Consulta: subjectFacets:"TLR4"
Registros recuperados: 4
Data/hora: 16/06/2024 15:56:06

Characterization of gene polymorphisms related to immune system physiology in Mangalarga horses
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Prioli,R.A.; Curi,R.A.; Chardulo,L.A.; Gomes,V.N.; Prioli,S.M.A.P.; Mota,M.D.S.
The objectives of this study were to standardize a PCR-RFLP genotyping method for the AY_731081:g.1900T&gt;C SNP of the equine CD14 gene, and to characterize this SNP and two other polymorphisms (AY_005808: c.1530A&gt;G of the TLR4 gene and AX_463789: g.133T&gt;C of the Cε gene) in Mangalarga horses, in order to contribute to future studies investigating the association between DNA markers and traits related to immune system physiology in this breed. A total of 151 Mangalarga horses of both sexes and variable ages, representative of the population of São Paulo State, were used. PCR-RFLP was found to be adequate for genotyping of the AY_731081: g.1900T&gt;C SNP of the equine CD14 gene. However, this polymorphism is probably not present in Mangalarga horses,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Horse; CD14; Cε; SNP; TLR4.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000500030

Effect of LPS on the Viability and Proliferation of Human Oral and Esophageal Cancer Cell Lines
Provedor de dados: Brazilian Archives of Biology and Technology
Autores: Gonçalves,Márcia; Cappellari,Ángelica Regina; Santos Junior,André Avelino dos; Marchi,Fernanda Olicheski de; Macchi,Fernanda Souza; Antunes,Krist Helen; Souza,Ana Paula Duarte de; Morrone,Fernanda Bueno.
The esophagus and mouth tumors are very frequent malignancies worldwide. Lipopolysaccharides (LPS) are capable of regulating gene expression of pro-inflammatory cytokines by binding to toll-like receptor 4 (TLR4). Recent studies show that LPS can increase the migration ability of human esophageal cancer cell line HKESC-2 by increasing its adhesion properties. However, the effect of LPS has not been tested on viability of human esophageal and oral cancer cells. This study aimed to determine the action of LPS on the cell proliferation and viability in OE19 (adenocarcinoma) and OE21 (squamous carcinoma) cell lines, representative of human esophageal cancer, and HN30 cell line, representative of human oral carcinoma. LPS was used as treatment to OE19 and OE21...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: LPS; Oral cancer; Esophageal cancer; TLR4.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100306

Saquinavir plus methylprednisolone ameliorates experimental acute lung injury
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Zhang,Guanghua; Zhang,Xue; Huang,Haidi; Ji,Yunxia; Li,Defang; Jiang,Wanglin.
Glucocorticoid insensitivity is an important barrier to the treatment of several inflammatory diseases, including acute lung injury (ALI). Saquinavir (SQV) is an inhibitor of the human immunodeficiency virus protease, and the therapeutic effects of SQV in ALI accompanied with glucocorticoid insensitivity have not been previously investigated. In this study, the effects of SQV on lipopolysaccharide (LPS)-mediated injury in human pulmonary microvascular endothelial cells (HPMECs), human type I alveolar epithelial cells (AT I), and alveolar macrophages were determined. In addition, the effects of SQV on an LPS-induced ALI model with or without methylprednisolone (MPS) were studied. In LPS-stimulated HPMECs, SQV treatment resulted in a decrease of high...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Saquinavir; ALI; Two-hit; HMGB1; TLR4.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000608

Swertiamarin attenuates carbon tetrachloride (CCl4)-induced liver injury and inﬂammation in rats by regulating the TLR4 signaling pathway
Provedor de dados: Brazilian Journal of Pharmaceutical Sciences
Autores: Wu,Tao; Zhang,Qianrui; Song,Hongping.
The aim of the present study is to illustrate the effects of swertiamarin (STM), a natural iridoid from herbal medicines, on hepatic inﬂammation induced by carbon tetrachloride (CCl4) in rats. Male Sprague Dawley rats were exposed to CCl4 with or without STM co-administration for 8 weeks. Our results revealed that STM administration (100 and 200 mg/kg b.w.) signiﬁcantly attenuated inflammation in livers of CCl4-treated rats. STM remarkably reduced the production of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), macrophage inflammatory protein-1a (MIP-1α), and monocyte chemotactic protein-1 (MCP-1) in liver tissue of CCl4-treated rats. In addition, STM treatment downregulated connective tissue growth factor (CTGF) and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Swertiamarin/effects; Carbon tetrachloride; Inﬂammation; TLR4; NF-κB.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400618