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Dose assessment by quantification of chromosome aberrations and micronuclei in peripheral blood lymphocytes from patients exposed to gamma radiation
Provedor de dados: Genetics and Molecular Biology
Autores: Silva-Barbosa,Isvânia; Pereira-Magnata,Símey; Amaral,Ademir; Sotero,Graça; Melo,Homero Cavalcanti.
Scoring of unstable chromosome aberrations (dicentrics, rings and fragments) and micronuclei in circulating lymphocytes are the most extensively studied biological means for estimating individual exposure to ionizing radiation (IR), which can be used as complementary methods to physical dosimetry or when the latter cannot be performed. In this work, the quantification of the frequencies of chromosome aberrations and micronuclei were carried out based on cytogenetic analyses of peripheral blood samples from 5 patients with cervical uterine cancer following radiotherapy in order to evaluate the absorbed dose as a result of partial-body exposure to 60Co source. Blood samples were collected from each patient in three phases of the treatment: before...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chromosome aberrations; Micronuclei; Biodosimetry; Partial-body irradiation; Lymphocyte.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000300021