Consulta: subjectFacets:"Wistar rats"
Registros recuperados: 22
Data/hora: 16/06/2024 10:46:32

Genotoxic effects of Tabebuia impetiginosa (Mart. Ex DC.) Standl. (Lamiales, Bignoniaceae) extract in Wistar rats
Provedor de dados: 74
Autores: Lemos,Odilon A.; Sanches,Júlio C.M.; Silva,Ícaro E.F.; Silva,Márcio L.A.; Vinhólis,Adriana H.C.; Felix,Mireille A.P.; Santos,Raquel A.; Cecchi,Andréa O.
Tabebuia sp. is native to tropical rain forests throughout Central and South America. Although the biological and pharmacological effects of bark extracts have been intensely studied, little is known on the extract obtained from the flower. Herein, the genotoxic potential of a flower extract from T. impetiginosa ("ipê roxo") on the blood and liver cells of Wistar rats was evaluated. Experimental procedures involved only male animals. Graduated concentrations of the extract, viz., 100, 300 and 500 mg kg-1 of body weight, were gavage-administered and 24 h latter cells were collected and processed for analysis. With the exception of the 100 mg kg-1 dose, a significant increase in DNA damage was noted, when compared with a negative control group. Although the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tabebuia impetiginosa; Comet assay; Wistar rats; Natural compounds.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572012000300017

In vivo cytogenetic effects of multiple doses of dietary vegetable oils
Provedor de dados: 74
Autores: Evangelista,Cristina Márcia Wolf; Antunes,Lusânia Maria Greggi; Bianchi,Maria de Lourdes Pires.
Polyphenols are potent antioxidants that are particularly abundant in the Mediterranean diet, with olive oil being the main fat source. A number of investigations have reported that phenolic compounds found in dietary oils are antioxidants and could provide protective effects by inhibiting DNA oxidative damage. However, few studies have been published on the biological activity of vegetable oils, including their possible mutagenic/antimutagenic effects. The objective of the current study was to investigate the cytogenetic effects of multiple doses of four vegetable oils in rat bone marrow cells and to examine the possible antimutagenic effects of these oils in chromosomal damage induced by the antitumor drug cisplatin. These oils are consumed by humans and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antimutagenesis; Chromosomal aberrations; Vegetable oils; Wistar rats.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000400024

Efecto Tóxico del Extracto Acuoso de Ruta graveolens del Norte de México sobre el Hígado de Rata Wistar
Provedor de dados: 77
Autores: Serrano-Gallardo,Luis B; Soto-Domínguez,Adolfo; Ruiz-Flores,Pablo; Nava-Hernández,Martha P; Morán-Martínez,Javier; García-Garza,Rubén; Martínez-Pérez,Edith F.
A Ruta graveolens se le atribuyen propiedades benéficas en medicina tradicional, sin embargo se ha demostrado que también puede producir efectos adversos. A la fecha no existe evidencia que ratifique que R. graveolens es totalmente inofensiva, por este motivo el objetivo de este estudio fue determinar el efecto tóxico del extracto acuoso de las hojas de esta especie vegetal en hígado de rata. Se utilizaron 25 ratas Wistar y se dividieron en 5 grupos (n=5). El grupo 1 correspondió al grupo control negativo, el grupo 2 o control positivo se trató con 100 mg de dexametasona/kg/día. Los grupos 3 y 4 se trataron con 30 y 100 mg de extracto de R. graveolens respectivamente. Al grupo 5 se le administraron 100 mg de dexametasona/kg/día combinado con 100 mg de...
Tipo: Journal article
Palavras-chave: Ruta graveolens; Extracto acuoso; Toxicidad hepática; Ratas Wistar; Ruta graveolens; Aqueous extract; Liver toxicity; Wistar rats.
Ano: 2013
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300043

