Consulta: subjectFacets:"SDF1-3'A polymorphism"
Registros recuperados: 1
Data/hora: 10/06/2024 00:37:50

Distribution of SDF1-3'A polymorphisms in three different ethnic groups from Brazil
Provedor de dados: 55
Autores: Grimaldi,Rogerio; Acosta,AX; Machado,TMB; Bomfim,TF; Galvão-Castro,B.
A mutation described as a G-to-A transition has been reported in SDF-1 gene (SDF1-3'A), being prevalent in all ethnic groups, except in Africans. This mutation is associated with the onset of AIDS progression. Our aim was to identify the frequency of this allele in different groups from Brazil: Tiriyó and Waiampi Amerindian tribes (Asian ancestry); selected blood donors from Joinville (German descendents); and from Salvador (predominance of African and Portuguese mixture). SDF1-3'A was screened by PCR/RFLP with MspI enzyme. Our results showed a high allelic frequency in Tiriyó tribe (0.24) and Joinville population (0.21), and a frequency of 0.17 and 0.05 in the Salvador population and in the Waiampi tribe, respectively. There was no statistical difference...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: SDF1-3'A polymorphism; Brazilian population; HIV-1 co-receptor.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200017