Consulta: subjectFacets:"Mechanism of action"
Registros recuperados: 6
Data/hora: 08/06/2024 09:31:48

An intimate link between antimicrobial peptide sequence diversity and binding to essential components of bacterial membranes
Provedor de dados: 5
Autores: Schmitt, Paulina; Rosa, Rafael D.; Destoumieux-garzon, Delphine.
Antimicrobial peptides and proteins (AMPs) are widespread in the living kingdom. They are key effectors of defense reactions and mediators of competitions between organisms. They are often cationic and amphiphilic, which favors their interactions with the anionic membranes of microorganisms. Several AMP families do not directly alter membrane integrity but rather target conserved components of the bacterial membranes in a process that provides them with potent and specific antimicrobial activities. Thus, lipopolysaccharides (LPS), lipoteichoic acids (LTA) or the peptidoglycan precursor Lipid II are targeted by a broad series of AMPs. Studying the functional diversity of immune effectors tells us about the essential residues involved in AMP mechanism of...
Tipo: Text
Palavras-chave: Functional diversity; Defensin; Anti-lipopolysaccharide factor; Mechanism of action; Resistance.
Ano: 2016
URL: http://archimer.ifremer.fr/doc/00286/39710/38165.pdf

Ergosterol isolated from the basidiomycete Pleurotus salmoneostramineus affects Trypanosoma cruzi plasma membrane and mitochondria
Provedor de dados: 80
Autores: Alexandre,Tatiana Rodrigues; Lima,Marta Lopes; Galuppo,Mariana Kolos; Mesquita,Juliana Tonini; Nascimento,Matilia Ana do; Santos,Augusto Leonardo dos; Sartorelli,Patricia; Pimenta,Daniel Carvalho; Tempone,Andre Gustavo.
Abstract  Background  Major drawbacks of the available treatment against Chagas disease (American trypanosomiasis) include its toxicity and therapeutic inefficiency in the chronic phase of the infection, which makes it a concern among neglected diseases. Therefore, the discovery of alternative drugs for treating chronic Chagas disease requires immediate action. In this work, we evaluated the mushroom Pleurotus salmoneostramineus in the search for potential antiparasitic compounds.  Methods  Fruit bodies of the basidiomycete Pleurotus salmoneostramineus were triturated and submitted to organic solvent extraction. After liquid-liquid partition of the crude extract, three fractions were obtained and the bioguided fractionation study was conducted to isolate...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pleurotus salmoneostramineus; Ergosterol; Trypanosoma cruzi; Mechanism of action.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100313

Poison as cure: a clinical review of botulinum toxin as an invaluable drug
Provedor de dados: 80
Autores: Bali,J.; Thakur,R.
Botulinum toxin is the most potent toxin known. It is readily absorbed from mucosal surfaces. If dispersed as an aerosol or mixed in the food or water it can lead to a large outbreak of botulism. The disease presents as a symmetric descending paralysis in an afebrile patient. Cranial nerve involvement with diplopia, dysarthria, dysphonia, dysphagia and respiratory paralysis is seen after a variable incubation period. The treatment is mainly supportive. The source of the toxin is Clostridium botulinum, an anaerobic gram-positive spore-forming organism. Some other species of Clostridium like C. butyricum and C. baratii also produce the toxin. The toxin is heat labile and can be inactivated by heating at 100°C for 10 minutes. The toxin acts at the peripheral...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Botulinum toxin; Mechanism of action; Botulism; Therapeutics.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000400003

Use of Herbicides in Sugarcane in the São Paulo State
Provedor de dados: 87
Autores: REIS,F.C.; VICTÓRIA FILHO,R.; ANDRADE,M.T.; BARROSO,A.A.M.
ABSTRACT: Sugarcane is one of the main agricultural cultivations of Brazil, and one of the crops in which herbicides are most applied. In the 2017/2018 season, the estimated sugarcane production was 694.54 million tons, with an estimated increase of 0.9% in yield for this season. In order to evaluate the use of herbicides in this crop in the São Paulo State during a five-year period, a survey was carried out with sugarcane farmers. The use of herbicides applied alone and in a formulated mixture, according to their mechanism of action, were evaluated from 2010 to 2014. Photosystem II inhibitor herbicides were the most used in this period and the total amount of herbicides of almost all mechanism of action increased from 2010 to 2014, except for photosystem...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Marketing; Mechanism of action; Research; Pesticides; Saccharum officinarum.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582019000100262

An alternative for antibiotic se in poultry: probiotics
Provedor de dados: 89
Autores: Edens,FW.
Over the past 50 years, there has been increasing amounts of antibiotics used prophylactically and as growth promoters. Today, there is a consumer and governmental outcry to eliminate that practice from poultry and livestock production. Evidence has been accumulated to show that there is a link between risk of zoonotic disease and growth promoting antibiotic usage in livestock and poultry. Therefore, alternatives to the use of growth promoting antibiotics must be found to promote growth or production at or near the genetic potential of the modern day broiler, turkey, and egg producer. The use of probiotics has many potential benefits and include modified host metabolism, immuno-stimulation, anti-inflammatory reactions, exclusion and killing of pathogens in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antibiotics; Antibiotic resistance; Benefits; Characteristics; Chickens; Defined culture; Functions; History; Human health risk; Mechanism of action; Probiotics; Turkeys; Undefined culture; Zoonotic disease.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2003000200001

Prebiotic inulin: Useful dietary adjuncts to manipulate the livestock gut microflora
Provedor de dados: 58
Autores: Samanta,A.K.; Jayapal,Natasha; Senani,S.; Kolte,A.P.; Sridhar,Manpal.
In recent years, there has been a growing appreciation on the relevance of gastrointestinal microflora in both ruminants and non-ruminants owing to revelation of their role in several physiological functions including digestion, nutrient utilization, pathogen exclusion, gastrointestinal development, immunity system, gut gene expression and quality of animal products. The ban imposed on the use of antibiotics and hormones in feed has compelled animal researchers in finding an alternative which could overcome the issues of conventional feed additives. Though the concept of prebiotic was evolved keeping in mind the gastrointestinal flora of human beings, presently animal researchers are exploring the efficiency of prebiotic (inulin) for modulating the gut...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Prebiotic; Inulin; Mechanism of action; Livestock.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000100001