Morphological Characteristics and Haematological Studies in Wistar Rats Subjected to Prolonged Treatment of Chloramphenicol
Provedor de dados: 77
Autores: Oyeyemi,Matthew Olugbenga; Adeniji,Deborah Adejoke.
The morphological characteristics and haematological studies were studied in fifteen male albino rats (Wistar Strain) aged between 12 and 14 weeks and with a body weight of 150- 180g. The rats were allowed to feed on commercially prepared rat pellet and provided with fresh water ad libitum. The rats were divided into three groups; the rats were in groups A, B and C of 5 rats each. Group A served as control of the study; Group B was treated with Chloramphenicol at the dose rate of 25mg/kg body weight per os for 20 days; while Group C was treated for 25 days. Semen used in this study was obtained from the caudal epididymides while morphological aberrations were determined from spermatozoa counted after stained with Wells and Awa stain. Results of the...
Tipo: Journal article
Palavras-chave: Chloramphenicol; Breeding; Spermatozoa; Wistar rats; Infertility.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100001

Evaluation of Some Biological Aspects of the Presence of Abrasive Silica and Thickening Silica  in Basic Formulations of Dentifrices
Provedor de dados: 77
Autores: Pedrazzi,Vinícius; Del Ciampo,José Orestes; do Nascimento,Cássio; Issa,João Paulo Mardegan.
The aim of this study was to evaluate some biological characteristics and toxicity of basic formulations of dentifrices containing such substances, and to compare them with two existing products in market which also contains silic in their formulations. In this way, it was evaluated some biological parameters: weight of the animals, oral toxicity, hematological parameters, urinary analysis, and histological evaluation. The thrombocytes were also statistically at normal levels. The glutamate-pyruvate transaminase (TGP) showed normal aspect in 5 of the tested groups, as in control. Meanwhile, the oxalacetic transaminase (AST) in one group had a small increase in the control group. Regarding urine, in exception the rats of one group, the rats of the 4 other...
Tipo: Journal article
Palavras-chave: Silica; Dentifrices; Histology; Wistar rats.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100028

Neonatal Administration of Fluoxetine Decreased Final Sertoli Cell Number in Wistar Rats
Provedor de dados: 77
Autores: Silva Junior,Valdemiro Amaro da; Lins Amorim,Marleyne José Afonso Accioly; Amorim Junior,Adelmar Afonso de; Pinto,Catarina Ferreira; Deiró,Tereza B. J.; Oliveira,João Ricardo M. de; Peixoto,Christina Alves; Manhães-de-Castro,Raul.
The aim of the present study was to test the hypothesis that the application of fluoxetine ­ a highly selective serotonin reuptake inhibitor (SSRI) ­ in rats during the suckling period induces changes in testicular development. Groups of newborn male rats were randomly assigned with different doses of fluoxetine 24 hours after birth. Each litter stayed with its respective mother during 21 days. Body weight (BW) was measured daily from the 1st -21st day to calculate daily doses of fluoxetine. 5 mg (T1), 10 mg (T2) 20 mg (T3) or deionized water, were injected intraperitoneally. On the 21st day, animals were heparinized, anesthetized and blood was collected by cardiac puncture to determine by radioimmunoassay the follicle stimulating hormone (FSH) levels....
Tipo: Journal article
Palavras-chave: Fluoxetine; Testis development; Sertoli cells; Wistar rats.
Ano: 2008
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000100009

Effects of Chronic Administration of Efavirenz on the Chromatophilic Substance of the Intracranial Auditory Relay Centres of Adult Wistar Rats
Provedor de dados: 77
Autores: Adjene,J. O; Igbigbi,P. S.
The effects of chronic administration of efavirenz commonly used as part of highly active antiretroviral therapy (HAART) for the treatment of Human Immunodeficiency Virus (HIV) type-1 therapy on the chromatophilic substance of the intracranial auditory relay centre namely the inferior colliculus and medial geniculate body of adult wistar rats were carefully studied. The rats of both sexes (n=20), with an average weight of 200g were randomly assigned into treatment (n=10) and control (n=10) groups. The rats in the treatment group received 600 mg/70kg body weight of efavirenz dissolved in distilled water daily for 30 days through the orogastric tube. The control group received equal volume of distilled water daily for 30 days through the same route. The rats...
Tipo: Journal article
Palavras-chave: Efavirenz; Chromatophilic substance; Inferior colliculus; Medial Geniculate body; Wistar rats.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300037

