Consulta: subjectFacets:"PLGA"
Registros recuperados: 11
Data/hora: 03/06/2024 19:03:35

Efecto Antimetastásico de Celecoxib/PLGA en un Modelo Murino de Adenocarcinoma Mamario TA3-MTX-R
Provedor de dados: International Journal of Morphology
Autores: Roa,Ignacio; Moraga,José; Cantín,Mario; Rosas,Carlos; Lemus,David.
La metástasis es el proceso de propagación de un foco cancerígeno a un órgano distinto de aquel en que se inició; ocurriendo generalmente por vía sanguínea o linfática. La localización más frecuentes de las metástasis son los órganos más irrigados como el cerebro, pulmones, hígado, huesos y glándulas suprarrenales. El objetivo fue analizar el patrón de metástasis hepática de tumor TA3-MTX-R, luego de la aplicación del antiangiogénico Celecoxib microencapsulado en PLGA en ratones, así como la disminución de áreas metastásicas a nivel lobulillar. Se utilizó un modelo de tumor experimental, inducido por células TA3-MTX-R, en 18 ratones, separados en 3 grupos de 6 animales, los cuales fueron tratados con dos presentaciones de Celecoxib en administración...
Tipo: Journal article
Palavras-chave: Metástasis; Hígado; TA3-MTX; Celecoxib; PLGA.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000200024

Angiogenesis and Tumor Progression Inhibition of Cyclooxygenase-2 Selective Inhibitor Celecoxib Associated with Poly (lactic-co-glycolic acid) in Tumor Cell Line Resistant to Chemotherapy
Provedor de dados: International Journal of Morphology
Autores: Roa,Ignacio; Cantín,Mario; Vilos,Cristian; Rosas,Carlos; Lemus,David.
Although, antineoplastic therapies have now been developed reduction of tumor progression,itis necessarytofind new therapeutic alternatives to suppress angiogenesis.Thus celecoxib (Cx) has been used for its antiangiogenic action in combination with certain polymeric compounds such as poly (lactic co-glycolic acid) (PLGA) acid, which help to improve the bioavailability and avoid effects of long drug administrations. For this purpose we used a murine tumor modelinduced by mammary adenocarcinoma cells resistant to chemotherapy (TA3-MTXR). CX/PLGA inhibits the microvascular density, VEGF expression and cell proliferationinaddition to increased apoptosis (P &lt;0.0001). Cx reduces tumor progression in a concentration of 1000 ppm associated with PLGA, reducing...
Tipo: Journal article
Palavras-chave: Angiogenesis; Cancer; Celecoxib; PLGA; Apoptosis; VEGF; CellProliferation.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200055

Morphometric and Histopathologic Changes in Skeletal Muscle Induced for Injectable PLGA Microparticles
Provedor de dados: International Journal of Morphology
Autores: Acuña,Luis; Suazo Galdames,Iván; Zavando,Daniela; Elgueta,Samanta; Velásquez,Luis; Vilos,Cristian; Cantín,Mario.
The administration of microencapsulated drug in a matrix acid poly(lactic-co-glycolic acid) (PLGA) by intramuscular (IM) in humans has been approved by the FDA for various applications though it is not clear what effect they have on the morphological parameters of muscle tissue. The aim of this study was to analyze the morphological changes in the skeletal muscle tissue with their use. We used 12 adult female Sprague Dawley rats (Rattus novergicus) that were injected into their right gastrocnemius muscle belly with: sterile vehicle solution (G1, n = 4), 0.5 mg PLGA microparticle (G2, n = 4) and 0.75 mg PLGA microparticle (G3, n = 4), both dissolved in a sterile vehicle solution. At 14 days post injection the number and diameter of muscle fibers, the level...
Tipo: Journal article
Palavras-chave: Skeletal muscle; Drug delivery; Polymeric microparticles; PLGA.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200016

