Consulta: subjectFacets:"Treatment"
Registros recuperados: 99
Data/hora: 09/06/2024 13:53:08

The Mathematical Biology of Human Infections
Provedor de dados: Ecology and Society
Autores: Nowak, Martin A; Institute for Advanced Study; nowak@ias.edu.
Humans are constant victims of infectious diseases. Biomedical research during this century has led to important insights into the molecular details of immune defense. Yet, many questions relating to disease require a quantitative understanding of the complex systems that arise from the nonlinear interactions between populations of immune cells and infectious agents. Exploration of such questions has lead to a newly emerging field of mathematical biology describing the spread of infectious agents both within and between infected individuals. This essay will discuss simple and complex models of evolution, and the propagation of virus and prion infections. Such models provide new perspectives for our understanding of infectious disease and provide guidelines...
Tipo: Peer-Reviewed Reports
Palavras-chave: CTL response; HIV; Antivirals; Epidemiology; Immune response; Infectious diseases; Mathematical biology; Models of evolution; Prions; Resistance; Treatment; Viruses.
Ano: 1999

The microbiome and inborn errors of metabolism: Why we should look carefully at their interplay?
Provedor de dados: Genetics and Molecular Biology
Autores: Colonetti,Karina; Roesch,Luiz Fernando; Schwartz,Ida Vanessa Doederlein.
Abstract Research into the influence of the microbiome on the human body has been shedding new light on diseases long known to be multifactorial, such as obesity, mood disorders, autism, and inflammatory bowel disease. Although inborn errors of metabolism (IEMs) are monogenic diseases, genotype alone is not enough to explain the wide phenotypic variability observed in patients with these conditions. Genetics and diet exert a strong influence on the microbiome, and diet is used (alone or as an adjuvant) in the treatment of many IEMs. This review will describe how the effects of the microbiome on the host can interfere with IEM phenotypes through interactions with organs such as the liver and brain, two of the structures most commonly affected by IEMs. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Inborn errors of metabolism; Microbiome; Microbiota; Diet; Treatment.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000400515

Tratamento de sementes de soja com fungicidas.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: HENNING, A. A.; KRZYZANOWSKI, F. C.; FRANCA NETO, J. B.; YORINORI, J. T.
bitstream/item/53971/1/49.pdf
Tipo: Comunicado Técnico (INFOTECA-E)
Palavras-chave: Soybean; Seed; Treatment; Fungicide.; Fungicida; Glycine Max; Semente; Tratamento; Soja.
Ano: 1991
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/445418

Qualidade da agua.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: PATERNIANI, J. E. S.; PINTO, J. M.
IMPORTÂNCIA DA ÁGUA NA AGRICULTURA; PRINCIPAIS CARACTERÍSTICAS DOS MANANCIAIS; AMOSTRAGEM DA ÁGUA PARA ANÁLISE; PARÂMETROS FÍSICOS, QUÍMICOS E BIOLÓGICOS DE QUALIDADE DA ÁGUA; INTRODUÇÃO ÀS TÉCNICAS DE TRATAMENTO DE ÁGUA PARA IRRIGAÇÃO; ESTUDO DE CASOS.
Tipo: Capítulo em livro técnico (INFOTECA-E)
Palavras-chave: Agua Qualidade; Treatment; Analysis; Análise; Agricultura; Irrigação; Tratamento; Agriculture; Irrigation; Water quality.
Ano: 2001
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/134369

DIACOM: diagnostico completo da qualidade da semente de soja.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: FRANCA NETO, J. de B.; HENNING, A. A.
DIACOM e o tratamento de sementes; Procedimentos do DIACOM; Beneficios propiciados pelo DIACOM.
Tipo: Circular Técnica (INFOTECA-E)
Palavras-chave: Teste; DIACOM; Controle; Soybean; Seed; Quality; Test; Disease; Control; Treatment; Brasil.; Doença; Qualidade; Semente; Tratamento; Soja.; Brazil.
Ano: 1992
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/445373

Efeito do Hinokitiol sobre Fusarium solani f. piperi agente da podridão das raízes e secamento dos ramos da pimenta-do-reino (Piper nigrum L.).
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: MABUCHI, N.; ALBUQUERQUE, F. C. de; DUARTE, M. de L. R.
bitstream/item/114578/1/COMUN-TECNICO-41.pdf
Tipo: Comunicado Técnico (INFOTECA-E)
Palavras-chave: Pimenta-do-reino; Controle; Secamento do ramo; Hinokitiol; Treatment; Pole; Control; Disease; Fungicide; Branch drying.; Estaca; Doença; Fungo; Fungicida; Fusarium Solani; Piper Nigrum; Podridão da Raiz; Tratamento.; Black pepper; Fungi; Root rot.
Ano: 1973
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/376041

Tratamento de acidentes com serpentes peçonhentas.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: MIRANDA, J. R.
Resultados de trabalhois realizados com a herpetofauna da regiâo semi-árida; Tratamento não dispondo do soro; Tratamento dispondo do soro; Tratamento local; Tratamento geral; Distincao entre serpentes venenosas e não venenosas; Orientação para prevenir o acidente ofídico.
Tipo: Documentos (INFOTECA-E)
Palavras-chave: Semi-Árido; Serpente peconhenta; Soro anticrotálico; Poisonous serpent; Treatment; Animal peçonheto.; Réptil; Cobra; Tratamento.; Herpetofauna.
Ano: 1982
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/132590

Respostas de N-P-Ka e Mg no desenvolvimento de mudas de dendê na região de Manaus-AM.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: PACHECO, A. R.; TAILLIEZ, B. J.; VIEGAS, I. de J. M.
bitstream/item/57412/1/Belem-BP4.pdf
Tipo: Séries anteriores (INFOTECA-E)
Palavras-chave: Manaus; Amazonas; Brasil; Oil palm; Seedling; Treatment; Fertilizer.; Adubação; Dendê; Muda; Tratamento.; Amazonia.
Ano: 1987
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/381107

Prevenção e tratamento das doenças dos caprinos.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: PADILHA, T. N.
Trata sobre algumas orientações das doenças dos caprinos: como prevenir e tratar as doenças dos caprinos; outros cuidados para evitar doenças nas criações.
Tipo: Documentos (INFOTECA-E)
Palavras-chave: Prevenção; Pathology; Prevention; Treatment; Goat.; Caprino; Doença; Tratamento.
Ano: 1986
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/132771

Tratamento de estacas de pimenta-do-reino com oito fungicidas.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: SILVA, H. M.; ALBUQUERQUE, F. C. de; DUARTE, M. de L. R.; MABUCHI, N.
bitstream/item/114588/1/COMUN-TECNICO-39.pdf
Tipo: Comunicado Técnico (INFOTECA-E)
Palavras-chave: Pimenta-do-reino; Propagação; Controle; Treatment; Pole; Fungicide; Propagation; Disease; Control.; Estaca; Fungo; Fungicida; Doença; Fusarium Solani; Tratamento.; Fungi.; Black pepper.
Ano: 1973
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/376352

Efeito de diferentes tratamentos anti-helmínticos sobre o OPG e ganho de peso de bezerros bubalinos lactentes.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: LAU, H. D.
bitstream/item/28926/1/CPATU-BP16.pdf
Tipo: Séries anteriores (INFOTECA-E)
Palavras-chave: Bubalino; Controle; OPG; Nematodeo gastrintestinal; Piperazina; Cloridrato de levamizol; Strongyloides papillosus; Belem; Pará; Brasil; Buffalo; Control; Helminthe; Treatment; Levamizal chloridrate.; Bezerro; Bubalus Bubalis; Helminto; Ganho de Peso; Neoascaris Vitulorum; Tratamento.; Amazonia; Gastrointestinal nematodes; Calves; Piperazine; Weight gain.
Ano: 1980
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/378281

Pesquisa da Embrapa define tratamento para controle de inseto que destroi palma.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: ALBUQUERQUE, S. G. de.
bitstream/item/176557/1/Separata-9376.pdf
Tipo: Artigo de divulgação na mídia (INFOTECA-E)
Palavras-chave: Palma; Controle; Control; Treatment; Cochonilha; Inseto; Tratamento; Insecta; Opuntia ficus-indica.
Ano: 2001
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/134287

Aspectos sobre desnutrição mineral em búfalos e método de tratamento.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: LAU, H. D.
bitstream/item/41017/1/Boletim-Pesquisa-89-CPATU.pdf
Tipo: Séries anteriores (INFOTECA-E)
Palavras-chave: Bubalino; Trataamento; Pará; Brasil; Buffalo; Treatment; Mineral deficiency.; Acara; Cálcio; Deficiência Mineral; Fósforo; Nutrição.; Amazonia; Calcium; Phosphorus.; Nutrition.
Ano: 1988
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/383834

Tratamento químico de sementes de caupi na erradicação de patógenos e sua influência no estande.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: POLTRONIERI, L. S.; SILVA, J. F. de A. F. da; TRINDADE, D. R.
bitstream/item/59310/1/CPATU-ComTec73.pdf
Tipo: Comunicado Técnico (INFOTECA-E)
Palavras-chave: Caupi; Controle; Estande; Cowpea; Seed; Treatment; Fungicide; Control.; Fungicida; Fungo; Semente; Tratamento.; Fungi.
Ano: 1993
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/380526

Eimerideos parasitos de búfalos no Estado do Pará.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: LAU, H. D.
bitstream/item/31912/1/CPATU-BP42.pdf
Tipo: Séries anteriores (INFOTECA-E)
Palavras-chave: Base Fisica do CPATU; Belem; Pará; Brasil; Buffalo; Treatment; Infestation.; Búfalo; Coccidiose; Infestação; Parasitismo; Tratamento.; Eimeria; Amazonia; Parasitism.
Ano: 1982
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/381149

Tratamentos pré-germinativos para sementes de grapia (Apuleia leiocarpa).
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: BIANCHETTI, A.; MARTINS, E. G.; FOWLER, J. A. P.; RAMOS, A.; ALVES, V. F.
bitstream/CNPF-2009-09/16536/1/com_tec02.pdf
Tipo: Comunicado Técnico (INFOTECA-E)
Palavras-chave: Grapia; Seed; Treatment; Propagação.; Espécie nativa; Grapiapunha; Germinação; Semente; Apuleia Leiocarpa; Tratamento.
Ano: 1995
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/290757

Citros: formação de mudas.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: RIBEIRO, S. I.
bitstream/item/61714/1/Belem-RecBas10.pdf
Tipo: Séries anteriores (INFOTECA-E)
Palavras-chave: Citro; Cultivo; Enxertia; Formação; Cultting; Cultivation; Seed; Fertilizer; Grafting; Seedbag; Treatment; Conservation; Nursery; Formation.; Adubação; Conservação; Muda; Semente; Sementeira; Tratamento; Viveiro.; Citrus.
Ano: 1989
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/381134

Manual de práticas sanitárias para bubalinos jovens.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: LAU, H. D.
bitstream/item/34026/1/CPATU-CirTec60.pdf
Tipo: Circular Técnica (INFOTECA-E)
Palavras-chave: Bubalino; Sanidade; Buffalo; Sanity; Treatment; Disease; Post-partum.; Doença; Pós-Parto; Tratamento.
Ano: 1991
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/379309

Ocorrência de pragas na cultura do repolho (Brassica oleracea var. Capitata L.) em Altamira-Pará.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: POLTRONIERI, M. C.; KATO, M. do S. A.
bitstream/item/57529/1/Belem-BP5.pdf
Tipo: Séries anteriores (INFOTECA-E)
Palavras-chave: Controle; Altamira; Pará; Brasil; Pest; Disease; Treatment; Control; Insecticide.; Doença; Inseticida; Praga; Repolho; Tratamento.; Amazonia; Cabbage.
Ano: 1987
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/381120

