Consulta: subjectFacets:"Neoplasm"
Registros recuperados: 18
Data/hora: 06/06/2024 05:39:40

Alterações histológicas em placas ósseas do peixe cascudo Rineloricaria strigilata (Hensel) (Teleostei, Loricariidae) e sua freqüência no lago Guaíba, Rio Grande do Sul, Brasil
Provedor de dados: Zoologia
Autores: Flores-Lopes,Fábio; Malabarba,Luiz R.; Pereira,Edson H.L.; Silva,José F. Pezzi da.
Little information is available about natural populations of fishes exposed to polluted waters in Brazil. Contaminants may be lethal or predispose fishes to sickness, being the analysis of aquatic organisms a good indicator of environmental quality. The violinha, Rineloricaria strigilata (Hensel, 1868), is a common loricariid catfish in the Guaíba lake basin, Rio Grande do Sul, Brazil, and has been selected as a bioindicator for being resident, occurring in more than 50% of the samples, and by showing externally detectable neoplasies. These are characterized by its dark pigmentation, bony plates hypertrophy, and hypertrophy and irregular arrangement of the odontodes. Histology showed hypertrophied epitelial tissues, with an increased number of secretory...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rineloricaria strigilata; Bioindicator; Neoplasm.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-81752001000300006

The Complex Link between Apoptosis and Autophagy: a Promising New Role for RB
Provedor de dados: Anais da Academia Brasileira de Ciências
Autores: DELOU,JOÃO M.A.; BIASOLI,DEBORAH; BORGES,HELENA L.
ABSTRACT Physiological processes, as autophagy, proliferation and apoptosis are affected during carcinogenesis. Restoring cellular sensitivity to apoptotic stimuli, such as the antineoplastic cocktails, has been explored as a strategy to eliminate cancer cells. Autophagy, a physiological process of recycling organelles and macromolecules can be deviated from homeostasis to support cancer cells survival, proliferation, escape from apoptosis, and therapy resistance. The relationship between autophagy and apoptosis is complex and many stimuli can induce both processes. Most chemotherapeutic agents induce autophagy and it is not clear whether and how this chemotherapy-induced autophagy might contribute to resistance to apoptosis. Here, we review current...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Retinoblastoma; Neoplasm; Autophagy; Cell death; Antineoplastic agents.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602257

Spindle cell sarcoma in Bothrops leucurus
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Marcello Jr.,H. B.; Maciel,R.; Ribeiro,C.A.; Caliari,M.V.; Cassali,G.D.
O presente relato descreve os achados anatomopatológicos de uma neoplasia maligna em jararaca (Bothrops leucurus), mantida em cativeiro durante sete anos. O animal apresentava massa nodular subcutânea localizada no lado direito do terço anterior. O exame histológico revelou tratar-se de neoplasia mesenquimal maligna, permitindo o diagnóstico de sarcoma fusocelular.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bothrops; Sarcoma; Neoplasm; Immunohistochemistry.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352002000300018

DNA flow cytometry of canine mammary tumors: comparative aspects with human breast tumors
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Cassali,G.D.; Salvador,A.; Freitas,C.; Dutra,A.P.; Schmitt,F.C.
Flow cytometric analysis of DNA content was performed on 28 samples of canine mammary tumors. Nine of them were benign and 19 were malignant. All benign tumors and 11 malignant tumors (57.9%) were diploid (P&lt;0.05). Form the aneuploid tumors, five (26.3%) were hyperdiploid, one (5.3%) hypodiploid, one (5.3%) near triploid and one (5.3%) multiploid. The analysis of the expression of the markers PR and CD31 revealed a significant difference between diploid and aneuploid tumors (P&lt;0.05). The immunoreactivity of PR was higher in diploid tumors, while the immunoreactivity of CD31 was stronger in aneuploid tumors. No difference between the markers MIB-1, c-erbB2, p53 and Cyclin D1 was observed (P&gt;0.05). Using the flow cytometry analysis and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dog; Breast cancer; Neoplasm; DNA flow cytometry; Immunohistochemistry.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000500011

