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The Mathematical Biology of Human Infections
Provedor de dados: 7
Autores: Nowak, Martin A; Institute for Advanced Study; nowak@ias.edu.
Humans are constant victims of infectious diseases. Biomedical research during this century has led to important insights into the molecular details of immune defense. Yet, many questions relating to disease require a quantitative understanding of the complex systems that arise from the nonlinear interactions between populations of immune cells and infectious agents. Exploration of such questions has lead to a newly emerging field of mathematical biology describing the spread of infectious agents both within and between infected individuals. This essay will discuss simple and complex models of evolution, and the propagation of virus and prion infections. Such models provide new perspectives for our understanding of infectious disease and provide guidelines...
Tipo: Peer-Reviewed Reports
Palavras-chave: CTL response; HIV; Antivirals; Epidemiology; Immune response; Infectious diseases; Mathematical biology; Models of evolution; Prions; Resistance; Treatment; Viruses.
Ano: 1999

Looking for exceptions on knowledge rules induced from HIV cleavage data set
Provedor de dados: 74
Autores: Prati,Ronaldo Cristiano; Monard,Maria Carolina; Carvalho,André C. P. L. F. de.
The aim of data mining is to find useful knowledge inout of databases. In order to extract such knowledge, several methods can be used, among them machine learning (ML) algorithms. In this work we focus on ML algorithms that express the extracted knowledge in a symbolic form, such as rules. This representation may allow us to ''explain'' the data. Rule learning algorithms are mainly designed to induce classification rules that can predict new cases with high accuracy. However, these sorts of rules generally express common sense knowledge, resulting in many interesting and useful rules not being discovered. Furthermore, the domain independent biases, especially those related to the language used to express the induced knowledge, could induce rules that are...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Data mining; Exceptions; HIV; Protease.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000400027

Investigation of SIRT1 gene variants in HIV-associated lipodystrophy and metabolic syndrome
Provedor de dados: 74
Autores: Tagliari,Carmela Farias da Silva; de Oliveira,Cáren Nunes; Vogel,Greice Meyer; da Silva,Patrícia Baptista; Linden,Rafael; Lazzaretti,Rosmeri Kuhmmer; Notti,Regina Kuhmmer; Sprinz,Eduardo; Mattevi,Vanessa Suñé.
Abstract HIV-infected individuals on chronic use of highly active antiretroviral therapy (HAART) are more likely to develop adipose tissue and metabolic disorders, such as lipodystrophy (LD) and metabolic syndrome (MetS). The development of these phenotypes is known to be multifactorial. Thus, variants in genes implicated in adipogenesis and lipid metabolism may increase susceptibility to LD and MetS. Sirtuin 1 (SIRT1) may influence the outcome of these disturbances due to its role in the regulation of transcription factors involved in energy regulation. Therefore, we genotyped four polymorphisms located in SIRT1 (rs2273773 T&gt;C, rs12413112 G&gt;A, rs7895833 A&gt;G, rs12049646 T&gt;C) in 832 HIV-infected patients receiving HAART by real-time polymerase...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Lipodystrophy; Metabolic syndrome; Sirtuin 1.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000100105

Beyond retrovirus infection: HIV meets gene therapy
Provedor de dados: 74
Autores: Silva,Flávia Helena da; Dalberto,Tiago Pires; Nardi,Nance Beyer.
The human immunodeficiency virus (HIV) is classified as a retrovirus because of its RNA genome and the fact that it requires reverse transcriptase to convert it into DNA. This virus belongs to the lentivirinae subfamily and is able to infect quiescent cells but is better known for its association with acquired immunodeficiency syndrome (AIDS) and can be described as one of the most effective vectors for gene transfer. Biosafety concerns are present whenever viral vectors are employed but are particularly pertinent to the development of HIV-based vectors. Insertional mutagenesis and the production of new replication-competent viruses (RCV) have been pointed to as major problems, but experimental data have shown that safe protocols can be developed for their...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; MLV; Retrovirus; Lentivirus; Gene therapy.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572006000200027

Analysis of the CCR5 gene coding region diversity in five South American populations reveals two new non-synonymous alleles in Amerindians and high CCR5*D32 frequency in Euro-Brazilians
Provedor de dados: 74
Autores: Boldt,Angelica B.W.; Culpi,Lodércio; Tsuneto,Luiza T.; Souza,Ilíada R.; Kun,Jürgen F.J.; Petzl-Erler,Maria Luiza.
The CC chemokine receptor 5 (CCR5) molecule is an important co-receptor for HIV. The effect of the CCR5*D32 allele in susceptibility to HIV infection and AIDS disease is well known. Other alleles than CCR5*D32 have not been analysed before, neither in Amerindians nor in the majority of the populations all over the world. We investigated the distribution of the CCR5 coding region alleles in South Brazil and noticed a high CCR5*D32 frequency in the Euro-Brazilian population of the Paraná State (9.3%), which is the highest thus far reported for Latin America. The D32 frequency is even higher among the Euro-Brazilian Mennonites (14.2%). This allele is uncommon in Afro-Brazilians (2.0%), rare in the Guarani Amerindians (0.4%) and absent in the Kaingang...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CCR5; Brazilian; Amerindian; HIV; Polymorphism.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572009000100002

Antiviral activity of animal venom peptides and related compounds
Provedor de dados: 80
Autores: Mata,Élida Cleyse Gomes da; Mourão,Caroline Barbosa Farias; Rangel,Marisa; Schwartz,Elisabeth Ferroni.
Abstract Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agents. Furthermore, proportionally to the great variety of diseases caused by viruses, very few viral vaccines are available, and not all are efficient. Thus, new antiviral substances obtained from natural products have been prospected, including those derived from venomous animals. Venoms are complex mixtures of hundreds of molecules, mostly peptides, that present a large array of biological activities and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiretroviral agents; Antiviral agents; HIV; Scorpion venom; Snake venom; Amphibian venom; Insect venom; Marine animal peptides.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100200

Listeria monocytogenes in HIV-infected patients in a hospital of Nova Iguaçu, Rio de Janeiro, Brazil
Provedor de dados: 80
Autores: Norberg,A. N.; Maure,E. A. P.; Svaiter,N.; Gonçalves,A. S.; Sanches,F. G.
A survey was carried out in a hospital of Nova Iguaçu, Rio de Janeiro, Brazil, in the period from July 1999 to March 2002, to determine the infection rate of Listeriamonocytogenes in HIV+ patients with diarrhea symptoms; 134 samples were processed by microbiological methods. The results demonstrated 12.68% of positive samples. However, no statistical differences were observed for age or sex in the studied group, suggesting that this microorganism should be regarded in the differential diagnosis of infectious processes in HIV+ patients in the area.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Listeriosis; HIV; Diarrhea.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000400016

Cryptosporidium SP in HIV-infected individuals attending a Brazilian University Hospital
Provedor de dados: 80
Autores: Langoni-Júnior,G.; Souza,L. R.
The aim of the current work was to evaluate the occurrence of Cryptosporidium sp in AIDS patients in a region of São Paulo State, Brazil. Patients were divided into groups according to CD4+ T lymphocyte count and use of potent antiretroviral treatment. Two hundred and ten fecal samples from 105 patients were fixed in 10% formalin and subjected to centrifuge formol-ether sedimentation. Slides were stained with auramine and confirmed by modified Ziehl-Neelsen. Cryptosporidiosis occurrence was 10.5% with no relationship among gender, age or the presence of diarrhea. The number of oocysts in all samples was small, independent of CD4+ T lymphocyte count, HIV plasma viral load, and presence of diarrhea. These results may be due to the reduced prevalence of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diarrhea; Viral load; HIV; HAART; Cryptosporidium; CD4-positive T-lymphocytes.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000400005

Different nutritional-state indicators of HIV-positive individuals undergoing antiretroviral therapy
Provedor de dados: 80
Autores: Geraix,J.; Carvalhaes,M. A. B. L.; Pereira,P. C. M.
This study aimed at learning about the nutritional profile of HIV-positive individuals undergoing antiretroviral therapy and at comparing the performance of nutritional-state indicators. A transversal study was performed on 94 patients attending the Tropical Diseases Outpatient Hospital of Botucatu Medical School (FMB) - UNESP. The body mass index (BMI) and the classification by Papini-Berto (PB) were used to evaluate nutritional state, aiming at detecting malnutrition and obesity. The waist-to-hips ratio (W/HR) and waist circumference (WC) were adopted for identification of abdominal obesity and lipodystrophy. According to BMI, most of the individuals were eutrophic, followed by 30.9% overweight and 6.4% malnourished. By using the PB classification, the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Antiretroviral therapy; Nutritional indicators.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000200011

Hepatitis B virus surface antigen seroconversion in HIV-infected individual after pegylated interferon-alpha treatment: a case report
Provedor de dados: 80
Autores: Delicio,Adriane Maira; Abati,Paulo Afonso Martins; Vigani,Aline Gonzalez.
Hepatitis B virus (HBV) infects from 6 to 14% of HIV-infected individuals. Concurrent HIV/HBV infection occurs due to the overlapping routes of transmission, particularly sexual and parenteral. HIV-infected patients that have acute hepatitis B have six times greater risk of developing chronic hepatitis B, with higher viral replication, rapid progression to end-stage liver disease and shorter survival. The coinfection is also associated with poor response to hepatitis B treatment with interferon-alpha and increased liver toxicity to the antiretroviral therapy. Herein, we describe the case of a 35-year-old man who engages in sex with men and presented with newly diagnosed HIV-1, serological markers for acute hepatitis B and progression to chronic hepatitis B...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Hepatitis B; HBsAg; Peginterferon.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992013000100503

Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy
Provedor de dados: 80
Autores: Almeida,R. A. M. B.; Souza,L. R.; Calvi,S. A.; Ikoma,M. R. V.; Silva,V. A.; Curi,P. R.; Meira,D. A.
The aim of this paper was to evaluate the immune reconstitution of HIV-1 patients subjected to highly active antiretroviral therapy (HAART) for two years or more according to CD45RA and CD45RO cell count; determination of IL-2, IFN-gamma, IL-4, IL-10 and TNF-alpha serum levels; CD4+ T and CD8+ T lymphocyte count; and plasma viral load (VL) determination. For this purpose, a cross sectional study was carried out in the Tropical Diseases Area, Botucatu School of Medicine, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil. Between June 2001 and April 2002, 37 HIV-1 infected patients were evaluated, 13 with treatment indication but untreated (G1), 9 subjected to HAART for 5-7 months (G2), and 15 treated for two years or more (G3); both treated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Immune reconstitution; Antiretroviral; HAART; Cytokines; CD45RA; CD45RO.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100008

Assessment of cytokine values in serum by RT-PCR in HIV-1 infected individuals with and without highly active anti-retroviral therapy (HAART)
Provedor de dados: 80
Autores: Meira,DA; Almeida,RAMB; Barbosa,AN; de Souza,LR; Olivo,TET; Henriques,RMS; Golim,MA; Araújo Jr,JP; Nagoshi,LR; Orikaza,CM; Calvi,SA.
A cross-sectional study was performed on HIV-1 infected individuals with or without antiretroviral treatment (ARV) in the AIDS Day Hospital, Botucatu Medical School, UNESP. Between August 2004 and October 2005, 73 HIV-1 infected individuals were divided into three groups: infected individuals with or without AIDS who had never received ARV (G1 = 15); patients on HAART that had had plasma HIV-1 RNA viral load (VL) equal to or greater than 50 copies/mL (G2 = 27); and patients on HAART with undetectable VL for at least the past six months (G3 = 31). There was also an additional group that comprised blood donors without any sign of the disease and with negative HIV serum tests (G4 = 20), which was the control group. Serum cytokine levels (values in pg/mL) were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: RT-PCR; ELISA; Cytokines; HIV; AIDS; HAART; Apoptosis.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992008000400011

Effects of a Sarcocystis gigantea Extract (SGE) on the Replication of Human Immunodeficiency Virus (HIV)
Provedor de dados: 19
Autores: Drösigk, U.; Tietz, H. J.; Pözsch, F.; Scholz, D.; Hiepe, T. H.
Palavras-chave: Sarcocystis gigantea; Lectin; Immunomodulation; Human Immunodeficiency Virus; HIV.
Ano: 1995
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/235

The Impacts of Prime-Age Adult Mortality on Rural Household Income, Assets, and Poverty in Mozambique
Provedor de dados: 31
Autores: Mather,   David; Donovan,   Cynthia.
Ministry of Agriculture and Rural Development, Directorate of Economics, Republic of Mozambique
Tipo: Working or Discussion Paper
Palavras-chave: Food security; Food policy; Mozambique; HIV; AIDS; Food Security and Poverty; Health Economics and Policy; Q18.
Ano: 2008
URL: http://purl.umn.edu/56071

Evidence of Returns to Schooling in Africa from Household Surveys: Monitoring and Restructuring the Market for Education
Provedor de dados: 31
Autores: Schultz,   T. Paul.
Wage-differentials by education of men and women are examined from African household surveys to suggest private wage returns to schooling. It is commonly asserted that returns are highest at primary school levels and decrease at secondary and postsecondary levels, whereas private returns in six African countries are today highest at the secondary and post secondary levels, and rates are similar for women as for men. The large public subsidies for postsecondary education in Africa, therefore, are not needed to motivate students to enroll, and those who have in the past enrolled in these levels of education are disproportionately from the better-educated families. Higher education in Africa could be more efficient and more equitably distributed if the...
Tipo: Working or Discussion Paper
Palavras-chave: Africa; Wage returns to schooling; Inequality; HIV; AIDS; Labor and Human Capital; 015; 055; J31; J24.
Ano: 2003
URL: http://purl.umn.edu/28481

Análise da Mortalidade de Adultos Nos Agregados Familiares Rurais em Moçambique e Implicações para Políticas.
Provedor de dados: 31
Autores: Mather,   David; de Marrule,   Higino Francisco; Donovan,   Cynthia; Weber,   Michael T.; Alage,   Albertina.
Resultados de pesquisa do Departmento de Análise de Políticas, MADER, Direcção de Economia
Tipo: Report
Palavras-chave: Food security; Food policy; Mozambique; AIDS; HIV; Health Economics and Policy; Q18.
Ano: 2004
URL: http://purl.umn.edu/55240

Analysis of Adult Mortality Within Rural Households in Mozambique and Implication For Policy
Provedor de dados: 31
Autores: Mather,   David; de Marrule,   Higino Francisco; Donovan,   Cynthia; Weber,   Michael T.; Alage,   Albertina.
Research results from the Department of Policy Analysis, MADER, Directorate of Economics
Tipo: Report
Palavras-chave: Food security; Food policy; Mozambique; AIDS; HIV; Health Economics and Policy; Q18.
Ano: 2004
URL: http://purl.umn.edu/55239

Aluminum hydroxy-interlayered minerals and chemical properties of a subtropical Brazilian Oxisol under no-tillage and conventional tillage
Provedor de dados: 90
Autores: Inda,Alberto Vasconcellos; Torrent,José; Barrón,Vidal; Bayer,Cimélio.
No tillage systems significantly influence the soil system, but knowledge about the effects on the mineralogy of tropical and subtropical soils is limited. This study evaluated the long-term effects (26 years) of no-tillage (NT) on aluminum hydroxy-interlayered minerals of a subtropical Oxisol in Southern Brazil (Guarapuava, PR), compared to the same soil under conventional tillage (CT). The clay fraction (&lt; 2 µm) in soil samples of the surface horizons of a field experiment under both management systems was analyzed by X-ray diffraction (XRD) to identify and characterize Al hydroxy-interlayered minerals before and after treatment with sodium citrate to remove intra-layer material. Soil liquid (solution) and solid phases were also characterized. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIS; HIV; Organic carbon; Soil management systems; Mineral stability.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-06832010000100004