Semente de soja: cuidados na aquisição e na utilização.
Provedor de dados: Informação Tecnológica em Agricultura (Infoteca-e)
Autores: KRZYZANOWSKI, F. C.; FRANCA NETO, J. de B.; HENNING, A. A.
Aquisicao da semente; Cuidados com o armazenamento da semente; Preparo da semente; Instalacao da lavoura.
Tipo: Comunicado Técnico (INFOTECA-E)
Palavras-chave: Armazenagem; Brasil; Soybean; Seed; Quality; Treatment; Production.; Produção; Qualidade; Semente; Tratamento; Soja.; Brazil; Storage.
Ano: 1992
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/445459

Choix de produits pour lutter contre la pollution du milieu marin par les hydrocarbures. IV. Toxicite relative de sept produits emulsionnants antipetrole.
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Maggi, Pierre.
Toxicity of seven emulsifying agents for treating oil spills (ISTPM designation E sub(22), E sub(30), E sub(41), E sub(46), E sub(47), E sub(52) and E sub(53)) was determined using eight marine species (three gastropods, one bivalve, two crustacean and one fish). Results are tabulated as LD sub(50). E sub(47) was least toxic to the species studied, but it could still perhaps harm other plant and animal species.
Tipo: Text
Palavras-chave: Treatment; Pollution; Oil spills; Toxicity.
Ano: 1972
URL: http://archimer.ifremer.fr/doc/1972/publication-2074.pdf

Bilan du suivi de l'exploitation industrielle de la crépidule en Bretagne Nord (baies de Saint-Brieuc et du Mont Saint-Michel) 2002-2005
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Blanchard, Michel; Hamon, Dominique.
The slipper-limpet (Crepidula fornicata) is a marine gastropod which causes serious perturbations in shellfish beds, because of spatial spreading and density rising. Along French coasts, in Northern Brittany, two bays are highly colonized : bay of Saint-Brieuc, centre for scallops fishery, and bay of Mont-Saint-Michel, a famous oyster-farming area, with a total limpet stock about 450 000 metric tons. The association AREVAL was founded in 2001 to manage there, an industrial collect of limpets by a succing-dredge, followed ashore by a treatment for calcareous soil improvement. The scientific survey, contracted to IFREMER, included measurements of long andshort-term dredge's effects on grounds and limpet population, and proposals to set up dredging...
Tipo: Text
Palavras-chave: France; Western Channel; Bay of Mont Saint Michel; Bay of Saint Brieuc; Impact; Dredging; Treatment; Crepidula fornicata; Slipper limpet; Manche Ouest; Baie du Mont Saint Michel; Baie de Saint Brieuc; Impact; Dragage; Exploitation; Crepidula fornicata; Crépidule.
Ano: 2006
URL: http://archimer.ifremer.fr/doc/2006/rapport-6301.pdf

Impact on non target organisms of anti-marine wood-borer treatments. Evaluation of stress imposed by treatments on organisms from test sites
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Goulletquer, Philippe; Geairon, Philippe; Faury, Nicole; Razet, Daniel; Soletchnik, Patrick; Gras, Paul; Adessi, L.
In European waters, significant economic damages to wooden structures are caused by bivalves molluscs and crustaceans. Treatments like copper-chrome-arsenic mixtures (CCA) were designed to prevent settlement of these wood borer species. However, limited and conflicting evidence regarding the toxicity to non-target organisms are available in the literature. This report aims to provide insights regarding the CCA leachates' toxicity to an important aquaculture species, the blue mussel Mytilus edulis for which much information on normal and stressed physiology is available for purposes of comparisons. The mussels are usually considered as a particularly suitable species for biological monitoring (Smaal and Widdows, 1994). To address the CCA leachate issue, two...
Tipo: Text
Palavras-chave: Bivalvia; Mussel; Mytilus edulis; Copper-chrome-arsenic (CCA); Treatment; Feeding; Absorption.
Ano: 1996
URL: http://archimer.ifremer.fr/doc/00043/15437/12788.pdf

Traitement des crevettes contre le noircissement .Mise au point d'une ligne de traitement
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Chantreau, Patrick.
Once fished, the shrimps must be cooled quickly in water cooled in order to slow down all chemical and bacteriological activities. In addition, in order to avoid blackening (mélanose) shrimps (céphalothorax and legs) it is necessary to treat those with an antioxydant product. The product currently used to inhibit this enzymatic change is the soda niétabisuifite (Na-&gt; S7 O5), until now, after being fished. the shrimps were directly soaked in a cooled water tank, containing the pesticide.  The solution of treatment was progressively prepared needs. The concentration of this one was approximately 2 to 3% of métabisulfite, that is to say 6 to 9 G of SO2 per liter for a starting product containing 320 G of SO2 approximately.  In order to preserve a good...
Tipo: Text
Palavras-chave: New Caledonia; Blackening; Treatment; Penaeus stylirostris; Shrimp; Nouvelle Calédonie; Noircissement; Traitement; Penaeus stylirostris; Crevette.
Ano: 1991
URL: http://archimer.ifremer.fr/doc/1991/rapport-1648.pdf

Impact on non target organisms of anti-marine wood-borer treatments. Evaluation of stress imposed by treatments on organisms form test sites - Final Report
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Goulletquer, Philippe; Geairon, Philippe; Faury, Nicole; Razet, Daniel; Soletchnik, Patrick; Adessi, L.; Gras, Paul.
Experiments were canied out to assess the copper-chrome-arsenic (CCA) trealment effeets on the Blue mussel Mytilus edulis physiology. Experimental design included two complementary approaches: 1) scope for growth esrimates based upon the energy balance between respiration energy loss and energy gained from feeding processes. 2) a biological early waming system for valve behavior monitoring under CCA exposures. Various temperature range (seasonal effeet). physiological status (mature &amp; immature mussels) as weil as CCA concentrations (from 0 to 48kg/m3) and rime exposure were tested. Significant monality rates for the experimental mussel populations were recorded in alI experimental modalities but the 2kg/m3 CCA treatment concentration. Overall results...
Tipo: Text
Palavras-chave: Bivalvia; Mussel; Mytilus edulis; Copper-Chrome-Arsenic (CCA); Treatment; Feeding; Absorption.
Ano: 1997
URL: http://archimer.ifremer.fr/doc/00077/18795/16372.pdf

Traitement des langoustines et des crevettes contre le noircissement
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Chantreau, Patrick; Vallet, Jean-luc.
The conservation of crawfish requires the use of chemical substances making it possible to limit blackening.  This phenomenon this blackening (melanine) is due to the coordinated action of three elements: - oxygen,   - an enzyme (cupro-protein),  - a suitable substrate, tyrosin or the dihydroxyphénylalanine.  The absence of the one of them allows a notorious reduction in the phenomenon.  Several antioxydant products, were used to prevent the formation of the mélanine. The métabisutfite of soda or potassium as well as soda bisulfite in acid solution, are currently used to treat crawfish and shrimps.  Several methods of use of these pesticides exist, we propose in this report to present the principal ones, as well as the control methods making it possible to...
Tipo: Text
Palavras-chave: Regulation; Sprinkling; Antioxydant; Technology; Treatment; Shrimp; Crawfish; Réglementation; Aspersion; Antioxydant; Technologie; Traitement; Crevette; Langoustine.
Ano: 1991
URL: http://archimer.ifremer.fr/doc/1991/rapport-1586.pdf

Effluents from land based marine farms: nature, treatment, valorisation, modelisation. Applications to fish and shrimp rearing
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Hussenot, Jerome; Lefebvre, Sebastien; Martin, Jean-louis.
Fish culture (seabass, turbot...) on the French metropolitan coast, and shrimp culture in the overseas territories (essentially New Caledonia and Tahiti) are subject to a regular development through land based farms. Three thematic of research on aquaculture ponds are carried out in CREMA-L’Houmeau, in collaboration with producers. The aim of the first one is to determine the optimal rearing conditions (stocking density, water renewal rate, input of oxygen, rate of feeding...) which allow to minimise the quantity of wastes for a similar final biomass. The second part aims to reduce the nutrient loading in the effluent, through open-air treatments: sedimentation ponds, foam fractionation, mass production of phytoplankton, and rearing of molluscs on the...
Tipo: Text
Palavras-chave: Fish; Shrimp; Pond management; Effluents; Treatment.
Ano: 2000
URL: http://archimer.ifremer.fr/doc/00016/12728/9650.pdf

Scientific Opinion on Norovirus (NoV) in oysters: methods, limits and control options
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
NoV is highly infectious, and there is no threshold infectivity limit for NoV detected by PCR. The probability of becoming infected increases with the dose but depends also on the characteristics of the organism, the food matrix and the host factors. The relationship between the number of infectious virus particles and the number of virus genome copies detected by quantitative PCR is not a constant, and it is important to realise that the infectious risk associated with low level positive oysters as determined by real-time PCR may be overestimated. Quantitative data on viral load from areas compliant with current EU legislative requirements (E. coli standards) during January-March 2010 in 3 selected member states, show that a viral limit of 100, 200, 500,...
Tipo: Text
Palavras-chave: Norovirus; Oysters; Diagnostic methods; Microbiological criteria; Treatment; Control.
Ano: 2012
URL: http://archimer.ifremer.fr/doc/00066/17735/15256.pdf

Bacterial inactivation using pulsed light
Provedor de dados: Institutional Archive of Ifreme (ArchiMer)
Autores: Elmnasser, Noura; Ritz, Magali; Leroi, Francoise; Orange, Nicole; Bakhrouf, Amina; Federighi, Michel.
Pulsed light is a new method intended for the decontamination of food surfaces using short, high frequency pulses of an intense broad spectrum. The effects of broad spectrum pulsed light on the survival of Listeria monocytogenes Scott A, Listeria monocytogenes CNL, Pseudomonas fluorescens MF37 and Photobacterium phosphoreum SF680 populations on agar and in a liquid medium were investigated during this study. The sterilisation system generated 1.5 J cm(-2) per pulse with eight lamps for 300 mu s. In the case of surface-seeded cells, a 7.8, 8.14 and &gt; 7.14 log reduction was obtained for L. monocytogenes, Ps. fluorescens MF37 and Ph. phosphoreum, respectively, after a single pulse of treatment. Inactivation levels were lower for depth-plated cells: indeed,...
Tipo: Text
Palavras-chave: Efficiency; Inactivation; Bacteria; Treatment; Pulsed light.
Ano: 2007
URL: http://archimer.ifremer.fr/doc/2007/publication-3041.pdf

Ejaculate Characteristics of Rabbits Infected with Trypanosoma congolense and Changes Caused after Treatment with Diminazene aceturate (Diminaveto®)
Provedor de dados: International Journal of Morphology
Autores: Leigh,Olufisayo Oluwadamilare; Fayemi,Oluremi Eric.
The effects of experimental Trypanosoma congolense infection on the ejaculate of rabbits and changes caused after treatment with Diminaveto® were investigated using 24 New Zealand White rabbits (bucks). The bucks were housed singly in standard rabbit cages and fed on specialized ration containing 10% Protein supplement, grains, legume, salt and fresh water ad libitum during the study. Data on ejaculate characteristics were collected from all the bucks in the first phase (i.e. before infection) and in the second phase (i.e. during infection, with 4.8x10(5) Trypanosoma congolense, intraperitoneally). Similar data were collected from 12 randomly selected bucks treated with 7.0mg/kg Diminaveto® following reconstitution during the third phase. Data collected...
Tipo: Journal article
Palavras-chave: Ejaculate; Bucks; Trypanosoma congolense; Treatment; Diminazene.
Ano: 2010
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200022

