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Prevalence of hereditary risk factors for thrombophilia in Belém, Brazilian Amazon
Provedor de dados: Genetics and Molecular Biology
Autores: Yoshioka,France Keiko Nascimento; Araújo,Amélia Góes; Tavella,Marli Haydee; Hamoy,Igor Guerreiro; Guerreiro,João Farias.
Different risk factors for venous thromboembolism (VTE) have been identified, including hereditary abnormalities in the mechanisms of coagulation and fibrinolysis. We investigated five genetic polymorphisms (FVL G1691A, FII G20210A, MTHFR C677T, TAFI A152G and TAFI T1053C) associated with VTE in individuals from the city of Belém in the Brazilian Amazon who had no history of VTE. No significant difference was found between the observed and expected genotype frequencies for the loci analyzed. We found high frequencies of MTHFR C677T (33.9%) and TAFI T1053C (74%) and low frequencies of FVL (1.6%), FII G20210A (0.8%) and TAFI A152G (0.8%). The FVL G1691A, FII G20210A and MTHFR C677T frequencies were similar to those for European populations and populations of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Factor V Leiden; Prothrombin; MTHFR; TAFI; Thrombophilia.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000100007