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A Simple and High-yield Synthesis of Hexadecyl Ferulate and Its In Vitro Antioxidant Potential
Provedor de dados: 52
Autores: Nadal,Jessica; Pedroso,Flávia de B.; Minozzo,Bruno Rodrigo; Brito,Priscilla Salles de; Farago,Paulo Vitor; Vellosa,José Carlos Rebuglio; Miyoshi,Edmar.
ABSTRACT Ferulic acid (FA) is a phenolic compound with well-known antioxidant potential that can be used as a promising anti-inflammatory and anti-cancer molecule. Furthermore, it has been reported to have neuroprotective activity. One of the main problems, which limit its clinical use, is its low bioavailability when administered orally. This limitation can be circumvented by changes in their structure and/or for preparing lipid-based formulations. The aim of this study was to synthesize a derivative of FA, the hexadecyl ferulate (HF). This compound would be more susceptible to pass through blood-brain barrier (BBB) due to its lipophilic character. The HF was obtained by Steglich esterification and yielded 76.77 ± 1.35%. Its structural characterization...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ABTS•+ assay; DPPH• assay; Ferulic acid derivative; Scavenger activity; Steglich esterification.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100428