CYP2B6 516 G&amp;gt;T polymorphism and side effects of the central nervous system in HIV-positive individuals under Efavirenz treatment: Study of a sample from southern Brazil
Provedor de dados: 42
Autores: MÜLLER,TALISE E.; ELLWANGER,JOEL H.; MICHITA,RAFAEL T.; MATTE,MARIA CRISTINA C.; RENNER,JANE D.P.
ABSTRACT This study aimed to identify the 516 G&gt;T polymorphism of the CYP2B6 gene and evaluate its influence on central nervous system (CNS) side effect development in HIV-positive individuals undergoing Efavirenz (EFV) treatment in a population from southern Brazil. Additionally, we performed a survey on the clinical and epidemiological characteristics of our sample. In addition to medical records evaluation, whole blood of 89 individuals was analyzed for viral load, T lymphocyte count (CD4+ and CD8+), and the polymorphism. Considering the side effects of the CNS reported by individuals but without considering the genetic variables, no statistically significant association was noted between the adverse effects and the antiretroviral treatment...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Efavirenz; Antiretroviral therapy; CYP2B6.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000200497

Surveillance programs for detection and characterization of emergent pathogens and antimicrobial resistance: results from the Division of Infectious Diseases, UNIFESP
Provedor de dados: 42
Autores: Colombo,Arnaldo L.; Janini,Mario; Salomão,Reinaldo; Medeiros,Eduardo A. S.; Wey,Sergio B.; Pignatari,Antonio C. C.
Several epidemiological changes have occurred in the pattern of nosocomial and community acquired infectious diseases during the past 25 years. Social and demographic changes possibly related to this phenomenon include a rapid population growth, the increase in urban migration and movement across international borders by tourists and immigrants, alterations in the habitats of animals and arthropods that transmit disease, as well as the raise of patients with impaired host defense abilities. Continuous surveillance programs of emergent pathogens and antimicrobial resistance are warranted for detecting in real time new pathogens, as well as to characterize molecular mechanisms of resistance. In order to become more effective, surveillance programs of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Emerging infectious diseases; HIV; AIDS; Candidemia; Antimicrobial resistance; Bacteremia; Sepsis; Nosocomial infectious.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300020

The challenge of the reference and counter-reference system in the prenatal assistance to pregnant women with infectious diseases
Provedor de dados: 42
Autores: Figueiredo,Elisabeth N.; Vianna,Lucila A. C.; Peixe,Marina B.; Ramos,Valdete M.; Succi,Regina C. M.
The objective of this study was to determine the prevalence of infectious diseases, such as syphilis, acquired immune deficiency syndrome (AIDS) and hepatitis B and C, in pregnant women who undertook their prenatal care in thirteen basic health units (BHU) in São Paulo city. The efficiency of the reference and counter-reference system in such prenatal infectious diseases was evaluated considering the medical recordings of the final result of the pregnancy and the vertical transmission rates of these diseases. It consists of an epidemiologic study whose observations were based on the notes of the prenatal medical and nurse records of pregnant women who had infectious diseases susceptible to vertical transmission and final infectious status registers of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Congenital syphilis; Hepatitis B; Hepatitis C; HIV; Prenatal care; Referral and consultation.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300018

Determinants of HIV-1 mother-to-child transmission in Southern Brazil
Provedor de dados: 42
Autores: Martínez,Ana M.B.; Hora,Vanusa P. da; Santos,Adriana L. dos; Mendoza-Sassi,Raul; Von Groll,Andréa; Soares,Esmeralda A.J.M.; D'Ávila,Nildo; Silveira,Jussara; Leal,Renata G.; Tanuri,Amilcar; Soares,Marcelo A.
Different human immunodeficiency virus type 1 (HIV-1) subtypes may have distinct biological, immunological and pathogenic properties. Efficiency of mother-to-child transmission (MTCT) may be among those properties, but few and controversial results have been described so far. In this study, 102 children born from HIV-1-infected mothers between 1998 and 2004 in the city of Rio Grande, Brazil were analyzed for potential risk factors associated with MTCT. That geographic region is characterized by a high proportion of subtype C-infected subjects, and it allowed comparison between subtypes B and C and their influence on MTCT. The analysis also included clinical, obstetric and immunological parameters. Multivariate regression analyses were conducted to evaluate...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; MTCT; Vertical transmission; Subtype C; Molecular epidemiology.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000100011

Paraconsistents artificial neural networks applied to the study of mutational patterns of the F subtype of the viral strains of HIV-1 to antiretroviral therapy
Provedor de dados: 42
Autores: SANTOS,PAULO C.C. DOS; LOPES,HELDER F.S.; ALCALDE,ROSANA; GONSALEZ,CLÁUDIO R.; ABE,JAIR M.; LOPEZ,LUIS F.
ABSTRACT The high variability of HIV-1 as well as the lack of efficient repair mechanisms during the stages of viral replication, contribute to the rapid emergence of HIV-1 strains resistant to antiretroviral drugs. The selective pressure exerted by the drug leads to fixation of mutations capable of imparting varying degrees of resistance. The presence of these mutations is one of the most important factors in the failure of therapeutic response to medications. Thus, it is of critical to understand the resistance patterns and mechanisms associated with them, allowing the choice of an appropriate therapeutic scheme, which considers the frequency, and other characteristics of mutations. Utilizing Paraconsistents Artificial Neural Networks, seated in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Artificial Neural Networks; HIV; Genotyping; Paraconsistent logic; Paraconsistents Artificial Neural Networks; Pattern recognition.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100323

Frequency of class I anti-HLA alloantibodies in patients infected by HIV-1
Provedor de dados: 52
Autores: Leite,Elza Regina Manzolli; Lima,Oswaldo Luiz Luz; Leite,Fábio Renato Manzolli; Costa,Paulo Inácio da.
The aim of this study was to evaluate the presence of class I anti-HLA alloantibodies in patients infected by HIV-1 and relate it with the different clinical courses of the disease. Blood samples were collected in EDTA tubes from 145 individuals. HIV-1 infection was confirmed by ELISA test. The presence of class I anti-HLA alloantibodies and HLA allele's were determined. Clinical evolution was set as fast (&lt;1 year between diagnostic and death), moderate (1-3 years) or slow (&gt;3 years). Class I anti-HLA alloantibodies presence was lower in healthy individuals than in those infected by HIV-1 (4.2% against 32.4%). However, an equal distribution of these alloantibodies was found among the individuals infected, independent on the clinical evolution. Thus,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; HIV; HLA antigens; Alloantibodies.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000100012

Risk of coronary artery disease in individuals infected with human immunodeficiency virus
Provedor de dados: 55
Autores: Vilela,Felippe Dantas; Lorenzo,Andrea Rocha de; Tura,Bernardo Rangel; Ferraiuoli,Giovanna Ianini; Hadlich,Marcelo; Barros,Marcelo Viana de Lima; Lima,Ana Beatriz Ribeiro; Meirelles,Vanderson.
Current treatment for human immunodeficiency virus (HIV) infection has improved survival and allowed infected patients to develop atherosclerotic coronary artery disease (CAD). Specific strategies to reduce cardiovascular risk in the infected population have not been developed. It is necessary to know the magnitude of cardiovascular risk in this population. OBJECTIVES: This study aimed to assess cardiovascular risk using a well-known clinical score and to investigate coronary artery calcium scoring (CACS) in this population. METHODS: This was a cross-sectional study. Adults with HIV infection were studied. Demographic, clinical and anthropometric data, serum glucose and lipids were obtained. Cardiovascular risk was calculated through Framingham risk score...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coronary artery disease; HIV; Cardiovascular diseases; HIV protease inhibitors.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600004

Bezafibrate for the treatment of hypertriglyceridemia in HIV1-infected patients on highly active antiretroviral therapy
Provedor de dados: 55
Autores: Geraix,Juliana; Souza,Micheli Evangelista de; Delatim,Francieli Cristina; Pereira,Paulo Câmara Marques.
The use of highly active antiretroviral therapy (HAART) in HIV-infected patients has been associated with the development of risk factors for cardiovascular diseases (CD) including dyslipidemia and insulin resistance, hypertriglyceridemia being the most frequent metabolic disturbance in these patients. Fibrates are indicated when hypertriglyceridemia is accentuated and persists for over six months. We evaluated the efficacy and safety of bezafibrate for the treatment of hypertriglyceridemia in HIV-infected individuals on HAART. All patients received 400mg/day of bezafibrate and were evaluated three times: Mo (pre-treatment), M1 (one month after treatment), and M2 (six months after treatment). Fifteen adult individuals, eight males and seven females with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HAART; Hypertriglyceridemia; Bezafibrate.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000300001

Xerostomy, dental caries and periodontal disease in HIV+ patients
Provedor de dados: 55
Autores: Cavasin Filho,Julio César; Giovani,Élcio Magdalena.
We studied xerostomy and its correlation with periodontal and dental cavity diseases in HIV patients, through measurement of salivary flow and through variables such as saliva buffer capacity, salivary pH, periodontal index, MDF index, dental carie risk and risk of periodontal disease. One hundred patients were analyzed. They were distributed into two groups: Group I (test) - 50 patients evidently HIV+, from whom information was collected and analyzed regarding age, gender, skin color, habits, general and oral diseases, levels of T-CD4 lymphocytes, viral load and highly active antiretroviral therapy (HAART); and Group II - (control) 50 HIV- patients, from whom information was collected and analyzed regarding age, gender, skin color, habits, general and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acquired Immune Deficiency Syndrome; HIV; Salivary flow; Xerostomy; Dental cavity; Periodontal disease.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000100005

HIV subtype, epidemiological and mutational correlations in patients from Paraná, Brazil
Provedor de dados: 55
Autores: Silva,Monica Maria Gomes da; Telles,Flavio Queiroz; Cunha,Clovis Arns da; Rhame,Frank S.
OBJECTIVE: Analyze patients with HIV infection from Curitiba, Paraná, their epidemiological characteristics and HIV RAM. METHODS: Patients regularly followed in an ID Clinic had their medical data evaluated and cases of virological failure were analyzed with genotypic report. RESULTS: Patients with complete medical charts were selected (n = 191). Demographic and clinical characteristics were compared. One hundred thirty two patients presented with subtype B infection (69.1%), 41 subtype C (21.5%), 10 subtype F (5.2%), 7 BF (3.7%) and 1 CF (0.5%). Patients with subtype B infection had been diagnosed earlier than patients with subtype non-B. Also, subtype B infection was more frequent in men who have sex with men, while non-B subtypes occurred more...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Aids; Subtypes; Subtype B; Subtype non-B; Genetic diversity; Antiretroviral; Brazil.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500012

Causes of death among people living with HIV/AIDS in Brazil
Provedor de dados: 55
Autores: Rezende,Erika Luiza Lage Fazito; Vasconcelos,Ana Maria Nogales; Pereira,Mauricio Gomes.
BACKGROUND: The monitoring of the underlying causes of death in people living with HIV/AIDS is important so that actions to reduce morbidity and mortality can be taken. OBJECTIVE: To describe the temporal trends of underlying causes of death among people living with HIV/AIDS between 2000 and 2007 in Brazil and to identify factors associated with it. METHODS: The Mortality Information System data for deaths occurred in Brazil between 2000 and 2007 that contained reference to HIV/AIDS in any of the death certificate fields was analyzed. Temporal trends of the underlying cause of death were studied. Differences in the underlying cause of death according to gender, age, region of residence, level of education, certifying officer, race and year of death were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Causes of death; HIV.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000600003

Self-reported adverse reactions among patients initiating antiretroviral therapy in Brazil
Provedor de dados: 55
Autores: Pádua,Cristiane A. Menezes de; César,Cibele C.; Bonolo,Palmira F.; Acurcio,Francisco A.; Guimarães,Mark Drew C.
A cross-sectional analysis was carried out to describe adverse reactions to antiretroviral therapy (ART) reported by HIV-infected patients initiating treatment at two public health AIDS referral centers in Belo Horizonte, Brazil, 2001-2003 and to verify their association with selected variables. Adverse reactions were obtained through interview at the first follow-up visit (first month) after the antiretroviral prescription. Socio-demographic and behavioral variables related to ART were obtained from baseline and follow-up interviews and clinical variables from medical charts. Patients with four or more reactions were compared to those with less than four. Odds ratio with 95% confidence interval were estimated using logistic regression model for both...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral therapy; Adverse reactions; Self-report.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100007

Human immunodeficiency virus and the central nervous system
Provedor de dados: 55
Autores: Almeida,Sergio Monteiro de; Letendre,Scott; Ellis,Ron.
The pandemic of HIV/AIDS continues to grow daily. Incident cases among women, intravenous drug users and ethnic minorities comprise the fastest growing segment of the HIV-infected population, and the number of HIV-infected individuals over the age of 50 is growing rapidly. Today, the central nervous system and the immune system are seen as main targets of HIV infection. Significant progress in the knowledge and treatment of AIDS has been obtained in recent years. The neurological manifestations directly related to HIV are acute viral meningitis, chronic meningitis, HIV-associated dementia (HAD), vacuolar myelopathy, and involvement of the peripheral nervous system.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; HIV dementia; Central nervous system; Cerebrospinal fluid; Viral load; Chemokines.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100009

Adolescents growing with HIV/AIDS: experiences of the transition from pediatrics to adult care
Provedor de dados: 55
Autores: Machado,Daisy Maria; Galano,Eliana; de Menezes Succi,Regina Célia; Vieira,Carla Maria; Turato,Egberto Ribeiro.
Abstract The main objective of this work is to describe the formation of the Transition Adolescent Clinic (TAC) and understand the process of transitioning adolescents with HIV/AIDS from pediatric to adult care, from the vantage point of individuals subjected to this process. A qualitative method and an intentional sample selected by criteria were adopted for this investigation, which was conducted in São Paulo, Brazil. An in-depth semi-structured interview was conducted with sixteen HIV-infected adolescents who had been part of a transitioning protocol. Adolescents expressed the need for more time to become adapted in the transition process. Having grown up under the care of a team of health care providers made many participants have reluctance toward...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Health care transition; Adolescent.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000300002

Parkinsonism in HIV infected patients during antiretroviral therapy – data from a Brazilian tertiary hospital
Provedor de dados: 55
Autores: Dehner,Luis Filipe; Spitz,Mariana; Pereira,João Santos.
Abstract  Introduction Advances in the treatment of HIV infection in the last decades have increased life expectancy of these patients and raise the question of what kind of effect chronic infection and its treatment might exert on the behavior of age-related conditions such as neurodegenerative diseases.  Patient data We performed a retrospective analysis of patients’ records to assess the frequency of the association between HIV infection and parkinsonian symptoms in our hospital population. Among 249 records we identified four individuals with reported parkinsonian symptoms initiated after HIV diagnosis. Three of them had no other identifiable cause of secondary parkinsonism. All had symptom onset before the age of 60. Based on this study sample one...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Parkinsonism; HIV; Antiretroviral therapy.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500499

Human immunodeficiency virus infection and its association with sarcopenia
Provedor de dados: 55
Autores: Pinto Neto,Lauro Ferreira da Silva; Sales,Marina Cerqueira; Scaramussa,Eduarda Sobral; da Paz,Clara Junia Calazans; Morelato,Renato Lirio.
Abstract Presarcopenia and sarcopenia were evaluated in HIV-infected individuals and in healthy elderly controls according to the consensus definitions of the European Working Group on Sarcopenia in Older People. Bioelectrical impedance, a hydraulic hand dynamometer, and gait speed were used to evaluate muscle mass, muscle strength, and physical performance, respectively. Adjusted and unadjusted binary logistic regression predicted the risk of sarcopenia. Predictor contribution was assessed by the Wald test. Significance was established at p ≤ 0.05. The HIV-infected group consisted of 33 patients on treatment (42.4% women; mean age 59 ± 7 years; mean BMI 25 ± 6 kg/m2; viral load undetectable in 30 cases). The HIV-uninfected group consisted of 60...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Sarcopenia; HIV; Frailty.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100099

