Consulta: subjectFacets:"Parthanatos"
Registros recuperados: 1
Data/hora: 11/06/2024 14:52:36

ADP-ribosylation: from molecular mechanisms to human disease
Provedor de dados: 74
Autores: Hoch,Nicolas C.; Polo,Luis M.
Abstract Post-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and initiates programmed cell death by parthanatos. Here, we present mechanistic aspects of ADP-ribose modification, PARP activation and the cellular functions of ADP-ribose signalling, and discuss how this knowledge is uncovering therapeutic avenues for the treatment of increasingly prevalent human diseases such as cancer, ischaemic damage and neurodegeneration.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ADP ribose; PARP; DNA damage response; DNA repair; Parthanatos.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200304