Consulta: subjectFacets:"Lipodystrophy"
Registros recuperados: 9
Data/hora: 29/05/2024 02:37:51

Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome
Provedor de dados: Genetics and Molecular Biology
Autores: Tagliari,Carmela Farias da Silva; de Oliveira,Cáren Nunes; Vogel,Greice Meyer; da Silva,Patrícia Baptista; Linden,Rafael; Lazzaretti,Rosmeri Kuhmmer; Notti,Regina Kuhmmer; Sprinz,Eduardo; Mattevi,Vanessa Suñé.
Abstract HIV-infected individuals on chronic use of highly active antiretroviral therapy (HAART) are more likely to develop adipose tissue and metabolic disorders, such as lipodystrophy (LD) and metabolic syndrome (MetS). The development of these phenotypes is known to be multifactorial. Thus, variants in genes implicated in adipogenesis and lipid metabolism may increase susceptibility to LD and MetS. Sirtuin 1 (SIRT1) may influence the outcome of these disturbances due to its role in the regulation of transcription factors involved in energy regulation. Therefore, we genotyped four polymorphisms located in SIRT1 (rs2273773 T&gt;C, rs12413112 G&gt;A, rs7895833 A&gt;G, rs12049646 T&gt;C) in 832 HIV-infected patients receiving HAART by real-time polymerase...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Lipodystrophy; Metabolic syndrome; Sirtuin 1.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100105

Cytokine profile and clinical metabolic alterations in HIV-1 infected individuals with and without lipodistrophy
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Pontes-Cardoso,L. C. R.; Souza,L. R.; Peraçoli,M. T. S.; Pereira,P. C. M.
The extensive use of Highly Active Antiretroviral Therapy (HAART) has transformed HIV infection into a chronic condition. Thus, metabolic alterations including lipodystrophy and dyslipidemia have been associated with the use of such medications. The objective of the present study was to analyze clinical metabolic alterations and the profile of TNF-alpha, IFN-Y, IL-2, IL-10, and TNF-alpha type II soluble receptor in serum of HIV-1 individuals with and without lipodystrophy. Eighty-four adults were evaluated, 42 males and 42 females, mean age 37 years, and HAART time of at least 15 months. Two groups were formed, G1: 42 individuals with lipodystrophy, and G2: 42 without lipodistropy. From the HAART used, stavudine was more associated with the lipodystrophy...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lipodystrophy; HIV-1; Hypertriglyceridemia; Cytokines.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000200009

Lipid profile and body composition of HIV-1 infected patients treated with highly active antiretroviral therapy
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Pontes,L. C. R.; Carvalho,L. R.; Souza,L. R.; Trindade,E. B. S. M.; Pereira,P. C. M.
Highly active antiretroviral therapy (HAART) has been associated with the development of a clinical group and metabolic disorders such as peripheral lipodystrophy syndrome in AIDS. The aim of this study was to analyze the lipid profile, the clinical aspects, and the body composition of HIV-1 infected individuals treated with or without protease inhibitor (PI) during the highly active antiretroviral therapy. In total, 62 individuals were evaluated in this study; 15 healthy individuals (Control Group: CG), 11 HIV-1 infected individuals treated without antiretroviral therapy (Group 1: G1), 14 HIV-1 infected individuals treated with antiretroviral therapy plus protease inhibitor (Group 2: G2), and 22 HIV-1 infected individuals treated with antiretroviral...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lipodystrophy; HIV-1; Highly active antiretroviral therapy; Dyslipidemia; Hypertriglyceridemia.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000200006

Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Alves,Crésio; Oliveira,Ana Cláudia; Brites,Carlos.
The introduction of highly active antiretroviral therapy (HAART) for the treatment of acquired immunodeficiency syndrome (AIDS) has resulted in greater survival of patients infected with the human immunodeficiency virus (HIV). However, the use of these drugs has been associated with lipodystrophic syndrome (LS), which is characterized by metabolic alterations (dyslipidemia, insulin resistance, diabetes, and lactic acidosis) and abnormal corporal fat distribution. Clinically, LS may manifest as three different forms: lipohipertrophy (accumulation of fat in the central part of the body), lipoatrophy (loss of fat in the extremities, face and buttocks) and mixed (lipohipertrophy + lipoatrophy). Although its physiopathology has not been elucidated, some...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Lipodystrophy; Highly active antiretroviral treatment; Children and adolescents.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400018