Hospitalization rates, length of stay and in-hospital mortality in a cohort of HIV infected patients from Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Coelho,Lara E.; Ribeiro,Sayonara R.; Veloso,Valdilea G.; Grinsztejn,Beatriz; Luz,Paula M.
Abstract In this study, we evaluated trends in hospitalization rates, length of stay and in-hospital mortality in a cohort of HIV-infected patients in Rio de Janeiro, Brazil, from 2007 through 2013. Among the 3991 included patients, 1861 hospitalizations occurred (hospitalization rate of 10.44/100 person-years, 95% confidence interval 9.98–10.93/100 person-years). Hospitalization rates decreased annually (per year incidence rate ratio 0.92, 95% confidence interval 0.89–0.95) as well as length of stay (median of 15 days in 2007 vs. 11 days in 2013, p-value for trend &lt; 0.001), and in-hospital mortality (13.4% in 2007 to 8.1% in 2013, p-value for trend = 0.053). Our results show that, in a middle-income setting, hospitalization rates are decreasing over...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Hospitalization; Length of stay; In-hospital mortality.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200190

Non tuberculous mycobacteria and toxoplasma co-infection of the central nervous system in a patient with AIDS
Provedor de dados: 55
Autores: Sardar,Partha; Bandyopadhyay,Dipanjan; Roy,Deeptarka; Guha,Pradipta; Guha,Goutam; Banerjee,Amit Kumar.
New-onset seizures are frequent manifestations in patients infected with Human Immunodeficiency Virus (HIV). We describe the clinical and radiological findings in an 25yr old AIDS patient presenting with new onset seizures as the primary manifestation of cerebral toxoplasmosis and Non Tuberculous Mycobacterial [NTM] co-infection. Cranial computed tomography showed a subtle ventricular dilatation whereas magnetic resonance imaging disclosed prominent temporal horn. Toxoplasma tachyzoites and rapidly growing mycobacteria were recovered from CSF. Seizures were complex partial in nature and refractory to antiepileptic therapy.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Non tuberculous Mycobacteria; Toxoplasmosis; HIV; Seizures.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000600011

Immune restoration in human immunodeficiency virus and hepatitis C virus coinfected patients after highly active antiretroviral therapy
Provedor de dados: 55
Autores: Antonello,Vicente Sperb; Appel-da-Silva,Marcelo Campos; Kliemann,Dimas Alexandre; Santos,Breno Riegel; Tovo,Cristiane Valle.
OBJECTIVE: To evaluate the influence of hepatitis C virus on immunological and virological responses after highly active antiretroviral therapy initiation in human immunodeficiency virus/hepatitis C virus coinfected patients compared to monoinfected human immunodeficiency virus-infected patients. METHODS: The study enrolled 65 human immunodeficiency virus-1-infected subjects who initiated highly active antiretroviral therapy and attended follow-up visits over 48 weeks from 2008 to 2010. They were grouped based on hepatitis C virus-RNA results. Virological and immunological responses were monitored at baseline and at the end of weeks 12, 24, 36, and 48. RESULTS: There were 35 human immunodeficiency virus monoinfected and 30 human immunodeficiency...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Hepatitis C; Coinfection; HAART; CD4; Immunological response.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000500007

HIV frequency among female sex workers in Imbituba, Santa Catarina, Brazil
Provedor de dados: 55
Autores: Trevisol,Fabiana Schuelter; Silva,Marcos Vinicius da.
We examined HIV frequency and probable risk factors among female sex workers in the port city of Imbituba, Southern Brazil. From December 2003 through February 2004, 90 female sex workers were interviewed in order to investigate demographic, socioeconomic and behavioral variables related to HIV infection. A blood sample of each woman was also collected to test for HIV antibodies. Six (6.7%) of the sex workers were HIV-positive; the significantly-correlated risk factors were the daily number of clients (p = 0.008), the use of inhaled illicit drugs by the sex workers (P = 0.053) and by their clients (p = 0.005), and the lack of condom use in sexual relations (p = 0.015). The HIV infection rate in these sex workers was higher than that in the general...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Prostitution; Risk behavior.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600008

Successful prevention of HIV transmission from mother to infant in Brazil using a multidisciplinary team approach
Provedor de dados: 55
Autores: Nogueira,Susie A.; Abreu,Thalita; Oliveira,Ricardo; Araújo,Lúcia; Costa,Tomaz; Andrade,Miriam; Psic,M. Fátima Garcia; Machado,Elizabeth; Rodrigues,Káris; Mercadante,Elizabeth Regina; Fernandes,Iraína; Sapia,M. Conceição; Lambert,John S.
OBJECTIVES: To determine the HIV vertical transmission rate (VTR) and associated risk factors by use of zidovudine and infant care education in Brazil. METHODS: Since 1995, a prospective cohort of HIV infected pregnant women has been followed at the Federal University of Rio de Janeiro. A multidisciplinary team was established to implement the best available strategy to prevent maternal-infant HIV transmission. Patients with AIDS or low CD4 and high viral load received anti-retroviral drugs in addition to zidovudine. Children were considered infected if they had 2 positive PCR-RNA tests between 1 and 4 months of age, or were HIV antibody positive after 18 months. Education regarding infant treatment and use of formula instead of breast feeding was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazil; HIV; Prevention; Perinatal transmission; Zidovudine.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000200006

Lipodystrophic syndrome in children and adolescents infected with the human immunodeficiency virus
Provedor de dados: 55
Autores: Alves,Crésio; Oliveira,Ana Cláudia; Brites,Carlos.
The introduction of highly active antiretroviral therapy (HAART) for the treatment of acquired immunodeficiency syndrome (AIDS) has resulted in greater survival of patients infected with the human immunodeficiency virus (HIV). However, the use of these drugs has been associated with lipodystrophic syndrome (LS), which is characterized by metabolic alterations (dyslipidemia, insulin resistance, diabetes, and lactic acidosis) and abnormal corporal fat distribution. Clinically, LS may manifest as three different forms: lipohipertrophy (accumulation of fat in the central part of the body), lipoatrophy (loss of fat in the extremities, face and buttocks) and mixed (lipohipertrophy + lipoatrophy). Although its physiopathology has not been elucidated, some...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Lipodystrophy; Highly active antiretroviral treatment; Children and adolescents.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400018

Changes health-related quality of life in HIV-infected patients following initiation of antiretroviral therapy: a longitudinal study
Provedor de dados: 55
Autores: Dutra,Brenda Soares; Lédo,Ana Paula; Lins-Kusterer,Liliane; Luz,Estela; Prieto,Indira Rodriguez; Brites,Carlos.
Abstract  Background: Several tools have been developed to evaluate HIV health-related quality of life (HRQoL) during and after antiretroviral therapy (ART). Few longitudinal studies evaluated the effect of ART on the quality of life of HIV patients.  Objective: To evaluate changes in HRQoL in HIV-infected individuals one year after initiating ART.  Methods: A prospective study was conducted from May 2016 to July 2018. Data on clinical and sociodemographic characteristics of 91 HIV-infected patients were collected prior to initiation of ART and one year thereafter. Demographic and clinical data were collected and the questionnaires 36-item Short Form Health Survey (SF-36) and HIV/AIDS-targeted quality of life (HAT-QoL) were administered in both periods....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Health-related quality of life; Antiretroviral Therapy; HIV; Patient Reported Outcome Measures.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400211

Impact of macrolide therapy on mortality of HIV-infected patients with community-acquired pneumonia in a tertiary teaching hospital
Provedor de dados: 55
Autores: Mello,Claudia Figueiredo; Negra,Marinella Della.
BACKGROUND: Bacterial pneumonia is one of the main causes of morbidity and mortality in patients infected by the human immunodeficiency virus (HIV). The main objective of this study was to evaluate the effect of macrolide therapy in combination with a beta-lactam based empiric regimen for inpatients with community-acquired pneumonia and HIV. METHODS: This is a retrospective cohort study of hospitalized patients. Adult patients who had received treatment with ceftriaxone or ceftriaxone plus clarithromycin were included. RESULTS: 76 patients met the inclusion criteria. Among baseline characteristics analyzed, only respiratory rate showed significant difference: patients who had received clarithromycin were more likely to have a respiratory rate &gt; 30/min...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Pneumonia; Macrolides; Mortality.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300014

Vasculitis: an unusual manifestation in an HIV-infected patient
Provedor de dados: 55
Autores: Manuel,Ana; Victório,Tânia; Gomes,Constança; Martins,Telmo; Dias Neto,António.
Human immunodeﬁciency virus (HIV) positive patients may develop vasculitis, either mediated by immunological factors or by direct vascular injury. We describe a patient who developed manifestations suggestive of extremities vasculitis with no identiﬁable risk factors other than HIV, Epstein Barr and Herpes Simplex Virus (HSV) type 1 co-infection. Physicians should be aware that vasculitis may have a heterogeneous presentation and occur associated with HIV infection. Although unusual, this association should be recognized for early proper treatment and prevention of ischemia.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Vasculitis; HIV; Epstein Barr virus; Herpes Simplex Virus.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400439

Detection of mycobacteria in the bloodstream of patients with Acquired Immunodeficiency Syndrome in a University Hospital in Brazil
Provedor de dados: 55
Autores: Oplustil,Carmen Paz; Leite,Olavo H.M.; Oliveira,Marilia S.; Sinto,Sumiko I.; Uip,David E.; Boulos,Marcos; Mendes,Caio F.
This study was done to determine the occurrence of mycobacteria in the bloodstreams of patients with fever and advanced AIDS in a Brazilian hospital. We also verified the capability of an automated method for recovering these bacteria. During a period of 19 months, 254 patients with AIDS were evaluated. Blood cultures were generally submitted in pairs and drawn separately. Blood cultures were processed by the BACTEC 460TB System (Becton Dickinson Microbiology Systems, Sparks, MD), using the Bactec 13A media (Becton Dickinson Microbiology Systems, Sparks, MD). Of the 530 vials submitted, 77 (14.5%) from 41 (16%) patients were positive. Mycobacterium avium complex was recovered from 45 (58.4%) of the 77 positive vials, corresponding to 22 (53.6%) patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterial infection; HIV; Automated diagnosis; AIDS.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000500003

Transfusion risk for hepatitis B, hepatitis C and HIV in the state of Santa Catarina, Brazil, 1991-2001
Provedor de dados: 55
Autores: Kupek,Emil.
We examined the time trend of residual risk of transfusing blood contaminated with HIV, hepatitis B and hepatitis C, in the largest blood bank of the state of Santa Catarina, Brazil, 1991-2001. The HIV risk was reduced approximately 10 times during the decade of 1990, to 1:48777, but then increased significantly by the end of 2001. A similar time trend was observed for hepatitis B and hepatitis C, although the increase was not significant in this case. Even during the period of lowest risk, the estimates were considerably higher than in developed countries.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Blood transfusion; HIV; Hepatitis B; Hepatitis C.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000300007

Anti-glomerular basement membrane glomerulonephritis in an HIV positive patient: case report
Provedor de dados: 55
Autores: Monteiro,Eduardo José Bellotto; Caron,Daiane; Balda,Carlos Alberto; Franco,Marcello; Pereira,Aparecido Bernardo; Kirsztajn,Gianna Mastroianni.
We report on a case of a patient with HIV infection, diagnosed 18 months prior to the development of an anti-glomerular basement membrane (anti-GBM) rapidly progressive glomerulonephritis; this is probably the first report of such an association. A 30-year-old white man presented with elevation of serum creatinine (1.3 - 13.5 mg/dL within one month). At admission, the urinalysis showed proteinuria of 7.2 g/L and 8,000,000 erythrocytes/mL. Renal biopsy corresponded to a crescentic diffuse proliferative glomerulonephritis mediated by anti-GBM, and serum testing for anti-GBM antibodies was positive; antinuclear antibodies (ANA) and anti-neutrophilic cytoplasmic antibodies (ANCA) were also positive. The patient underwent hemodyalisis and was treated with...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Anti-GBM glomerulonephritis; HIV; Urinary abnormalities.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100011

Clinical and epidemiological features of patients with chronic hepatitis C co-infected with HIV
Provedor de dados: 55
Autores: Eduardo Lorens,Braga; André Castro,Lyra; Fabrizio,Ney-Oliveira; Lourianne,Nascimento; Adriano,Silva; Carlos,Brites; Rosicreuza,Marbak; Luiz Guilherme Costa,Lyra; Manuel L.,Ribeiro Neto; Koonj Asvin,Shah.
Co-infection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is increasingly common and affects the clinical course of chronic hepatitis C. Highly active antiretroviral therapy has improved the life expectancy of HIV infected patients, but, by extending survival, it permits the development of HCV cirrhosis. This study tried to evaluate clinical and epidemiological features of patients with chronic hepatitis C co-infected with HIV. We evaluated 134 HCV-infected patients: i) group A - 65 co-infected HCV/HIV patients, ii) group B - 69 mono-infected HCV patients. The impact of HIV infection on HCV liver disease was analyzed using Child's score, ultrasound findings and liver histology. Patients were subjected to HCV genotyping and anti-HBs...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; HIV; Co-infection; Clinical course; HCV genotype.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000100004

HLA-B*5701 frequency in Chilean HIV-infected patients and in general population
Provedor de dados: 55
Autores: Poggi,Helena; Vera,Alejandra; Lagos,Marcela; Solari,Sandra; Rodríguez P,Luis; Pérez,Carlos M.
It has been demonstrated that HLA-B*5701 screening reduces the risk for hypersensitivity reaction to abacavir in HIV-infected patients. Since B*5701 prevalence varies among different populations, it is important to determine the carrier frequency prior to its use for the screening of HIV-infected patients.The aim of this study was to determine HLA-B*5701 carrier frequency in Chilean general population and HIV-infected patients referred for B*5701 typing. For that purpose 300 blood bank donors and 492 abacavir-naïve HIV-infected patients from Chile were screened for B*5701 by a sequence specific primer PCR.We detected 14/300 (4.7%) B*57-positive individuals in the Chilean general population, 11 (3.7%) were B*5701 positive, and 3 (1%) had another subtype.All...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HLA-B*5701; HIV; Abacavir; Chile; Pharmacogenetics.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500015

Dyslipidemia in AIDS patients on highly active antiretroviral therapy
Provedor de dados: 55
Autores: Nery,Max Weyler; Martelli,Celina Maria Turchi; Turchi,Marília Dalva.
Highly active antiretroviral therapy (HAART) reduces AIDS-related morbidity and mortality, however it has been associated with metabolic abnormalities. This study estimated the prevalence of lipid abnormalities and related factors among patients on HAART. A cross-sectional study was conducted on adult patients, in central Brazil. Patients were interviewed, and blood obtained for lipids measurement. Dyslipidemia was defined as total cholesterol (TC) &amp;gt; 240 mg/dL, low-density lipoprotein (LDL) &amp;gt; 160 mg/dL, triglycerides (TG) &amp;gt; 200 and/or high-density lipoprotein (HDL) &lt; 40 mg/dL. Multiple logistic regression analyses were performed (SPSS 13.0). One hundred and thirteen patients were recruited. Mean age was 39.3 years; 68.1% were males;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Prevalence; Dyslipidemia; HIV; AIDS; HAART.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000200010

Clinical and epidemiological characteristics associated with unfavorable tuberculosis treatment outcomes in TB-HIV co-infected patients in Brazil: a hierarchical polytomous analysis
Provedor de dados: 55
Autores: Prado,Thiago Nascimento do; Rajan,Jayant V.; Miranda,Angélica Espinosa; Dias,Elias dos Santos; Cosme,Lorrayne Beliqui; Possuelo,Lia Gonçalves; Sanchez,Mauro N.; Golub,Jonathan E.; Riley,Lee W.; Maciel,Ethel Leonor.
Abstract  Background: TB patients co-infected with HIV have worse treatment outcomes than non-coinfected patients. How clinical characteristics of TB and socioeconomic characteristics influence these outcomes is poorly understood. Here, we use polytomous regression analysis to identify clinical and epidemiological characteristics associated with unfavorable treatment outcomes among TB-HIV co-infected patients in Brazil.  Methods: TB-HIV cases reported in the Brazilian information system (SINAN) between January 1, 2001 and December 31, 2011 were identified and categorized by TB treatment outcome (cure, default, death, and development of MDR TB). We modeled treatment outcome as a function of clinical characteristics of TB and patient socioeconomic...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; HIV; Coinfection; Logistic regression.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200162

