Consulta: subjectFacets:"L-NAME"
Registros recuperados: 10
Data/hora: 01/06/2024 18:23:10

Beneficial Effects of Angiotensin II AT1 Blocker on Cardiovascular Adverse Remodeling Due to Nitric Oxide Synthesis Blockade
Provedor de dados: International Journal of Morphology
Autores: Fernandes-Santos,Caroline; Mendonça,Leonardo de Souza; Mandarim-de-Lacerda,Carlos Alberto.
We studied with morphological tools the effects of different doses of Losartan upon the cardiovascular remodeling in nitric oxide deficient rats. At 15 weeks of age, thirty Wistar rats were separated in six groups: control (C), L-NAME (LN), and four groups were LN was given plus Losartan at different doses (1, 5, 20 and 40 mg/kg/day). The L-NAME was given for 9 weeks, the Losartan administration starting on the 2nd week of experiment. We studied the heart, thoracic aorta and superior mesenteric artery with light microscopy and stereology. The blood pressure (BP) increased since the first week of L-NAME administration, the Losartan treatment at doses of 20 and 40 mg/kg/day was efficient to reduce BP after the 7th week of treatment. The cardiac adverse...
Tipo: Journal article
Palavras-chave: Losartan; Angiotensin II; L-NAME; Hypertension; Renin-angiotensin system; Stereology; L-NAME.
Ano: 2006
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400003

Nitric oxide modulation of the hypothalamo-neurohypophyseal system
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Kadekaro,M.
Nitric oxide (NO), a free radical gas produced endogenously from the amino acid L-arginine by NO synthase (NOS), has important functions in modulating vasopressin and oxytocin secretion from the hypothalamo-neurohypophyseal system. NO production is stimulated during increased functional activity of magnocellular neurons, in parallel with plastic changes of the supraoptic nucleus (SON) and paraventricular nucleus. Electrophysiological data recorded from the SON of hypothalamic slices indicate that NO inhibits firing of phasic and non-phasic neurons, while L-NAME, an NOS inhibitor, increases their activity. Results from measurement of neurohypophyseal hormones are more variable. Overall, however, it appears that NO, tonically produced in the forebrain,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: L-NAME; Vasopressin; Oxytocin; CGMP; ODQ; Microdialysis.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000400001

Effects of a neuronal nitric oxide synthase inhibitor on lipopolysaccharide-induced fever
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Perotti,C.A.A.; Nogueira,M.S.; Antunes-Rodrigues,J.; Cárnio,E.C.
It has been demonstrated that nitric oxide (NO) has a thermoregulatory action, but very little is known about the mechanisms involved. In the present study we determined the effect of neuronal nitric oxide synthase (nNOS) inhibition on thermoregulation. We used 7-nitroindazole (7-NI, 1, 10 and 30 mg/kg body weight), a selective nNOS inhibitor, injected intraperitoneally into normothermic Wistar rats (200-250 g) and rats with fever induced by lipopolysaccharide (LPS) (100 µg/kg body weight) administration. It has been demonstrated that the effects of 30 mg/kg of 7-NI given intraperitoneally may inhibit 60% of nNOS activity in rats. In all experiments the colonic temperature of awake unrestrained rats was measured over a period of 5 h at 15-min intervals...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nitric oxide; 7-nitroindazole; Body temperature; LPS; L-NAME.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100008

Participation of nitric oxide in the nucleus isthmi in CO2-drive to breathing in toads
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Gargaglioni,L.H.; Branco,L.G.S.
The nucleus isthmi (NI) is a mesencephalic structure of the amphibian brain. It has been reported that NI plays an important role in integration of CO2 chemoreceptor information and glutamate is probably involved in this function. However, very little is known about the mechanisms involved. Recently, it has been shown that nitric oxide synthase (NOS) is expressed in the brain of the frog. Thus the gas nitric oxide (NO) may be involved in different functions in the brain of amphibians and may act as a neurotransmitter or neuromodulator. We tested the hypothesis that NO plays a role in CO2-drive to breathing, specifically in the NI comparing pulmonary ventilation, breathing frequency and tidal volume, after microinjecting 100 nmol/0.5 µl of L-NAME (a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nitric oxide; Amphibian; Hypercapnia; Ventilation; Nucleus isthmi; Toad; CO2; L-NAME.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100010

Nitric oxide synthase blockade and body fluid volumes
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Balaszczuk,A.M.; Tomat,A.; Bellucci,S.; Fellet,A.; Arranz,C.
The influence of chronic nitric oxide synthase inhibition with N G-nitro-L-arginine methyl ester (L-NAME) on body fluid distribution was studied in male Wistar rats weighing 260-340 g. Extracellular, interstitial and intracellular spaces, as well as plasma volume were measured after a three-week treatment with L-NAME (~70 mg/kg per 24 h in drinking water). An increase in extracellular space (16.1 ± 1.1 vs 13.7 ± 0.6 ml/100 g in control group, N = 12, P&lt;0.01), interstitial space (14.0 ± 0.9 vs 9.7 ± 0.6 ml/100 g in control group, P&lt;0.001) and total water (68.7 ± 3.9 vs 59.0 ± 2.9 ml/100 g, P&lt;0.001) was observed in the L-NAME group (N = 8). Plasma volume was lower in L-NAME-treated rats (2.8 ± 0.2 ml/100 g) than in the control group (3.6 ± 0.1...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Nitric oxide; Kidney; Heart; Body fluid; Hypertension; Extracellular space; Intracellular space; L-NAME.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100019