INFECTIONS IN THE BITE SITE AFTER ENVENOMING  BY SNAKES OF THE Bothrops GENUS
Provedor de dados: Journal of Venomous Animals and Toxins
Autores: JORGE,M. T.; RIBEIRO,L. A.
Envenomation caused by snakes of the Bothrops genus produces a lesion in the bite site and can result in extensive necrosis. The dead tissue can be secondarily infected by bacteria that come from the snake, and the bacteria can be inoculated at the moment of the bite. The bacteria that most commonly cause infection are the enterobacteria, mainly Morganella morganii, Proteus rettgeri, Enterobacter sp., and Escherichia coli. Group D streptococci including here Enterococcus sp. and the Bacteroides sp. are also involved. Based on a study of the sensibility of these bacteria, it has been suggested that this infection must be treated with chloramphenicol, as a sole antimicrobial agent, or with the combinations of benzylpenicillin or ampicillin with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Snakebite; Bothrops; Infection; Antimicrobial agents; Treatment.
Ano: 1997
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79301997000200002

Efficacy of sertraline against Trypanosoma cruzi: an in vitro and in silico study
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Ferreira,Daiane Dias; Mesquita,Juliana Tonini; Silva,Thais Alves da Costa; Romanelli,Maiara Maria; Batista,Denise da Gama Jaen; Silva,Cristiane França da; Gama,Aline Nefertiti Silva da; Neves,Bruno Junior; Melo-Filho,Cleber Camilo; Soeiro,Maria de Nazare Correia; Andrade,Carolina Horta; Tempone,Andre Gustavo.
Abstract  Background: Drug repurposing has been an interesting and cost-effective approach, especially for neglected diseases, such as Chagas disease.  Methods: In this work, we studied the activity of the antidepressant drug sertraline against Trypanosoma cruzi trypomastigotes and intracellular amastigotes of the Y and Tulahuen strains, and investigated its action mode using cell biology and in silico approaches.  Results: Sertraline demonstrated in vitro efficacy against intracellular amastigotes of both T. cruzi strains inside different host cells, including cardiomyocytes, with IC50 values between 1 to 10 μM, and activity against bloodstream trypomastigotes, with IC50 of 14 μM. Considering the mammalian cytotoxicity, the drug resulted in a selectivity...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trypanosoma cruzi; Drug; Treatment; Sertraline; Drug repurposing; Drug repositioning.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100321

Use of antivenoms for the treatment of envenomation by Elapidae snakes in Guinea, Sub-Saharan Africa
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Baldé,Mamadou C; Chippaux,Jean-Philippe; Boiro,Mamadou Y; Stock,Roberto P; Massougbodji,Achille.
Background In Guinea Elapids are responsible for 20% of envenomations. The associated case fatality rate (CFR) ranged 15-27%, irrespective of treatment. Results We studied 77 neurotoxic envenomations divided in 3 groups: a set of patients that received only traditional or symptomatic treatments, and two other groups that received either 2 or 4 initial vials of Antivipmyn® Africa renewed as necessary. CFR was 27.3%, 15.4% and 17.6%, respectively. Although antivenom treatment was likely to reduce CFR, it didn’t seem to have an obvious clinical benefit for the patients, suggesting a low treatment efficacy. Mean delay to treatment or clinical stages were not significantly different between the patients who recovered and the patients who died, or between...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Elapid; Neurotoxins; Treatment; Antivenom; Guinea; Africa.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100304

Epidemiological and clinical characteristics of scorpion stings in children in fez, Morocco
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Abourazzak,S; Achour,S; El Arqam,L; Atmani,S; Chaouki,S; Semlali,I; Soulaymani Bencheikh,R; Bouharrou,A; Hida,M.
Scorpion stings are a public health problem in Morocco, especially among children, who experience the most severe cases. Epidemiological and clinical findings on scorpion stings in Fez, Morocco, were evaluated in this investigation. Of 163 cases that required medical attention, 62.6% were male children. The mean age of patients was 4.8 ± 3.4 years. The mean time between stings and first medical attention was 3.36 ± 2.5 hours. Almost all cases occurred in the summer (94%) and extremities represented the most frequent sting sites (86.5%). Local pain, hyperemia, scarification, vomiting, sweating, restlessness, tachycardia and tachypnea were the observed clinical symptoms. Regarding severity, 55.2% of patients belonged to class III, followed by class II...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Scorpion sting; Clinical symptoms; Envenomation; Treatment; Children; Morocco.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000200008

Trichomoniasis in Bothrops jararaca (serpentes, viperidae)
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Vilela,F. C.; Silva,M. G. da; Barrella,T. H.; Silva,R. J. da.
We describe a case of trichomoniasis in a Bothrops jararaca (Serpentes, Viperidae) donated to the Center for the Study of Venoms and Venomous Animals - CEVAP/UNESP. The animal had diarrhea with great quantity of flagellated protozoa in the feces. Microscopic examination of fecal smears stained with Giemsa revealed the presence of trichomonads, morphologically similar to Trichomonas acosta. Trichomonads were not detected in fecal exams after treatment with a single dose of 40 mg/kg metronidazole (Flagyl®).
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trichomoniasis; Trichomonas sp.; Bothrops jararaca; Treatment; Metronidazole.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992003000100007

Histopathological evaluation in experimental envenomation of dogs with Crotalus durissus terrificus venom
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Sangiorgio,F.; Sakate,M.; Nogueira,R. M. B.; Tostes,R. A.
The present work evaluated histopathological aspects in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into three groups of seven animals each: Group I - only venom; Group II - venom + 50ml antiophidic serum + fluid therapy; Group III - venom + 50ml antiophidic serum + fluid therapy + urine alkalization. Lyophilized venom of Crotalus durissus terrificus was reconstituted in saline solution and inoculated subcutaneously at the dose of 1mg/kg body weight. Three animals of each group were subjected to euthanasia, and their muscular tissue, brain, spleen, kidneys, heart, lungs, stomach, small and large intestines, and popliteal lymph node fragments were collected for histopathological...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Histopathology; Crotalus durissus terrificus; Dogs; Treatment; Intoxication.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000100007

Pre-hospital treatment of snake envenomation in patients presented AT a tertiary care hospital in Northwestern India
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Chauhan,S.; Faruqi,S.; Bhalla,A.; Sharma,N.; Varma,S.; Bali,J.
Snakebite is an important medical emergency. Anti-snake venom along with supportive care is the only specific treatment. However, many people put their faith in non-registered medical practitioners. Where medical aid is available, lack of trained health personnel jeopardizes the situation. This retrospective study, the first of its kind, was aimed at studying the pre-hospital treatment as well as the behavior of patients bitten by snakes and referred to the Postgraduate Institute of Medical Education and Research, Chandigarh, India. A total of 88 cases that occurred between January 1997 and December 2001 were studied. Seventy patients received treatment prior to admission (the majority was treated by non-registered medical practitioners, registered medical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Snake envenomation; Clinical features; Treatment; First aid.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000300006

Rabies review: immunopathology, clinical aspects and treatment
Provedor de dados: Journal of Venomous Animals and Toxins Including Tropical Diseases
Autores: Consales,C. A.; Bolzan,V. L.
Among the diseases of viral origin, rabies is unique in its distribution and range of victims since it can afflict all warm-blooded animals. The interaction between the virus and the host population has facilitated the survival of the disease. The rabies virus (RV) has not changed in any significant way and has been capable of taking advantage of conditions suited to the continuance of rabies. Infection by RV is invariably lethal in the absence of protective immune response which, however, can contribute to the pathogenesis of rabies. Proinflammatory cytokines might affect, directly or indirectly, the levels of neurotrophins, growth factors, neurotransmitters and neurotoxins in the brain by activating glia, neurons, and vascular and immune cells. Although...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rabies; Immunopathology; Clinical aspects; Treatment.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000100002

乳牛と新生子牛の血中ビタミンB1、B2、B6およびB12濃度
Provedor de dados: Obihiro University of Agriculture and Veterinary Medicine Academic Repository (OAK)
Autores: 佐藤, 基佳; 佐々木, 雄介; 望月, 均; 上野, 博史; 山田, 一孝; 大谷, 昌之; SATO, Motoyoshi; SASAKI, Yusuke; MOTIDUKI, Hitoshi; UENO, Hiroshi; YAMADA, Kazutaka; OTANI, Masayuki.
乳牛のビタミンB群製剤の適正な補給を目的に、健康牛（泌乳中期および乾乳期）と新生子牛のビタミンB1、B2、B6、B12の血中濃度を測定した。泌乳中期群(n=5)ではB1、B2、B6、B12の血中濃度は51.2±1.2ng/ml、92.1±3.9ng/ml、37.8±1.7ng/ml、220.2±16.3pg/ml、乾乳期群(n=4)では39.5±3.3ng/ml、75.2±4.6ng/ml、42.6±2.2ng/ml、406.8±48.1pg/mlで、泌乳中期群と比較してB1、B2で低値、B12で高値（p&lt;0.05)を示した。新生子牛群(n=9)では、出生直後のビタミンB1、B2、B6、B12の血中濃度は47.0±3.6ng/ml、169.9±6.7ng/ml、4.1±0.2ng/ml、357.4±44.2pg/mlで、生後20日目では30.0±1.4ng/ml、130.9±6.4ng/ml、16.5±0.6ng/ml、230.4±13.9pg/mlを示し、ビタミンB6を除くビタミンB群の血中濃度は生後漸減した。 　以上の成績から飼養状況および個体の状況により血中濃度が異なるため、適正な補給に当たっては対象牛のビタミンB群の血中濃度を把握し、今回の測定値を参考として適量の薬用量の決定が必要であると考えられた。Blood concentrations of the vitamin B  complex (B1，B2，B6，and B12) were measured in healthy cows both during the lactation period and during the non-lactation period，and in calves from 1 to 20 days...
Palavras-chave: 乳牛; 予防; 治療; ビタミンB群; Dairy cattle; Prevention; Treatment; Vitamin B complex.
Ano: 2003
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2931

Strategies for the Control of Surra in Asia
Provedor de dados: Obihiro University of Agriculture and Veterinary Medicine Academic Repository (OAK)
Autores: Ozawa, Y.
Palavras-chave: Diagnostic methods; Epidemiology; Treatment; Trypanosoma evansi.
Ano: 1998
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/284

Anthracnose control of ‘Prata-Ana’ banana with pre-harvest phosphite application
Provedor de dados: Revista Brasileira de Fruticultura
Autores: Rodrigues,Maria Luísa Mendes; Souza,Samuel Gustavo Ribeiro de; Mizobutsi,Edson Hiydu; Pinheiro,Juceliandy Mendes da Silva; Monção,Flávio Pinto; Mizobutsi,Gisele Polete.
Abstract  The aim of this study was to evaluate the anthracnose intensity in ‘Prata-Anã’ banana with the application of three phosphite formulations in two application intervals in the developing banana bunches and to evaluate the physical and chemical characteristics of fruits. In the field, in addition to producer management, three phosphite formulations were evaluated: FCu1 (4% Cu + 20% P2O5), FCu2 (4% Cu + 22% P2O5) and FK (42% P2O5 + 27.7% K2O) sprayed on banana bunches at different application frequencies: four and eight times. The experiment was carried out in a randomized blocks design following a 5 x 2 factorial scheme, with 3 phosphite formulations, pure water and no application and two application intervals. Pure water and no application were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Colletotrichum musae; Severity; Musa spp; Phosphites; Treatment.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-29452020000300401