Disseminated tuberculosis presenting as mesenteric and cerebral abscess in HIV infection: case report
Provedor de dados: 55
Autores: Pandit,Vinay; Valsalan,Rohith; Seshadri,Shubha; Bahuleyan,Shibu.
Disseminated tuberculosis in HIV infection involves multiple organs. Pulmonary and lymph node involvement are the commonest form of tuberculosis in HIV infection [1, 2]. Other forms of tuberculosis in the absence of lung and lymph node involvement are rare. Various forms of abdominal [3, 4] and neurological [5, 6] tubercular involvement in HIV infection have been reported. But tuberculosis presenting simultaneously with mesenteric and brain abscess has not been reported yet. We report a case of disseminated tuberculosis presenting as mesenteric and cerebral abscess in a HIV case without involving lung and lymph nodes. Bone marrow smears and fine needle aspiration cytology (FNAC) from mesenteric lesion were positive for acid fast bacilli (AFB) and the...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Tuberculosis; Abscess.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500014

Cascade of access to interventions to prevent HIV mother to child transmission in the metropolitan area of Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Araujo,Elaine S. Pires; Friedman,Ruth Khalili; Camacho,Luis Antonio Bastos; Derrico,Monica; Moreira,Ronaldo Ismério; Calvet,Guilherme Amaral; Oliveira,Marília Santini de; Veloso,Valdilea Gonçalves; Pilotto,José Henrique; Grinsztejn,Beatriz.
OBJECTIVES: To describe the access to the interventions for the prevention of Human Immunodeficiency Virus (HIV) mother to child transmission and mother to child transmission rates in the outskirts of Rio de Janeiro, from 1999 to 2009.METHODS: This is a retrospective cohort study. Prevention of HIV mother to child transmission interventions were accessed and mother to child transmission rates were calculated.RESULTS: The study population is young (median: 26 years; interquartile range: 22.0-31.0), with low monthly family income (40.4% up to one Brazilian minimum wage) and schooling (62.1% less than 8 years). Only 47.1% (n = 469) knew the HIV status of their partner; of these women, 39.9% had an HIV-seronegative partner. Among the 1259 newborns evaluated,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HIV vertical transmission; Antiretroviral chemoprophylaxis; Cohort studies; Brazil.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000300252

Prevalence of lipodystrophy and risk factors for dyslipidemia in HIV-infected children in Brazil
Provedor de dados: 55
Autores: Papi,Luanda; Menezes,Ana Carolina G.B.; Rocha,Hélio; Abreu,Thalita F.; Oliveira,Ricardo Hugo de; Frota,Ana Cristina C.; Evangelista,Lucia de A.; Hofer,Cristina B.
The aim of present study was to describe the frequency of lipodystrophy syndrome associated with HIV (LSHIV) and factors associated with dyslipidemia in Brazilian HIV infected children. HIV infected children on antiretroviral treatment were evaluated (nutritional assessment, physical examination, and laboratory tests) in this cross-sectional study. Univariate analysis was performed using Mann-Whitney test or Fisher's exact test followed by logistic regression analysis. Presence of dyslipidemia (fasting cholesterol &gt;200 mg/dl or triglycerides &gt;130 mg/dl) was the dependent variable. 90 children were enrolled. The mean age was 10.6 years (3-16 years), and 52 (58%) were female. LSHIV was detected in 46 children (51%). Factors independently associated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Lipodystrophy; Dyslipidemia; Children.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400394

Chlamydia trachomatis infection among HIV-infected women attending an AIDS clinic in the city of Manaus, Brazil
Provedor de dados: 55
Autores: Silva,Leila Cristina Ferreira; Miranda,Angélica Espinosa; Batalha,Rosieny Santos; Sabino,Carolina; Dib,Elizabeth Cristina Dantas; Costa,Carolina Marinho da; Ramasawmy,Rajendranath; Talhari,Sinésio.
This was a cross-sectional study aimed to determine the prevalence of and to identify risk factors for Chlamydia trachomatis (CT) among human immunodeficiency virus (HIV)-infected women attending the acquired immunodeficiency syndrome (AIDS) clinic in the city of Manaus, Brazil, in 2009-2010. Participants answered a questionnaire containing demographic, epidemiological, and clinical data. A genital specimen was collected during examination to detect CT-DNA by hybrid capture, and blood samples were taken to determine CD4+T and HIV viral load. There were 329 women included in the study. Median age was 32 years (IQR = 27-38) and median schooling was nine years (IQR = 4-11). The prevalence of CT was 4.3% (95%CI: 2.1-6.5). Logistic regression analysis showed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chlamydia trachomatis; HIV; Women; Amazonas.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400004

Survival of HIV patients with tuberculosis started on simultaneous or deferred HAART in the THRio cohort, Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Saraceni,Valeria; Durovni,Betina; Cavalcante,Solange C.; Cohn,Silvia; Pacheco,Antonio Guilherme; Moulton,Lawrence H.; Chaisson,Richard E.; Golub,Jonathan E.
Background:The timing of highly active antiretroviral therapy (HAART) after a tuberculosis diagnosis in HIV-infected patients can affect clinical outcomes and survival. We compared survival after tuberculosis diagnosis in HIV-infected adults who initiated HAART and tuberculosis therapy simultaneously to those who delayed the start of HAART for at least two months.Methods:The THRio cohort includes 17,983 patients receiving HIV care in 29 public clinics in Rio de Janeiro, Brazil. HAART-naïve patients at the time of a new TB diagnosis between September 2003 and June 2008 were included. Survival was measured in days from diagnosis of TB. We compared survival among patients who initiated HAART within 60 days of TB treatment (simultaneous – ST) to those who...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Tuberculosis; Antiretroviral therapy; Survival.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500491

Aging, neurocognitive impairment and adherence to antiretroviral therapy in human immunodeficiency virus-infected individuals
Provedor de dados: 55
Autores: Pinheiro,Cezar Arthur Tavares; Souza,Luciano Dias de Mattos; Motta,Janaína Vieira dos Santos; Kelbert,Evelin Franco; Martins,Clarissa de Souza Ribeiro; Souza,Marília Silva de; Pinheiro,Karen Amaral Tavares; Coelho,Fábio Monteiro da Cunha; Pinheiro,Ricardo Tavares.
ABSTRACT  Background/objective: There is an increasing number of older patients with human immunodeficiency virus infection due to the success of antiretroviral therapy, the improved prognosis and life expectancy of patients, and the higher number of new infections among older individuals. The main objective of the present study was to compare the characteristics of older human immunodeficiency virus patients with those of younger patients.  Materials and methods: We conducted a cross-sectional study with human immunodeficiency virus-infected patients who were treated at the Specialized Care Service (Serviço de Assistência Especializada) for human immunodeficiency virus/AIDS in the city of Pelotas, South Brazil. Sociodemographic information as well as data...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; HIV; Neurocognitive impairment; Adherence.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600599

Factors associated with mortality in HIV patients failing antiretroviral therapy, in Salvador, Brazil
Provedor de dados: 55
Autores: Haguihara,Tatiana; Silva,Márcio da Oliveira; Rebouças,Monaliza Cardozo; Martins Netto,Eduardo; Brites,Carlos.
ABSTRACT Highly active antiretroviral therapy (HAART) has significantly improved survival of people living with HIV/Aids (PLWHA). However, poor treatment adherence to HAART and other problems, still cause therapy failure and contribute to increased morbidity and mortality of PLWHA. In this retrospective cohort study (2013-2015), we sought to evaluate the factors associated with mortality of PLWHA failing HAART in 2013, who were receiving care at a reference center for sexually transmitted diseases (STD) and HIV/AIDS. A total of 165 individuals over 18 years of age who were failing antiretroviral therapy were evaluated. In two-year follow-up, 19 (11.5%) deaths were documented. There were a significant association between mortality and report of illicit drug...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Virologic failure; Mortality; HIV.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000300160

Vascular access-related infections in HIV patients undergoing hemodialysis: case description and literature review
Provedor de dados: 55
Autores: Castro,Carlos E. Figueroa; Madariaga,Miguel G.
Poor immune status, the use of a vascular access different from an AV fistula, and intravenous drug use (IDU) may favor increased rates of vascular access infections among HIV infected patients on hemodialysis. Staphylococcus spp. and Streptococcus spp. are the main cause of these infections, but Gram-negative rods and fungi have been found as well. Using an AV fistula when possible, and eliciting a history of IVDU on every visit may prevent this type of infection. When infections are present, coverage for both Gram-positive and negative organisms is recommended. Additional studies specifically addressing the issue of vascular access infection in HIV infected patients are required.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Chronic kidney disease; Renal dialysis; Catheter-related infections.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000600017

Lipid accumulation product index in HIV-infected patients: a marker of cardiovascular risk
Provedor de dados: 55
Autores: Guimarães,Milena Maria Moreira; Greco,Dirceu Bartolomeu; Moreira,Allyson Nogueira; Guimarães,Nathalia Sernizon; Freire,Cláudia Maria Vilas; Rohlfs,Bruna Guimarães; Machado,Lucas José de Campos.
ABSTRACT The lipid accumulation product (LAP) index is an emerging cardiovascular risk marker. We aimed to assess the accuracy of this index as a marker of cardiovascular risk in HIV-infected patients. A cross-sectional study of 133 HIV-infected patients on antiretroviral drugs and 20 non-infected controls was conducted at the outpatient clinic of a referral center of infectious and parasitic diseases. Evaluations included LAP index, homeostasis model assessment (HOMA) index, anthropometric measurements, blood pressure, glucose tolerance test, and cholesterol and triglyceride levels. Body mass index (BMI) was similar in both groups; however, waist circumference was greater in the HIV-infected patients. Triglyceride levels were significantly higher (p &lt;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Hyperlipidemia; Atherosclerosis; Lipid accumulation product index; Cardiovascular risk; Insulin resistance.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300171

Magnetic bead technology for viral RNA extraction from serum in blood bank screening
Provedor de dados: 55
Autores: Albertoni,Guilherme Ambrozio; Arnoni,Carine Prisco; Araujo,Patricia Regina Barboza; Andrade,Sheila Siqueira; Carvalho,Fabrício Oliveira; Girão,Manoel João Batista Castello; Schor,Nestor; Barreto,José Augusto.
Nucleic acid amplification testing (NAT) was recently recommended by Brazilian legislation and has been implemented at some blood banks in the city of São Paulo, Brazil, in an attempt to reduce blood-born transmission of human immunodeficiency virus (HIV) and hepatitis C virus. OBJECTIVE: Manual magnetic particle-based extraction methods for HIV and HCV viral nucleic acids were evaluated in combination with detection by reverse transcriptase - polymerase chain reaction (RT-PCR) one-step. METHODS: Blood donor samples were collected from January 2010 to September 2010, and minipools of them were submitted to testing. ELISA was used for the analysis of anti-HCV/HIV antibodies. Detection and amplification of viral RNA was performed using real-time PCR....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HCV; HIV; Infection; Reverse transcriptase polymerase chain reaction; Blood banks.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600008

Vaccination status of people living with HIV/AIDS in outpatient care in Fortaleza, Ceará, Brazil
Provedor de dados: 55
Autores: Cunha,Gilmara Holanda da; Galvão,Marli Teresinha Gimeniz; Medeiros,Camila Martins de; Rocha,Ryvanne Paulino; Lima,Maria Amanda Correia; Fechine,Francisco Vagnaldo.
Abstract Antiretroviral therapy has increased the survival of patients with HIV/AIDS, thus necessitating health promotion practice with immunization. Vaccines are critical components for protecting people living with HIV/AIDS (PLWHA). The purpose of study was to analyze the vaccination status of PLWHA in outpatient care in Fortaleza, Ceará, Brazil. Cross-sectional study performed from June 2014 to June 2015. The screening was done with patients in antiretroviral therapy, 420 patients underwent screening, but only 99 met the inclusion criteria. Data were collected for interviews using forms to characterize sociodemographic, clinical and vaccination situations. Only 14 patients had complete vaccination schedules. The most used vaccines were hepatitis B,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acquired immunodeficiency syndrome; HIV; Health promotion; Immunization; Immunization schedule.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500487

High vertical HIV transmission rate in the Midwest region of Brazil
Provedor de dados: 55
Autores: Matos,Vanessa Terezinha Gubert de; Batista,Fabiani de Morais; Versage,Naiara Valera; Pinto,Clarice Souza; Oliveira,Vanessa Marcon de; Vasconcelos-Pereira,Érica Freire de; Matos,Roberta Barbeta dos Rios de; Fabbro,Márcia Maria Ferrairo Janini Dal; Oliveira,Ana Lúcia Lyrio de.
ABSTRACT  Objectives To estimate vertical HIV transmission rate in a capital city of the Midwest region of Brazil and describe the factors related to transmission.  Methods A descriptive epidemiological study based on the analysis of secondary data from the Notifiable Diseases Information System (SINAN). The analysis considered all HIV-infected pregnant women with delivery in Campo Grande-MS in the years 2007-2013 and their HIV-exposed infants.  Results A total of 218 births of 176 HIV-infected pregnant women were identified during the study period, of which 187 infants were exposed and uninfected, 19 seroconverted, and 12 were still inconclusive in July 2015. Therefore, the overall vertical HIV transmission rate in the period was 8.7%. Most (71.6%) of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vertical transmission; HIV; Disease prevention; Antiretroviral therapy; Prenatal follow-up; Health services; Social environment.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000300177

Psychopathology and psychosocial adjustment in patients with HIV-associated lipodystrophy
Provedor de dados: 55
Autores: Barata,Anna; Malouf,Jorge; Gutierrez,Mar; Mateo,Gracia María; Sambeat,Maria Antònia; Gich,Ignasi; Cadafalch,Josep; Wulff,Juan; Domingo,Pere.
OBJECTIVE: To study whether patients with HIV-1 associated lipodystrophy (LD) on highly active antiretroviral treatment (HAART) have more psychopathology and worse psychosocial adjustment than a similar group without this syndrome. METHODS: In a cross-sectional, observational study we compared 47 HIV-1 infected patients with LD (LD group) with 39 HIV-1 infected patients without LD (non-LD group). All participants were on HAART. The Beck Depression Inventory (BDI), the State and Trait Anxiety Inventory (STAI) and the Goldberg Health Questionnaire (GHQ-60) were administered. Levels of familial, work and social adjustment and adjustment to stressful events were evaluated in a semi-structured interview. Clinical information was extracted from the clinical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Lypodystrophy; Psychopathology; Psychosocial.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400010

Bone mineral density and vitamin D concentration: the challenges in taking care of children and adolescents infected with HIV
Provedor de dados: 55
Autores: Carmo,Fabiana Bononi; Terreri,Maria Teresa; Succi,Regina Célia de Menezes; Beltrão,Suenia Vasconcelos; Gouvea,Aida de Fátima Tomé Barbosa; Paulino,Erica Regina Cruz; Machado,Daisy Maria.
ABSTRACT  Background: The increase in life expectancy for patients living with human immunodeficiency virus (HIV) infection has resulted in health complications related to a chronic disease.  Objectives: To evaluate the prevalence of bone mineral density (BMD) alterations and vitamin D concentrations in HIV-infected children and adolescents and to verify the variations in those parameters during a 12-month interval.  Methods: A prospective cohort study with a dual period of evaluation was conducted in 57 patients perinatally HIV-infected and one patient with sexual abuse in early infancy. Demographic, anthropometric, pubertal stage, viral load, T CD4+ cell count and antiretroviral therapy were evaluated. Biochemical tests and total body (TB) and lumbar...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral; Infant; Diagnosis; Metabolism; Bone.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300270

