Consulta: subjectFacets:"Propranolol"
Registros recuperados: 9
Data/hora: 16/06/2024 09:04:17

Use of lidocaine, propranolol, amiodarone, and verapamil in toad envenoming (genus bufo) in dogs
Provedor de dados: 79
Autores: SAKATE,M.; OLIVEIRA,P. C. LUCAS DE.
Toad envenoming in dogs can cause death by cardiac fibrilation (CVF). Traditional therapy consists mainly of atropine and propranolol, the last one used to prevent the CVF, that is preceded by negative ventricular deflections (NVDs) in the QRS complex of the electrocardiogram. This study intended to verify, comparatively, the lidocaine, propranolol, amiodarone, and verapamil abilities to prevent CVF in experimentally envenomed dogs. Thirty-six dogs were divided into 6 groups (GL, GP, GA, GV, GST, and GSV) with n=6; the dogs were submitted to volatile anaesthesia. The animals of the groups GL, GP, GA, and GV received 0.38g of toad venom through oro-gastric catheter and were treated with the following drugs respectively: lidocaine (4mg/Kg), propranolol...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toad; Bufo; Envenoming; Intoxication; Lidocaine; Propranolol; Amiodarone; Verapamil; Dogs; Atropine; Cardiac fibrilation; Antiarrythmic drugs.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302001000200008

Effects of atropine and propranolol on lung inflammation in experimental envenomation: comparison of two buthidae venoms
Provedor de dados: 80
Autores: Saidi,Hadjer; Adi-Bessalem,Sonia; Hammoudi-Triki,Djelila; Laraba-Djebari,Fatima.
Background Previous works had shown that scorpion venom induced neurotransmitter elevation and an inflammatory response associated with various anatomo-pathological modifications. The most dangerous scorpions species in Algeria responsible for these effects are Androctonus australis hector (Aah) and Androctonus amoreuxi (Aam). Results Comparison of the physiopathological effects induced by the two venoms showed differences in the kinetic of cytokine release and in lung injury. The lung edema was only observed in response to Aah venom and it was correlated with cell infiltration. In order to better understand the involved mechanism in inflammatory response, we used two antagonists, atropine (non-selective muscarinic antagonist) and propranolol (β adrenergic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Scorpion venoms; Cytokines; Lung inflammation; Acetylcholine; Atropine; Propranolol.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100305

Efectos sobre la temperatura, frecuencia respiratoria, frecuencia cardiaca y electrocardiograma de Maytenus macrocarpa (Ruiz &amp;amp; Pav.) Briq. (chuchuhuasi)
Provedor de dados: 98
Autores: Huaccho Rojas,Juan Jesús; Cavero Aguilar,Evelyn Sally; Quezada Rojas,Melissa Andrea; Lara Paredes,Andrea Mercedes; Lluen Escobar,Silvana Estela; Paragulla Bocángel,Ahmed Alberto; Rojas Villacorta,Fernando Junior; Loja Herrera,Berta; Alvarado Yarasca,Ángel; Mujica Calderón,José; Salazar Granara,Alberto.
Introducción: estudios de árboles del género Maytenus, especies forsskaoliana, ilicifolia y krukovii revelan efectos depresores a nivel cardiovascular sobre la presión arterial y frecuencia cardiaca. Objetivos: analizar experimentalmente los efectos de las hojas de Maytenus macrocarpa "chuchuhuasi" sobre la frecuencia cardiaca, patrones electrocardiográficos, frecuencia respiratoria, y temperatura. Métodos: investigación de tipo exploratorio, analítico y experimental. Se utilizaron ratas albinas en 9 grupos de 8 ratas. Grupo 1 (control: Halatal), grupo 2 (placebo: agua destilada), grupo 3 (adrenalina), grupo 4 (atropina), grupo 5 (acetilcolina), grupo 6 (propranolol), grupo 7 (chuchuhuasi 500 mg/kg), grupo 8 (chuchuhuasi 1 000 mg/kg) y grupo 9 (chuchuhuasi...
Tipo: Journal article
Palavras-chave: Maytenus macrocarpa; Chuchuhuasi; Electrocardiograma; Frecuencia cardiaca; Frecuencia respiratoria; Temperatura; Adrenalina; Atropina; Propranolol.
Ano: 2012
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962012000300004

The development and characterization of Propranolol Tablets using Tapioca starch as excipient
Provedor de dados: 42
Autores: FERNANDES,JULYANE B.M.; CELESTINO,MAÍSA T.; TAVARES,MARIA I.B.; FREITAS,ZAIDA M.F.; SANTOS,ELISABETE P. DOS; RICCI JÚNIOR,EDUARDO; MONTEIRO,MARIANA S.S.B.
Abstract: Tapioca starch (TS) is produced from Cassaca roots and it is differentiated from other starches because it contains about 17–20% amylase and low amount of residual substances. Propranolol (POP) is a non-selective beta-adrenergic blocking agent and it is in the World Health Organization’s List of Essential Medicines. The aim of this work was to investigate the potential of TS in the development of POP tablets by means of direct compression. Its evaluation was performed by X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), Nuclear Magnetic Resonance (NMR) relaxometry, scanning electron microscopy (SEM), uniformity of weight, drug content, disintegration, friability, hardness, dissolution test and drug release kinetics. The TS...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tapioca starch; Propranolol; Tablet; NMR relaxation.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100806

