Consulta: subjectFacets:"Lipid metabolism"
Registros recuperados: 13
Data/hora: 04/06/2024 16:54:07

Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women
Provedor de dados: 74
Autores: Oliveira,Jéssica de; Tureck,Luciane Viater; Santos,Willian dos; Saliba,Louise Farah; Schenknecht,Caroline Schovanz; Scaraboto,Débora; Souza,Ricardo Lehtonen R.; Furtado-Alle,Lupe.
Abstract Butyrylcholinesterase (BChE) activity and polymorphisms in its encoding gene had previously been associated with metabolic traits of obesity. This study investigated the association of three single nucleotide polymorphisms (SNPs) in the BCHE gene: -116G &gt; A (rs1126680), 1615GA (rs1803274), 1914A &lt; G (rs3495), with obesity and lipid metabolism markers, body mass index (BMI), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglyceride (TG) levels, and BChE enzymatic activity in obese (BMI≥30/n = 226) and non-obese women (BMI &lt; 25/n = 81). BCHE SNPs genotyping was obtained by TaqMan allelic discrimination assay and by RFLP-PCR. Plasmatic BChE activity was measured using...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: BCHE gene; Obesity; Lipid metabolism; Polymorphisms.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000300408

Host Cholesterol Synthesis Contributes to Growth of Intracellular Toxoplasma gondii in Macrophages
Provedor de dados: 19
Autores: NISHIKAWA, Yoshifumi; IBRAHIM, Hany M.; KAMEYAMA, Kyohko; SHIGA, Ikumi; HIASA, Jun; XUAN, Xuenan; 西川, 義文; 玄, 学南.
The intracellular protozoan Toxoplasma gondii lacks the ability to synthesize sterol and scavenges cholesterol from the lowdensity lipoprotein receptor (LDLR) pathway of its host to facilitate replication. Sterol biosynthesis inhibitors, however, have a demonstrated anti-Toxoplasma effect. In this study, we examined the host mevalonate pathway as a novel source of cholesterol for T. gondii and its effects on parasite growth in macrophages. Parasite growth did not significantly change in the absence of LDLR or when LDL was exogenously supplemented. Lovastatin and compactin, both inhibitors of hydroxymethylglutaryl-CoA (HMG-CoA) reductase in the mevalonate pathway, significantly inhibited T. gondii growth in both wild-type and LDLR-knockout macrophages....
Palavras-chave: Cholesterol; Lipid metabolism; Macrophage; Parasitology; Toxoplasma gondii.
Ano: 2011
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3583

Effect of Ultra-fine Traditional Chinese Medicine Compounds on Regulation of Lipid Metabolism and Reduction in Egg Cholesterol of Laying Hens
Provedor de dados: 89
Autores: Song,Y; Zhu,J; Wang,T; Zhang,C; Yang,F; Guo,X; Liu,P; Cao,H; Hu,G.
ABSTRACT This study has the objective of investigating the effects of traditional Chinese medicine prescriptions (TCM) on serum lipid, abdominal and hepatic fat percentage, cholesterol content in eggs, and mRNA expression of genes apoA I and apoB100. One hundred and thirty five healthy (300-day-old) layers were randomly assigned to three treatments. The hens in control group were fed with the basal diet. The hens in the experimental groups (TCM 1 and TCM 2) were fed with the basal diet supplemented with 1% TCM 1 and 1% TCM 2 respectively over a period of 60 days. Laying performance and the serum parameters relevant to fat metabolism were measured. The results showed that no significant differences were found in average daily feed intake and egg weight...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Laying hens; Cholesterol; Traditional Chinese medicine; Lipid metabolism; Apolipoprotein.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2018000100153