Opioid system manipulation during testicular development: results on sperm production and sertoli cells population - doi: 10.4025/actascibiolsci.v33i2.5940
Provedor de dados: 3
Autores: Cajú, Fernanda Mafra; Universidade Federal Rural de Pernambuco; Queiroz, Gian Carlo D'Angelo; Universidade Federal Rural de Pernambuco; Torres, Sandra Maria; Universidade Federal Rural de Pernambuco; Tenório, Bruno Mendes; Universidade Federal Rural de Pernambuco; Silva Júnior, Valdemiro Amaro; Universidade Federal Rural de Pernambuco.
The Sertoli cell has fundamental importance to the development and maintenance of spermatogenesis, as well as it has a directly proportional numerical relationship to sperm production. The proliferative period of this cell in rats occurs between 13 days pre-natal and 21 days pos-natal, when is established the final population in adult animals. The Leydig cell can modulate the Sertoli cell proliferation during fetal and neonatal period through &amp;beta;-endorphin. The manipulation of opioidergic system can promote changes in parameters related to development of nervous, endocrine and reproductive systems. By the way, the main purpose of this present work was to compare the effects of the blockade of opioid receptor blocking in Sertoli cells using...
Tipo: Estudo histomorfológico
Palavras-chave: 2.06.00.00-3; 2.06.03.00-2; 2.07.02.00-0 Naltrexone; Testis development; Spermatogenesis; Wistar rats Morfologia; Histologia; Fisiologia de Órgão e Sistemas Naltrexone; Testis development; Spermatogenesis; Wistar rats.
Ano: 2011
URL: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/5940

Relationship between testicular lesion and hormone levels in male rats infected with Trypanosoma evansi
Provedor de dados: 42
Autores: FACCIO,LUCIANA; SILVA,ALEKSANDRO S. DA; TONIN,ALEXANDRE A.; OBERHERR,LUCAS; GRESSLER,LUCAS T.; OLIVEIRA,CAMILA B.; OLIVEIRA,DIONATAN T.; SANGOI,MANUELA B.; MORESCO,RAFAEL N.; SAMARA,YASMIN N.; VEIGA,MARCELO; DUARTE,MARTA M.M.F.; MONTEIRO,SILVIA G.
The aim of this study was to evaluate the relationship between testicular lesions and hormone levels in rats experimentally infected with Trypanosoma evansi. For that, the measurement of reproductive hormones, histopathology and biomarkers of cellular injury were carried out in twenty-four animals, which were divided into two groups with 12 animals each. Group A was the negative control, or uninfected, while group B was composed by animals infected with T. evansi. Both groups were divided again into two other subgroups (n=6), from which serum and testicular fragments were collected on days 5 (A1 and B1) and 15 (A2 and B2) post-infection (PI). The morphological analysis showed increased alterations of head and tail of sperm in infected rats when compared...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Protozoa; Wistar rats; Testicular lesion; Reproduction; Oxidative stress.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652014000301537

Recognition memory and DNA damage in undernourished young rats
Provedor de dados: 42
Autores: MOLZ,PATRÍCIA; ELLWANGER,JOEL H.; ZENKNER,FERNANDA F.; CAMPOS,DEIVIS DE; PRÁ,DANIEL; PUTZKE,MARISA T.L.; FRANKE,SILVIA I.R.
ABSTRACT This study evaluated the recognition memory and the levels of DNA damage (blood and hippocampus) in undernourished young Wistar rats. The experiment was conducted along 14-week with rodents divided in control group (CG, n=8) and undernourished group (UG, n=12) which was submitted to caloric restriction. Nutritional status for undernutrition was defined by Body Mass Index (BMI) ≤0.45g/cm2 and by weighting the organs/tissue (liver, spleen, intestine, peritoneal fat, kidney and encephalon). The Novel Object Recognition Test assessed recognition memory and the Comet Assay evaluated the levels of DNA damage. Student t test, 2-way ANOVA and Pearson's correlation analysis were used and the significance level was of p&lt;0.05. The UG showed lower BMI and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: DNA damage; Memory; Nutritional status; Undernutrition; Wistar rats.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000501863