Celecoxib/PLGA Suprime Angiogénesis y Metástasis Pulmonar de un Cáncer Mamario Murino Experimental
Provedor de dados: International Journal of Morphology
Autores: Roa,Ignacio; Cantín,Mario; Muñoz,Mariela; Rosas,Carlos; Lemus,David.
La angiogénesis y metástasis son eventos esenciales en el proceso de invasión tumoral. Su relación íntima los hace buenos blancos en la terapia antitumoral. El objetivo fue analizar el patrón de metástasis pulmonar y angiogénesis, luego de la aplicación del antiangiogénico Celecoxib microencapsulado en ácido poli(láctico-co-glicólico) en ratones. Se utilizó un modelo de tumor experimental, inducido por células TA3-MTX-R, en 18 ratones, separados en 3 grupos de 6 animales, los cuales fueron tratados con dos presentaciones de Celecoxib en administración intramuscular (Grupo Control; Grupo Cx 1000 ppm y Grupo Cx 1000 ppm+PLGA). Los ratones fueron sacrificados y procesados histológicamente para ser teñidos con H&amp;E y Tricrómico de Arteta. El estudio reveló...
Tipo: Journal article
Palavras-chave: Angiogénesis; Metástasis; Pulmón; Cáncer; Celecoxib; PLGA.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100048

Characterization and in vitro antitumor activity of polymeric nanoparticles loaded with Uncaria tomentosa extract
Provedor de dados: Anais da Academia Brasileira de Ciências
Autores: RIBEIRO,ANA F.; SANTOS,JULIANA F.; MATTOS,RÔMULO R.; BARROS,ELIANE G.O.; NASCIUTTI,LUIZ EURICO; CABRAL,LÚCIO M.; SOUSA,VALERIA P. DE.
Abstract  Uncaria tomentosa (UT) extracts have been shown to have promising anti-tumor activity. We hypothesized that its incorporation into nanostructured systems could improve the anticancer properties. Here, poly-e-caprolactone (PCL) and poly-d,l-lactide-co-glycolide (PLGA) were employed to generate nanoparticles loaded with UT extract in a single emulsion solvent evaporation method. The nanoparticles were characterized by particle size, zeta potential, morphology and entrapment efficiency along with stability and release profiles. The nanoparticles presented entrapment efficiencies above 60% and a mean diameter below 300nm. UT-PCL nanoparticles presented higher entrapment efficiency and mean particle size as well as a slow release rate. The UT-PLGA...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nanoparticles; Prostate cancer; PLGA; PCL; Anti-tumor; Anti-cancer; Cat’s Claw.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652020000100908

Development of VEGF-loaded PLGA matrices in association with mesenchymal stem cells for tissue engineering
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Rosa,A.R.; Steffens,D.; Santi,B.; Quintiliano,K.; Steffen,N.; Pilger,D.A.; Pranke,P.
The association of bioactive molecules, such as vascular endothelial growth factor (VEGF), with nanofibers facilitates their controlled release, which could contribute to cellular migration and differentiation in tissue regeneration. In this research, the influence of their incorporation on a polylactic-co-glycolic acid (PLGA) scaffold produced by electrospinning on cell adhesion and viability and cytotoxicity was carried out in three groups: 1) PLGA/BSA/VEGF; 2) PLGA/BSA, and 3) PLGA. Morphology, fiber diameter, contact angle, loading efficiency and controlled release of VEGF of the biomaterials, among others, were measured. The nanofibers showed smooth surfaces without beads and with interconnected pores. PLGA/BSA/VEGF showed the smallest water contact...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Emulsion electrospinning; VEGF; Stem cells; PLGA; Biomaterials.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000900601

Tadalafil-loaded PLGA microspheres for pulmonary administration: preparation and evaluation
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: Yang,Zhenlei; Wang,Longmei; Tian,Liu; Zhang,Xiuping; Huang,Guihua.
Tadalafil, a long-acting PED-5 inhibitor, is commonly used for the treatment of pulmonary arterial hypertension (PAH). However, its efficacy and clinical application are severely limited by the poor water solubility, low bioavailability and a series adverse effects (e.g. headaches, indigestion). In this study, tadalafil was prepared and loaded into biodegradable PLGA (poly(lactic-co-glycolic acid)) microspheres (TDF-PLGA-MS) via emulsification-solvent evaporation. The resulting microspheres were processed into pulmonary inhalant by freeze drying. The TDF-PLGA-MS was spherical and uniform, with an average particle diameter ~10.29 µm. The encapsulation efficiency and drug loading yield of TDF-PLGA-MS were 81.68% and 8.52%, respectively. The investigation of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pulmonary arterial hypertension; Tadalafil; PLGA; Microspheres; Pulmonary administration; Micromeritic; In vitro release; Pharmacokinetic; Tissue distribution.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100587

