Consulta: subjectFacets:"Phosphodiesterase type 5 inhibitors/biological samples"
Registros recuperados: 1
Data/hora: 09/06/2024 09:24:39

A review of analytical methods for the determination of four new phosphodiesterase type 5 inhibitors in biological samples and pharmaceutical preparations
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: Codevilla,Cristiane Franco; Castilhos,Tamara dos Santos; Bergold,Ana Maria.
The introduction of oral phosphodiesterase type 5 inhibitor therapy in 1998 revolutionized the treatment of erectile dysfunction. Erectile dysfunction is the most common sexual problem in men. It often has a profound effect on intimate relationships and quality of life. The analysis of pharmaceuticals is an important part of the drug development process as well as for routine analysis and quality control of commercial formulations. Whereas the determination of sildenafil citrate, vardenafil and tadalafil are well documented by a variety of methods, there are few publications about the determination of udenafil, lodenafil carbonate, mirodenafil and avanafil. The paper presents a brief review of the action mechanism, adverse effects, pharmacokinetics and the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Phosphodiesterase type 5 inhibitors/determination; Phosphodiesterase type 5 inhibitors/pharmaceutical preparations; Phosphodiesterase type 5 inhibitors/determination; Phosphodiesterase type 5 inhibitors/biological samples; Analytical methods; Erectile dysfunction.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100002