Effect of Cottonseed Meal Fermented with Yeast on the Lipid-related Gene Expression in Broiler Chickens
Provedor de dados: 89
Autores: Nie,CX; Zhang,WJ; Ge,WX; Liu,YF; Wang,YQ; Liu,JC.
ABSTRACT Fermented cottonseed meal (FCSM) is widely used in poultry diets in China. This study was conducted to investigate the effect of FCSM on lipid-related gene expression in broilers. Initially, 180 broiler chickens (21-days-old, equal number of males and females) were randomly divided into three groups, with six pens per group and 10 birds per pen. The chickens in the control group were fed a diet containing unfermented cottonseed meal, and those in the treatment groups were fed with diets including either CSM fermented by Candida tropicalis (Ct group) or CSM fermented by Candida tropicalis plus Saccharomyces cerevisae (Ct-Sc group) until 64 days old. The results revealed that, compared with the control group (p&lt;0.05), the mRNA expression of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Fermented cottonseed meal; Fermented feed; Lipid metabolism; Gene expression; Broilers.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2015001000057

Influence of dietary fat sources and conjugated fatty acid on egg quality, yolk cholesterol, and yolk fatty acid composition of laying hens
Provedor de dados: 96
Autores: Keum,Moung-Cheul; An,Byoung-Ki; Shin,Kyoung-Hoon; Lee,Kyung-Woo.
ABSTRACT This study was conducted to investigate the effects of dietary fats (tallow [TO] or linseed oil [LO]) or conjugated linoleic acid (CLA), singly or in combination, on laying performance, yolk lipids, and fatty acid composition of egg yolks. Three hundred 50-week-old laying hens were given one of five diets containing 2% TO; 1% TO + 1% CLA (TO/CLA); 2% LO; 1% LO + 1% CLA (LO/CLA); and 2% CLA (CLA). Laying performance, egg lipids, and serum parameters were not altered by dietary treatments. Alpha-linolenic acid or long-chain ω-3 fatty acids including eicosapentaenoic and docosahexaenoic acids were elevated in eggs of laying hens fed diets containing LO (i.e., LO or LO/CLA groups) compared with those of hens fed TO-added diets. Dietary CLA, alone or...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lipid metabolism; Linseed oil; Ω-3 fatty acids.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982018000100521

Dietary canitine maintains energy reserves and delays fatigue of exercised african catfish (Clarias gariepinus) fed high fat diets
Provedor de dados: 63
Autores: Ozório,Rodrigo; Van Ginneken,Vincent; van den Thillart,Guido; Verstegen,Martin; Verreth,Johan.
Lipids, together with proteins, are traditionally considered as primary fuels during aerobic swimming. The effects of dietary fat and carnitine supplements and exercise on the energy metabolism of juvenile fish were investigated. One hundred African catfish (Clarias gariepinus) were fed four isonitrogenous diets containing a fat level of 100 or 190 g kg-1 diet and one of the two levels of carnitine (15 and 1000 mg kg-1). Fish grew from 61 to 162 g in 10 wk. Thereafter, 6 fish per group swam vigorously for 3 h and the results were compared with unexercised groups. Fish receiving 1,000 mg carnitine accumulated 2- to 3-fold more carnitine than fish receiving 15 mg carnitine. Plasma acyl-carnitine level was affected by an interaction between dietary treatment...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lipid metabolism; Catfish; Stress; Intensive aquaculture; Exhaustive swimming.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162005000300002

High Postprandial Triglycerides Serum Levels: Is Obesity a Good Predictor?
Provedor de dados: 42
Autores: NOGAROTO,VIVIANE; RODRIGUES,MARCOS R.S.; VICARI,MARCELO R.; ALMEIDA,MARA C. DE; MILLÉO,FÁBIO Q.; SANTOS,FÁBIO A. DOS; ARTONI,ROBERTO F.
The aim of this study was to analyze the correlation between triglyceride (TG) serum levels in obese and non-obese patients in a simulated postprandial state. Both groups showed TG levels &lt; 150 mg/dL when fasting. After 12 h fasting, the subjects ingested a lipid overload diet and blood samples were collected. The variation between fasting and the postprandial TG peak levels were analyzed. The peak of postprandial TG levels occurred 4 h after the lipid overload in both groups. When the subjects were not fasting, the majority of non-obese subjects remained within the range of normal TG values, but the values for the obese group remained elevated. There was a significant correlation between Body Mass Index (BMI) and TG at each time point until 2 h after...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Body mass index; Lipid metabolism; Risk factor; ROC curve.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000100437

