Consulta: subjectFacets:"Protease Inhibitors"
Registros recuperados: 1
Data/hora: 09/06/2024 14:55:46

Antiangiogenic VEGF165b Expression in Human Breast MCF-7 and MCF-10A Cells Exposed to Reverse Transcriptase and Protease Inhibitors
Provedor de dados: 77
Autores: Adefolaju,Gbenga Anthony; Scholtz,Kathrine Elizabeth; Hosie,Margot Jill.
The combined antiretroviral therapy (cART), a multidrug combination regimen, usually consisting Nucleoside Reverse Transcriptase Inhibitors, non- Nucleoside Reverse Transcriptase Inhibitors and Protease Inhibitors has altered the morbidity pattern affecting HIV-infected individuals to include non-AIDS-defining malignancies (nADMs). The speculation is rife; does cART induce or promote the progression of nADMs such as breast cancer? This study was therefore designed to investigate of the effects of some antiretroviral drugs (at clinically relevant concentrations) on the expression of anti-angiogenic gene; VEGF165b in two human breast cell lines; MCF-7 and MCF-10A by Real Time qPCR and immuno-fluorescence. All of the antiretroviral drugs and combinations...
Tipo: Journal article
Palavras-chave: Reverse Transcriptase Inhibitors; Protease Inhibitors; VEGF165b; Breast cancer; MCF-7; MCF-10A.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100024