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Autoimmune diseases in the TH17 era
Provedor de dados: 56
Autores: Mesquita Jr.,D.; Cruvinel,W.M.; Câmara,N.O.S.; Kállas,E.G.; Andrade,L.E.C.
A new subtype of CD4+ T lymphocytes characterized by the production of interleukin 17, i.e., TH17 cells, has been recently described. This novel T cell subset is distinct from type 1 and type 2 T helper cells. The major feature of this subpopulation is to generate significant amounts of pro-inflammatory cytokines, therefore appearing to be critically involved in protection against infection caused by extracellular microorganisms, and in the pathogenesis of autoimmune diseases and allergy. The dynamic balance among subsets of T cells is important for the modulation of several steps of the immune response. Disturbances in this balance may cause a shift from normal immunologic physiology to the development of immune-mediated disorders. In autoimmune diseases,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Autoimmune diseases; Cytokines; TH17 cells; IL-17; IL-22; IL-23.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600002