Beneficial effects of exercise training (treadmill) on insulin resistance and nonalcoholic fatty liver disease in high-fat fed C57BL/6 mice
Provedor de dados: 56
Autores: Marques,C.M.M.; Motta,V.F.; Torres,T.S.; Aguila,M.B.; Mandarim-de-Lacerda,C.A.
C57BL/6 mice develop signs and symptoms comparable, in part, to the human metabolic syndrome. The objective of the present study was to evaluate the effects of exercise training on carbohydrate metabolism, lipid profile, visceral adiposity, pancreatic islet alterations, and nonalcoholic fatty liver disease in C57BL/6 mice. Animals were fed one of two diets during an 8-week period: standard (SC, N = 12) or very high-fat (HF, N = 24) chow. An exercise training protocol (treadmill) was then established and mice were divided into SC and HF sedentary (SC-Sed, HF-Sed), exercised groups (SC-Ex, HF-Ex), or switched from HF to SC (HF/SC-Sed and HF/SC-Ex). HF/HF-Sed mice had the greatest body mass (65% more than SC/SC-Sed; P &lt; 0.0001), and exercise reduced it by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Obesity; Lipid metabolism; Metabolic syndrome; Aerobic training; Fatty liver; Stereology.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500008

Effects of high-intensity intermittent training on carnitine palmitoyl transferase activity in the gastrocnemius muscle of rats
Provedor de dados: 56
Autores: Carnevali Jr,L.C.; Eder,R.; Lira,F.S.; Lima,W.P.; Gonçalves,D.C.; Zanchi,N.E.; Nicastro,H.; Lavoie,J.M.; Seelaender,M.C.L.
We examined the capacity of high-intensity intermittent training (HI-IT) to facilitate the delivery of lipids to enzymes responsible for oxidation, a task performed by the carnitine palmitoyl transferase (CPT) system in the rat gastrocnemius muscle. Male adult Wistar rats (160-250 g) were randomly distributed into 3 groups: sedentary (Sed, N = 5), HI-IT (N = 10), and moderate-intensity continuous training (MI-CT, N = 10). The trained groups were exercised for 8 weeks with a 10% (HI-IT) and a 5% (MI-CT) overload. The HI-IT group presented 11.8% decreased weight gain compared to the Sed group. The maximal activities of CPT-I, CPT-II, and citrate synthase were all increased in the HI-IT group compared to the Sed group (P &lt; 0.01), as also was gene...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: High-intensity intermittent training; Lipid metabolism; Carnitine palmitoyl transferase.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000800013

Apolipoprotein and lipid abnormalities in chronic liver failure
Provedor de dados: 56
Autores: Spósito,A.C.; Vinagre,C.G.; Pandullo,F.L; Mies,S.; Raia,S.; Ramires,J.A.F.
Total serum lipids, as well as apolipoproteins A-I (apo A-I) and B (apo B), were determined in 74 patients with chronic liver failure without cholestasis and in 82 normal subjects. The VLDL, LDL and HDL lipid fractions were reduced in the liver failure group by 36%, 24% and 46%, respectively (P&amp;lt;0.001). Apolipoproteins A-I and B were also reduced by 26% and 25%, respectively (P&amp;lt;0.001). However, the reduction of HDL cholesterol (HDLc) was more pronounced than that of apo A-I and the HDLc:apo A-I ratio was significantly lower in the liver failure group. After separating these patients into groups with plasma albumin lower than 3.0, between 3.0 and 3.5, and higher than 3.5 g/dl, the HDLc:apo A-I ratio was proportional to plasma albumin, but the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic liver disease; Liver failure; Apolipoprotein A; Apolipoprotein B; LCAT; HDL cholesterol; VLDL cholesterol; Lipid metabolism.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100004