Association of nucleolar organizing regions and Ki-67 expression with recurrence rate of hair follicle tumor in dogs
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Souza,P.C.; Ocarino,N.M.; Tavares,W.L.F.; Boeloni,J.N.; Cassali,G.D.; Serakides,R.
Mitotic index, nuclear diameter, number of nucleolar organizing regions, and Ki-67 expression, in hair follicle tumors of 82 dogs were evaluated. Tissue specimens were used to prepare sections for histological staining for number of nucleolar organizing region and immunohistochemical staining for Ki-67. Tumors were classified as trichoblastoma (n=32), benign trichoepithelioma (n=30), pilomatricoma (n=7), malignant trichoepithelioma (n=6), infundibular keratinizing acanthoma (n=5), and tricholemmoma (n=2). Head, dorsum, and limbs were the most affected sites. Malignant trichoepithelioma presented significantly higher mitotic index, number of nucleolar organizing regions and Ki-67 expression. Regarding benign neoplasms, trichoblastoma presented significantly...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dog; Neoplasm; AgNOR; Hair follicle; Ki-67.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352008000500006

Analysis of EGFR and HER-2 expressions in ductal carcinomas in situ in canine mammary glands
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Silva,I.L.D.; Dias,A.P.M.; Bertagnolli,A.C.; Cassali,G.D.; Ferreira,E.
Biomolecular evidence has shown that ductal carcinoma in situ(DCIS) may develop into invasive carcinoma of the canine mammary gland, and mutations in proto-oncogenes HER2 and EGFR; two members of the family of epidermal growth factor receptors, may be involved in this process. The purpose of this study was the characterization of the immunohistochemical expression of the EGFR and HER2 proteins in the process of neoplastic transformation, supposedly present in ductal carcinomas in situin canine mammary glands. Fifteen cases of DCIS were evaluated, with a higher expression of HER2 and EGFR being observed in low-grade carcinomas when compared with high-grade neoplasms, and with a high positive statistical correlation in the latter. Results suggest that...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dog; Neoplasm; Immunohistochemistry; EGFR; CerbB2.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000300763

Detection of mutations within exons 4 to 8 of the p53 tumor suppressor gene in canine mammary glands
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Souza,D.M.B.; Barros,M.G.O.; Silva,J.S.C.; Silva,M.B.; Coleto,Z.F.; Jimenez,G.C.; Adrião,M.; Wischral,A.
Fifteen female canines with mammary tumors and 6 normal females were used to study mutations in exons 4 to 8 of the p53 gene. DNA samples from the tumors, respective adjacent normal mammary tissue and mammary glands from healthy animals were sequenced and analyzed for the presence of mutations. Mutations were found in 71.8% of the samples and the most frequent were missense mutations. The most attacked exons in the mammary tumor were 5, 7 and 8, with 23.4, 31.6 and 23.4% mutations, respectively. Canine mammary tumors are related to mutations in gene p53 and mutations mostly occur in the region of the protein that is linked to the DNA in the cell nucleus, which can change the functionality of the cell and propitiate tumor growth. Despite being...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bitch; DNA; Mamma; Molecular biology; Neoplasm; PCR.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000200013

Squamous cell carcinoma (Bowen’s disease) in situ in three cats
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Conceição,L.G.; Camargo,L.P.; Costa,P.R.S.; Kuwabara,D.A.; Fonterrada,C.O.
Três casos de carcinoma multicêntrico in situ de células escamosas (doença de Bowen) são descritos na espécie felina. As neoplasias ocorreram em gatos idosos e acometeram a região pré-auricular, cervical, abdominal e flancos. Um gato apresentou lesão única e os demais apresentaram lesões multifocais, que se caracterizaram por placas que variavam de hiperceratóticas a verruco-crostosas e eram hiperpigmentadas. Algumas eram ulceradas, com fissuras que sangravam facilmente. Histologicamente, as células neoplásicas encontravam-se confinadas à epiderme e aos folículos pilosos, sem o envolvimento da membrana basal. Em um dos casos houve melhora significativa das lesões após terapia oral com acitretina.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cat; Neoplasm; Multicentric squamous cell; Bowen’s disease; Dermatosis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352007000300039

Cytological and histopathological aspects of lipomas in Bothrops moojeni
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Cassali,G.D.; Amaral,V.F.; Silva,A.E.; Macri,I.; Maciel,R.
O presente relato descreve os achados citológicos e histológicos de seis neoplasias benignas em cinco ofídios da espécie Bothrops moojeni mantidas em cativeiro por um período médio de 11,4 anos. Os animais apresentavam nódulos subcutâneos com localização variada desde o terço anterior até a porção mediana. Os exames citológico e histopatológico revelaram tratar-se de tumores lipomatosos benignos compatíveis com o subtipo lipoma fusocelular.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bothrops moojeni; Lifoma; Tumor; Neoplasm.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352004000600017