Survival analysis of acquired immune deficiency syndrome patients with and without hepatitis C virus infection at a reference center for sexually transmitted diseases/acquired immune deficiency syndrome in São Paulo, Brazil
Provedor de dados: 55
Autores: Alencar,Wong Kuen; Duarte,Paulo Schiavom; Waldman,Eliseu Alves.
INTRODUCTION:Survival of patients with acquired immune deficiency syndrome has improved with combination antiretroviral therapy; mortality due to liver diseases, however, has also increased in these patients.OBJECTIVES:To estimate the accumulated probability of survival in human immunodeficiency virus-hepatitis C virus coinfected and non-coinfected patients and to investigate factors related to acquired immune deficiency syndrome patients' survival.METHODS:Non-concurrent cohort study using data from surveillance information systems of acquired immune deficiency syndrome patients over 13 years of age. Hepatitis C and B, human immunodeficiency virus exposure category, CD4+ T cell count, age group, schooling, race, sex, and four acquired immune deficiency...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Acquired immunodeficiency syndrome; Hepatitis viruses; Survival analysis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000200150

Hepatitis C virus infection and spontaneous clearance in HTLV-1 and HIV co-infected patients in Salvador, Bahia, Brazil
Provedor de dados: 55
Autores: Marchand,Chloe Le; Bahia,Fabianna; Page,Kimberly; Brites,Carlos.
ABSTRACTBACKGROUND: While 20-40% of patients with hepatitis C virus (HCV) monoinfection will spontaneously clear the virus, less is known regarding clearance with coinfections. HCV, human immunodeficiency virus (HIV), and human T-cell lymphotrophic virus 1 and 2 (HTLV-1/2) coinfection occurs due to shared routes of transmission and is prevalent in Brazil.OBJECTIVES:To compare the proportion of patients who have spontaneously cleared HCV in patients with HCV monoinfection to patients coinfected by HCV/HIV, or HCV/HIV/HTLV-1.METHODS:Using medical records from two clinics in Salvador, Brazil, including demographic data and serological markers of HCV, HIV and HTLV-I/II, cross-sectional data was obtained from 197 patients. Patients who were anti-HCV positive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HTLV-1; HIV; Hepatitis C; Brazil; Spontaneous HCV clearance.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500486

Estimation of the residual risk for the transmission of HIV in blood donors from the mountain region of Santa Catarina
Provedor de dados: 55
Autores: Spada,Celso; Souza,Marli Adelina; Treitinger,Arício.
The HIV, in hemotheraphy, may be transmitted by erythrocyte, platelets, crioprecipitated, frozen fresh plasma and possibly, by other blood components. Appropriate legislations for this new reality were elaborated normatizing the hemotheraphy practices in Brazil, creating a set of procedures and actions aiming at guaranteeing the quality of the blood, during, during the whole process. However, the residual risk remains, and it can be calculated as a product of the incidence and period of the immunological window. The objetive of the present study was to determine the rate of residual risk of the HIV blood transmission, in the blood donors from the Mountain Region of Santa Catarina. In order to calculate the residual risk of the HIV markers, 4,857 donors of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Blood donors; Residual risk; Transfusion security; Immunological window.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600006

Pain in hospitalized HIV-positive patients: clinical and therapeutical issues
Provedor de dados: 55
Autores: Aires,Elisa Miranda; Bammann,Ricardo H.
Pain is frequently reported by patients infected with Acquired Immunodeficiency Virus (HIV), and its causes and specific treatment should be appropriately investigated. We evaluated 197 hospitalized HIV-positive patients with serial interviews and analysis of prescriptions and clinical evolution charts. The main characteristics of pain reported by these patients were: high intensity (60.7%), high frequency (72.0%) and well-known causes (88.8%). Fifty-two per cent of the patients reported persistent or frequent pain during the two weeks before hospital admission. Parameters such as gender, educational level and Karnofsky Index showed no direct relation to the presence or absence of pain. The most commonly affected sites were the head (28.0%) and the abdomen...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pain; HIV; AIDS; Analgesic treatment; Undertreatment; Pain management index.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300002

Nephrotoxicity during tenofovir treatment: a three-year follow-up study in a Brazilian reference clinic
Provedor de dados: 55
Autores: Pinto Neto,Lauro Ferreira da Silva; Bassetti,Bil Randerson; Fraga,Igor Hernandes Valvassoura; Oliveira Santos,Carolina Rocio; Ximenes,Paula Daher; Miranda,Angélica Espinosa.
Abstract In this study, 275 patients in use of tenofovir were retrospectively followed-up for three years to evaluate risk factors involved in impaired renal function. Analysis of variance (ANOVA) and Tukey's test were used to verify any differences in creatinine levels and estimated clearance at 0, 6, 12, 24 and 36 months, adjusting for the co-variables sex, skin color, age &gt;50 years, arterial hypertension, diabetes and the use of the ritonavir-boosted protease inhibitors (PI/r) lopinavir/r or atazanavir/r. The software package STATISTICA 10® was used for statistical analysis. The patients’ mean age was 43.2 ± 10.7 years. Systemic arterial hypertension (SAH) and diabetes were found in 20.4% and 8.7% of the patients, respectively. Overall, 96.7% were on...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tenofovir; Nephrotoxicity; Impaired renal function; HIV.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000100014

Impaired bone mineral accrual in prepubertal HIV-infected children: a cohort study
Provedor de dados: 55
Autores: Palchetti,Cecília Zanin; Szejnfeld,Vera Lúcia; Succi,Regina Célia de Menezes; Patin,Rose Vega; Teixeira,Patrícia Fonseca; Machado,Daisy Maria; Oliveira,Fernanda Luisa Ceragioli.
ABSTRACT  OBJECTIVE:  To evaluate bone mass accrual and determine the influence of clinical, anthropometric, dietary and biochemical parameters on bone mass.  METHODS:  A cohort study including 35 prepubertal HIV-infected children, between 7 and 12 years, attended at a referral center. At time 1 (T1) and time 2 (T2), patients were assessed according to clinical, anthropometric, dietary, biochemical parameters and bone mineral density (BMD). At T2, patients were divided into prepubertal and pubertal.  RESULTS:  Despite the increase in bone mass absolute values, there was no improvement in lumbar spine BMD (LSBMD) Z-score (p = 0.512) and worsening in total body BMD (TBMD) Z-score (p = 0.040). Pubertal patients (n = 19) showed higher bone mineral content...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Child; Body composition; Bone mineral density.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600623

Lipid and acute-phase protein alterations in HIV-1 infected patients in the early stages of infection: correlation with CD4+ lymphocytes
Provedor de dados: 55
Autores: Treitinger,Arício; Spada,Celso; Silva,Laura Maria D. da; Hermes,Elizabeth Martins; Amaral,Jorge Antônio; Abdalla,Dulcineia Saes Parra.
Lipid and acute-phase protein alterations have been described in various infection diseases, and they have been recorded during the early stages of HIV infection. Lipid and acute-phase protein profiles also have been correlated with cellular immunological abnormalities. To document these correlations during HIV infection, we studied 75 HIV-infected patients and 26 HIV-negative controls. Patients were classified according to the criteria proposed by the Walter Reed Army Institute: as WR-1 (CD4 lymphocytes, 1154 ± 268/mm³), WR-2 (CD4, 793 ± 348/mm³) and WR3/4 (CD4, 287±75 mm³). Triglycerides, total cholesterol and HDL-cholesterol concentrations were measured by enzymatic methods. Immunoglobulins (IgA and IgG) and acute-phase proteins (haptoglobin, a1-acid...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; CD4+; Triglycerides; IgA; A1-acid glycoprotein; Haptoglobin.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000400005

Identifying risk factors of immune reconstitution inflammatory syndrome in AIDS patients receiving highly active anti-retroviral therapy
Provedor de dados: 55
Autores: He,Bo; Zheng,Yuhuang; Liu,Meng; Zhou,Guoqiang; Chen,Xia; Mamadou,Diallo; He,Yan; Zhou,Huaying; Chen,Zi.
Immune reconstitution inflammation syndrome typically occurs within days after patients undergo highly active anti-retroviral therapy and is a big hurdle for effective treatment of AIDS patients. In this study, we monitored immune reconstitution inflammation syndrome occurrence in 238 AIDS patients treated with highly active anti-retroviral therapy. Among them, immune reconstitution inflammation syndrome occurred in 47 cases (19.7%). Immune reconstitution inflammation syndrome patients had significantly higher rate of opportunistic infection (p &lt; 0.001) and persistently lower CD4+ cell count (p &lt; 0.001) compared to the non-immune reconstitution inflammation syndrome patients. In contrast, no significant differences in HIV RNA loads were observed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: IRIS; AIDS; HIV; HAART.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000200009

Prevalence and risk factors for chronic hepatitis B in HIV patients attended at a sexually-transmitted disease clinic in Vitoria, Brazil
Provedor de dados: 55
Autores: Zago,Adriana Marchon; Machado,Thayla Ferrari; Cazarim,Flavia Lagrota; Miranda,Angélica Espinosa.
This study assessed the prevalence of and correlated factors for chronic hepatitis B infection (HBV) among HIV patients attending the Reference Center for Sexually Transmitted Infections (STI) and AIDS in Vitória, ES, Brazil. HIV patients were studied from 1993 to 2004, using information recorded in a database of the STI Clinic. Demographic data, clinical characteristics, patterns of risk behavior and test results (ELISA-HIV, IFA-HIV, HBsAg, viral load and CD4 counts) were analyzed. We analyzed 851 HIV patients. Median age was 35.0 (interquartile range 30; 42) years and median years of education was 8.0 (IQR 5; 11). The prevalence of chronic HBV was 3.8% (95% CI 2.5-5.1). Illicit drug use was reported in 185 (21.7%) cases, alcohol abuse in 80 (9.4%) cases,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBV; HIV; Prevalence; STI clinic.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000500007

Validity and reliability of the 36-Item Short Form Health Survey questionnaire version 2 among people living with HIV in Brazil
Provedor de dados: 55
Autores: Lins-Kusterer,Liliane; Valdelamar,Juliet; Aguiar,Carolina Villa Nova; Menezes,Marta Silva; Martins Netto,Eduardo; Brites,Carlos.
ABSTRACT  Background: The 36-Item Short Form Health Survey questionnaire (SF-36) is a widely used instrument for evaluating health-related quality-of-life (HRQoL). The psychometric validation of the SF-36 version 2.0 (SF-36v2) in HIV-infected patients had not yet conducted in Brazil.  Aim: To test data quality, reliability and validity of the SF-36v2 as a measure of HRQoL among Brazilian individuals living with HIV.  Methods: A cross-sectional study included 393 HIV-infected patients in whom HRQoL was assessed by using the SF-36v2 questionnaire. Demographic characteristics, socioeconomic status and clinical data were also collected. The SF-36 version 1 translated into Brazilian-Portuguese was adapted and introduced version 2 improvements according to the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Health-related quality of life; Factor analysis; Validation studies.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500313

Prior history of sexually transmitted diseases in women living with AIDS in São Paulo, Brazil
Provedor de dados: 55
Autores: Pinto,Valdir Monteiro; Tancredi,Mariza Vono; Golub,Jonathan Eric; Coelho,Ariane de Castro; Tancredi Neto,Antonio; Miranda,Angelica Espinosa.
OBJECTIVES: To describe the epidemiological profile, risk behaviors, and the prior history of sexually transmitted diseases (STDs) in women living with acquired immunodeficiency syndrome (AIDS). METHODS: Cross-sectional study, performed at the Centro de Referência e Treinamento em DST/AIDS of São Paulo. The social, demographic, behavioral, and clinical data such as age, schooling, marital status, age at first sexual intercourse, number of sexual partners, parity, use of drugs, time of HIV diagnosis, CD4 count, and viral load determination were abstracted from the medical records of women living with AIDS who had gynecological consultation scheduled in the period from June 2008 to May 2009. RESULTS: Out of 710 women who were scheduled to a gynecological...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sexually transmitted diseases; Women; HIV; Behavior.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000300002

Audiological and electrophysiological evaluation of children with acquired immunodeficiency syndrome (AIDS)
Provedor de dados: 55
Autores: Matas,Carla Gentile; Leite,Renata Aparecida; Magliaro,Fernanda Cristina Leite; Gonçalves,Isabela Crivellaro.
We examined the peripheral auditory system and the auditory brainstem pathway of children with Acquired Immunodeficiency Syndrome (AIDS). One hundred and one children, 51 with AIDS diagnosis and 50 normal children were evaluated. Audiological assessment included immittance measures, pure tone and speech audiometry and auditory brainstem response (ABR). The children with AIDS more frequently had abnormal results than did their matched controls, presenting either peripheral or auditory brainstem impairment. We suggest that AIDS be considered a risk factor for peripheral and/or auditory brainstem disorders. Further research should be carried out to investigate the auditory effects of HIV infection along the auditory pathway.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Children; Hearing; Auditory Brainstem Response (ABR); HIV.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400010

Is an HIV vaccine possible?
Provedor de dados: 55
Autores: Wilson,Nancy A.; Watkins,David I.
The road to the discovery of a vaccine for HIV has been arduous and will continue to be difficult over the ensuing twenty years. Most vaccines are developed by inducing neutralizing antibodies against the target pathogen or by using attenuated strains of the particular pathogen to engender a variety of protective immune responses. Unfortunately, simple methods of generating anti-HIV antibodies have already failed in a phase III clinical trial. While attenuated SIV variants work well against homologous challenges in non-human primates, the potential for reversion to a more pathogenic virus and recombination with challenge viruses will preclude the use of attenuated HIV in the field. It has been exceedingly frustrating to vaccinate for HIV-specific...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Vaccine; Challenges.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400013

Prevalence and characteristics of HIV/HBV and HIV/HCV coinfections in Tuscany
Provedor de dados: 55
Autores: Puglia,Monia; Stasi,Cristina; Da Frè,Monica; Voller,Fabio.
Abstract  Introduction Worldwide about 30% of HIV-infected patients are coinfected with HCV or HBV. The HIV/HCV coinfection is more common in individuals who have a history of drug addiction. The aims of this study were to assess the HCV and HBV prevalence in HIV-infected patients and analyze their characteristics.  Methods We considered the new HIV diagnoses notified by the regional surveillance system of Tuscany from 2009 to 2013. Descriptive analyses were conducted on the socio-demographic characteristics, routes of transmission, and reason to perform the test. In coinfected patients we assessed the risk for being late presenter (LP) or the risk of having AIDS.  Results In 5 years of surveillance a total of 1354 new HIV diagnoses were notified: 1188...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HBV; HCV; Coinfections.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400330

Hybrid capture as a tool for cervical lesions screening in HIV-infected women: insights from a Brazilian cohort
Provedor de dados: 55
Autores: Jalil,Emilia Moreira; Luz,Paula M.; Quintana,Marcel; Friedman,Ruth Khalili; Madeira,Rosa M. Domingues S.; Andrade,Angela Cristina; Chicarino,Janice; Moreira,Ronaldo Ismerio; Derrico,Monica; Levi,José Eduardo; Russomano,Fabio; Veloso,Valdilea Gonçalves; Grinsztejn,Beatriz.
ABSTRACT  Introduction: Cervical cancer remains an important burden for HIV-infected women in the era of combination antiretroviral therapy. Recommendations for cervical screening in these women diverge and may include high-risk HPV (HRHPV) testing. We aimed to evaluate the clinical usefulness of a single HRHPV testing for cervical screening of HIV-infected women.  Methods: 723 HIV-infected women from a Brazilian prospective cohort were included between 1996 and 2012. Inclusion criteria were: normal cervical cytology at baseline and having a HRHPV-test at baseline. We calculated incidence rates of any squamous intraepithelial lesion (SIL) and high grade SIL+ (HSIL+) and negative predictive values (NPV) within 12 and 36 months. Hazard Ratios were obtained...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; HIV; Women; Cohort; Incidence.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000100016

