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Anti-ophidian activity of Bredemeyera floribunda Willd. (Polygalaceae) root extract on the local effects induced by Bothrops jararacussu venom
Provedor de dados: 56
Autores: Alves,N.T.Q.; Ximenes,R.M.; Jorge,R.J.B.; Silveira,J.A.M.; Santos,J.V.A.; Rodrigues,F.A.P.; Costa,P.H.S.; Xavier Jr.,F.A.F.; Evangelista,J.S.A.M.; Havt,A.; Soares,V.C.G.; Toyama,M.H.; Oliveira,A.N.A.; Araújo,R.M.; Alves,R.S.; Monteiro,H.S.A.
Bredemeyera floribunda roots are popularly used to treat snakebites in the semiarid region of Northeast Brazil, and previous studies indicate the anti-ophidian actions of triterpenoid saponins found in its roots. To assess B. floribunda root extract (BFRE) activity against the effects of Bothrops jararacussu venom (BjuV), antiphospholipasic, antiproteolytic, antihemorrhagic, antinecrotic, and anti-edematogenic activities were investigated in mice. Phytochemical analysis revealed the presence of saponins, flavonoids, and sugars, with rutin and saccharose being the major constituents of BFRE. Acute toxicity was determined and BFRE was nontoxic to mice. Phospholipase A2 and proteolytic activities induced by BjuV were inhibited in vitro by BFRE at all...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bredemeyera floribunda; Snakeroot; Snake venom; Rutin; Antihemorrhagic; Anti-edematogenic.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000100608