Gemistocytic astrocytoma in the spinal cord in a dog: a case report
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Chaves,R.O.; Bazzi,T.; Copat,B.; Feranti,J.P.S.; Müller,D.C.M.; Corrêa,L.F.D.; Fighera,R.A.; Mazzanti,A.
ABSTRACT This paper reports a case of a rare variant of the cervical spinal cord astrocytoma diagnosed in a dog with progressive neurological signs, initially asymmetrical, not ambulatory tetraparesis, segmental reflexes and normal muscle tone in all four limbs and absence of pain upon palpation of the cervical spine. Myelography revealed attenuation of the ventral and dorsal contrast line in the third region of the fifth cervical vertebra. At necropsy intramedullary cylindrical mass that stretched from the third to the sixth cervical vertebra, which replaced all the gray matter of the spinal cord was observed. In the histological study, there was the replacement of the substance by neoplastic cells mantle arranged loosely. The cells were large and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Canine; Neoplasm; Glioma; Spinal cord.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000400901

Subcutaneous administration of ketoprofen delays Ehrlich solid tumor growth in mice
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Souza,C.M.; Auler,P.A.; Reis,D.C.; Lavalle,G.E.; Ferreira,E.; Cassali,G.D.
Ketoprofen, a nonsteroidal anti-inflammatory drug (NSAID) has proven to exert anti-inflammatory, anti-proliferative and anti-angiogenic activities in both neoplastic and non-neoplastic conditions. We investigated the effects of this compound on tumor development in Swiss mice previously inoculated with Ehrlich tumor cells. To carry out this study the solid tumor was obtained from cells of the ascites fluid of Ehrlich tumor re-suspended in physiological saline to give 2.5x106cells in 0.05mL. After tumor inoculation, the animals were separated into two groups (n = 10). The animals treated with ketoprofen 0.1µg/100µL/animal were injected intraperitoneally at intervals of 24h for 10 consecutive days. Animals from the control group received saline. At the end...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Inflammation; Cell proliferation; Ketoprofen; Neoplasm.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352014000501376

Glycogen-rich clear cell carcinoma of the feline mammary gland: case report
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Campos,C.B.; Gamba,C.O.; Damasceno,K.A.; Lavalle,G.E.; Cassali,G.D.
ABSTRACT The aim of this report is to describe the first histopathological, immunohistochemical, and clinical characteristics of a feline glycogen-rich clear cell carcinoma (GRCCC). A Persian queen was admitted with mammary gland tumors and underwent radical unilateral mastectomy. Overall survival was considered 33 days and death was due to clinical evolution of the disease. Microscopic evaluation demonstrated epithelial cells arranged in a predominantly solid pattern, tumor cells presented an ample, granular, and foamy clear cytoplasm, and moderate cellular pleomorfism. The presence of cytoplasmatic glycogen was confirmed through diastase digestion followed by PAS staining. Histopathological and histochemical findings lead to the diagnosis of GRCCC with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Feline; Mammary gland; Neoplasm; Glycogen-rich clear cell carcinoma.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352016000501117

Outcome of adjuvant chemotherapy with lomustine, vinblastine and chlorambucil on management of canine mast cell tumour of high to intermediate risk
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Horta,R.S.; Lavalle,G.E.; Costa,M.P.; Moura,L.L.; Marcinowska,A.; Araújo,R.B.
ABSTRACT In spite of the many available protocols, the use of chemotherapy for the management of canine mast cell tumours (MCT) remains empirical, and there is lack of criteria for the choice of protocol and definition of patients who may benefit from treatment. The objective of this study was to evaluate the outcome of dogs with MCT after adjuvant chemotherapy according to the risk of recurrence or metastasis proposed on the literature. This prospective study included 89 followed up dogs with prognosis assesment including clinical, histological, immunohistochemical and genetic features of canine MCT. Patients were grouped according to risk of recurrence and metastasis and recommended treatment with lomustine followed by chlorambucil if considered at...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dog; Neoplasm; Mast cells; Ki-67; C-kit.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352017000601426

Exploring the shared genes of hypertension, diabetes and hyperlipidemia based on microarray
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: Dong,Wenzhu; Chen,Hangping; Wang,Lu; Cao,Xiaoqian; Bu,Xiawei; Peng,Yan; Dong,Aiqing; Ying,Mengjiang; Chen,Xu; Zhang,Xin; Yao,Li.
Given their relationship with metabolic syndrome and systematic inflammatory diseases, the pathogenesis of hypertension, hyperglycemia, and hyperlipidemia is closely related. To explore the common genes among these three conditions, spontaneous hypertensive rats (SHR), spontaneous diabetic Goto-Kakizaki rats (GK) and hyperlipidemia rats (HMR) were reared for experiments. Gene array was used to identify the genes of SHR, GK and HMR compared with normal Wistar rats using TBtools software. First, real-time PCR was applied to verify these genes, and Cytoscape software was used to construct networks based on the National Center for Biotechnology Information (NCBI) database. Second, Kyoto Encyclopedia of Genes and Genomes (KEGG) database analysis was performed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hypertension; Diabetes; Hyperlipidemia; Genes; Microarray; Neoplasm.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100566

