respiratory systems and plasma glucose levels of the winter bullfrog Rana catesbeiana. Body temperature was maintained at 10, 15, 25 and 35oC for measurements of breathing frequency, heart rate, arterial blood pressure, metabolic rate, plasma glucose levels, blood gases and acid-base status. Reducing body temperature from 35 to 10oC decreased (P&amp;lt;0.001) heart rate (bpm) from 64.0 ± 3.1 (N = 5) to 12.5 ± 2.5 (N = 6) and blood pressure (mmHg) (P&amp;lt;0.05) from 41.9 ± 2.1 (N = 5) to 33.1 ± 2.1 (N = 6), whereas no significant changes were observed under hypoxia. Hypoxia-induced changes in breathing frequency and acid-base status were...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Temperature; Hypoxia; Rana; Breathing frequency; Blood pressure; Heart rate; Acid-base status; Hyperglycemia.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000100019

Streptozotocin-induced mechanical hypernociception is not dependent on hyperglycemia
Provedor de dados: 56
Autores: Cunha,J.M.; Funez,M.I.; Cunha,F.Q.; Parada,C.A.; Ferreira,S.H.
Since streptozotocin (STZ)-induced diabetes is a widely used model of painful diabetic neuropathy, the aim of the present study was to design a rational protocol to investigate whether the development of mechanical hypernociception induced by STZ depends exclusively on hyperglycemia. Male Wistar rats (180-200 g; N = 6-7 per group) received a single intravenous injection of STZ at three different doses (10, 20, or 40 mg/kg). Only the higher dose (40 mg/kg) induced a significant increase in blood glucose levels, glucose tolerance and deficiency in weight gain. However, all STZ-treated rats (hyperglycemic or not) developed persistent (for at least 20 days) and indistinguishable bilateral mechanical hypernociception that was not prevented by daily insulin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptozotocin; Mechanical hyperalgesia; Hyperglycemia; Insulin and glucose tolerance test.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200008

Determination of in vitro antidiabetic effects of Zingiber officinale Roscoe
Provedor de dados: 60
Autores: Sattar,Naila Abdul; Hussain,Fatma; Iqbal,Tahira; Sheikh,Munir Ahmad.
Aqueous extracts of Zingiber officinale rhizomes were studied to evaluate their antidiabetic effects on protein glycation and on the diffusion of glucose in vitro in the present study. Zingiber officinale rhizome aqueous extract were examined at concentrations of 5, 10, 20 and 40 g/L. The antidiabetic effects were found to be dose-dependent. Antidiabetic potential of Zingiber officinale was mainly through inhibition of the glucose diffusion and to a limited extent by reducing the glycation. However, further studies are needed to determine in vitro effects of therapeutic potential by restraining postprandial glucose absorptions and plasma protein glycations in diabetic subjects.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Zingiber officinale/pharmacognosy; Zingiber officinale/antidiabetic effects; Zingiber officinale/in vitro study; Diabetes mellitus; Hyperglycemia; Proteins/glycation; Glucose/diffusion in vitro.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400003

Effect of molecular weight on hypolipidemic and hypoglycemic activities of fermented Auriculaia auricula supernatant
Provedor de dados: 116
Autores: BAO,Yi-Hong; SUN,Kai-Feng; GUO,Yang.
Abstract Auriculaia auricula is considered as species of Mu Er in Chinese medicine and today are used interchangeably. A. auricula polysaccharides have been shown anti-cholesterol and anti-hyperglycemia. The aim of this research was to investigate the hypolipidemic and anti-hyperglycemic effects of extracts from different molecular weight fragments of A. auricula fermentation supernatant (AAFS). A. auricula was through mixed fermentation by Saccharomyces cerevisiae and Bifidobacterium. The results shown that with the molecular weight of AAFS increases, the ability to lower blood lipids and blood glucose gradually increases. In the lowering blood lipids, the AAFS of above 300 kDa has the strongest sodium bovine cholate binding capacity and sodium...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Auriculaia auricula; Fermentation; Hyperglycemia; Hyperlipidemia.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612020005006201

Effects of different concentrations of passion fruit peel (Passiflora edulis) on the glicemic control in diabetic rat
Provedor de dados: 116
Autores: Salgado,Jocelem Mastrodi; Bombarde,Talita Aparecida Dias; Mansi,Débora Niero; Piedade,Sonia Maria de Stefano; Meletti,Laura Maria Molina.
Diabetes mellitus, an endocrine disorder, is the major cause of morbidity in developing countries, and it is considered the fourth leading cause of death worldwide. The conventional therapy for diabetes is insulin treatment. The peel of the Passion fruit is rich in fiber and prevents the absorption of carbohydrates, and thus can control and reduce the blood sugar rate. The objective of this study was to analyze the effect of the passion fruit peel flour on the glicemia of diabetic rats, as well as to study the probable action mechanisms. Wistar rats were used in the experiment and were offered the flours of the passion fruit peel in three concentrations: 5, 10, and 15%, and a casein diet as control. The most significant effect on the reduction of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hyperglycemia; Diets; Passion fruit; Diabetes; Rats.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612010000300034