Early fragmentation of polyester urethane sheet neither causes persistent oxidative stress nor alters the outcome of normal tissue healing in rat skin
Provedor de dados: 42
Autores: SGROTT,SANDRO M.; NEVES,RODRIGO D.; D’ACAMPORA,ARMANDO J.; BERNARDES,GERALDO J.S.; BELMONTE,LUIZ; MARTINS,THIAGO C.; BOBINSKI,FRANCIANE; CARGNIN-FERREIRA,EDUARDO; HOEPERS,ANDREZA; COMIM,CLARISSA M.; MARTINS,DANIEL F.; PIOVEZAN,ANNA P.
Abstract Silicone breast implant is associated with complications inherent to the surgical procedure. Prosthesis coating with polyurethane, however, commonly reduces the incidence of such complications. In this paper, the authors evaluated the inflammatory histomorphometric profile and oxidative damage associated to the implant of polyester urethane sheets. Forty-eight Wistar rats were divided into Sham or polyester urethane groups (n = 8/group) and underwent a polyester urethane implant in the dorsal skinfold. Tissue samples were collected on days seven, 30, and 90 after surgery and subjected to histomorphometric analysis and biochemical tests. Results were analyzed by one-way ANOVA (p ≤ 0.05). Peri-implant tissue samples exhibited characteristic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Polyurethane; Inflammation; Cytokines; Oxidative stress; Wistar rats.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000502211

Evaluation of protein quality from genetically modified and organic soybean in two consecutives generations of wistar rats
Provedor de dados: 52
Autores: Daleprane,Julio Beltrame; Pacheco,Juliana Tomaz; Boaventura,Gilson Teles.
The aim of this study was to evaluate the cumulative effects of using genetically modified and organic soybean in two generations of rats. Two consecutive generations of 64 Wistar rats denominated F0 and F1 were used. The animals from each generation were divided into three groups (n=8) and fed chow made of organic soybean, genetically modified soybean and casein. The PER, NPR and CAE were determined. ANOVA was applied to the results. In both the generations, a statistically significant (p&lt;0.05) difference was found between the experimental groups and the control group. The organic soybean supplement with L-cystine provided a better use of this protein in comparison to the genetically modified soybean protein, which demonstrated that the soybean...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Soybeans; Wistar rats; Protein quality; Generations.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132009000400007

Health Status of Male Adult Wistar Rats from Two Experimental Animal Houses of UFMG: Leukocyte Counts, Feces and Lung Histological Exams
Provedor de dados: 52
Autores: Andrade,Bruno Horta; Chaves,Miriam Martins; Ribeiro,Angela Maria.
A study was conducted to compare health status of male adult Wistar rats from two Experimental Animal Houses of UFMG with literature data of SPF (free from specific pathogens) and conventional rats. The animals were divided into two groups: Group I (n=10), rats from the experimental animal houses of FAFICH and Group II (n=10) from ICB and following aspects were studied: a) evident clinical signs (behavior modification, hair loss (alopecia), b) leukocyte counts, c) feces exam and d) histological study of the lungs. The rats did not show clinical signs. However, when compared with SPF and conventional rats, both the groups showed a significant increase (p&lt;0,05) of leukocyte count. On feces exam we detected some parasites and on lung histological exam we...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Wistar rats; Animal houses; Cellular count.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132002000300006

Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
Provedor de dados: 52
Autores: Guimarães,Fernando; Schanoski,Alessandra Soares; Cavalcanti,Tereza Cristina Samico; Juliano,Priscila Bianchi; Viera-Matos,Ana Neuza; Rettori,Ovídio.
The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p&lt;0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tumor growth rate; Spontaneous tumor regression; Wistar rats; Walker 256.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000500014

Comparison of Pavlovian serial conditional discrimination in rats and hamsters in the same experimental situation
Provedor de dados: 56
Autores: Bueno,J.L.O.; Figueiredo,T.H.; Mello,F.M.C.
The present study compares behavioral changes between two distinct rodent groups, hamsters (Mesocricetus auratus) and Wistar rats, when submitted in the same homogeneous experimental situations to a serial conditional discrimination procedure which involves water deprivation and the processing of temporal variables. Both hamsters and rats acquired serial positive conditional discrimination as indicated by higher frequencies of magazine-oriented behavior during the tone followed by reinforcement (T+) and preceded by the feature stimulus light (L) and during the empty interval, than during the tone alone not followed by reinforcement (T-). Rats' frequencies of magazine-oriented behavior were high during T+ and T-, initially during training, and decreased...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Conditional discrimination; Hamsters; Wistar rats; Behavior repertoire.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001200012