Osteoarticular complications related to HIV infection and highly active antiretroviral therapy
Provedor de dados: 55
Autores: Lima,Ana Lúcia Lei Munhoz; Zumiotti,Arnaldo Valdir; Camanho,Gilberto Luis; Benegas,Eduardo; Santos,Alexandre Leme Godoy dos; D'Elia,Caio Oliveira; Oliveira,Priscila Rosalba Domingos.
With the significant increase in life expectancy for HIV-infected patients in the era of high potency antiretroviral therapy, major metabolic changes have been observed due to the prolonged period of the viral infection and the treatment itself. Osteoarticular changes resulting from these processes are mainly reported in long term HIV-infected patients receiving high potency antiretroviral therapy and include osteopenia/osteoporosis, osteonecrosis, carpal tunnel syndrome and adhesive capsulitis of the shoulder.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Acquired immunodeficiency syndrome; Osteoarticular; Antiretroviral agents.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400012

HBV, HCV and HIV seroprevalence among blood donors in Istanbul, Turkey: how effective are the changes in the national blood transfusion policies?
Provedor de dados: 55
Autores: Acar,Ali; Kemahli,Sabri; Altunay,Husnu; Kosan,Erdogan; Oncul,Oral; Gorenek,Levent; Cavuslu,Saban.
The national blood transfusion policies have been changed significantly in recent years in Turkey. The purpose of this study was to determine the prevalence of HBV, HCV, and HIV in blood donors at the Red Crescent Center in Istanbul and to evaluate the effect of changes in the national blood transfusion policies on the prevalence of these infections. The screening results of 72695 blood donations at the Red Crescent Center in Istanbul between January and December 2007 were evaluated retrospectively. HBsAg, anti-HCV, and anti-HIV-1/2 were screened by microparticle enzyme immunoassay (MEIA) method. Samples found to be positive for anti-HIV 1/2 and anti-HCV were confirmed by Inno-Lia HCV Ab III and Inno-Lia HIV I/II Score, respectively. The seropositivity...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HBV; HCV; HIV; Seroprevalence; Blood donors; Turkey.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100009

Transmitted drug resistance in patients with acute/recent HIV infection in Brazil
Provedor de dados: 55
Autores: Ferreira,Ana Cristina G.; Coelho,Lara E.; Grinsztejn,Eduarda; Jesus,Carlos S. de; Guimarães,Monick L.; Veloso,Valdiléa G.; Grinsztejn,Beatriz; Cardoso,Sandra W.
Abstract  Introduction: The widespread use of antiretroviral therapy increased the transmission of antiretroviral resistant HIV strains. Antiretroviral therapy initiation during acute/recent HIV infection limits HIV reservoirs and improves immune response in HIV infected individuals. Transmitted drug resistance may jeopardize the early goals of early antiretroviral treatment among acute/recent HIV infected patients.  Methods: Patients with acute/recent HIV infection who underwent resistance test before antiretroviral treatment initiation were included in this analysis. HIV-1 sequences were obtained using an in house protease/reverse transcriptase genotyping assay. Transmitted drug resistance was identified according to the Stanford HIV Database for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Infection; Transmission; Primary resistance; Antiretroviral therapy.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400396

A review of the epidemiology, prevention and treatment of human immunodeficiency virus infection in Nigeria
Provedor de dados: 55
Autores: Entonu,P.E.; Agwale,S.M.
In order to amalgamate research findings on HIV/AIDS in Nigeria as well as the trend of the infection in a concise manner, we reviewed published articles on the HIV/AIDS situation in Nigeria. We categorized this review into several subheadings. The HIV prevalence rate has continued to rise steadily from less than 0.1% in 1987, to 5.8% in 2001, with a slight decrease in 2003 to 5.0%. Although the knowledge about HIV and its mode of transmission is widespread, it is however disheartening to note that this did not result into appreciable attitudinal change and behavior modification among Nigerians. Both HIV-1 and HIV-2 have been identified in Nigeria, with HIV-1 being the predominant type. Furthermore, several subtypes like subtypes A, B, C, G and J have been...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Review; Nigeria.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000600011

Behavioral and biological risks of women seeking HIV test in an anonymous testing center
Provedor de dados: 55
Autores: Ribeiro Filho,Ayrton Daniel; Giraldo,Paulo César; Silva,Maria José Penna Maisonnette de Attayde; Amaral,Rose Luce Gomes do; Eleutério Junior,José; Gonçalves,Ana Katherine da Silveira.
Due to the high prevalence and morbidity sexually transmitted diseases are highly relevant to public health, especially for women. OBJECTIVES: To determine and compare the behavioral and biological risks associated with human immunodeficiency virus acquisition. METHODS: A group of 253 women who voluntarily sought anonymous testing were interviewed to find out their behavioral risk. Biological risk was identified by means of gynecological exam, colposcopy as well as blood and cervicovaginal sampling for serological and microbiological exams. Using known traditional risk factors, a table of scores classified the subjects into high, low and absent for behavioral and biological risks. Frequency and percentage of each risk was tabulated and the correlation...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Sexually transmitted diseases; Women.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400010

Prediction of brain atrophy using three drug scores in neuroasymptomatic HIV-infected patients with controlled viremia
Provedor de dados: 55
Autores: Novakovic,Marko; Turkulov,Vesna; Maric,Daniela; Kozic,Dusko; Rajkovic,Uros; Bjelan,Mladen; Lucic,Milos; Brkic,Snezana.
ABSTRACTBACKGROUND: Despite potent antiretroviral therapy, HIV still causes brain damage. Better penetration into the CNS and efficient elimination of monocyte/macrophages reservoirs are two main characteristics of an antiretroviral drug that could prevent brain damage. The aim of our study was to assess efficacy of three antiretroviral drug scores to predict brain atrophy in HIV-infected patients.METHODS:A cross sectional study consisting of 56 HIV-infected patients with controlled viremia, who had no clinically evident neurocognitive impairment. All patients had MRI of the head. A typical T2 transversal slice was analyzed and ventricles-brain ratio (VBr) as an overall brain atrophy index was calculated. Three antiretroviral drug scores were used and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: CPE; Monocyte efficacy score; Brain atrophy; HAART; HIV.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500503

High-risk human papillomavirus and cervical lesions among women living with HIV/AIDS in Brazilian Amazon, Brazil
Provedor de dados: 55
Autores: Silva,Leila da; Miranda,Angélica; Batalha,Rosieny; Ferreira,Luiz; Santos,Mayara; Talhari,Sinésio.
ABSTRACT  OBJECTIVE:  The goal of this study was to determine the prevalence of human papillomavirus infection infection and cervical lesions and its associated factors among HIV infected women attending an AIDS clinic in Amazonas state, Brazil.  METHODS:  Cross-sectional study. Women attending an AIDS clinic in the city of Manaus between March and December 2011 for gynecological examination were invited to participate. Enrolled patients answered a standardized interview including demographical, behavioral, and clinical data. Additionally, patients underwent a gynecological evaluation with collection of cervical samples for cytological analysis and high-risk human papillomavirus infection hybrid capture. A blood sample was also obtained to determine CD4...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HPV; HIV; Cervical cancer; Brazilian Amazon.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600557

Comparison between the gold standard DXA with calcaneal quantitative ultrasound based-strategy (QUS) to detect osteoporosis in an HIV infected cohort
Provedor de dados: 55
Autores: Roldan,Eugenia Quiros; Brianese,Nigritella; Raffetti,Elena; Focà,Emanuele; Pezzoli,Maria Chiara; Bonito,Andrea; Ferraresi,Alice; Lanza,Paola; Porcelli,Teresa; Castelli,Francesco.
ABSTRACT  Introduction: Osteoporosis represents one of the most frequent comorbidity among HIV patients. The current standard method for osteoporosis diagnosis is dual-energy X-ray absorptiometry. Calcaneal quantitative ultrasound can provide information about bone quality. The aims of this study are to compare these two methods and to evaluate their ability to screen for vertebral fracture.  Methods: This cross-sectional study was conducted in HIV patients attending the Clinic of Infectious and Tropical Diseases of Brescia during 2014 and who underwent lumbar/femoral dual-energy X-ray absorptiometry, vertebral fracture assessment and calcaneal quantitative ultrasound. The assessment of osteoporosis diagnostic accuracy was performed for calcaneal...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Osteoporosis; HIV; Calcaneal ultrasound.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600581

Comparison among the BED capture enzyme immunoassay test and AxSYM avidity index assay for determining recent HIV infection and incidence in two Voluntary Counselling and Testing Centres in Northeast Brazil
Provedor de dados: 55
Autores: Salustiano,Daniela Medeiros; Lima,Kledoaldo Oliveira de; Cavalcanti,Ana Maria Salustiano; Diaz,Ricardo Sobhie; Lacerda,Heloisa Ramos.
The aims of this study were to compare the automated AxSYM avidity assay index with the BED capture enzyme immunoassay test and to calculate the HIV-1 incidence using the BED capture enzyme immunoassay and AxSYM avidity assay index algorithms within a population seeking the Voluntary Counselling and Testing Centres in two municipalities in the Metropolitan Region of Recife, Northeast of Brazil. An analysis was conducted in 365 samples that tested positive for HIV infection from frozen serum collected during the period 2006-2009. There was a similar proportion of males and females; most patients were heterosexual (86%) with a median age of 29 years. Of the 365 samples, 102 (28%) and 66 (18.1%) were identified as recent infections by BED capture enzyme...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Recent infection; Avidity index assay; BED-CEIA.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400449

Avascular necrosis of the femoral head in HIV infected patients
Provedor de dados: 55
Autores: Matos,Marcos Almeida; Alencar,Rafael Watt de; Matos,Simone Souza da Rocha.
Avascular necrosis (AVN) of the femoral head is an emerging complication in HIV infected patients. It has been suggested that the increased incidence of AVN in this population may be caused by an increased prevalence of predisposing factors for osteonecrosis, including protease inhibitors, hyperlipidemia, corticosteroid use, alcohol and intravenous drug abuse. The aim of this study was to assess the risk factors for avascular necrosis developing in the femoral head of HIV infected individuals. This study consisted of meta-analysis of the secondary data extracted from current literature. The selected articles allowed two study groups to be drawn up for comparison. Group 1 comprised 324 individuals infected by the HIV virus, who did not present femoral head...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; HIV; Avascular necrosis.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100009

The clinical effectiveness of pegylated interferon and ribavirin for the treatment of chronic hepatitis C in HIV-infected patients in Brazil: a multicentric study
Provedor de dados: 55
Autores: Ferreira,Paulo Roberto Abrão; Silva,Mariliza Henrique da; Brandão-Melo,Carlos Eduardo; Rezende,Rosamar Eulira; Gonzalez,Mário; Reuter,Tânia; Urbaez,Jose David; Gianini,Reinaldo Jose; Martinelli,Ana; Mendes-Correa,Maria Cássia.
Introduction: in Brazil, chronic hepatitis C in patients coinfected with the human immunodeﬁciency virus (HIV) is treated with pegylated interferon (Peg-IFN) and ribavirin (RBV). However, few studies have evaluated the effectiveness of this treatment in this particular population. The identiﬁcation of the factors that predict sustained virological response (SVR) under current clinical practice would enable clinicians to more accurately estimate the probability of achieving an SVR and therefore utilize the appropriate therapeutics, especially in the era of direct-acting antiviral (DAA) agents.Aims: the primary aim of our study was to determine the SVR rate under current clinical practice. The secondary aims were as follows: (1) to determine the factors...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Interferon Ribavirin HCV; HIV.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000100015

Use of new antiretroviral drugs and classes in Bahia, Brazil: a real life experience on salvage therapy of AIDS patients
Provedor de dados: 55
Autores: Brites,Carlos; Nóbrega,Isabella; Netto,Eduardo Martins.
ABSTRACTAntiretroviral therapy has significantly evolved in the last decade, with an increasing number of new drugs and classes. Currently, even heavily experienced patients can be successfully treated with new regimens. In Brazil, the recent incorporation of some new antiretroviral drugs made it possible to suppress HIV plasma viremia in most treated patients, with significant benefits in terms of quality of life and survival. However, little has been published on outcomes of patients under new drugs-based regimens. We reviewed the safety and efficacy of antiretroviral regimens using recently introduced drugs in Bahia. Our results confirm that patients using darunavir, raltegravir, enfuvirtide, or etravirine presented with a high rate of virological...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Antiretroviral; Salvage therapy.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500529

Cutaneous mucormycosis in advanced HIV disease
Provedor de dados: 55
Autores: Moreira,José; Ridolfi,Felipe; Almeida-Paes,Rodrigo; Varon,Andrea; Lamas,Cristiane C.
ABSTRACT Angionvasive mucormycosis is an emerging fungal disease known to affect mainly diabetics or subjects with profound neutropenia. Infection usually occurs through the inhalation route, but cutaneous inoculation may occur after trauma or burns. However, mucormycosis remains unusual in HIV infection. We report a fatal case of cutaneous mucormycosis due to Rhizopus arrhizus involving the scalp following herpes zoster infection. The patient was a 42-year-old man with advanced AIDS failing on salvage antiretroviral therapy. The fungus was diagnosed on the basis of histopathology and culture. Our case emphasizes the need to consider mucormycosis in the differential diagnosis of necrotic cutaneous lesions in patients with late-stage HIV disease.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Mucormycosis; Rhizopus; AIDS.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600637

Functional assesment of patients with AIDS disease
Provedor de dados: 55
Autores: Zonta,Marise Bueno; Almeida,Sérgio Monteiro de; Carvalho,Mirian T. M. de; Werneck,Lineu César.
We documented the types and degree of functional disability in 74 patients with AIDS at the Hospital de Clínicas of the Federal University of Paraná, Brazil. Few of these patients are referred for rehabilitation services and there is only a limited team approach in their care. We found that 91% of the patients had some degree of functional impairment; in 81% the complaint was weakness and in 47% it was neurological involvement. According to the Barthel Index, 79% were considered functionally independent, 14% partially dependent and 7% dependent. For most of them, independence requires effort and their quality of life is reduced. Severe disability was rather unusual, while mild or moderate disability levels were not. The functional physical disability found...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Rehabilitation; Functional disability; Health status; Neurological manifestation.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500004

Acute HIV infection with rapid progression to AIDS
Provedor de dados: 55
Autores: Silva,Marcio de Oliveira; Bastos,Milena; Martins Netto,Eduardo; Gouvea,Nancy Alves de Lima; Torres,Alex Jose Leite; Kallas,Esper; Watkins,David I; Altfeld,Marcus; Brites,Carlos.
Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Acute infection; Progression; AIDS.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016

Development and validation of a simple and rapid way to generate low volume of plasma to be used in point-of-care HIV virus load technologies
Provedor de dados: 55
Autores: Vasconcellos,Isabelle; Mariani,Diana; Azevedo,Marcelo C.V.M. de; Ferreira Jr.,Orlando C.; Tanuri,Amilcar.
ABSTRACT A new point-of-care HIV viral load, mPIMA HIV-1/2 VL, Abbott, USA, has been recently developed. This point-of-care viral load requires no skilled person to run and uses a small plasma volume (50 µL). However, obtaining 50 µL of plasma can be a challenge in limited resource settings. We validated a simple and easy method to obtain enough amount of plasma to run a point-of-care viral load. The study utilized 149 specimens from patients failing antiretroviral therapy. At least 250 µL of whole blood was collected in a microtube/EDTA from fingerstick (fs-plasma) and immediately centrifuged. Parallel collection of venous blood to obtain plasma (vp-plasma) was used to compare performance in a point-of-care viral load assay and in methodology used in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: POC VL; HIV viral load; HIV; Point-of-care; Fingerstick-plasma; MPIMA.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702020000100030

HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil
Provedor de dados: 55
Autores: Silva,Edinete Melo da; Acosta,Angelina Xavier; Santos,Eduardo José Melo; Netto,Eduardo Martins; Lemaire,Denise Carneiro; Oliveira,Adriano Silva; Barbosa,Carolina Matos; Bendicho,Maria Teresita; Galvão-Castro,Bernardo; Brites,Carlos.
Host genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. OBJECTIVE: To evaluate the association between serological epitopes HLA-Bw4 and HLA-Bw6 and prognostic markers in AIDS. METHODS: 147 HIV-infected individuals in Bahia, Northeast Brazil, were genotyped for HLA class I locus. HLA class I genotyping was performed by hybridization with sequence-specific oligonucleotide probes following amplification of the corresponding HLA-A, HLA-B and HLA-C genes. Statistical analysis was performed using Fisher's exact and ANOVA tests for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; MHC; HLA; Polymorphism.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000500008

Lopinavir/ritonavir dosing during pregnancy in Brazil and maternal/infant laboratory abnormalities
Provedor de dados: 55
Autores: Peixoto,Mario Ferreira; Pilotto,José Henrique; Stoszek,Sonia Karolina; Kreitchmann,Regis; Mussi-Pinhata,Marisa Márcia; Melo,Victor Hugo; João,Esaú Custodio; Ceriotto,Mariana; Souza,Ricardo da Silva de; Read,Jennifer.
OBJECTIVES: To describe laboratory abnormalities among HIV-infected women and their infants with standard and increased lopinavir/ritonavir (LPV/r) dosing during the third trimester of pregnancy. METHODS: We evaluated data on pregnant women from NISDI cohorts (2002-2009) enrolled in Brazil, who received at least 28 days of LPV/r during the third pregnancy trimester and gave birth to singleton infants. RESULTS: 164 women received LPV/r standard dosing [(798/198 or 800/200 mg/day) (Group 1)] and 70 increased dosing [(&gt; 800/200 mg/day) (Group 2)]. Group 1 was more likely to have advanced clinical disease and to use ARVs for treatment, and less likely to have CD4 counts &gt; 500 cells/mm³. Mean plasma viral load was higher in Group 2. There were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pregnancy; HIV; HIV protease inhibitors; Drug toxicity.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300013

The importance of the doctor-patient relationship in adherence to HIV/AIDS treatment: a case report
Provedor de dados: 55
Autores: Garcia,Rosa; Lima,Manuela Garcia; Gorender,Miriam; Badaró,Roberto.
In this case report, which includes a statement related by the patient himself, the authors also discuss the importance of a good doctor-patient relationship in treating HIV patients and in assuring the patient's adherence to his treatment. Related issues, such as the importance of treating psychiatric comorbidities, of preserving the patient's hope and motivation, and of giving him an adequate amount of information regarding the disease and its treatment, are also discussed.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Adherence; Doctor-patient relationship; HIV; AIDS; Psychiatric comorbidities.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000300008

Incidence and risk factors of immune reconstitution inflammatory syndrome in HIV-TB coinfected patients
Provedor de dados: 55
Autores: Dibyendu,De; Sarkar,Rathindra Nath; Phaujdar,Sibaji; Bhattacharyya,Kuntal; Pal,Hare Krishna.
Tuberculosis is one of the leading causes of development of Immune reconstitution inflammatory syndrome (IRIS) in HIV patients receiving antiretroviral therapy (ART). OBJECTIVE: To determine the incidence of IRIS in HIV-TB coinfected patients, and to find out the possible risk factors associated with IRIS. MATERIALS AND METHODS: Study commenced with 96 patients adhered to standard antitubercular therapy (ATT) and ART without defaultering, and followed up for six months. RESULT: The mean (± SD) CD4 count and CD4 percentage at baseline was 59.16 (± 24.63) per mm³ and 4.59% (± 1.73) respectively. Only 18.75% developed IRIS after 57.05 (± 14.12) days of initiation of ART. Extrapulmonary tuberculosis was the most significant factor associated with IRIS (83.33%)...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Tuberculosis; Immune reconstitution inflammatory syndrome; CD4 lymphocyte count.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000600009

Durability of the first combined antiretroviral regimen in patients with AIDS at a reference center in Belo Horizonte, Brazil, from 1996 to 2005
Provedor de dados: 55
Autores: Ribeiro,Flávia Andrade; Tupinambás,Unaí; Fonseca,Marise Oliveira; Greco,Dirceu Bartolomeu.
Finding a better first antiretroviral regimen is one of the strategies used to improve span and quality of life of HIV/AIDS patients. 891 patients were followed during 24 months or until interruption/abandonment of treatment, changing regimen or death. At the end of 6 months, 69% of the patients were still being treated with the first regimen, 54% at 12 months, 48% at 18 months and 39% at 24 months. AZT-3TC-EFV was the most prescribed regimen and with the lesser discontinuation. NNRTI regimens showed high effectiveness and durability compared to PI regimens. Irregular medication dispensation was the only risk factor for failure/interruption of treatment in multivariate analyses. Intolerance/adverse effects were mainly responsible for first regimen...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; HAART; Durability; Efficacy.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000100005

Trends and predictors of HIV-1 acquired drug resistance in Minas Gerais, Brazil: 2002–2012
Provedor de dados: 55
Autores: Duani,Helena; Aleixo,Agdemir Waleria; Tupinambás,Unaí.
Abstract Several studies show that the prevalence of multidrug-resistant HIV-1 virus is declining over time. A retrospective cohort study was carried out to evaluate the trends of drug resistance in antiretroviral treatment-exposed individuals in a state of a middle-income country, Minas Gerais, southeast region of Brazil. We analyzed 2115 HIV-1 sequences from 2002 up to 2012, from 52 cities of Minas Gerais. The groups were analyzed according to the definitions: "IAS – 3 class mutations", if ≥1 drug resistance mutation from IAS 2015 list (DRM) was present in each class; "No fully susceptible drugs" as the absence of any fully susceptible drug in Stanford algorithm; and "GSS ≥ 2″, when a maximum calculated GSS (genotypic susceptibility score) was ≥2 or ≥3,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral; Resistance; Genotyping; Epidemiology.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200148

Non Hodgkin's lymphoma with cutaneous involvement in AIDS patients: report of five cases and review of the literature
Provedor de dados: 55
Autores: Corti,Marcelo; Carolis,Luis De; Solari,Rubén; Villafañe,María F; Schtirbu,Ricardo; Lewi,Daniel; Narbaitz,Marina.
Cutaneous B cell lymphoma (CBCL) is a lymphoproliferative disorder of neoplastic B cell of the skin with a wide range of clinical manifestations. Commonly, the clinical features of CBCL are plaques, nodules, or ulcerative lesions. Skin is one of the common sites for extra-nodal lymphomas in patients with AIDS and B cell type is less common than T cell type. Only recently, the existence of B cell lymphomas presenting clinically in the skin without evidence of extra-cutaneous involvement has been accepted as primary CBCL. Here, we are presenting 5 patients with cutaneous involvement in the setting of HIV/AIDS disease. Two of them were primary cutaneous non-Hodgkin lymphomas. All were CBCL; 3 were immunoblastic, 1 was plasmablastic, and the other was a...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: AIDS; HIV; Cutaneous lymphoma.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000100016

Extra-pulmonary Pneumocystis jiroveciinfection: a case report
Provedor de dados: 55
Autores: Karam,Mehrdad Bakhshayesh; Mosadegh,Leila.
In physical examination abdominal tenderness, gate disturbance and penile herpetic lesions were detected. Decreased disc height at T11-T12 level was detected in chest X-ray. Abdominal sonography and CT scan revealed hypo dense lesions in Lt left Lobe of liver and multiple hypo dense splenic and pancreatic lesions, ascitis, Lt left sided pleural effusion, thickening of jejuneal mucosa and edema of bowel wall. Vertebral body lesion and paravertebral abscess, bony calvarial involvement and adjacent extra axial brain lesion were observed in imaging were other findings. RNA analysis for HIV was positive. Vertebral lesion biopsy and aspiration of splenic lesion were performed and pathology revealed Pneumocystis jirovecii suggestive of extra pulmonary...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Extrapulmonary; HIV; Pneumocystis Jirovecia.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600681

Prevalence of hepatitis B and C infection and associated factors in people living with HIV in Midwestern Brazil
Provedor de dados: 55
Autores: Brandão,Natália Alberto Alves; Pfrimer,Irmtraut Araci Hoffmann; Martelli,Celina Maria Turchi; Turchi,Marília Dalva.
This study aimed to estimate the prevalence of infection by the hepatitis B virus (HBV) and hepatitis C virus (HCV) in people infected by the human immunodeﬁciency virus (HIV) and analyze sociodemographic and behavioral factors associated with such co-infection. A cross-section study was performed in 495 individuals treated at a public center in the city of Goiânia. Participants were interviewed and blood collected for evaluation of serological and molecular markers for HBV and HCV. The rate of exposure to HBV was 33.5% (95% CI 29.4-37.9). Nineteen patients (3.8%) were diagnosed as HBV carriers, of whom 68.4% were HBV DNA positive. The prevalence of anti-HCV was 9.7% (95% CI 7.3-12.7). Genotype 1a was identiﬁed in 72.7% of the PCR samples positive for HCV....
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Hepatitis; Co-infection; Prevalence.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400426

Trichomonas vaginalis and associated factors among women living with HIV/AIDS in Amazonas, Brazil
Provedor de dados: 55
Autores: Silva,Leila Cristina Ferreira; Miranda,Angélica Espinosa; Batalha,Rosieny Santos; Monte,Rossicléia Lins; Talhari,Sinésio.
OBJECTIVES: Our goal was to determine the prevalence of Trichomonas vaginalis and its associated factors among women living with HIV attending an AIDS clinic in Manaus, Amazonas, Brazil. METHODS: Cross-sectional study among women attending an AIDS clinic in Manaus between March and December 2010 for gynecological examination were invited to participate. Enrolled patients answered a face-to-face interview including demographic, behavioral and clinical data. They also underwent a gynecological evaluation and cervical scrape samples were collected for wet mount, Gram stain, culture and cytological analysis. A blood sample was obtained to determine TCD4+ lymphocytes and viral load. RESULTS: A total of 341 (91.2%) women participated in the study. The prevalence...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Trichomonas vaginalis; HIV; Associated factors; Amazonas.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000600012

Sampling studies to estimate the HIV prevalence rate in female commercial sex workers
Provedor de dados: 55
Autores: Pascom,Ana Roberta Pati; Szwarcwald,Célia Landmann; Barbosa Júnior,Aristides.
INTRODUCTION: We investigated sampling methods being used to estimate the HIV prevalence rate among female commercial sex workers. METHODS: The studies were classified according to the adequacy or not of the sample size to estimate HIV prevalence rate and according to the sampling method (probabilistic or convenience). RESULTS: We identified 75 studies that estimated the HIV prevalence rate among female sex workers. Most of the studies employed convenience samples. The sample size was not adequate to estimate HIV prevalence rate in 35 studies. DISCUSSION: The use of convenience sample limits statistical inference for the whole group. It was observed that there was an increase in the number of published studies since 2005, as well as in the number of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Commercial sex workers; Sampling.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400014

Occult hepatitis B virus infection in immunocompromised patients
Provedor de dados: 55
Autores: Jardim,Ruth Nogueira Cordeiro Moraes; Gonçales,Neiva Sellan Lopes; Pereira,Josiane Silveira Felix; Fais,Viviane Cristina; Gonçales Junior,Fernando Lopes.
Occult hepatitis B infection is characterized by hepatitis B virus (HBV) DNA in the serum in the absence of hepatitis B surface antigen (HBsAg). We assessed occult HBV infection prevalence in two groups of immunocompromised patients (maintenance hemodialysis patients and HIV-positive patients) presenting HBsAg-negative and anti-HBc positive serological patterns, co-infected or not by HCV. Thirty-four hemodialysis anti-HIV negative patients, 159 HIV-positive patients and 150 blood donors who were anti-HBc positive (control group) were selected. HBV-DNA was detected by nested-PCR. Occult hepatitis B infection was not observed in the hemodialysis patients group but was found in 5% of the HIV-patients and in 4% of the blood donors. Immunosuppression in HIV...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Occult HBV infection; HBV-DNA; Anti-HBc alone; Hemodialysis; HIV; Immunosupressed patients.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400008

Predictors of undetectable plasma viral load in HIV-positive adults receiving antiretroviral therapy in Southern Brazil
Provedor de dados: 55
Autores: Silveira,Marysabel Pinto Telis; Draschler,Maria de Lourdes; Leite,José Carlos de Carvalho; Pinheiro,Cezar Arthur Tavares; Silveira,Vera Lúcia da.
Factors associated with undetectable viral load (&lt;80 copies/ml) were investigated among non-pregnant adults in antiretroviral treatment in a specialized service for HIV/AIDS in Southern Brazil. Use of antiretrovirals was investigated in two interviews (one month interval). Clinical data were collected from the clinical records; viral load previous to adherence measurement was defined the viral load previous to the first interview; the final viral load, the viral load subsequent to the second interview (interval between measures approximately 6 months). Undetectable final viral load occurred in 48% of the patients and was positively associated with levels of treatment adherence (p&lt;0.001), being 19% for less than 60% of adherence and about 60% for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral therapy; Adherence; Viral load; Predictors; Risk factors.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000400003

Body composition and lipodystrophy in prepubertal HIV-infected children
Provedor de dados: 55
Autores: Palchetti,Cecilia Zanin; Patin,Rose Vega; Gouvêa,Aída de Fátima Thomé Barbosa; Szejnfeld,Vera Lúcia; Succi,Regina Célia de Menezes; Oliveira,Fernanda Luisa Ceragioli.
OBJECTIVE: To identify lipodystrophy in prepubertal HIV-infected children using anthropometric parameters and body composition assessment. METHODS: Cross-sectional study including 40 prepubertal HIV-infected children of both genders seen at the Care Center of the Division of Pediatric Infectious Diseases - Universidade Federal de São Paulo, São Paulo city, Brazil, was carried out from August to December 2008. Age, clinical and immunological status, prophylaxis, transmission and highly active antiretroviral therapy were recorded. Body mass index z-score and height-for-age z-score were calculated to characterize the nutritional status. Circumferences were measured with flexible tape and skinfolds were assessed by an adipometry. Fat mass and lean mass were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Child; Lipodystrophy; Body composition; Anthropometry.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000100001

Changing patterns of AIDS: impact on the indications and diagnostic yield of bone marrow biopsies
Provedor de dados: 55
Autores: Morais,José Carlos; Machado,Marcel; Biasoli,Irene; Barroso,Paulo Feijó; Milito,Cristiane; Spector,Nelson.
After the advent of HAART, the clinical course of HIV infection has dramatically improved. Therefore, it seems appropriate to reevaluate the performance of bone marrow biopsy (BMB) as a diagnostic tool. The aim of the present study was to compare the reasons for performing a BMB and its diagnostic yield in HIV-patients before and after HAART. A total of 165 BMB specimens obtained from HIV-infected patients receiving care at the Hospital of Universidade Federal do Rio de Janeiro in two different periods (1986-1994 and 1999-2004) were analysed. The main reason for BMB examination in the first period was fever (88%), which decreased in the second period (57%, p &lt; 0.0001), when cytopenia (51%) was the leading reason for BMB, whereas in the first period it...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Bone marrow biopsy; HIV; HAART.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400019