Intake and performance of feedlot cattle fed diets based on high and low Brix sugar cane with or without calcium oxide and corn silage
Provedor de dados: Revista Brasileira de Zootecnia
Autores: Magalhães,Felipe Antunes; Valadares Filho,Sebastião de Campos; Menezes,Gustavo Chamon de Castro; Gionbelli,Mateus Pies; Zanetti,Diego; Machado,Marcelo Grossi; Pina,Douglas dos Santos; Komura,Koiti.
The objective of this study was to evaluate low and high Brix diets, treated or not with 5 g of calcium oxide per kg of natural matter, and corn silage on intake, digestibility and performance of beef cattle. Forty cattle with initial body weight (BW) of 350 kg were used: five composed the control group, 30 were distributed into random blocks (control) and the other five were distributed in a 5 × 5 incomplete Latin square, with the objective of determining digestibility. The 30 animals evaluated for performance were slaughtered and empty body weight (EPW), carcass dressing and meat cuts were determined. The diet with corn silage (CS) presented the best intake of the other ingredients and the best weight gain, except for neutral detergent fiber intake in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Digestibility; Ethanol; Fermentation; Treatment.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-35982012000600026

Surveillance and control reservoirs of visceral leishmaniasis in Brazil: technical and legal aspects
Provedor de dados: Revista de Educação Continuada em Medicina Veterinária e Zootecnia do CRMV-SP
Autores: Donato, Lucas Edel; Lima Júnior, Francisco Edilson Ferreira de; Alburquerque, Rafaella; Gomes, Marcia Leite Sousa.
It made an assessment of the technical and legal aspects related to the control of visceral leishmaniasis in Brazil, highlighting the treatment of infected dogs, euthanasia of seropositive dogs and laboratory diagnosis of canine visceral leishmaniasis (CVL).
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dog visceral leishmaniasis; Treatment; Euthanasia; Laboratory diagnosis; Public health Leishmaniose visceral canina; Tratamento; Eutanásia; Diagnóstico laboratorial.
Ano: 2013
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/16219

Nitrogen removal from swine wastewater by combining treated effluent with raw manure
Provedor de dados: Scientia Agricola
Autores: Kunz,Airton; Steinmetz,Ricardo; Damasceno,Simone; Coldebela,Arlei.
Effluents from swine raising can be harmful to the environment if not correctly managed. Nitrogen (N) is usually the main element present at high concentrations in the effluent. Since the use as biofertilizer is not always a feasible alternative, the treatment of swine wastewater is necessary. Variations in N species and water solubility make the treatment difficult and expensive. Additional N removal at low cost via denitrification may be possible by recirculating nitrified effluent in the barns. In this study, raw manure (RM) was homogenized with treated effluent (TE) at RM/(RM + TE) ratios of 1.0, 0.9, 0.8, 0.7, 0.6, 0.5 and 0 in order to simulate the effect of reused water on swine wastewater nitrogen removal. Samples were collected daily during four...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Nutrient removal; Swine effluent; Treatment; Water reuse.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162012000600002

Design and Construction of an Affordable Potable Water Treatment Unit for Domestic Usage
Provedor de dados: Agricultural Engineering International : The CIGR e-journal
Autores: Isikwue, Martins Okechukwu; Ato, Jeremiah A.; Ayua, Isaac T.
An affordable potable water treatment unit was designed and constructed. The components were coagulation unit, sedimentation unit, slow sand filter unit, utraviolet unit and the storage unit. Filtrate from the chamber was compared with International acceptable standards. The result showed that the treatment chamber proved effective and can produce at least 100 litres of portable water per day. The physical and chemical parameters monitored were reduced to the acceptable limit by WHO (World Health Organisation), NAFDAC(National Agency for Food and Drug Administration and Control) Nigeria and Nigerian Standard for Drinking Water Quality (NSDWQ). However, coliform was not totally removed but the count was reduced by 99.4%.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Land and Water Management; Water Quality; Raw water; Filtration; Treatment; Potable water; Domestic usage.
Ano: 2015
URL: http://www.cigrjournal.org/index.php/Ejounral/article/view/2872

Design and Construction of an Affordable Potable Water Treatment Unit for Domestic Usage
Provedor de dados: Agricultural Engineering International : The CIGR e-journal
Autores: Martins Okechukwu Isikwue; Dept of Agric &amp; Environmental Engineering, University of Agriculture, Makurdi, Nigeria; Jeremiah A. Ato; Dept of Agric &amp; Environmental Engineering, Univ. of Agric Makurdi; Isaac T. Ayua; Agric. &amp; Environmental Engineering, Univ. of Agriculture Makurdi.
An affordable potable water treatment unit was designed and constructed. The components were coagulation unit, sedimentation unit, slow sand filter unit, utraviolet unit and the storage unit. Filtrate from the chamber was compared with International acceptable standards. The result showed that the treatment chamber proved effective and can produce at least 100 litres of portable water per day. The physical and chemical parameters monitored were reduced to the acceptable limit by WHO (World Health Organisation), NAFDAC(National Agency for Food and Drug Administration and Control) Nigeria and Nigerian Standard for Drinking Water Quality (NSDWQ). However, coliform was not totally removed but the count was reduced by 99.4%.
Palavras-chave: Land and Water Management; Water Quality; Raw water; Filtration; Treatment; Potable water; Domestic usage.
Ano: 2015
URL: http://www.cigrjournal.org/index.php/Ejounral/article/view/2872

Short and long period optimization of drug doses in the treatment of AIDS
Provedor de dados: Anais da Academia Brasileira de Ciências
Autores: CAETANO,MARCO A. L.; YONEYAMA,TAKASHI.
Numerical optimization techniques are useful in solving problems of computing the best inputs for systems described by mathematical models and when the objectives can be stated in a quantitative form. This work concerns the problem of optimizing the drug doses in the treatment of AIDS in terms of achieving a balance between the therapeutic response and the side effects. A mathematical model describing the dynamics of HIV viruses and CD4 cells is used to compute the short term optimal drug doses in the treatments of patients with AIDS by a direct method of optimization using a cost function of Bolza type. The model parameters were fitted to actual published clinical data. In order to simplify the numerical procedures, the control law is expressed as a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Modeling; Simulation; Drugs; Treatment; AIDS.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000300002

Mesenchymal stem cells for the treatment of neurodegenerative and psychiatric disorders
Provedor de dados: Anais da Academia Brasileira de Ciências
Autores: COLPO,GABRIELA D.; ASCOLI,BRUNA M.; WOLLENHAUPT-AGUIAR,BIANCA; PFAFFENSELLER,BIANCA; SILVA,EMILY G.; CIRNE-LIMA,ELIZABETH O.; QUEVEDO,JOÃO; KAPCZINSKI,FLÁVIO; ROSA,ADRIANE R.
Mesenchymal stem cells (MSCs) are multipotent progenitor cells that have the capacity to differentiate into all lineages of mesodermal origin, e.g., cartilage, bone, and adipocytes. MSCs have been identified at different stages of development, including adulthood, and in different tissues, such as bone marrow, adipose tissue and umbilical cord. Recent studies have shown that MSCs have the ability to migrate to injured sites. In this regard, an important characteristic of MSCs is their immunomodulatory and anti-inflammatory effects. For instance, there is evidence that MSCs can regulate the immune system by inhibiting proliferation of T and B cells. Clinical interest in the use of MSCs has increased considerably over the past few years, especially because...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mesenchymal stem cells; Treatment; Neurodegenerative disease; Psychiatric disorders.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652015000301435

Células mononucleares da medula óssea no tratamento da ruptura total dos tendões flexores e ligamento suspensor do boleto em equino
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Yamada,A.L.M.; Oliveira,P.G.G.; Carvalho,A.M.; Watanabe,M.J.; Hussni,C.A.; Alves,A.L.G.
This paper describes the case of a horse treated in a Teaching Veterinary Hospital. The sutures of the flexor apparatus associated with cell therapy, the stem cell, provided a rapid response of repair compared to other cases treated in routine of the Hospital. The association of conventional treatments with the mononuclear fraction of bone marrow significantly contributed to the reduction of the hyperextension of the metatarsophalangeal joint. Ultrasound images showed rapid fill cell and decrease in inflammation.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Equine; Tendon; Treatment; Injury; Mononuclear.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352011000600041

An outbreak of acute bovine mastitis caused by Klebsiella pneumoniae in a dairy herd
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Silva,N.; Costa,G.M.
An outbreak of coliform mastitis is described in a dairy herd from the State of Rio de Janeiro, Brazil. During a four-month period 14 fatal cases of Klebsiella pneumoniae-related mastitis were observed in a herd of 104 lactating cows. The symptoms included peracute enterotoxemia in which the cows died 6 to 12 h after the detection of mastitis by CMT. Staphylococcus aureus and Streptococcus agalactiae Streptococcus agalactiae were also isolated although could not be associated with cases of acute fatal mastitis. Milking practices were also evaluated. The milking machine was being used correctly and adequate precautions for hygiene and pre-milking and post-milking teat dipping were used. The organism was sensitive to gentamicin. Therapy for acute toxic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dairy cow; Acute bovine mastitis; Outbreak; Klebsiella pneumoniae; Vaccination; Treatment.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352001000400001

Efficacy of Ocimum gratissimum essential oil against the monogenean Cichlidogyrus tilapiae gill parasite of Nile tilapia
Provedor de dados: Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Autores: Meneses,J.O.; Couto,M.V.S. do; Sousa,N.C.; Cunha,F. dos S.; Abe,H.A.; Ramos,F.M.; Chagas,E.C.; Chaves,F.C.M.; Martins,M.L.; Maria,A.N.; Carneiro,P.C F.; Fujimoto,R.Y.
ABSTRACT The phythotherapy is an alternative to use of chemotherapeutical agents against monogenean infection. This study evaluated the anthelmintic activity of essential oil Ocimum gratissimum against monogenean Cichlidogyrus tilapiae as well as its acute toxicity in tilapia juveniles. The mean lethal concentration (LC50) and different concentrations of the essential oil, both in vitro and in vivo assays (short and long-term baths) were assessed. The LC50 was 40.70mg.L-1 and in the in vitro assay this concentration showed 80% efficacy at the last two hours and in the in vivo assay 65.87% efficacy in long-term bath. However, it provoked morphological alterations on the gills such as hyperplasia and edema. The parasites exposure at the highest concentration...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Disease; Freshwater fish; Helminth; Natural product; Treatment.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000200497

Effect of temperature on two-phase anaerobic reactors treating slaughterhouse wastewater
Provedor de dados: Brazilian Archives of Biology and Technology
Autores: Beux,Simone; Nunes,Ezequiel; Barana,Ana Cláudia.
The effectiveness of the anaerobic treatment of effluent from a swine and bovine slaughterhouse was assessed in two sets of two-phase anaerobic digesters, operated with or without temperature control. Set A, consisting of an acidogenic reactor with recirculation and an upflow biological filter as the methanogenic phase, was operated at room temperature, while set B, consisting of an acidogenic reactor without recirculation and an upflow biological filter as the methanogenic phase, was maintained at 32°C. The methanogenic reactors showed COD (Chemical Demand of Oxygen) removal above 60% for HRT (Hydraulic Retention Time) values of 20, 15, 10, 8, 6, 4, and 2 days. When the HRT value in those reactors was changed to 1 day, the COD percentage removal decreased...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Effluent; Slaughterhouse; Treatment; Anaerobic; Two-phase.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000700017