TP53 codon 72 polymorphism as a risk factor for cardiovascular disease in a Brazilian population
Provedor de dados: 56
Autores: Smith,M.A.C.; Silva,M.D.A.; Cendoroglo,M.S.; Ramos,L.R.; Araujo,L.M.Q.; Labio,R.W.; Burbano,R.R.; Chen,E.S.; Payão,S.L.M.
TP53, a tumor suppressor gene, has a critical role in cell cycle, apoptosis and cell senescence and participates in many crucial physiological and pathological processes. Identification of TP53 polymorphism in older people and age-related diseases may provide an understanding of its physiology and pathophysiological role as well as risk factors for complex diseases. TP53 codon 72 (TP53:72) polymorphism was investigated in 383 individuals aged 66 to 97 years in a cohort from a Brazilian Elderly Longitudinal Study. We investigated allele frequency, genotype distribution and allele association with morbidities such as cardiovascular disease, type II diabetes, obesity, neoplasia, low cognitive level (dementia), and depression. We also determined the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cardiovascular risk factors; HDL; Lipid metabolism; TP53 polymorphism codon 72; Age-related diseases; Elderly cohort.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100007

Association of ApoE polymorphisms with prevalent hypertension in 1406 older adults: the Bambuí Health Aging Study (BHAS)
Provedor de dados: 56
Autores: Fuzikawa,A.K.; Peixoto,S.V.; Taufer,M.; Moriguchi,E.H.; Lima-Costa,M.F.
Apolipoprotein E (ApoE) polymorphism influences lipid metabolism, but its association with arterial hypertension is controversial. The objective of this study was to examine the association between ApoE polymorphism and prevalent hypertension in a large unselected population of older adults. Participants from the baseline of the Bambuí Health Aging Study whose ApoE genes had been genotyped were selected for this study (N = 1406, aged 60-95 years). These subjects represented 80.7% of the total elderly residents in Bambuí city, MG, Brazil. Hypertension was defined as a systolic blood pressure ³140 mmHg and/or a diastolic blood pressure ³90 mmHg, or the use of anti-hypertensive medication. The exposure variable was the ApoE genotype as follows: e3 carriers,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Apolipoprotein E; Hypertension; Low-density lipoprotein cholesterol; Triglycerides; Lipid metabolism.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200002

Substitution of ractopamine by safflower or coconut oil as an additive in finishing pig diets
Provedor de dados: 65
Autores: Costa,Clara Viviane Silva da; Moreira,José Aparecido; Marinho,Andreza Lourenço; Silva,Natália Rocha; Carmo,Myllena Emelly de Paiva; Ramalho,Adriana Margarida Zambotto; Aguiar,Emerson Moreira; Souza,Janete Gouveia de; Teixeira,Elisanie Neiva Magalhães.
ABSTRACT: The objective of this study was to explore the substitution of ractopamine by coconut or safflower oil in finishing pig diets. The study included 24 crossbred barrows weighing 78.00 ± 8.76 kg distributed in a randomized block design with four treatments and six replicates composed of: basal ration (BR), BR + 10 ppm ractopamine, BR + four 1 g capsules of safflower oil, and BR + four 1 g capsules of coconut oil. Performance evaluation showed that safflower oil, ractopamine, and coconut oil supplementation had a significant effect (P &lt; 0.05) on weight gain and feed conversion. Carcass-related variables were also affected by the treatments (P &lt; 0.05), with fat thickness 3 (FT3) reduced by the use of safflower oil, ractopamine, and coconut oil....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Β-adrenergic; Fat deposition; Lipid metabolism; Vegetable oils.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782020000600651