Cutaneous myxoma in a pintagol (Sporagra magellanica X Serinus canaria)
Provedor de dados: Ciência Rural
Autores: Blume,Guilherme Reis; Pereira,Fernanda Mara Aragão Macedo; Reis Júnior,Janildo Ludolf; Sant'Ana,Fabiano José Ferreira de.
Myxomas are benign mesenchymal tumors rarely described in birds. This report describes the clinical and pathological findings in a case of myxoma in a pintagol (Sporagra magellanicaX Serinus canaria). The animal had a nodule on the dorsal region of the third digit on the left hindlimb. Grossly, it was a 0.9×0.5×0.4cm, soft, white nodule, with black and yellow areas on the cut surface. Microscopically, a well-differentiated monomorphic population of spindle cells arranged in an abundant Alcian blue-positive myxoid matrix was observed. The diagnosis of myxoma was based on the microscopic findings
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dermatopathology; Neoplasm; Oncology.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015000901641

Vertebral chondrosarcoma in a blue-fronted parrot (Amazona aestiva)
Provedor de dados: Ciência Rural
Autores: Blume,Guilherme Reis; Oliveira,Ayisa Rodrigues de; Mattioli,Mariana Portugal; Oliveira,Letícia Batelli de; Reis Junior,Janildo Ludolf; Sant'Ana,Fabiano José Ferreira de.
Chondrosarcoma is a malignant mesenchymal tumor in which the neoplastic cells produce cartilaginous matrix and is uncommonly described in birds. This report describes the clinical and pathological findings of one case of chondrosarcoma in a blue-fronted parrot (Amazona aestiva). Macroscopically a 3.6x3.5x1.8cm, nodular, ulcerated, and firm mass was identified in the dorsal synsacrum. Microscopically, the mass was composed of a monomorphic proliferation of pleomorphic spindle chondrocytes with abundant cartilaginous matrix, consistent with chondrosarcoma
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Oncology; Psittacine; Neoplasm.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015000300525

Carcinoid of the gallbladder in two dogs
Provedor de dados: Ciência Rural
Autores: Argenta,Fernando Froner; Pereira,Paula Reis; Bertolini,Marianna; Fratini,Letícia Mendes; Saccaro,Renata de Oliveira; Sonne,Luciana; Driemeier,David; Pavarini,Saulo Petinatti.
ABSTRACT: A carcinoid is a rare neoplasm derived from neuroendocrine cells that may arise in the hepatobiliary system. This report described two cases of carcinoid of the gallbladder in dogs, with emphasis on the clinical, pathological and immunohistochemical aspects. Case 1 was a 10-year-old female Shih Tzu, with a history of prostration and occasional episodes of diarrhea and vomiting. Case 2 was a 10-year-old male Cocker Spaniel, with a history of diarrhea and abdominal pain. Abdominal ultrasonography suggested a neoplasm of the gallbladder in both cases. The dogs underwent cholecystectomy, and 10% formalin-fixed samples were sent for pathological examination. Histologically, a neoplastic proliferation of neuroendocrine cells was observed in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Canine; Neoplasm; Neuroendocrine carcinoma; Immunohistochemistry.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782020000200551

Metastasizing oral melanoma in a cow
Provedor de dados: Ciência Rural
Autores: Brito,Marilene de Farias; França,Ticiana Nascimento; Jabour,Flávia Figueiraujo; Seixas,Josilene Nascimento; Andrade,Gisele Braziliano; Oliveira,Laura Iglesias; Peixoto,Paulo Vargas.
A malignant dendritic melanoma of the oral cavity with metastases widely spread in a cow is described. The clinicopathological manifestations, developed during a two-year period, was characterized by the difficulty in mastication and swallowing, progressive weight loss, weakness and profuse sialorrhea. At the necropsy, an ulcerated black mass was found at the left jaw projecting into the oral cavity. The tumor reached the chin, inferior lip and tongue. Metastases were detected within the tongue, parotid gland, lymph nodes, trachea, thyroid, pleura, lungs, heart, peritoneum, omentum, and serosal membranes of the forestomach and abomasum, liver, and intima of some hepatic vessels, mammary gland, and muscles and fasciae of the left hind leg. No reference to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Oral dendritic melanoma; Cattle; Pathology; Neoplasm.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782009000400045