Effect of obesity on rat reproduction and on the development of their adult offspring
Provedor de dados: 56
Autores: Campos,K.E.; Volpato,G.T.; Calderon,I.M.P.; Rudge,M.V.C.; Damasceno,D.C.
The aim of the present study was to assess the reproductive parameters of obese Wistar rats and to determine the frequency of their obese adult offspring. Neonatal rats were divided into two groups: F1 generation, induced to obesity by monosodium glutamate (MSG; F1MSG, N = 30), and rats given saline (F1CON, N = 13). At 90 days of age all animals were mated, producing the F2 offspring (F2CON, N = 28; F2MSG, N = 15). Reproductive parameters (fertility, pregnancy, and delivery indexes) were evaluated in F1 rats. F2 newborns were weighed, and the obesity parameter for F1 and F2 generations was determined from months 5 to 7 of life. At month 7, periovarian fat was weighed and no differences were found. Mean newborn weight also did not differ. The F1 and F2MSG...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Obesity; Offspring; Fertility; Wistar rats; Monosodium glutamate; Transgeneration.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200008

Motor behavioral abnormalities and histopathological findings of Wistar rats inoculated with HTLV-1-infected MT2 cells
Provedor de dados: 56
Autores: Câmara,C.C.; Oriá,R.B.; Felismino,T.C.; Silva,A.P. da; Silva,M.A.M. da; Alcântara,J.V.A.; Costa,S.B.C.; Vicente,A.C.P.; Teixeira-Santos,T.J.; Castro-Costa,C.M. de.
The objective of the present study was to describe motor behavioral changes in association with histopathological and hematological findings in Wistar rats inoculated intravenously with human T-cell lymphotropic virus type 1 (HTLV-1)-infected MT2 cells. Twenty-five 4-month-old male rats were inoculated with HTLV-1-infected MT2 cells and 13 control rats were inoculated with normal human lymphocytes. The behavior of the rats was observed before and 5, 10, 15, and 20 months after inoculation during a 30-min/rat testing time for 5 consecutive days. During each of 4 periods, a subset of rats was randomly chosen to be sacrificed in order to harvest the spinal cord for histopathological analysis and to obtain blood for serological and molecular studies....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Motor behaviors; HTLV-1-infected MT2 cells; Wistar rats; Experimental myelopathy.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000700008

Opposite lipemic response of Wistar rats and C57BL/6 mice to dietary glucose or fructose supplementation
Provedor de dados: 56
Autores: Barbosa,C.R.; Albuquerque,E.M.V.; Faria,E.C.; Oliveira,H.C.F.; Castilho,L.N.
The metabolic effects of carbohydrate supplementation in mice have not been extensively studied. In rats, glucose- and fructose-rich diets induce hypertriacylglycerolemia. In the present study, we compared the metabolic responses to two monosaccharide supplementations in two murine models. Adult male Wistar rats (N = 80) and C57BL/6 mice (N = 60), after 3 weeks on a standardized diet, were submitted to dietary supplementation by gavage with glucose (G) or fructose (F) solutions (500 g/L), 8 g/kg body weight for 21 days. Glycemia was significantly higher in rats after fructose treatment (F: 7.9 vs 9.3 mM) and in mice (G: 6.5 vs 10 and F: 6.6 vs 8.9 mM) after both carbohydrate treatments. Triacylglycerolemia increased significantly 1.5 times in rats after G...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Glucose or fructose supplementation; Triacylglycerolemia; Insulin resistance; C57BL/6 mice; Wistar rats.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000300007

