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Effect of a submaxillary gland extract on Ehrlich tumor growth in mice
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Weill,P.; Frussa-Filho,R.; Bonamin,L.V.
Ablation of host submaxillary glands modifies Ehrlich tumor growth and tumor-infiltrating leukocytes, possibly by modifications in the serum level of growth factors produced by this gland. To extend this research, 7-month-old male EPM-1 mice (N = 30) were divided into two groups: 1) inoculated with tumor cells previously incubated with submaxillary salivary gland extract (SGE) in PBS for 30 min at 37%; 2) inoculated with tumor cells previously incubated with PBS, under the same conditions. Animals were inoculated into the footpad with 40 µl of a suspension containing 4.5 x 107 tumor cells/ml, and footpad thickness was measured daily for 10 days. Sections and smears of tumor cells were prepared from the tumor mass to determine mitosis frequency, percent of...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Ehrlich ascites carcinoma; Submaxillary salivary gland; Growth factors.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001000005