Osteoarthritis in horses - Part 2: a review of the intra-articular use of corticosteroids as a method of treatment
Provedor de dados: Brazilian Archives of Biology and Technology
Autores: Souza,Maria Verônica de.
ABSTRACT: The problem considered in this review is related to the frequent use of corticosteroids (COs) (i.e. steroids) in the practice of equine medicine and surgery as a therapeutic strategy in the treatment of degenerative joint disease, commonly known as osteoarthritis (OA). This disease is one of the most common among the equine musculoskeletal diseases, and is clinically characterized by pain, lameness, joint effusion at the initial stage, which usually reduces with the progression of the disease, and reduced physical performance. Although steroids are considered excellent drugs in the control of clinical signs resulting from osteoarthritis, they also influence cellular activity through activation of various signaling mechanisms. However, they can...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Equine; Degenerative joint disease; Steroids; Intra-articular drugs; Treatment.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132016000100324

Successful treatment of vancomycin-resistant enterococcus ventriculitis in a child
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Silva,Paulo Sérgio Lucas da; Monteiro Neto,Henrique; Sejas,Lílian Márcia.
Enterococci are an uncommon cause of CNS infection. A 20 month-old boy, diagnosed with hydrocephalus with ventriculoperitoneal shunt and history of lengthy hospitalization and use of wide spectrum antibiotics, was admitted to the pediatric intensive care unit diagnosed with ventriculitis. On the 14th day of empirical antibiotic therapy (vancomycin and meropenem) the child presented fever while the CSF sample culture evidenced vancomycin-resistant Enterococcus faecium. The patient received intravenous linezolid achieving cerebrospinal fluid sterilization. Conclusion: Intravenous linezolid appears to be a safe and effective therapy for vancomycin-resistant enterococcus ventriculoperitoneal shunt infection.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Vancomycin; Resistance; Treatment.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200027

Are anti-interferon antibodies the cause of failure in: chronic HCV hepatitis treatment?
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Barone,Antonio Alci; Tosta,Rose Aparecida Borges; Tengan,Fátima Mitiko; Marins,José Humberto Caetano; Cavalheiro,Norma de Paula; Cardi,Bruno Andrade.
A follow-up study was made of 94 chronic hepatitis C patients at a hepatitis clinic in Brazil, after interferon alpha (IFN-alpha) therapy, to determine the influence of anti-interferon antibodies on treatment outcome. Patients diagnosed as having chronic hepatitis C, confirmed by PCR (HCV RNA) and liver biopsy, were treated with interferon alpha 2a or 2b for at least six months, and were followed up for 24 weeks after termination of treatment in order to assess biochemical, virological and clinical pathology responses. Only 6% of the 94 patients developed anti-IFN antibodies, 70% presented a biochemical response and 23% maintained a sustained virological response. Clinical evaluation revealed that in only 2 patients was there progression of fibrosis; the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Interferon-alpha; Antibodies; Chronic HCV; Treatment.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000100002

Antibiotics for the empirical treatment of acute infectious diarrhea in children
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Diniz-Santos,Daniel R.; Silva,Luciana R.; Silva,Nanci.
While the routine use of antibiotics for infectious diarrhea in children must be avoided, because it brings little benefit in most cases and is associated with the risk of increasing antimicrobial resistance, selected cases may require antimicrobial therapy, and the choice of the antimicrobial agent often has to be made empirically. Physicians prescribing antimicrobials in such a setting have not only to be aware of the most likely pathogens, but also of their characteristic antimicrobial susceptibility pattern and the safety profile of the various drugs. We reviewed the literature on the use of ampicillin, beta-lactamase inhibitors, trimethoprim-sulfamethoxazole, chloramphenicol, tetracyclines, nalidixic acid, fluoroquinolones, third-generation...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diarrhea; Antibiotics; Children; Treatment.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300011

Brazilian guidelines for the management of candidiasis - a joint meeting report of three medical societies: Sociedade Brasileira de Infectologia, Sociedade Paulista de Infectologia and Sociedade Brasileira de Medicina Tropical
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Colombo,Arnaldo Lopes; Guimarães,Thaís; Camargo,Luis Fernando Aranha; Richtmann,Rosana; Queiroz-Telles,Flavio de; Salles,Mauro José Costa; Cunha,Clóvis Arns da; Yasuda,Maria Aparecida Shikanai; Moretti,Maria Luiza; Nucci,Marcio.
Candida infections account for 80% of all fungal infections in the hospital environment, including bloodstream, urinary tract and surgical site infections. Bloodstream infections are now a major challenge for tertiary hospitals worldwide due to their high prevalence and mortality rates. The incidence of candidemia in tertiary public hospitals in Brazil is approximately 2.5 cases per 1000 hospital admissions. Due to the importance of this infection, the authors provide a review of the diversity of the genus Candida and its clinical relevance, the therapeutic options and discuss the treatment of major infections caused by Candida. Each topography is discussed with regard to epidemiological, clinical and laboratory diagnostic and therapeutic recommendations...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candidiasis; Candidemia; Treatment; Antifungals.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300001

Community-acquired pneumonia at the Hospital de Clínicas de Porto Alegre: evaluation of a care protocol
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Mocelin,Clei Angelo; Santos,Rodrigo Pires dos.
To assess the adequacy of medical prescriptions for community-acquired pneumonia at the emergency department of the Hospital de Clínicas de Porto Alegre, we conducted a prospective cohort study, from January through April 2011. All patients with suspected pneumonia were selected from the first prescription of antimicrobials held in the emergency room. Patients with a description of pneumonia, community-acquired pneumonia, respiratory infection, or other issues related to community-acquired pneumonia were selected for review. Two-hundred and fifteen patients were studied. Adherence to the hospital care protocol was: 11.2% for the initial recommended tests (chest X-ray and collection of sputum sample), 34.4% for blood cultures, and 92.1% for the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pneumonia; Community; Treatment.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500001

Detection of HCV by PCR in serum and PBMC of patients with hepatitis C after treatment
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Cavalheiro,Norma de Paula; Filgueiras,Thelma Cristina; Melo,Carlos Eduardo; Morimitsu,Suzana Rie; Araújo,Evaldo Stanislau Affonso de; Tengan,Fátima Mitiko; Barone,Antonio Alci.
Although hepatitis C is mainly hepatotropic, some studies suggest that hepatitis C virus (HCV) infects peripheral blood mononuclear cells (PBMC), using them as a reservoir, which might contribute to the development of resistance to treatment. Fifty-four hepatitis-C patients, who had been submitted to treatment, were selected. Blood samples were collected on the same day for the detection of HCV RNA in serum and PBMC by PCR, using the Amplicor HCV 2.0 assay (Roche Diagnostics). HCV genotyping was performed using the INNO-LiPA HCV kit (Versant, Bayer Diagnostics). HCV RNA was detected in both serum and PBMC in 35 (64%) patients and no RNA in 16 (29.6%). Disagreement between the serum and PBMC results was observed for three patients (5.6%), with HCV RNA being...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: PCR; Hepatitis C; PBMC; Treatment.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500006

Cost-effectiveness of entecavir versus lamivudine for the suppression of viral replication in chronic hepatitis B Patients in Brazil
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Costa,Anna Maria N.; L.'Italien,Gilbert; Nita,Marcelo Eidi; Araujo,Evaldo Stanislau A.
Hepatitis B virus infection is an important public-health issue. Chronic patients have a higher risk of death due to complications, which increases health-care expenses in. Cost-effectiveness analysis of entecavir (ETV) versus lamivudine (LVD) for treatment of chronic hepatitis B, in e antigen (AgHBe)-positive and negative patients, based on two phase 3, controlled and randomized studies. A decision analysis model was developed, using the following endpoints: cost per patient with undetectable viral load and cost per quality life year (QALY) gained. Risks for complications (compensated or decompensated cirrhosis and hepatocellular carcinoma) were based on the cohort study REVEAL, published in 2006. The REVEAL parameters were applied to the results of the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic hepatitis B; Cost; Treatment.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500005

Long-term treatment of persistent disseminated Nocardia cyriacigeorgica infection
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Özgenç,Onur; Avcı,Meltem; Arı,Alpay; Çelebi,İsmail Yunus; Coşkuner,Seher Ayten.
In this paper a disseminated persistent Nocardia cyriacigeorgicainfection in an immunocompetent patient is described. The patient's long-term treatment, as well as its implications for managing similar cases in the future, is emphasized. Presenting with high fever, multiple nodules, and ulcerative cutaneous lesions of body sites, the patient was treated with various antimicrobials. Under combined therapy, empyema and arthritis, leading to disseminated nocardiosis, were seen. The overall treatment course was 28 months. It can be concluded that the choice of the antibiotics and optimal duration of treatment are uncertain; therefore the treatment of nocardiosis requires expertise.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Nocardia cyriacigeorgica; Chronic infection; Treatment.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500556

Epidemiology and clinical characteristics of herpes zoster in a tertiary care hospital in Brazil
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Antoniolli,Luciana; Rodrigues,Camila; Borges,Rafael; Goldani,Luciano Z.
ABSTRACT  Background: There is little information on herpes zoster from hospital registries in South America. The aim of this study was to describe the epidemiological and clinical aspects of herpes zoster (HZ) in hospitalized patients.'  Methods: We searched for hospital-based records during the period from March 2000 to January 2017 in a 700-bed tertiary-care hospital located in southern Brazil. The medical records of all eligible patients were reviewed, and data regarding demographics, medical history, clinical and laboratory characteristics, treatment regimens, and clinical outcomes were collected. Patients were also evaluated for mortality.  Results: There were 801 records of herpes zoster according to the proposed criteria. Most patients with HZ...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Herpes zoster; Clinical manifestations; Epidemiology; Treatment.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200143

Biochemical association between essential trace elements and susceptibility to Leishmania major in BALB/c and C57BL/6 mice
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Amini,Marzyeh; Nahrevanian,Hossein; Khatami,Shohreh; Farahmand,Mahin; Mirkhani,Fatemeh; Javadian,Seifoddin.
Several enzymes that contribute to immune system responses require zinc and copper as trace elements for their activity. We examined zinc and copper levels in two susceptible Balb/c mouse lines and resistant C57bl/6 mice infected with Leishmania major MRHO/IR/75/ER, a prevalent strain that causes cutaneous leishmaniasis in Iran. Serum Zn and Cu were determined by flame atomic absorption spectrophotometry. Higher Cu levels were found in infected C57bl/6 mice and higher Zn levels were found in infected Balb/c mice. Also, Cu/Zn ratios were increased in both the Balb/c and the C57bl/6 mice. We conclude that concentrations of essential trace elements vary during cutaneous leishmaniasis infection and that this variation is associated with...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Balb/c; C57bl/6; CL; Iran; Leishmania major; Treatment; Cu; Zn.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000200002

Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Ramos Júnior,Wilson M; Sardinha,José FJ; Costa,Mônica RF; Santana,Marli S; Alecrim,Maria GC; Lacerda,Marcus VG.
This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine. The most frequent findings accompanying hemolysis were fever and leukocytosis, in addition to anemia requiring red blood cell transfusion, and development of acute renal failure. Hemolysis in patients using primaquine is not infrequent and contributes to the morbidity of infection caused by Plasmodium vivax.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Malaria; Plasmodium vivax; Treatment; Primaquine; Hemolysis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400017