Clinical and biochemical evaluation of HIV-related lipodystrophy in an ambulatory population from the Hospital Universitário Cassiano Antonio de Morais, Vitória, ES, Brazil
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Monnerat,Bruno Zanotelli; Cerutti Junior,Crispim; Caniçali,Sheila Cristina; Motta,Tânia Reuter.
We designed a retrospective cohort study to identify factors associated with HIV-1 related lipodystrophy at a tertiary HIV-care center in Vitória, ES, Brazil. Inclusion criteria were documented HIV diagnosis, anti-retroviral therapy and age above 17 years. Highly active antiretroviral therapy (HAART) was initially the exposure variable, but a second analysis was also performed, as a nested case-control, based on the presence or absence of lipodystrophy. Use of protease inhibitors (PI) was associated with an increase in serum triglycerides (243.7 ± 189 mg/dL vs. 172.7 ± 131 mg/dL, p = 0.015), but not of total cholesterol (TC) or HDL fraction levels. Non-nucleoside reverse transcriptase inhibitors (NNRTI) were associated with an increase in serum TC (180.6 ±...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lipodystrophy; Dyslipidemia; Brazil; AIDS; ARV therapy; Cohort study.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400002

Prevalence of lipodystrophy and risk factors for dyslipidemia in HIV-infected children in Brazil
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Papi,Luanda; Menezes,Ana Carolina G.B.; Rocha,Hélio; Abreu,Thalita F.; Oliveira,Ricardo Hugo de; Frota,Ana Cristina C.; Evangelista,Lucia de A.; Hofer,Cristina B.
The aim of present study was to describe the frequency of lipodystrophy syndrome associated with HIV (LSHIV) and factors associated with dyslipidemia in Brazilian HIV infected children. HIV infected children on antiretroviral treatment were evaluated (nutritional assessment, physical examination, and laboratory tests) in this cross-sectional study. Univariate analysis was performed using Mann-Whitney test or Fisher's exact test followed by logistic regression analysis. Presence of dyslipidemia (fasting cholesterol &gt;200 mg/dl or triglycerides &gt;130 mg/dl) was the dependent variable. 90 children were enrolled. The mean age was 10.6 years (3-16 years), and 52 (58%) were female. LSHIV was detected in 46 children (51%). Factors independently associated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Lipodystrophy; Dyslipidemia; Children.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400394

Body composition and lipodystrophy in prepubertal HIV-infected children
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Palchetti,Cecilia Zanin; Patin,Rose Vega; Gouvêa,Aída de Fátima Thomé Barbosa; Szejnfeld,Vera Lúcia; Succi,Regina Célia de Menezes; Oliveira,Fernanda Luisa Ceragioli.
OBJECTIVE: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. METHODS: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care Center of the Division of Pediatric Infectious Diseases - Universidade Federal de São Paulo, São Paulo city, Brazil, was carried out from August to December 2008. Age, clinical and immunological status, prophylaxis, transmission and highly active antiretroviral therapy were recorded. Body mass index z-score and height-for-age z-score were calculated to characterize the nutritional status. Circumferences were measured with flexible tape and skinfolds were assessed by an adipometry. Fat mass and lean mass were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Child; Lipodystrophy; Body composition; Anthropometry.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100001

Antiretroviral therapy-associated dyslipidemia in patients from a reference center in Brazil
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Ceccato,M.G.B.; Bonolo,P.F.; Souza Neto,A.I.; Araújo,F.S.; Freitas,M.I.F.
The aim of this study was to determine the impact of antiretroviral therapy on the lipid profile of human immunodeficiency virus (HIV) patients before and after the initiation of highly active antiretroviral therapy (HAART). This was a cross-sectional analysis of patients receiving HAART at a reference center in Belo Horizonte, Brazil, on the basis of medical records from 2002 to 2006. Patients were included if they had at least one lipid test or a clinical or laboratory diagnosis of dyslipidemia/lipodystrophy. Among the 692 patients, 620 met the eligibility criteria. The majority were males (66.5%), middle age (average 39 years), had a low educational level (60.4%), and low income (51.0%). HAART duration ranged from 11 days to 4.6 years, with a mean of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiretroviral therapy; Dyslipidemia; Lipodystrophy; Management.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011001100015

Cardiovascular complications and increased levels of circulating modified low density lipoprotein in HIV patients and patients with lipodystrophy
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Ronchini,K.R.O.M.; Duarte,A.J.S.; Casseb,J.S.R.; Gidlund,M.
The introduction of highly active antiretroviral therapy (HAART) for patients infected with HIV has significantly prolonged the life expectancy and to some extent has restored a functional immune response. However, the premature introduction of HAART has led to a significant and alarming increase in cardiovascular complications, including myocardial infarction and the appearance of abnormal distribution of body fat seen as lipodystrophy. One key element in the development of ischemic coronary artery disease is the presence of circulating and tissue-fixed modified low density lipoprotein (mLDL) that contributes to the initiation and progression of arterial lesions and to the formation of foam cells. Even though not completely elucidated, the most likely...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Oxidized LDL; Modified low density lipoprotein; Lipodystrophy; Coronary artery disease.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100016