Consulta: subjectFacets:"Metronidazole"
Registros recuperados: 6
Data/hora: 04/06/2024 02:23:08

The bone marrow micronucleus test and metronidazole genotoxicity in different strains of mice (Mus musculus)
Provedor de dados: 74
Autores: Abrevaya,Ximena C.; Carballo,Marta A.; Mudry,Marta D.
The mouse (Mus musculus) bone marrow micronucleus test was carried out using 24 outbred National Institutes of Health (NIH) mice, 24 inbred Swiss Webster (CFW) mice and 20 inbred Bagg albino/color locus Jackson (BALB/cJ) mice. The mice in the experimental group (n = 32) were injected intraperitoneally with 133 mg kg-1 of metronidazole parenteral solution and the control group consisted of mice (n = 36) which had not been injected with metronidazole. There was no significant difference (p &gt; 0.05) between the sexes regarding the micronucleus frequency in either the experimental or the control group. When the Mn frequencies of the three strains were compared, the results for the CFW and BALB/cJ strains did not differ statistically (p &gt; 0.05) for either...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: BALB/cJ; Bone marrow micronucleus test; CFW; Genotoxicity; Metronidazole; NIH.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000600018

Trichomoniasis in Bothrops jararaca (serpentes, viperidae)
Provedor de dados: 80
Autores: Vilela,F. C.; Silva,M. G. da; Barrella,T. H.; Silva,R. J. da.
We describe a case of trichomoniasis in a Bothrops jararaca (Serpentes, Viperidae) donated to the Center for the Study of Venoms and Venomous Animals - CEVAP/UNESP. The animal had diarrhea with great quantity of flagellated protozoa in the feces. Microscopic examination of fecal smears stained with Giemsa revealed the presence of trichomonads, morphologically similar to Trichomonas acosta. Trichomonads were not detected in fecal exams after treatment with a single dose of 40 mg/kg metronidazole (Flagyl®).
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trichomoniasis; Trichomonas sp.; Bothrops jararaca; Treatment; Metronidazole.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992003000100007

THE RADIO SENSITIZING EFFECT OF METRONIDAZOLE IN MAIZE
Provedor de dados: 53
Autores: VICCINI,LYDERSON FACIO; SARAIVA,LUIZ SÉRGIO; ALMEIDA FILHO,JOSÉ DE; CRUZ,COSME DAMIÃO; ANDRADE,ROGÉRIO ALVAREZ DE.
The identification of chemical substances which increase the efficiency of radiation is important to make easier the obtention of plants with structural chromosome aberrations which may be used in an alternative program for hybrid maize production. The present work was carried out to investigate the effect of the chemical substance metronidazole in maize seedlings submitted to gamma radiation. Several treatments were done, soaking the seeds in solutions with varied concentrations of the active substance combined with solution filtration and gamma radiation. On the third day of the experiment, germination percentage, root and stem lengths were evaluated. At a high concentration (1,250 mg/50 mL) metronidazole behaved as a radiosensibilizer in the presence of...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Corn; Zea mays; Gamma radiation; Metronidazole.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0006-87051997000200004

A meta-analysis of metronidazole and vancomycin for the treatment of Clostridium difﬁcile infection, stratiﬁed by disease severity
Provedor de dados: 55
Autores: Di,Xiuzhen; Bai,Nan; Zhang,Xin; Liu,Bin; Ni,Wentao; Wang,Jin; Wang,Kai; Liang,Beibei; Liu,Youning; Wang,Rui.
The aim of this meta-analysis was to compare the efﬁcacy of metronidazole and vancomycin for the treatment of Clostridium difﬁcileinfection, especially to investigate which agent was superior for treating either mild or severe C. difﬁcileinfection. A meta-analysis of randomized controlled trials and cohort studies identiﬁed in Pubmed, Embase, and the Cochrane Library was conducted. Four randomized controlled trials and two cohort studies involving 1218 patients were included in this meta-analysis. Metronidazole was inferior to vancomycin for treating C. difﬁcileinfection in terms of both initial clinical cure rates (risk ratio, RR = 0.91, 95% conﬁdence interval, CI = 0.84-0.98, p= 0.02) and sustained cure rates (RR = 0.88, 95% CI = 0.82-0.96, p= 0.003)....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Clostridium difﬁcile; Clostridium difﬁcileinfection (CDI); Vancomycin; Metronidazole.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400339

Plasma hydroxy-metronidazole/ metronidazole ratio in hepatitis C virus-induced liver disease
Provedor de dados: 56
Autores: Marchioretto,M.A.M.; Ecclissato,C.; Silva,C.M.F. da; Cassiano,N.M.; Calafatti,S.A.; Mendonça,S.; Ribeiro,M.L.; Bernasconi,G.C.R.; Degger,M.F.; Piovesan,H.; Pedrazzoli Jr.,J.
It has been suggested that the measurement of metronidazole clearance is a sensitive method for evaluating liver function. The aim of this study was to evaluate the usefulness of plasma hydroxy-metronidazole/metronidazole ratios as indicators of dynamic liver function to detect changes resulting from the various forms of chronic hepatitis C virus (HCV) infection. A total of 139 individuals were studied: 14 healthy volunteers, 22 healthy, asymptomatic, consecutive anti-HCV-positive HCV-RNA negative subjects, 81 patients with chronic hepatitis C (49 with moderate/severe chronic hepatitis and 34 with mild hepatitis), and 20 patients with cirrhosis of the liver. HCV status was determined by the polymerase chain reaction. Plasma concentrations of metronidazole...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Metronidazole; Liver function; Hepatitis C; Cytochrome P450.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000300015

Effect of stearic acid on the properties of metronidazole/methocel K4M floating matrices
Provedor de dados: 60
Autores: Lara-Hernández,Belem; Hernández-León,Alejandra; Villafuerte-Robles,Leopoldo.
The properties of metronidazole/Methocel K4M sustained release floating tablets have been studied varying the proportion of the lubricant, stearic acid, on formulations with and without sodium bicarbonate. The variables studied include technological properties of the tablets such as tablet hardness and ejection pressure, the drug release profile, the hydration kinetics and the floating behaviour. The presence of stearic acid and sodium bicarbonate improves the floating behaviour for more than 8 hours. The hydration volume, the tablet hardness and the ejection pressure decrease as the stearic acid content increases and the polymer content decreases. Drug dissolution increases with increasing proportions of stearic acid and decreasing proportions of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Metronidazole; Methocel K4M; Stearic acid; Matrices hydration; Gastric retention; Sodium bicarbonate; Sustained release; Drugs/release mechanism.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300016