Oral miltefosine treatment in children with visceral leishmaniasis: a brief review
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Palumbo,Emilio.
Visceral leishmaniasis (VL) or kala-azar is an infection disease caused by hemiflagellate protozoan parasites (Leishmania donovani) and transmitted to humans by the phlebotomine sandfly. Leishmaniasis is distributed worldwide and 13 million people are estimated to be infected, with about 1.8 million new cases each year. All antileishmanial drugs are toxic and most have to be used parenterally for prolonged period. The therapy has been further complicated by large number of infected children and declining effectiveness of pentavalent antimonial compounds. Although the lipid formulations of amphotericin B are an important advance in therapy, their high cost precludes their use. Miltefosine, a phosphocholine analogue originally developed as antimalignant...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Miltefosine; Treatment; Children; Leishmaniasis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000100002

Infection by Mycoplasma pneumoniae and its importance as an etiological agent in childhood community-acquired pneumonias
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Vervloet,Letícia Alves; Marguet,Christophe; Camargos,Paulo Augusto Moreira.
This manuscript reviewed the literature on infection by Mycoplasma pneumoniae with emphasis on etiological aspects of childhood community-acquired pneumonias. Bibliographical research was carried out from Pubmed Medline, MDConsult, HighWire, LILACS, and direct research over the past 10 years with the following keywords: Mycoplasma pneumoniae, pneumonia, and childhood. Fifty-four articles were selected. Mycoplasma pneumoniae has a high incidence in childhood. Clinical presentation includes respiratory and extrarespiratory symptoms. Mycoplasma pneumoniae lung infection can be confused with viral or bacterial pneumonia and is unresponsive to beta-lactams. In addition, co-infections have been reported. Mycoplasma pneumoniae infection occurs in all age groups,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycoplasma pneumoniae; Pneumonia; Extrapulmonary findings; Diagnosis; Treatment.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500012

The impact of ocular tuberculosis on vision after two months of intensive therapy
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Oliveira,Suzana Batista Vereza de; Passos,Ângelo Ferreira; Hadad,David Jamil; Zbyszynski,Lorena; Sousa de Almeida Júnior,Pedro; Castellani,Luiz Guilherme Schmidt; Dietze,Reynaldo; Palaci,Moisés.
ABSTRACT Tuberculosis is an infectious disease of global importance with major economic and social burden accounting for 25% of all avoidable deaths in developing countries. Extrapulmonary involvement may occur either in association with clinically apparent pulmonary tuberculosis or in isolation. This cross-sectional descriptive study aimed to evaluate the impact of ocular tuberculosis in visual acuity at baseline and after two months of intensive anti-tuberculous therapy. A sample of 133 pulmonary tuberculosis patients, seven disseminated tuberculosis, and three pleural tuberculosis patients was evaluated. All patients underwent routine ophthalmic evaluation, including assessment of visual acuity, biomicroscopy, applanation tonometry, indirect...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Eye; Visual acuity; Treatment.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300159

Multidrug-resistant tuberculosis
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Lemos,Antônio Carlos Moreira; Matos,Eliana Dias.
Despite the efforts made worldwide to reduce the number of cases of drug-susceptible tuberculosis, multidrug-resistant tuberculosis (MDR-TB) constitutes an important public health issue. Around 440,000 new cases of MDR-TB are estimated annually, although in 2008 only 7% of these (29,423 cases) were notified. The laboratory tests for diagnosing resistance may be phenotypic (based on culture growth in the presence of drugs) or genotypic (i.e. identification of the presence of mutations that confer resistance). The urgent need for a rapid means of detecting resistance to anti-TB drugs has resulted in the development of many genotypic methods over recent years. The treatment of MDR-TB is expensive, complex, prolonged (18-24 months) and associated with a higher...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Multidrug-resistant tuberculosis; Review; Diagnosis; Treatment.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200018

Noncompliance with tuberculosis treatment by patients at a tuberculosis and AIDS reference hospital in midwestern Brazil
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Rabahi,Marcelo Fouad; Rodrigues,Adriana Batista; Mello,Fernanda Queiroz de; Almeida Netto,Joaquim Caetano de; Kritski,Afrânio Lineu.
Introduction: In developing countries, there is little information about the risk factors that predict noncompliance with tuberculosis (TB) treatment in hospitals. Objective: This study analyzes possible factors associated with noncompliance with TB treatment among patients treated at HAA. Design: A retrospective cohort study was made including all patients who initiated TB treatment at HAA, from January to December 1998. A standard form was used to review medical records and to collect data on each patient. This data was evaluated in comparison with data from the state TB control program. Results: Of the 341 patients included in the study, 186 (61.2%) were considered cured and 67 (22%) were non-compliant. The factors associated with noncompliance were:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; Treatment; Compliance; TB control program; Goiânia.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000200002

Retrospective analysis of hepatitis B virus chronic infection in 247 patients: clinical stages, response to treatment and poor prognostic factors
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Cunha-Silva,Marlone; Marinho,Fábio R.T.; Oliveira,Paulo F.; Lopes,Tirzah M.; Sevá-Pereira,Tiago; Lorena,Sonia L.S.; Almeida,Jazon R.S.
Abstract  Background: Chronic hepatitis B is a major cause of cirrhosis, and the natural history of the disease has several clinical stages that should be thoroughly understood for the implementation of proper treatment. Nonetheless, curing the disease with antiviral treatment remains a challenge.  Aims: To describe the clinical course, response to treatment, and poor prognostic factors in 247 hepatitis B virus chronic infection patients treated in a tertiary hospital in Brazil.  Methods: This was a retrospective and observational study, by analyzing the medical records of HBV infected patients between January 2000 and January 2015.  Results: Most patients were male (67.2%) and 74.1% were HBeAg negative. Approximately 41% had cirrhosis and 8.5% were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis B; Clinical stages; Treatment; Liver cirrhosis; Hepatocellular carcinoma.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400441

Use of rhu-GM-CSF in pulmonary tuberculosis patients: results of a randomized clinical trial
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Pedral-Sampaio,Diana Brasil; Netto,Eduardo Martins; Brites,Carlos; Bandeira,Antonio Carlos; Guerra,Conceição; Barberin,Maria Goreth; Badaró,Roberto.
It has been postulated that deficient or incomplete clinical and/or microbiological response to tuberculosis treatment is associated with cell-mediated immunological dysfunction involving monocytes and macrophages. A phase 2 safety trial was conducted by treating patients with either recombinant human granulocyte-macrophage colony-stimulating factor (rhu-GM-CSF) or a placebo, both in combination with anti-tuberculosis chemotherapy. Thirty-one patients with documented pulmonary tuberculosis were treated with rifampin/isoniazid for six months, plus pyrazinamide for the first two months. At the beginning of treatment, rhu-GM-CSF (125µg/M²) was randomly assigned to 16 patients and injected subcutaneously twice weekly for four weeks; the other 15 patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; GM-CSF; Treatment.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000400004

Pulmonary cryptococcosis in non-AIDS patients
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: ,Jin-Quan; Tang,Ke-Jing; Xu,Bing-Ling; Xie,Can-Mao; Light,Richard W.
OBJECTIVE: To investigate the clinical features, management, and prognosis of pulmonary cryptococcosis in non-acquired immunodeficiency syndrome (AIDS) patients. METHOD: 24 cases of pulmonary cryptococcosis with accurate pathological diagnosis were retrospectively studied. RESULTS: 15 male patients and nine female patients were diagnosed at the first affiliated hospital of Sun Yat-sen University from November 1999 to November 2011. The mean age at the time of diagnosis was 44.2 ± 11.3 years (range: 24 to 65 years). Among these patients, 13 had other comorbidities. 15 were symptomatic and the other nine were asymptomatic. The most common presenting symptoms were cough, chest tightness, expectoration, and fever. None had concurrent cryptococcal meningitis....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pulmonary cryptococcosis; Clinical presentation; Diagnosis; Treatment; HIV negative.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600006

Bartonellosis: suggestive case reports in adult and pediatric patients and therapeutic issues
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Manfredi,Roberto; Sabbatani,Sergio.
Cat-scratch disease warrants extensive investigation, from an epidemiological, a diagnostic, but especially a therapeutic point of view. Two suggestive episodes of Bartonella henselae-caused cat-scratch disease are reported, and discussed in the light of the most recent literature evidence. The first case occurred in a 60-year-old man, thus suggesting that it is important to maintain an elevated level of suspicion for this disease in adults as well. Both episodes were characterized by a very prolonged and complicated disease course (with the involvement of three lymph node sets in the first case), a need for lymph-node drainage, and apparently negligible activity of many antimicrobial courses, with a very slow local cure. While specific culture and...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Adults; Antimicrobial chemotherapy; Bartonellosis; Bartonella henselae; Case reports; Children; Clinical presentation; Outcome; Treatment.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000600012

The evaluation of bacteriology in perianal abscesses of 81 adult patients
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Ulug,Mehmet; Gedik,Ercan; Girgin,Sadullah; Celen,Mustafa Kemal; Ayaz,Celal.
OBJECTIVE: Treatment of perianal abscesses requires prompt surgical drainage and antimicrobial therapy. However, we should encourage the selective use of antimicrobial agents on a case-by-case basis, especially because there is no evidence that uncomplicated perianal abscesses can be safely treated only with drainage. For this reason, it is important to identify the causative organisms; therefore, we accessed the microbiological analysis of these patients. PATIENTS AND METHODS: In this study, 81 consecutive adult patients with perianal abscesses, who presented at a university hospital in Diyarbakir from January 2004 to December 2006, were included. Clinical and laboratory data, and results of microbiological analysis were recorded. RESULTS: All specimens,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Perianal abscess; Adult; Bacteriology; Aerobic bacteria; Treatment.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300005

Extended treatment with interferon and ribavirin in a hemodialysis patient with chronic hepatitis C
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Vigani,Aline Gonzalez; Pavan,Maria HP; Tozzo,Raquel; Gonçales,Eduardo SL; Lazarini,Maria SK; Oliveira,Alexandre Macedo de; Gonçales Jr,Fernando L.
Hemodialysis patient with chronic HCV infection,who was started on monotherapy with interferon.Qualitative HCV RNA remained positive at 12 weeks of treatment; ribavirin was associated. HCV RNA was negative at week 24 and treatment was extended to 72 weeks. HCV RNA negative six months after treatment.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Hepatitis C virus; Hemodialysis; Treatment; Interferon; Ribavirin.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200016

Risk factors for mortality in patients with ventilator-associated pneumonia caused by carbapenem-resistant Enterobacteriaceae
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Tuon,Felipe F.; Graf,Maria Esther; Merlini,Alexandre; Rocha,Jaime L.; Stallbaum,Suellen; Arend,Lavinia N.; Pecoit-Filho,Roberto.
Abstract  Background: The ideal therapeutic option for ventilator associated pneumonia caused by carbapenem-resistant Enterobacteriaceae is not defined. The aim of this study was to assess mortality-associated risk factors in patients with VAP by CRE and determine the outcome of several treatment options.  Methods: This was a retrospective study performed in two tertiary hospitals involving patients with VAP caused by CRE between January 2010 and August 2014. The outcomes were mortality within 30 days of VAP diagnosis and overall mortality during hospital admission. Risk factors for mortality were assessed by comparing variables of survivors and non-survivors.  Results: One hundred and twelve patients with CRE-VAP were included, 73 (65%) male, median age...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Carbapenemase-producing Klebsiella pneumoniae; Ventilator-associated pneumonia; Risk factors; Mortality; Treatment.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100001