Functional expression of kinin B1 and B2 receptors in mouse abdominal aorta
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Felipe,S.A.; Rodrigues,E.S.; Martin,R.P.; Paiva,A.C.M.; Pesquero,J.B.; Shimuta,S.I.
Previous studies have shown that the vascular reactivity of the mouse aorta differs substantially from that of the rat aorta in response to several agonists such as angiotensin II, endothelin-1 and isoproterenol. However, no information is available about the agonists bradykinin (BK) and DesArg9BK (DBK). Our aim was to determine the potential expression of kinin B1 and B2 receptors in the abdominal mouse aorta isolated from C57BL/6 mice. Contraction and relaxation responses to BK and DBK were investigated using isometric recordings. The kinins were unable to induce relaxation but concentration-contraction response curves were obtained by applying increasing concentrations of the agonists BK and DBK. These effects were blocked by the antagonists Icatibant...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Kinin B1 and B2 receptors; Bradykinin; DesArg9bradykinin; Indomethacin; L-NAME.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500007

Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Soares de Moura,R.; Cardoso,M.
The aim of the present study was to investigate the role of bradykinin in the inhibitory action of captopril in hypertension induced by L-NAME in anesthetized rats. Male Wistar rats (260-320 g) were anesthetized with chloralose and arterial blood pressure was recorded with a polygraph pressure transducer. The hypertensive effect of L-NAME was studied in rats pretreated with saline, captopril or HOE 140 plus captopril. The effect of captopril was also studied during the sustained pressor effect of L-NAME. The acute pressor effect of L-NAME (10 mg/kg, iv) was significantly reduced by iv pretreatment with 2 mg/kg captopril (&lt;!-- $MVD$:face("Symbol") --&gt;&lt;FONT FACE="Symbol"&gt;D&lt;/font&gt; increase of 49 ± 4.9 mmHg reduced to 20 ± 5.4 mmHg, P =...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: L-NAME.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001000013

Angiotensin-(1-7) potentiates the coronary vasodilatatory effect of bradykinin in the isolated rat heart
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Almeida,A.P.; Frábregas,B.C.; Madureira,M.M.; Santos,R.J.S.; Campagnole-Santos,M.J.; Santos,R.A.S.
It has been shown that angiotensin-(1-7) (Ang-(1-7)) infusion potentiates the bradykinin (BK)-induced hypotensive response in conscious rats. The present study was conducted to identify Ang-(1-7)-BK interactions in the isolated rat heart perfused according to the Langendorff technique. Hearts were excised and perfused through the aortic stump under a constant flow with Krebs-Ringer solution and the changes in perfusion pressure and heart contractile force were recorded. Bolus injections of BK (2.5, 5, 10 and 20 ng) produced a dose-dependent hypotensive effect. Ang-(1-7) added to the perfusion solution (2 ng/ml) did not change the perfusion pressure or the contractile force but doubled the hypotensive effect of the lower doses of BK. The BK-potentiating...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Angiotensin-(1-7); Bradykinin; Coronary artery; Rat heart; L-NAME; Prostaglandins; Bradykinin potentiation.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600012

Liver lipid peroxidation and antioxidant capacity in cerulein-induced acute pancreatitis
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Batcioglu,K.; Gul,M.; Uyumlu,A.B.; Esrefoglu,M.
The aim of this study was to evaluate the role of oxidative damage in pancreatitis-induced hepatic injury. Thirty-five rats were divided into five groups (each of 7 rats): control, cerulein (100 µg/kg body weight), cerulein and pentoxifylline (12 mg/kg body weight), cerulein plus L-NAME (10 mg/kg body weight) and cerulein plus L-arginine (160 mg/kg body weight). The degree of hepatic cell degeneration differed significantly between groups. Mean malondialdehyde levels were 7.00 ± 2.29, 20.89 ± 10.13, 11.52 ± 4.60, 18.69 ± 8.56, and 8.58 ± 3.68 nmol/mg protein for the control, cerulein, pentoxifylline, L-NAME, and L-arginine groups, respectively. Mean catalase activity was 3.20 ± 0.83, 1.09 ± 0.35, 2.05 ± 0.91, 1.70 ± 0.60, and 2.85 ± 0.47 U/mg protein for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute pancreatitis; Liver injury; Oxidative damage; Pentoxifylline; L-NAME; L-arginine.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000900001

L-arginine, a nitric oxide precursor, reduces dapsone-induced methemoglobinemia in rats
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: Moraes,Natália Valadares de; Bergamaschi,Mateus Machado; Bianchi,Maria de Lourdes Pires; Bragheto,Juliana Bordinassi; Malfará,Wilson Roberto; Queiroz,Regina Helena Costa.
Dapsone use is frequently associated to hematological side effects such as methemoglobinemia and hemolytic anemia, which are related to N-hydroxylation mediated by the P450 enzyme system. The aim of the present study was to evaluate the influence of L-arginine supplementation, a precursor for the synthesis of nitric oxide, as single or multiple dose regimens on dapsone-induced methemoglobinemia. Male Wistar rats were treated with L-arginine at 5, 15, 30, 60 and 180 mg/kg doses (p.o., gavage) in single or multiple dose regimens 2 hours prior to dapsone administration (40 mg/kg, i.p.). The effect of the nitric oxide synthase inhibitor L-NAME was investigated by treatment with multiple doses of 30 mg/kg (p.o., gavage) 2 hours before dapsone administration....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dapsone; Methemoglobinemia; L-arginine; Nitric oxide; L-NAME.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000100010