Experimental anxiety and the reinforcing effects of ethanol in rats
Provedor de dados: 56
Autores: Blatt,S.L.; Takahashi,R.N.
In order to examine the relationship between anxiety and reinforcing effects of alcohol, drug-naive male Wistar rats weighing 250-300 g were classified as "anxious" and "non-anxious" in the elevated plus-maze test. A conditioned place preference test was then used to investigate the reinforcing effects of ethanol (EtOH) on these animals. On 2 alternate days, groups of "anxious", "non-anxious" and "normal" rats received intraperitoneal (ip) injections of EtOH (0.5, 1.0 or 1.5 g/kg) immediately before a 15-min confinement to the white compartment. On the 2 intervening days the same rats received ip injections of saline before confinement to the opposite compartment. On day 5, a 15-min free-choice test was carried out with no injections. Rats classified as...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anxiety; Plus-maze; Place preference; Ethanol; Wistar rats.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000400013

Effects of exercise and metformin on the prevention of glucose intolerance: a comparative study
Provedor de dados: 56
Autores: Molena-Fernandes,C.; Bersani-Amado,C. A.; Ferraro,Z. M.; Hintze,L. J.; Nardo Jr.,N.; Cuman,R. K. N.
We aimed to evaluate the effects of aerobic exercise training (4 days) and metformin exposure on acute glucose intolerance after dexamethasone treatment in rats. Forty-two adult male Wistar rats (8 weeks old) were divided randomly into four groups: sedentary control (SCT), sedentary dexamethasone-treated (SDX), training dexamethasone-treated (DPE), and dexamethasone and metformin treated group (DMT). Glucose tolerance tests and in situ liver perfusion were undertaken on fasting rats to obtain glucose profiles. The DPE group displayed a significant decrease in glucose values compared with the SDX group. Average glucose levels in the DPE group did not differ from those of the DMT group, so we suggest that exercise training corrects dexamethasone-induced...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Exercise; Glucose intolerance; Dexamethasone; Wistar rats; Diabetes mellitus; Prevention and control.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001201101

Glomerular filtration is reduced by high tidal volume ventilation in an in vivo healthy rat model
Provedor de dados: 56
Autores: Luque,A.; Shimizu,M.H.M.; Andrade,L.; Sanches,T.R.; Seguro,A.C.
Mechanical ventilation has been associated with organ failure in patients with acute respiratory distress syndrome. The present study examines the effects of tidal volume (V T) on renal function using two V T values (8 and 27 mL/kg) in anesthetized, paralyzed and mechanically ventilated male Wistar rats. Animals were randomized into two groups of 6 rats each: V T8 (V T, 8 mL/kg; 61.50 ± 0.92 breaths/min; positive end-expiratory pressure, 3.0 cmH2O; peak airway pressure (PAW), 11.8 ± 2.0 cmH2O), and V T27 (V T, 27 mL/kg; 33.60 ± 1.56 breaths/min; positive end-expiratory pressure, none, and PAW, 22.7 ± 4.0 cmH2O). Throughout the experiment, mean PAW remained comparable between the two groups (6.33 ± 0.21 vs 6.50 ± 0.22 cmH2O). For rats in the V T27 group,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Artificial respiration; Kidney; Physiology; Glomerular filtration rate; Wistar rats.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100017

Experimental model of intervertebral disc degeneration by needle puncture in Wistar rats
Provedor de dados: 56
Autores: Issy,A.C.; Castania,V.; Castania,M.; Salmon,C.E.G.; Nogueira-Barbosa,M.H.; Bel,E. Del; Defino,H.L.A.
Animal models of intervertebral disc degeneration play an important role in clarifying the physiopathological mechanisms and testing novel therapeutic strategies. The objective of the present study is to describe a simple animal model of disc degeneration involving Wistar rats to be used for research studies. Disc degeneration was confirmed and classified by radiography, magnetic resonance and histological evaluation. Adult male Wistar rats were anesthetized and submitted to percutaneous disc puncture with a 20-gauge needle on levels 6-7 and 8-9 of the coccygeal vertebrae. The needle was inserted into the discs guided by fluoroscopy and its tip was positioned crossing the nucleus pulposus up to the contralateral annulus fibrosus, rotated 360° twice, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Intervertebral disc degeneration; Animal models; Histology; Wistar rats.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300235