Quinine levels in patients with uncomplicated falciparum malaria in the Amazon region of Brazil
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Vieira,José Luiz Fernandes; Borges,Larissa Maria Guimarães; Nascimento,Margareth Tavares Silva; Gomes,Andreza de L.S.
We examined the plasmatic concentrations of quinine in patients with uncomplicated falciparum malaria in an endemic area of the Amazon region in Brazil in a prospective clinical trial, in which a standard three-day course of oral quinine plus doxycycline was used. We measured the quinine in the plasma samples on days 0 and 3by high performance liquid chromatography. The mean concentration of quinine was 6.04 ±2.21 µg/mL in male patients and 5.98 ±1.95 µg/mL in female patients. No significant differences in quinine concentration were observed between these two groups. All samples collected before starting treatment were negative for quinine. This information could help in the development of strategies for the rational use of antimalarial drugs in Brazil.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Falciparum malaria; Quinine; Treatment.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500001

Treatment of methicillin-resistant Staphylococcus aureus in Latin America
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Luna,Carlos M; Rodríguez-Noriega,Eduardo; Bavestrello,Luis; Gotuzzo,Eduardo.
The global spread of methicillin-resistant Staphylococcus aureus (MRSA) means it is now a pathogen of worldwide public health concern. Within Latin America, MRSA is highly prevalent, with the proportion of S. aureus isolates that are methicillin-resistant on the rise, yet resources for managing the infection are limited. While several guidelines exist for the treatment of MRSA infections, many are written for the North American or European setting and need adaptation for use in Latin America. In this article, we aim to emphasize the importance of appropriate treatment of MRSA in the healthcare and community settings of Latin America. We present a summary of the available guidelines and antibiotics, and discuss particular considerations for clinicians...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MRSA; Treatment; Antibiotic therapy; Latin America.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000800007

Lack of effect of motivation on the adherence of HIV-positive/AIDS patients to antiretroviral treatment
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Garcia,Rosa; Pondé,Milena; Lima,Manuela; Souza,Alba Regina de; Stolze,Silvia Maria de O.; Badaró,Roberto.
As a result of the potent drug combinations of reverse transcriptase inhibitors and protease inhibitors currently available, it is now possible to achieve extreme reductions in the numbers of viral particles in the peripheral blood of HIV-positive patients undergoing treatment, to the point that they are undetectable. Moreover, the immunological recovery resulting from continued and prolonged use of these drugs significantly reduces both mortality and the incidence of opportunistic infections. However, the strict therapeutic regimens required, the number of pills, adverse events and the stigma of a disease that requires the patient to introduce pill-taking into his/her lifestyle brings into question one aspect of mental health, which is motivation to do...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Motivation; Adherence; HIV-Positive/AIDS; Treatment.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600007

Barriers to treatment of hepatitis C in HIV/HCV coinfected adults in Brazil
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Mendes-Corrêa,Maria Cássia; Martins,LG; Ferreira,PA; Tenore,S; Leite,OH; Leite,AG; Cavalcante,AJW; Shimose,M; Silva,MH; Uip,DE; Abrão Ferreira,PR.
The objective of this study was to assess the prevalence of barriers to interferon treatment in a population of HIV/HCV coinfected patients. A cross-sectional study was conducted at two AIDS Outpatient Clinics in Brazil. The study included all HIV infected patients followed at these institutions from January 2005 to November 2007. Medical records of 2,024 HIV-infected patients were evaluated. The prevalence of anti-HCV positive patients among them was 16.7%. Medical records of HCV/HIV coinfected patients were analyzed. 189 patients with the following characteristics were included in our study: mean age 43 years; male gender 65%; former IDUs (52%); HCV genotype 1 (66.4%); HCV genotype 3 (30.5%); median CD4+ T cell count was 340 cells/mm³. Among 189 patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; HIV; Coinfected; Treatment.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300007

Strategies to reduce mortality and morbidity due to AIDS-related cryptococcal meningitis in Latin America
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Vidal,Jose E.; Oliveira,Augusto C. Penalva de; Dauar,Rafi F.; Boulware,David R.
Latin America is the region with the third most AIDS-related cryptococcal meningitis infections globally. Highly active antiretroviral therapy (HAART) has reduced the number of infections; however, the number of deaths and the case-fatality rate continues to be unacceptable. In this review, we focus on the burden of AIDS-related cryptococcosis in Latin America and discuss potential strategies to reduce early mortality from Cryptococcus. In this review, we highlight the importance of: (1) earlier HIV diagnosis and HAART initiation with retention-in-care to avoid AIDS; (2) pre-HAART cryptococcal antigen (CRAG) screening with preemptive fluconazole treatment; (3) better diagnostics (e.g. CRAG testing); and (4) optimal treatment with aggressive management of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cryptococcal meningitis; Cryptococccosis; Epidemiology; Diagnosis; Treatment; Mortality; Latin America.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300008

Case report of lymph nodal, hepatic and splenic tuberculosis in an HIV-positive patient
Provedor de dados: Brazilian Journal of Infectious Diseases
Autores: Barone,Bianca; Kreuzig,Patrícia Lago; Gusmão,Patricia Medeiros; Chamié,Daniel; Bezerra,Sabrina; Pinheiro,Pedro; Coscarelli,Pedro; Paiva,Daurita; Fonseca,Leila; Marsico,Anna; Cirigliano,André; Perez,Mário.
We describe a case of a male patient, 38 years old, HIV-positive (most recent CD4 count about 259/mm³), with abdominal pain, nausea, vomiting, anorexia, weight loss, and vespertine high fever with chills. His hemogram showed normocytic and normochromic anemia, with a high erythrocyte sedimentation rate (ESR) and gross granulations in the neutrophils. Transaminases were normal. Bone marrow biopsy evidenced a chronic disease anemia pattern and a lack of infectious agents. Abdominal ultrasound examination showed a normal-size spleen, which exhibited heterogeneous parenchyma and multiple small hypoechoic images, together with small ascites, peripancreatic and para-aortic lymphadenopathy. These findings were confirmed by abdominal CT. The liver was normal in...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Tuberculosis; HIV; Treatment.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200014

Classical and recent advances in the treatment of inflammatory bowel diseases
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Sales-Campos,H.; Basso,P.J.; Alves,V.B.F.; Fonseca,M.T.C.; Bonfá,G.; Nardini,V.; Cardoso,C.R.B.
Crohn's disease (CD) and ulcerative colitis (UC) are intestinal disorders that comprise the inflammatory bowel diseases (IBD). These disorders have a significant effect on the quality of life of affected patients and the increasing number of IBD cases worldwide is a growing concern. Because of the overall burden of IBD and its multifactorial etiology, efforts have been made to improve the medical management of these inflammatory conditions. The classical therapeutic strategies aim to control the exacerbated host immune response with aminosalicylates, antibiotics, corticosteroids, thiopurines, methotrexate and anti-tumor necrosis factor (TNF) biological agents. Although successful in the treatment of several CD or UC conditions, these drugs have limited...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Treatment; Immune modulation; Cellular therapy.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000200096

Effect of strontium ranelate on pain behavior in an experimental model of osteoarthritis
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Rodrigues,T.A.; Sampaio Junior,A.J.B.; Nunes,I.D.P.; Cartágenes,M.S.S.; Garcia,J.B.S.
Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects of decreasing the risk of fractures and an indication of reducing the progression of osteoarthritis (OA). This study aimed to investigate the effects of SrRan as either a prophylactic or a treatment drug, using an OA rat model to assess pain behavior. A monoiodoacetate (MIA)-induced knee joint OA model in Wistar rats was used. Thirty Wistar rats (both sexes, 60 days old) were distributed in five groups of 6 rats each: the control group, that received no intervention; a prophylactic group, that received oral administration of 25 mg·kg-1·day-1 of SrRan for 28 days before induction of OA; a group treated with 25 mg·kg-1·day-1 of SrRan for 28 days after OA...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Osteoarthritis; Strontium ranelate; Pain; Treatment; Prophylaxis.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000900602

Chronic obstructive pulmonary disease is underdiagnosed and undertreated in São Paulo (Brazil): results of the PLATINO study
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Nascimento,O.A.; Camelier,A.; Rosa,F.W.; Menezes,A.M.B.; Pérez-Padilla,R.; Jardim,J.R.
Chronic obstructive pulmonary disease (COPD) is a common disease in adults over 40 years of age and has a great social and economic impact. It remains little recognized and undertreated even in developed countries. However, there are no data about its diagnosis and treatment in Brazil. The objectives of the present study were to evaluate the proportion of COPD patients who had never been diagnosed and to determine if the COPD patients who had been identified were receiving appropriate treatment. The Latin American Project for the Investigation of Obstructive Lung Disease (PLATINO) was a randomized epidemiological study of adults over 40 years living in five metropolitan areas, including São Paulo. The studied sample was randomly selected from the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chronic obstructive pulmonary disease; Diagnosis; Treatment; Vaccination; Smoking; Latin American Project for the Investigation of Obstructive Lung Disease.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700001

Strontium ranelate as a possible disease-modifying osteoarthritis drug: a systematic review
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Rodrigues,T.A.; Freire,A.O.; Bonfim,B.F.; Cartágenes,M.S.S.; Garcia,J.B.S.
Considering that osteoarthritis (OA) is the most prevalent joint disease worldwide, multiple pharmacological treatments have been proposed to alter the articular structure with potential benefit in the progression of the disease. The so-called disease-modifying OA drugs have been frequently investigated but conclusive findings are rare. Strontium ranelate (SrRan) is a drug usually prescribed to treat osteoporosis, with proven effects in decreasing the risk of fractures and possible effect in reducing the progression of OA. The objective of this review was to demonstrate the current panorama of knowledge on the use of SrRan in clinical and experimental models, clarifying its mechanisms of action and describing possible anti-nociceptive and anti-inflammatory...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Osteoarthritis; Strontium ranelate; Treatment; Pain; Symptoms.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000800302

Extracellular vesicles: structure, function, and potential clinical uses in renal diseases
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Borges,F.T.; Reis,L.A.; Schor,N.
Interest in the role of extracellular vesicles in various diseases including cancer has been increasing. Extracellular vesicles include microvesicles, exosomes, apoptotic bodies, and argosomes, and are classified by size, content, synthesis, and function. Currently, the best characterized are exosomes and microvesicles. Exosomes are small vesicles (40-100 nm) involved in intercellular communication regardless of the distance between them. They are found in various biological fluids such as plasma, serum, and breast milk, and are formed from multivesicular bodies through the inward budding of the endosome membrane. Microvesicles are 100-1000 nm vesicles released from the cell by the outward budding of the plasma membrane. The therapeutic potential of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Extracellular vesicles; Cell biology; Kidney diseases; Diagnosis; Treatment.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000824

Treatment of a subdural empyema complicated by intracerebral abscess due to Brucella infection
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Zhang,J.; Chen,Z.; Xie,L.; Zhao,C.; Zhao,H.; Fu,C.; Chen,G.; Hao,Z.; Wang,L.; Li,W.
A 55-year-old male presented with fever, stupor, aphasia, and left hemiparesis. A history of head trauma 3 months before was also reported. Cranial magnetic resonance imaging revealed slight contrast enhancement of lesions under the right frontal skull plate and right frontal lobe. Because of deterioration in nutritional status and intracranial hypertension, the patient was prepared for burr hole surgery. A subdural empyema (SDE) recurred after simple drainage. After detection of Brucella species in SDE, craniotomy combined with antibiotic treatment was undertaken. The patient received antibiotic therapy for 6 months (two doses of 2 g ceftriaxone, two doses of 100 mg doxycycline, and 700 mg rifapentine for 6 months) that resulted in complete cure of the...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Subdural empyema; Neurobrucellosis; Craniotomy; Infection; Treatment.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000500501