Evaluation of polymeric PLGA nanoparticles conjugated to curcumin for use in aPDT
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: Pietra,Renata Celi Carvalho de Souza; Cruz,Rosana Carvalho; Melo,Carla Nunes; Rodrigues,Lívia Bomfim; Santos,Patrícia Campi; Bretz,Gabriel Pissolati Matos; Soares,Betânia Maria; Sousa,Gerdal Roberto de; Ferreira,Marcus Vinícius Lucas; Cisalpino,Patrícia Silva; Magalhães,Paula Prazeres; Farias,Luiz de Macêdo; Pinotti,Marcos.
ABSTRACT Antimicrobial photodynamic therapy (aPDT) involves the association of a photosensitizing agent with a light source with the goal of causing apoptosis or microbial lysing. The use of compounds with natural active principles is gaining prominence throughout the world. Several studies from groups that are linked to the development of innovations in the pharmaceutical market have used natural dyes, such as curcumin, the efficacy of which has been demonstrated in aPDT trials. Difficulties related to physicochemical stability, solubility and cell penetration are some of the challenges associated with this field. The present work aimed to prepare, investigate the characteristics and improve the photodynamic activity of PLGA-based nanoparticles loaded...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Curcumin/study; Nanoparticles/evaluation; PLGA; Antimicrobial photodynamic therapy (aPDT).
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200629

PLGA-corosolic acid implants for potential application in ocular neovascularization diseases
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: Toledo,Cibele Rodrigues; Pereira,Vinícius Viana; Andrade,Gracielle Ferreira; Silva-Cunha,Armando.
Angiogenesis is the formation of new blood vessels from preexisting vasculature. Uncontrolled angiogenesis is associated with progression of several ocular pathologies, such as diabetic retinopathy and macular degeneration. Thus, the inhibition of this process consists in an interesting therapeutic target. Corosolic acid (CA) is a natural derivative of ursolic acid, found in many medicinal herbs and exhibits numerous biological properties, including the antiangiogenic activity. The present study reports the production of CA-loaded poly d,l-lactidecoglycolide acid (PLGA) devices by melt technique. HPLC-UV method was developed and validated to evaluate the uniformity and the release profile of the developed systems. The devices were also characterized by...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Corosolic acid; PLGA; Antiangiogenic activity; Implant.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100569

Preparation and physicochemical characterization of prazosin conjugated PLGA nanoparticles for drug delivery of flutamide
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: Fattahi,Ali; Ghiasi,Mansoureh; Mohammadi,Pardis; Hosseinzadeh,Leila; Adibkia,Khosro; Mohammadi,Ghobad.
In the current work, a sustained drug delivery system of flutamide (FLT) was developed using Poly(D,L-lactide-co-glycolide) (PLGA) decorated bypoly(ethylene glycol) (PEG) grafted prazosin (PLGA-PEG-Praz) as a targeting moiety. In a multi-step reaction, PLGA was linked to PEG and prazosin. The structure of the synthesized polymers was confirmed by FTIR and 1H-NMR. Flutamide-loaded nanoparticles were prepared by quasi-emulsion solvent diffusion technique. The nanoparticles were evaluated for size, zeta potential, polydispersity index, drug crystallinity, loading efficiency, and release properties. Also, the physicochemical properties of the nanoparticles were analyzed using Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry, and Powder...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nanoparticle; PLGA; Flutamide; Prazosin; Prostate cancer; Drug delivery.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400609

Effect of an intravitreal dexamethasone device on ocular inflammation after phacoemulsification in dogs
Provedor de dados: Ciência Rural
Autores: Lima,Tiago Barbalho; Padua,Ivan Martinez; Kobashigawa,Karina Kamachi; Aldrovani,Marcela; Chacaltana,Flor Diana Yocoay Claros; Santo,Paloma do Espírito; Vieira,Lorena Carla; Barros Sobrinho,Alexandre Augusto Franchi; Cunha Junior,Armando Silva; Laus,José Luiz.
ABSTRACT: This study examined the efficacy of an intravitreal dexamethasone-loaded device for the control of postoperative ocular inflammation in dogs following phacoemulsification. Twenty dogs with bilateral mature senile cataracts were prepared for surgery using routine protocols. A biodegradable poly (lactic-co-glycolic acid) copolymer device was inserted through the pars plana into the vitreous chamber immediately before phacoemulsification (device group [DG], n=20). Following surgery, a conventional group (CG) received local and systemic steroids, mydriatics, and antibiotic therapy. The same treatment protocol was adopted in DG, except for steroids. All eyes were examined before surgery and at various times after phacoemulsification. Ultrasonography...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dog; Cataract surgery; Inflammation; PLGA; Dexamethasone.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016001202216