Consulta: subjectFacets:"Tubular-interstitial nephritis"
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Data/hora: 09/06/2024 06:48:47

Baicalein alleviates tubular-interstitial nephritis in vivo and in vitro by down-regulating NF-κB and MAPK pathways
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Chen,Yan; Zheng,Yu; Zhou,Zhihong; Wang,Jinjun.
Tubular-interstitial nephritis (TIN) is characterized by tubular cell damage and inflammatory lesions of kidneys. Baicalein (BAI) is a flavonoid compound found in the roots of Scutellaria baicalensis Georgi. The present study was undertaken to explore the anti-inflammatory and anti-oxidative effects of BAI on TIN patients and a lipopolysaccharide (LPS)-induced TIN cell model. The expression levels of interleukin-6 (IL-6), IL-10, and tumor necrosis factor α in serum samples of TIN patients and culture supernatants of renal proximal tubular epithelial cells (RPTECs) were evaluated using enzyme-linked immunosorbent assay. Creatinine clearance was calculated using the Cockcroft-Gault equation. Activities of malondialdehyde, superoxide dismutase, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tubular-interstitial nephritis; Baicalein; Lipopolysaccharide; Anti-inflammatory effects; NF-κB pathway; MAPK pathway.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001000606