A randomized crossover clinical study showing that methylphenidate-SODAS improves attention-deficit/hyperactivity disorder symptoms in adolescents with substance use disorder
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Szobot,C.M.; Rohde,L.A.; Katz,B.; Ruaro,P.; Schaefer,T.; Walcher,M.; Bukstein,O.; Pechansky,F.
Our objective was to evaluate the effectiveness of a long-acting formulation of methylphenidate (MPH-SODAS) on attention-deficit/hyperactivity disorder (ADHD) symptoms in an outpatient sample of adolescents with ADHD and substance use disorders (SUD). Secondary goals were to evaluate the tolerability and impact on drug use of MPH-SODAS. This was a 6-week, single-blind, placebo-controlled crossover study assessing efficacy of escalated doses of MPH-SODAS on ADHD symptoms in 16 adolescents with ADHD/SUD. Participants were randomly allocated to either group A (weeks 1-3 on MPH-SODAS, weeks 4-6 on placebo) or group B (reverse order). The primary outcome measures were the Swanson, Nolan and Pelham Scale, version IV (SNAP-IV) and the Clinical Global Impression...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Attention deficit/hyperactivity disorder; Methylphenidate; Substance use disorder; Treatment; Adolescents.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300012

Mirtazapine versus fluoxetine in the treatment of panic disorder
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Ribeiro,L.; Busnello,J.V.; Kauer-Sant'Anna,M.; Madruga,M.; Quevedo,J.; Busnello,E.A.D.; Kapczinski,F.
Mirtazapine is an antidepressant whose side effect profile differs from that of first-line agents (selective serotonin reuptake inhibitors) used in the treatment of panic disorder. The present study compared the effect of mirtazapine and fluoxetine in the treatment of panic disorder in a double-blind, randomized, flexible-dose trial conducted with outpatients. After a 1-week single-blind placebo run-in, 27 patients entered an 8-week double-blind phase in which they were randomly assigned to treatment with either mirtazapine or fluoxetine. Both groups improved significantly in all but one efficacy measure (P&lt;=0.01). ANOVA showed no significant differences between the two treatment groups in number of panic attacks, Hamilton Anxiety Scale or Sheehan...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Mirtazapine; Fluoxetine; Panic disorder; Treatment; Randomized trial.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000010

Hereditary angioedema with C1 inhibitor (C1-INH) deficit: the strength of recognition (51 cases)
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Fragnan,N.T.M.L.; Tolentino,A.L.N.; Borba,G.B.; Oliveira,A.C.; Simões,J.A.; Palma,S.M.U.; Constantino-Silva,R.N.; Grumach,A.S.
Hereditary angioedema (HAE) is a rare autosomal dominant disease due to C1 esterase inhibitor deficiency (C1-INH). The disease is characterized by subcutaneous and submucosal edema in the absence of urticaria due to the accumulation of bradykinin. This descriptive study aimed to evaluate the clinical characteristics of patients with a confirmed diagnosis of HAE referred to our Outpatient Clinic between December 2009 and November 2017. Fifty-one patients (38 F, 13 M) with a mean age of 32 years (range: 7–70 y) were included. Family history of HAE was reported in 70% (36/51) of the cases; 33/46 patients became symptomatic by 18 years of age. The median time between onset of symptoms and diagnosis was 13 years (3 mo–50 y). The most frequent triggering factors...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hereditary angioedema; C1 esterase inhibitor; Diagnosis; Treatment; Complement.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001200607

In vitro and in vivo inhibition of rabies virus replication by RNA interference
Provedor de dados: Brazilian Journal of Microbiology
Autores: Ono,Ekaterina A. Durymanova; Iamamoto,Keila; Castilho,Juliana G.; Carnieli Jr.,Pedro; Oliveira,Rafael de Novaes; Achkar,Samira M.; Carrieri,Maria L.; Kotait,Ivanete; Brandão,Paulo E.
Rabies is a zoonotic disease that affects all mammals and leads to more than 55,000 human deaths every year, caused by rabies virus (RABV) (Mononegavirales: Rhabdoviridae: Lyssavirus). Currently, human rabies treatment is based on the Milwaukee Protocol which consists on the induction of coma and massive antiviral therapy. The aim of this study was to assess the decrease in the titer of rabies virus both in vitro and in vivo using short-interfering RNAs. To this end, three siRNAs were used with antisense strands complementary to rabies virus nucleoprotein (N) mRNA. BHK-21 cells monolayers were infected with 1000 to 0.1 TCID50 of PV and after 2 hours the cells were transfected with each of tree RNAs in separate using Lipofectamine-2000. All three siRNAs...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rabies; RNA interference; SiRNAs; Antiviral; Treatment.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822013000300034

Mycobacterium avium subsp. Paratuberculosis and the expression of selected virulence and pathogenesis genes in response to 6°c, 65°c and ph 2.0
Provedor de dados: Brazilian Journal of Microbiology
Autores: Pribylova,Radka; Kralik,Petr; Donnelly,Neysan; Matiasovic,Jan; Pavlik,Ivo.
The aim of this work was to study the expression of selected Mycobacterium avium subsp. paratuberculosis (MAP) genes connected with MAP virulence, adhesion and stress response. The temperature of 6°C and 65°C were chosen with regard to the food industry, storage conditions (refrigerator) and low-temperature pasteurization. A pH of 2.0, using lactic acid, was selected to mimic the natural environment of the stomach. Expression of selected genes was studied using real time reverse transcription PCR on three different MAP isolates. MAP isolates were chosen according to the number of their preceding cultivations. While isolates 8672 and 8819 were previously cultivated only once, MAP isolate 12146 went through four passages. Different expression profiles were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: MAP; Johne's disease; Stress; Treatment; Real time PCR.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000200049

Short interfering RNAs targeting a vampire-bat related rabies virus phosphoprotein mRNA
Provedor de dados: Brazilian Journal of Microbiology
Autores: Ono,Ekaterina Alexandrovna Durymanova; Taniwaki,Sueli Akemi; Brandão,Paulo.
Abstract The aim of this study was to assess the in vitro and in vivo effects of short-interfering RNAs (siRNAs) against rabies virus phosphoprotein (P) mRNA in a post-infection treatment for rabies as an extension of a previous report (Braz J Microbiol. 2013 Nov 15;44(3):879-82). To this end, rabies virus strain RABV-4005 (related to the Desmodus rotundus vampire bat) were used to inoculate BHK-21 cells and mice, and the transfection with each of the siRNAs was made with Lipofectamine-2000™. In vitro results showed that siRNA 360 was able to inhibit the replication of strain RABV-4005 with a 1 log decrease in virus titter and 5.16-fold reduction in P mRNA, 24 h post-inoculation when compared to non-treated cells. In vivo, siRNA 360 was able to induce...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rabies; Treatment; RNA interference.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822017000300566

An update on equine laminitis
Provedor de dados: Ciência Rural
Autores: Laskoski,Luciane Maria; Valadão,Carlos Augusto Araújo; Dittrich,Rosangela Locatelli; Deconto,Ivan; Faleiros,Rafael Resende.
ABSTRACT: Laminitis is a severe podal affection, which pathophysiology remains partially renowned. Ischemic, enzymatic, metabolic and inflammatory mechanisms are connected to the development of laminar lesions. However, few therapeutic measures are effective to prevent or control the severity of acute laminitis and its prodromal stage, which often determines serious complications such as rotation and/or sinking of the distal phalanx and even the loss of hoof. The purpose of this study is to compile the actual knowledge in respect to the pathophysiology and treatment of equine laminitis.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Horse; Pathophysiology; Treatment; Podal disease.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000300547

The measurement of urine pH to predict the amount of buffer used in the treatment of acute rumen lactic acidosis in cattle
Provedor de dados: Ciência Rural
Autores: Maruta,Celso Akio; Leal,Marta Lizandra do Rego; Mendes Netto,Daniel; Mori,Clara Satsuki; Antonelli,Alexandre Coutinho; Ortolani,Enrico Lippi.
The purpose of the present study was to establish a practical, fast, precise and low-cost procedure to estimate the degree of metabolic acidosis in cattle with acute rumen lactic acidosis for further treatment. The rumen acidosis was induced experimentally in 40 crossbreed rumen-cannulated 1.5-year-old steers. The induction caused the development of the most characteristic clinical signs of acute rumen lactic acidosis, severe rumen acidosis and a moderate metabolic acidosis, which was evidenced by low blood pH, and blood bicarbonate concentration and base excess (BE). A highly positive correlation (r=0.80) between urinary pH and BE concentration, and between urinary pH and blood pH (r=0.75) was observed. The BE concentration estimated by urinary pH was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lactic acidosis; Urine pH; Cattle; Base excess; Treatment.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782008000300019

A weight loss protocol and owners participation in the treatment of canine obesity
Provedor de dados: Ciência Rural
Autores: Carciofi,Aulus Cavalieri; Gonçalves,Karina Nogueira Venturelli; Vasconcellos,Ricardo Souza; Bazolli,Rodrigo Sousa; Brunetto,Márcio Antonio; Prada,Flávio.
The success of a weight loss program for pets depends on the owners collaboration. Their compliance is fundamental in establishing the correct food management. The objective of this study was to compare the effectiveness of a weight loss program in two groups of dogs, one maintained under experimental conditions and the other with their owners. The same hypocaloric food was used to feed all animals, the amount being restricted to 60% of the estimated maintenance energy requirement for a 15% reduction of the present body weight of the dog. The animals were followed during 90 days. A standard questionnaire was used to study the owners' perception of obesity and its treatment. The protocol and the diet were found to be effective. The control dogs had an...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dogs; Obesity; Treatment; Diet.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782005000600016

Economic impact of digital dermatitis treatment on a dairy farm: an application of the break-even analysis
Provedor de dados: Ciência Rural
Autores: Akin,Ibrahim; Akin,Tugba.
ABSTRACT: This study aimed to evaluate the economic efficiency of DD treatment on milk yield in lame cows suffering from DD. A total of 33 Holstein dairy cows with DD were included in the study. The milk yields were assessed as (1st); beginning milk production (BMP), (2nd); peak milk production before the diagnosis (PMPBD), (3rd); diagnosis day milk production (DMP), and (4th); post-treatment milk production (TMP). In the first stage of analyses, using the E-views equity test of means program, cows were classified into three groups for diagnosis time of DD according to the day in milk (DIM) (Group 1: 0 ≤ DIM ≤ 50, Group 2: 51 ≤ DIM ≤ 100, and Group 3: 101 ≤ DIM ≤ 150). Analysis of variance (ANOVA F-Test) and the Welch F-Test were conducted to compare the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Dairy cow; Digital dermatitis; Treatment; Dairy economics; Break-even analysis.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000800604

Hydrogen peroxide and chlorine dioxide against parasite Ichthyophthirius multifiliis (Protozoa, Ciliophora) in jundiá fingerlings
Provedor de dados: Ciência Rural
Autores: Marchiori,Natalia da Costa; Silva,Fabiano Muller; Martins,Maurício Laterça; Amaral Junior,Hilton; Silva,Bruno Corrêa da.
ABSTRACT: Ichthyophthiriasis is a worldwide fish disease with great financial impact on freshwater fish farming due to its associated high mortality rates. Current study assesses the parasiticidal capacity of hydrogen peroxide (H2O2) and chlorine dioxide (ClO2) against the causative agent, Ichthyophthirius multifiliis, in jundiá. Median lethal concentration (LC50, 96h) of each chemical agent was established, as well as the minimum inhibitory concentration of hydrogen peroxide for the parasite´s infectious larval phase (theront). Products were tested asynchronously in parasitized fingerlings for short and long baths at the following concentrations and exposure times: 1. Hydrogen peroxide: (T1) continuous bath - 30ppm and (T2) 50ppm; (T3) short bath -...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: “ich”; Parasite; Rhamdia quelen drug; Treatment.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017001200501