Propranolol inhibits the proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms
Provedor de dados: 56
Autores: Chen,Y.Z.; Bai,N.; Bi,J.H.; Liu,X.W.; Xu,G.Q.; Zhang,L.F.; Li,X.Q.; Huo,R.
The aim of this study was to investigate the mechanism of propranolol on the regression of hemangiomas. Propranolol-treated hemangioma tissues were collected and the expression of hypoxia inducible factor-1α (HIF-1α) was examined. We also established HIF-1α overexpression and knockdown hemangioma cells, and determined the effects of HIF-1α on the hemangioma cells proliferation, apoptosis, migration and tube formation. Significantly increased HIF-1α level was found in the hemangioma tissues compared to that in normal vascular tissues, whereas propranolol treatment decreased the HIF-1α level in hemangioma tissues in a time- and dose-dependent manner. Moreover, propranolol treatment significantly decreased cell proliferation, migration and tube formation as...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Propranolol; Hemangiomas; Hypoxia inducible factor-1α; Knockdown; Regression.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200601

Glucocorticoids, master modulators of the thymic catecholaminergic system?
Provedor de dados: 56
Autores: Pilipović,I.; Kosec,D.; Radojević,K.; Perišić,M.; Pešić,V.; Stojić-Vukanić,Z.; Leposavi,G.
There is evidence that the major mediators of stress, i.e., catecholamines and glucocorticoids, play an important role in modulating thymopoiesis and consequently immune responses. Furthermore, there are data suggesting that glucocorticoids influence catecholamine action. Therefore, to assess the putative relevance of glucocorticoid-catecholamine interplay in the modulation of thymopoiesis we analyzed thymocyte differentiation/maturation in non-adrenalectomized and andrenalectomized rats subjected to treatment with propranolol (0.4 mg·100 g body weight-1·day-1) for 4 days. The effects of β-adrenoceptor blockade on thymopoiesis in non-adrenalectomized rats differed not only quantitatively but also qualitatively from those in adrenalectomized rats. In...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Catecholamines; Glucocorticoids; Β-adrenoceptors; Propranolol; Thymocyte apoptosis; Thymocyte proliferation; Thymocyte differentiation.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000300009

Cardiopulmonary bypass alters the pharmacokinetics of propranolol in patients undergoing cardiac surgery
Provedor de dados: 56
Autores: Carmona,M.J.C.; Malbouisson,L.M.S.; Pereira,V.A.; Bertoline,M.A.; Omosako,C.E.K.; Le Bihan,K.B.; Auler Jr.,J.O.C.; Santos,S.R.C.J.
The pharmacokinetics of propranolol may be altered by hypothermic cardiopulmonary bypass (CPB), resulting in unpredictable postoperative hemodynamic responses to usual doses. The objective of the present study was to investigate the pharmacokinetics of propranolol in patients undergoing coronary artery bypass grafting (CABG) by CPB under moderate hypothermia. We evaluated 11 patients, 4 women and 7 men (mean age 57 ± 8 years, mean weight 75.4 ± 11.9 kg and mean body surface area 1.83 ± 0.19 m²), receiving propranolol before surgery (80-240 mg a day) and postoperatively (10 mg a day). Plasma propranolol levels were measured before and after CPB by high-performance liquid chromatography. Pharmacokinetic Solutions 2.0 software was used to estimate the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Propranolol; Pharmacokinetics; Cardiopulmonary bypass.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500008

Pharmacokinetics and pharmacodynamics of propranolol in hypertensive patients after sublingual administration: systemic availability
Provedor de dados: 56
Autores: Mansur,A.P.; Avakian,S.D.; Paula,R.S.; Donzella,H.; Santos,S.R.C.J.; Ramires,J.A.F.
The bioavailability of propranolol depends on the degree of liver metabolism. Orally but not intravenously administered propranolol is heavily metabolized. In the present study we assessed the pharmacokinetics and pharmacodynamics of sublingual propranolol. Fourteen severely hypertensive patients (diastolic blood pressure (DBP) &lt;FONT FACE="Symbol"&gt;³&lt;/font&gt;115 mmHg), aged 40 to 66 years, were randomly chosen to receive a single dose of 40 mg propranolol hydrochloride by sublingual or peroral administration. Systolic (SBP) and diastolic (DBP) blood pressures, heart rate (HR) for pharmacodynamics and blood samples for noncompartmental pharmacokinetics were obtained at baseline and at 10, 20, 30, 60 and 120 min after the single dose. Significant...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Propranolol; Pharmacokinetics; Pharmacodynamics; Arterial hypertension; Sublingual vs peroral administration.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000500014

Effect of cardiopulmonary bypass on the pharmacokinetics of propranolol and atenolol
Provedor de dados: 56
Autores: Carmona,M.J.C.; Pereira,V.A.; Malbouisson,L.M.S.; Auler Jr.,J.O.C.; Santos,S.R.C.J.
The pharmacokinetics of some β-blockers are altered by cardiopulmonary bypass (CPB). The objective of this study was to compare the effect of coronary artery bypass graft (CABG) surgery employing CPB on the pharmacokinetics of propranolol and atenolol. We studied patients receiving oral propranolol with doses ranging from 80 to 240 mg (N = 11) or atenolol with doses ranging from 25 to 100 mg (N = 8) in the pre- and postoperative period of CABG with moderately hypothermic CPB (32°C). On the day before and on the first day after surgery, blood samples were collected before β-blocker administration and every 2 h thereafter. Plasma levels were determined using high-performance liquid chromatography and data were treated by pharmacokinetics-modelling....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Propranolol; Atenolol; Pharmacokinetics; Coronary artery bypass grafting surgery; Cardiopulmonary bypass.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000600016