Consulta: subjectFacets:"T-lymphocytes"
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Data/hora: 16/06/2024 01:43:00

Immunomodulatory effect of mesenchymal stem cells
Provedor de dados: 56
Autores: Herrero,C.; Pérez-Simón,J.A.
Mesenchymal stem cells (MSC) are multipotential nonhematopoietic progenitor cells capable of differentiating into multiple mesenchymal tissues. MSC are able to reconstitute the functional human hematopoietic microenvironment and promote engraftment of hematopoietic stem cells. MSC constitutively express low levels of major histocompatibility complex-I molecules and do not express costimulatory molecules such as CD80, CD86 or CD40, thus lacking immunogenicity. Furthermore, they are able to suppress T- and B-lymphocyte activation and proliferation and may also affect dendritic cell maturation. Based on these properties, MSC are being used in regenerative medicine and also for the treatment of autoimmune diseases and graft-versus-host disease. On the other...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mesenchymal stem cells; T-lymphocytes; B-lymphocytes; Dendritic cells; Graft-versus-host disease; Allogeneic transplanta.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500002