Amylose content in rice (Oryza sativa) affects performance, glycemic and lipidic metabolism in rats
Provedor de dados: 65
Autores: Denardin,Cristiane Casagrande; Boufleur,Nardeli; Reckziegel,Patrícia; Silva,Leila Picolli da; Walter,Melissa.
This research aimed at evaluating the effect of diets with high, intermediate and low amylose content of rice on performance, glycemic and lipidic metabolism in rats. Male Wistar rats were fed diets with grains of cooked rice of the cultivars 'IRGA 417', 'IRGA 416' and 'MOCHI' with high, intermediate and low amylose content, respectively. Wet and dry fecal production and serum HDL cholesterol were not affected by amylose content. The animals in the treatments with high amylose content ('IRGA 417') presented lower feed intake, body weight gain and apparent digestibility, higher fecal water content and nitrogen excretion, reduced fecal pH, lower postprandial blood glucose response, serum total cholesterol and triglycerides levels and pancreas weight, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rice grains; Hyperglycemia; Metabolic responses; Rats.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782012000200030

Repression of Ppargcla Gene in Liver of Hyperglycemic Rats Induced with High Fat Diet Combined with Streptozotocin
Provedor de dados: 77
Autores: Hernández,Alfonso; Curi,Rui; Salazar,Luis A.
Type 2 diabetes mellitus implies deregulation of multiple metabolic processes, being the maintenance of glycemia one of the most important. Many genes are involved in the deregulation of this particular process. Therefore, the aim of this study was to evaluate gene expression of genes related to type 2 diabetes mellitus, in the liver and pancreas of rats with hyperglycemia induced by high fat diet along with a low single dose of streptozotocin. Ahsg and Ppargc1a genes were studied in liver, whereas Kcnj11 and Slc2a2 genes were analyzed in pancreas. For this purpose, 210-240 g female rats were fed a high fat diet or a control diet for three weeks. At day 14, animals fed with high fat diet were injected with a single low dose of streptozotocin (35 mg/kg) and...
Tipo: Journal article
Palavras-chave: Gene Expression; Hyperglycemia; Ppargcla.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000200047

PROGRESSIVE EFFECTS OF DIABETES MELLITUS ON THE SKIN EPITHELIUM OF THE RA
Provedor de dados: 77
Autores: Benetti Tanga,Marcelo; Buttros,Kemli Raquel; Nakao,Cristiano; Chinali Komesu,Marilena.
Skin serves as interface between inner aand outer environment, and acts a a mechanical barrier. Changes in its characteristics may lead to a higher pathogenicity, less defense capacity, or both. Diabetes mellitus is a heterogeneous group of chronic hyperglycemic disorders, considered a syndrome rather than a simple disease. Complications by diabetes are mostly associated with the chronicity of the disease and very little information exists about its early pathological processes. Animal models are considered very useful for the study of early diabetes. Wistar rats with lloxan induccced diabetes were used in a way to study the progresive effects of diabetes mellitus on the skin epithelium. Five animals were sacrificed at 7 days (Phase I) and five others at...
Tipo: Journal article
Palavras-chave: Diabetes mellitus; Hyperglycemia; Skin; Rat.
Ano: 2003
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022003000200008

SCORPION ANTIVENOM REVERSES METABOLIC, ELECTROCARDIOGRAPHIC, AND HORMONAL DISTURBANCES CAUSED BY THE INDIAN RED SCORPION Mesobuthus tamulus concanesis, Pocock ENVENOMATION
Provedor de dados: 79
Autores: MURTHY,K. RADHA KRISHNA; ZARE,M. ABBAS.
Electrocardiographic (ECG) changes were induced in dogs by injection of scorpion venom from Mesobuthus tamulus concanesis, Pocock. Venom (3 mg/kg body weight) was given subcutaneously (SQ) while 10 ml of scorpion antivenom (SAV) was administered intravenously (IV) to experimental dogs. Group 1 received only the venom; Groups 2, 3, and 4 received SAV at 0, 30, and 60 min, respectively, following envenoming. Thick, ropy and profuse salivation; muscle fasciculation; clonus and tetany-like contractions; frequent urination; and bowel emptying sometimes stained with bile and occasionally blood and bile were observed 20-25 minutes after envenoming. Following envenoming, hyperglycemia, increase in free fatty acid (FFA) levels, and reduction in triglyceride levels...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antivenom; Scorpion venom; Mesobuthus tamulus concanesis; Hyperglycemia; Free fatty acids; Triglycerides; Insulin; Hyperinsulinemia; Insulin resistance; Electrocardiographic changes.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000100004

Consequences of Mesobuthus tamulus gangeticus (Pocock, 1900) envenomation in albino mice
Provedor de dados: 80
Autores: Chaubey,MK.
The present study aimed to investigate the effects of Mesobuthus tamulus gangeticus Pocock (Buthidae) venom on albino mice (NIH strain). Whole venom was obtained by electrical stimulation and its toxicity was determined in albino mice by subcutaneous envenomation. The venom LD50 was 2.5 mg kg-1 of mouse body weight. Toxic effects on different biochemical and enzymatic parameters in blood serum and other tissues of albino mice were determined after experimental envenomation with sublethal doses of M. tamulus gangeticus venom. Increased levels of glucose, uric acid and cholesterol, as well as decreased serum total proteins, were observed at 2 and 4 hours after the envenomation. In the liver and muscles, glycogen content dropped after venom injection....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mesobuthus tamulus gangeticus; Scorpion venom; Hyperglycemia; Serum enzymes.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992010000300011