Consulta: subjectFacets:"Neglected diseases"
Registros recuperados: 2
Data/hora: 03/06/2024 02:19:25

Second-generation pterocarpanquinones: synthesis and antileishmanial activity
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Faiões,Viviane dos Santos; Frota,Lívia C. R. M. da; Cunha-Junior,Edézio Ferreira; Barcellos,Julio C. F.; Silva,Thayssa Da; Daher Netto,Chaquip; Da-Silva,Silvia Amaral Gonçalves; Silva,Alcides J. M. da; Costa,Paulo R. R.; Torres-Santos,Eduardo Caio.
Abstract  Background: Despite the development of new therapies for leishmaniasis, among the 200 countries or territories reporting to the WHO, 87 were identified as endemic for Tegumentary Leishmaniasis and 75 as endemic for Visceral Leishmaniasis. The identification of antileishmanial drug candidates is essential to fill the drug discovery pipeline for leishmaniasis. In the hit molecule LQB-118 selected, the first generation of pterocarpanquinones was effective and safe against experimental visceral and cutaneous leishmaniasis via oral delivery. In this paper, we report the synthesis and antileishmanial activity of the second generation of pterocarpanoquinones.  Methods: The second generation of pterocarpanquinones 2a-f was prepared through a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmania; Pterocarpanquinone; LQ-118; Phenotypic assay; Leishmaniasis; Drug discovery; Neglected diseases.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100325

Detection and differentiation of Entamoeba histolytica and Entamoeba dispar in clinical samples through PCR-denaturing gradient gel electrophoresis
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: López-López,P.; Martínez-López,M.C.; Boldo-León,X.M.; Hernández-Díaz,Y.; González-Castro,T.B.; Tovilla-Zárate,C.A.; Luna-Arias,J.P.
Amebiasis is one of the twenty major causes of disease in Mexico; however, the diagnosis is difficult due to limitations of conventional microscopy-based techniques. In this study, we analyzed stool samples using polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) to differentiate between Entamoeba histolytica (pathogenic) and E. dispar (non-pathogenic). The target for the PCR amplification was a small region (228 bp) of the adh112 gene selected to increase the sensitivity of the test. The study involved 62 stool samples that were collected from individuals with complaints of gastrointestinal discomfort. Of the 62 samples, 10 (16.1%) were positive for E. histolytica while 52 (83.9%) were negative. No sample was positive for E....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Amebiasis; Neglected diseases; Diagnostic; PCR; DGGE; Adh112 gene.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000400607