Consulta: subjectFacets:"Metabolic disease"
Registros recuperados: 4
Data/hora: 10/06/2024 04:52:41

Animal Models of Nutritional Induction of Type 2 Diabetes Mellitus
Provedor de dados: 77
Autores: Barbosa-da-Silva,Sandra; Sarmento,Isabele Bringhenti; Bargut,Thereza C. Lonzetti; Souza-Mello,Vanessa; Aguila,Marcia Barbosa; Mandarim-de-Lacerda,Carlos A.
Type 2 diabetes mellitus (DM2) is the most common chronic metabolic disease, affecting approximately 6% of the adult population in the Western world. This condition is a major cause of cardiovascular disease, blindness, renal failure, and amputations, with increasing prevalence worldwide. The inuence of obesity on type 2 diabetes risk is determined by the degree of obesity and by body fat localization, with insulin resistance (IR) being the main link between these metabolic diseases. Experimental studies have shown that dietary factors, and particularly lipids, are strongly positively associated with body mass (BM) gain; IR; and, consequently, type 2 diabetes. Similarly, excessive consumption of energy-dense carbohydrate-rich foods can trigger the onset of...
Tipo: Journal article
Palavras-chave: Animal models; Nutritional induction; Metabolic disease; Type 2 diabetes mellitus.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100046

Presence of ascites in bullfrog breeders reared and kept on a frog farm
Provedor de dados: 45
Autores: Seixas Filho,J.T.; Santana,A.C.; Martins,A.C.P.F.; Mesquita,E.F.M.; Mello,S.C.R.P.; Hipolito,M.
ABSTRACT Ascites is a pathology characterized by the extravasation of fluid from blood vessels and its accumulation in the abdominal cavity, caused by several associated factors. In this paper, we report the occurrence of this syndrome in breeding male and female Bullfrogs fed a commercial fish feed with 40% crude protein. Liver malformation was already observed due to lack of protein deposition in adult animals from the same spawning. The culture of ascitic fluid showed absence of bacterial growth. Kidney histopathology showed, in both sexes, a large number of tubular structures with strongly eosinophilic hyaline material suggesting colloid growth in both the cortical region and spinal cord. The analysis also revealed granulomas in various stages of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Captive breeding; Feeding; Histopathology; Metabolic disease; Lithobates catesbeianus.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352019000601955

Bradykinin, insulin, and glycemia responses to exercise performed above and below lactate threshold in individuals with type 2 diabetes
Provedor de dados: 56
Autores: Asano,R.Y.; Browne,R.A.V.; Sales,M.M.; Arsa,G.; Moraes,J.F.V.N.; Coelho-Júnior,H.J.; Moraes,M.R.; Oliveira-Silva,I.; Atlas,S.E.; Lewis,J.E.; Simões,H.G.
The aim of this study was to analyze the acute responses of bradykinin, insulin, and glycemia to exercise performed above and below lactate threshold (LT) in individuals with type 2 diabetes mellitus (T2D). Eleven participants with a diagnosis of T2D randomly underwent three experimental sessions 72 h apart: 1) 20 min of exercise performed at 120% of LT (120%LT), 2) 20 min of exercise performed at 80% of LT (80%LT), and 3) 20 min of control session. Blood glucose was analyzed before, during, and at 45 min post-exercise. Bradykinin and insulin were analyzed before and at 45 min post-exercise. Both exercise sessions elicited a parallel decrease in glucose level during exercise (P≤0.002), with a greater decrease being observed for 120%LT (P=0.005). Glucose...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Metabolic disease; Aerobic exercise; Peptide; Insulin resistance.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001100607

Successful domino liver transplantation in maple syrup urine disease using a related living donor
Provedor de dados: 56
Autores: Feier,F.H.; Miura,I.K.; Fonseca,E.A.; Porta,G.; Pugliese,R.; Porta,A.; Schwartz,I.V.D.; Margutti,A.V.B.; Camelo Jr,J.S.; Yamaguchi,S.N.; Taveira,A.T.; Candido,H.; Benavides,M.; Danesi,V.; Guimaraes,T.; Kondo,M.; Chapchap,P.; Neto,J. Seda.
Maple syrup urine disease (MSUD) is an autosomal recessive disease associated with high levels of branched-chain amino acids. Children with MSUD can present severe neurological damage, but liver transplantation (LT) allows the patient to resume a normal diet and avoid further neurological damage. The use of living related donors has been controversial because parents are obligatory heterozygotes. We report a case of a 2-year-old child with MSUD who underwent a living donor LT. The donor was the patient's mother, and his liver was then used as a domino graft. The postoperative course was uneventful in all three subjects. DNA analysis performed after the transplantation (sequencing of the coding regions of BCKDHA, BCKDHB, andDBT genes) showed that the MSUD...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Heterozygous donor; Metabolic disease; Branched-chain ketoacid dehydrogenase mutation; Leucine; Genotype.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000600522