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Enhancement of domoic acid neurotoxicity on Diptera larvae bioassay by marine fungal metabolites
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Ruiz, Nicolas; Petit, Karina; Vansteelandt, Marieke; Kerzaon, Isabelle; Baudet, Joseph; Amzil, Zouher; Biard, Jean-francois; Grovel, Olivier; Pouchus, Yves Francois.
Peptaibols are small linear fungal peptides which are produced in the marine environment. They exhibit neurotoxicity by forming pores in neuronal membranes. This work describes their combine effect with domoic acid, a neurotoxic phycotoxin, on Diptera larvae. The Acute toxicity bioassay on this biological model was tested with a panel of different toxins (microbial, algal or fungal). It allowed the discrimination of neurotoxins and non-neurotoxic toxins, and an evaluation of the toxicity level (MED and ED50) which were correlated with published LD50 in mice for neurotoxins tested. The highest activities on this test were found for Na+ channel blockers tetrodotoxin (ED50 = 0.026 mg/kg) and saxitoxin (ED50 = 0.18 mg/kg). Domoic acid was less active with an...
Tipo: Text
Palavras-chave: Domoic acid; Peptaibol; Synergism; Neurotoxicity; Marine-derived fungal metabolite; Diptera larvae bioassay.
Ano: 2010
URL: http://archimer.ifremer.fr/doc/00002/11279/7886.pdf