Consulta: subjectFacets:"Metastatic colorectal cancer"
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Data/hora: 16/06/2024 06:21:13

Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer
Provedor de dados: 56
Autores: Erkasap,N.; Ozkurt,M.; Erkasap,S.; Yasar,F.; Uzuner,K.; Ihtiyar,E.; Uslu,S.; Kara,M.; Bolluk,O.
The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases) and metastatic colon (13 cases) cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA) and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR) for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leptin; Colorectal cancer; Metastatic colorectal cancer; Leptin receptor (Ob-R); Real-time PCR.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300306