Consulta: subjectFacets:"Procoagulant activity"
Registros recuperados: 2
Data/hora: 08/06/2024 18:07:12

In vivo evaluation of homeostatic effects of Echis carinatus snake venom in Iran
Provedor de dados: 80
Autores: Salmanizadeh,Hossein; Babaie,Mahdi; Zolfagharian,Hossein.
Background The venom of the family Viperidae, including the saw-scaled viper, is rich in serine proteinases and metalloproteinases, which affect the nervous system, complementary system, blood coagulation, platelet aggregation and blood pressure. One of the most prominent effects of the snake venom of Echis carinatus (Ec) is its coagulation activity, used for killing prey. Materials and methods Subfractions F1A and F1B were isolated from Ec crude venom by a combination of gel chromatography (Sephadex G-75) and ion exchange chromatography on a DEAE-Sepharose (DE-52). These subfractions were then intravenously (IV) injected into NIH male mice. Blood samples were taken before and after the administration of these subfractions. Times for prothrombin, partial...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Snake venom; Procoagulant activity; Blood coagulation; Echis carinatus; Chromatography; LD50.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100302

Endothelial cells, tissue factor and infectious diseases
Provedor de dados: 56
Autores: Lopes-Bezerra,L.M.; Filler,S.G.
Tissue factor is a transmembrane procoagulant glycoprotein and a member of the cytokine receptor superfamily. It activates the extrinsic coagulation pathway, and induces the formation of a fibrin clot. Tissue factor is important for both normal homeostasis and the development of many thrombotic diseases. A wide variety of cells are able to synthesize and express tissue factor, including monocytes, granulocytes, platelets and endothelial cells. Tissue factor expression can be induced by cell surface components of pathogenic microorganisms, proinflammatory cytokines and membrane microparticles released from activated host cells. Tissue factor plays an important role in initiating thrombosis associated with inflammation during infection, sepsis, and organ...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tissue factor; Endothelial cell; Fungus; Infectious diseases; Procoagulant activity.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000800004