The beta-chemokines MIP-1alpha and RANTES and lipoprotein metabolism in HIV-infected brazilian patients
Provedor de dados: 55
Autores: Mikawa,Angela Yumico; Malavazi,Iran; Tagliavini,Sandra Antonia; Abrão,Emiliana P.; Costa,Paulo Inácio da.
HIV patients are predisposed to the development of hypertriglyceridemia and hypercholesterolemia as a result of both viral infection and HIV infection therapy, especially the protease inhibitors. Chemokines and cytokines are present at sites of inflammation and can influence the nature of the inflammatory response in atherosclerosis. We investigated the correlation between biochemical variables and beta-chemokines (MIP-1alpha and RANTES) and the apolipoprotein E genotype in HIV-infected individuals. The apolipoproteins were measured by nephelometry. Triglycerides and total cholesterol were determined by standard enzymatic procedures. The beta-chemokines were detected by ELISA. The genetic category of CCR5 and apolipoprotein E were determined by PCR...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Beta- chemokine; HIV; Genotype; Lipoproteins; Cholesterol; Triglyceride.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000400008

Factors associated with clinical, immunological and virological responses in protease-inhibitor-experienced brazilian children receiving highly active antiretroviral therapy containing Lopinavir-Ritonavir
Provedor de dados: 55
Autores: Machado,Daisy Maria; Gouvêa,Aída de Fátima Barbosa; Cardoso,Maria Regina; Beltrão,Suênia Vasconcelos; Cunegundes,Kelly Simone; Bononi,Fabiana; Almeida,Fernanda; Cavalheiro,Kaline; Angelis,Daniela Souza Araújo de; Succi,Regina Célia de Menezes.
This study evaluates clinical, virological and immunological responses to antiretroviral (ARV) therapy based on Lopinavir/ritonovir (LPV/r) in previously protease -inhibitor-experienced children. The study included 29 Brazilian children (median age = 5.91 years) who had failed previous ARV therapy and had begun a regimen based on LPV/r. At 12 months follow-up, a good virological response to LPV/r therapy was defined as achieving an undetectable viral load or as a decrease in plasma HIV RNA levels to &gt; 1 log. A good immunological response was defined as an increase in CD4+ cell count from baseline sufficient to attain a better CDC immune stage classification. The number of infectious episodes 12 months before and 12 months after beginning LPV/r was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Children; HAART; Lopinavir/ritonavir.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100006

Prevalence of Chlamydia trachomatis and Neisseria gonorrhea and associated factors among women living with Human Immunodeficiency Virus in Brazil: a multicenter study
Provedor de dados: 55
Autores: Miranda,Angelica E.; Silveira,Mariangela F.; Travassos,Ana Gabriela; Tenório,Teresinha; Val,Isabel Cristina Chulvis do; Lannoy,Leonor de; Mattos Junior,Hortensio Simões de; Carvalho,Newton Sergio de.
Abstract  Background: Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (GC) cause infections in the female genital tract, increasing susceptibility to and infectiousness of HIV. The objectives of the present study were to determine the prevalence and associated factors of CT and GC infection among HIV-infected women in Brazil.  Methods: Cross-sectional study conducted from March to December 2015, including HIV-infected women attending referral centers in nine states of Brazil, aged 18-49 years, nonpregnant. An interview was conducted including socio-demographic, epidemiological and clinical characteristics. After the interview, gynecological examination was conducted to collect cervical cytology and vaginal secretion to C. trachomatis and N....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Chlamydia trachomatis; Neisseria gonorrhoeae; HIV; Women; Brazil.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400402

Enteric parasitic infections in HIV/AIDS patients before and after the highly active antiretroviral therapy
Provedor de dados: 55
Autores: Bachur,Tatiana Paschoalette Rodrigues; Vale,Josias Martins; Coêlho,Ivo Castelo Branco; Queiroz,Telma Régia Bezerra Sales de; Chaves,Cristina de Souza.
Enteroparasites are related to gastrointestinal alterations among patients with HIV/AIDS, some causing severe manifestations in the period before the institution of the highly active antiretroviral therapy (HAART). The prevalence of enteroparasitoses in patients with HIV/AIDS seen at two hospitals in Ceará , Brazil, was compared in the pre-HAART (Group 1; n = 482) and HAART (Group 2; n = 100) eras. Fecal parasitologic examinations (FPE) were performed using the direct, Lutz, Baermann-Moraes and modified Ziehl-Neelsen methods. The following parasites were detected in Groups 1 and 2, respectively: Strongyloides stercoralis - 30.1% and 11% (p&lt;0.0001), Ascaris lumbricoides - 15.6% and 2% (p&lt;0.0001), hookworms - 13.7% and 2% (p&lt;0.0001), Trichuris...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Enteric parasitic infections; HIV; AIDS; Antiretroviral therapy.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000200004

Effectiveness of the prevention of mother-to-child HIV transmission in Bahia, Brazil
Provedor de dados: 55
Autores: Patricio,Fátima Rejane Lemos; Rutherford,George Williams; Barreto,José Henrique Silva; Rodamilans,Cynthia; Badaró,Roberto.
ABSTRACTINTRODUCTION: Antiretroviral therapy and prophylaxis during the antepartum, intrapartum and postpartum periods, cesarean delivery and avoidance of breast milk significantly reduce vertical transmission of HIV.OBJECTIVE:To evaluate the effectiveness prevention of mother-to-child transmission of HIV and determine the rate of vertical transmission in a public sexually transmitted infection and HIV referral center in Salvador, Bahia, in the period immediately prior to the initiation of universal antiretroviral therapy in pregnant women.METHODS:Cross-sectional study using data collected from medical records of children born to HIV infected mothers in Bahia from 2005 to 2008 who were referred to the Reference Center for Diagnosis and Research of Sexually...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Vertical transmission; Effectiveness; Brazil.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000500538

Towards the complete eradication of mother-to-child HIV/HBV coinfection at Saint Camille Medical Centre in Burkina Faso, Africa
Provedor de dados: 55
Autores: Ilboudo,Denise; Simpore,Jacques; Ouermi,Djeneba; Bisseye,Cyrille; Sagna,Tani; Odolini,Silvia; Buelli,Fabio; Pietra,Virginio; Pignatelli,Salvatore; Gnoula,Charlemagne; Nikiema,Jean-Baptiste; Musumeci,Salvatore.
The coinfection of HIV and hepatitis B virus (HBV) and their vertical transmission constitute a public health problem in sub-Saharan countries of Africa. The objectives of this research are: i) identify the pregnant women that are coinfected by HIV and HBV at Saint Camille Medical Centre; ii) use three antiretroviral drugs (zidovudine, nevirapine and lamivudine) to interrupt the vertical transmission of HIV and HBV from infected mothers; and iii) use the PCR technique to diagnose children who are vertically infected by these viruses in order to offer them an early medical assistance. At Saint Camille Medical Centre, 115 pregnant women, aged from 19 to 41 years, were diagnosed as HIV-positive and, among them, 14 coinfected with HBV. They had at least 32...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pregnant women; HIV; HBV; MTCT; Lamivudine; HAART; Burkina Faso.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300004

Neurologic complications of HIV in the HAART era: where are we?
Provedor de dados: 55
Autores: Silva,Monica M. Gomes da.
Human immunodeficiency virus (HIV)-associated neurological complications continue to occur despite the development in antiretroviral treatment. New forms of old opportunistic infections and increased prevalence of neurocognitive disorders are the challenges that infectious diseases specialists face in daily clinic. How to screen and treat these disorders are subject of debate and new studies are underway to answer these questions. This review focuses on a brief discussion about opportunistic infections still present in late diagnosed HIV-infected patients and describes new forms of HIV-related neurological complications.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Neurological complication; HAND; Cognitive impairment.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000400011

Incidence of antiretroviral adverse drug reactions in pregnant women in two referral centers for HIV prevention of mother-to-child-transmission care and research in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Santini-Oliveira,Marilia; Friedman,Ruth Khalili; Veloso,Valdilea Gonçalves; Cunha,Cynthia Braga; Pilotto,José Henrique; Marins,Luana Monteiro Spindola; João,Esaú Custódio; Torres,Thiago Silva; Grinsztejn,Beatriz.
Mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) infection remains an important cause of new HIV infections worldwide, especially in low and middle-resource limited countries. Safety data from studies involving pregnant women and prenatal antiretroviral (ARV) exposure are still needed once these studies are often small and with a limited duration to assess adverse drug reactions (ADR). The aim of this study was to estimate the incidence of ADR related to the use of antiretroviral therapy (ART) in pregnant women in two referral centers in Rio de Janeiro State. A prospective study was carried out from February 2005 to May 2006. Women were classified according to their ART status during pregnancy diagnosis: ARV-experienced (ARTexp) or...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral; Prevention of mother-to-child transmission; Adverse drug reaction; Toxicity.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400372

Metabolic syndrome in HIV-infected patients receiving antiretroviral therapy in Latin America
Provedor de dados: 55
Autores: Alvarez,C; Salazar,R; Galindez,J; Rangel,F; CastaÃ±eda,ML; Lopardo,G; Cuhna,CA; Roldan,Y; Sussman,O; Gutierrez,G; Cure-Bolt,N; Seas,C; Carcamo,C; Castrillo,M.
OBJECTIVE: To evaluate the prevalence of and the associated factors for metabolic syndrome (MS) among Latin American HIV-infected patients receiving antiretroviral therapy (ART) using baseline data from the RAPID II study. METHODS: A longitudinal study to evaluate the metabolic profile, cardiovascular disease (CVD) risk and associated treatment practices to reduce this risk has been conducted in seven Latin American countries (the RAPID II study). Adult HIV patients with at least six months of RT were enrolled. MS was defined following ATP-III criteria. Demographic and anthropometric data, serum biochemical and clinical parameters were compared in patients with and without MS using bivariate and multivariate analysis. RESULTS: A total of 4,010 patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Metabolic syndrome (MS); HIV; ART; Latin America.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300010

Evaluation of techniques for the diagnosis of Strongyloides stercoralis in human immunodeficiency virus (HIV) positive and HIV negative individuals in the city of Itajaí, Brazil
Provedor de dados: 55
Autores: Blatt,Jucelene Marchi; Cantos,Geny Aparecida.
Human immunodeficiency virus (HIV) and intestinal parasites are common in Brazil. Previous studies have shown that infection with Strongyloides stercoralis is frequently associated with HIV infection. Strongyloidiasis is difficult to diagnosis and stool examination with conventional techniques fails to detect the helminth larvae. We made a prospective study, to test the efficacy of the agar plate technique to detect S. stercoralis in 211 HIV-positive patients and 213 HIV-negative patients in the city of Itajaí, Brazil, between September 2001 and June 2002. The feces samples of these patients were processed and analyzed according to the following methods: Lutz, formalin ethyl acetate, Baermann, Harada-Mori and agar plate culture. HIV-positive patients were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Agar plate culture; HIV; Strongyloides stercoralis.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000600008

Epidemiology of HIV/HCV coinfection in patients cared for at the Tropical Medicine Foundation of Amazonas
Provedor de dados: 55
Autores: Victoria,Marilú Barbieri; Victoria,Flamir da Silva; Torres,Kátia Luz; Kashima,Simone; Covas,Dimas Tadeu; Malheiro,Adriana.
The association of HIV infection and hepatitis C virus (HCV) infection often occurs because both viruses share the same transmission routes, increasing the possibility of HIV/HCV coinfection. World prevalence greater than 30% of coinfected cases is estimated, and it can reach 90% depending on the transmission route. With the aim of determining the frequency and profile of HIV/HCV coinfected patients, a descriptive analysis was carried out with patients with HIV/AIDS whose serology was positive for hepatitis C virus (HCV), cared for at the Fundação de Medicina Tropical do Amazonas from 2000 to 2007. In the present study, of the 2,653 AIDS cases notified in SINAN, 1,582 patients underwent serology test for hepatitis C, and a frequency of 4.42% (n = 70) of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coinfection; Hepatitis C; HIV; Epidemiology; Transmission.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200004

Prevalence of human immunodeficiency virus/hepatitis C virus co-infection in Brazil and associated factors: a review
Provedor de dados: 55
Autores: Kuehlkamp,Valdete Meurer; Schuelter-Trevisol,Fabiana.
The hepatitis C virus and human immunodeficiency virus share the same transmission routes, which makes co-infection an unfavorable condition for the natural history of both viral diseases. In this context, it should be highlighted that the knowledge of the extent of co-infection and associated risk factors is a vital tool for prevention and control over infectious diseases. The aim of this study was to review the literature, seeking to examine the prevalence of human immunodeficiency virus/hepatitis C virus co-infection reported in studies conducted in Brazil, and identify the main risk factors associated with co-infection. The electronic search was conducted in the Medline, Lilacs and SciELO databases. The following keywords were used: human...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Hepatitis C; Co-infection; Brazil.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400012

Cardiovascular disease in human immunodeﬁciency virus-infection as a cause of hospitalization: a case-series in a General Hospital in Peru
Provedor de dados: 55
Autores: Valenzuela-Rodríguez,Germán; Mezones-Holguín,Edward; Mendo-Urbina,Fernando; Rodríguez-Morales,Alfonso J.
Background: Cardiovascular disease in the context of human immunodeﬁciency virus infection has become a major clinical concern in recent years. In the current report we assess hospitalizations due to cardiovascular disease in human immunodeﬁciency virus patients in a Social Security reference hospital in Peru.Methods:A retrospective study was carried out between January 1996 and December 2012 in a General Hospital in Lima, Peru.Results: We included 26 patients hospitalized due to cardiovascular disease. Mean age was 46.3 years (SD 12.5), predominantly male (57.7%). Ten patients (38.4%) were in Acquired Immunodeﬁciency Syndrome stages. Seventeen (65.4%) received high-active-antiretroviral therapy. Eleven (42.3%) had cardiac involvement and 15 (57.7%) had...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Cardiovascular diseases; HIV; Acquired Immunodeﬁciency; Syndrome; Peru.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000400431

Metabolic profile and cardiovascular risk factors among Latin American HIV-infected patients receiving HAART
Provedor de dados: 55
Autores: Cahn,P; Leite,O; Rosales,A; Cabello,R; Alvarez,CA; Seas,C; Carcamo,C; Cure-Bolt,N; L'Italien,Gp; Mantilla,P; Deibis,L; Zala,C; Suffert,T.
OBJECTIVE: Determine the prevalence of metabolic abnormalities (MA) and estimate the 10-year risk for cardiovascular disease (CVD) among Latin American HIV-infected patients receiving highly active anti-retroviral therapy (HAART). METHODS: A cohort study to evaluate MA and treatment practices to reduce CVD has been conducted in seven Latin American countries. Adult HIV-infected patients with at least one month of HAART were enrolled. Baseline data are presented in this analysis. RESULTS: A total of 4,010 patients were enrolled. Mean age (SD) was 41.9 (10) years; median duration of HAART was 35 (IQR: 10-51) months, 44% received protease inhibitors. The prevalence of dyslipidemia and metabolic syndrome was 80.2% and 20.2%, respectively. The overall 10-year...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HAART; HIV; Metabolic parameters; Cardiovascular risk factors; Metabolic syndrome; Dyslipidemia.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000200008

Unusual oral findings of the toxic epidermal necrolysis in an HIV-infected patient: a case report
Provedor de dados: 55
Autores: Vieira,Vinicius da Costa; Sarmento,Viviane Almeida; Ribeiro,Patricia Miranda Leite; Martins Netto,Eduardo; Brites,Carlos; Lins-Kusterer,Liliane.
ABSTRACT Erythema multiforme (EM), Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (TEN) have been reported as possible adverse effects of some classes of first-line antiretroviral drugs (ART) for HIV treatment. Herein we report an unusual presentation of TEN lesions associated with ART in an HIV-infected patient. The patient presented disseminated cutaneous eruption and oral lesions from the lips to the oropharynx region, causing odynophagia and dysphagia. In the tongue, circular, atypical erythematous lesions appeared, increasing in diameter over seven days and coalescing since then to complete remission. TEN treatment included efavirenz interruption, use of methylprednisolone, prophylactic antibiotic, and daily laser therapy with low-intensity...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Toxic epidermal necrolysis; Stevens-Johnson syndrome; Antiretroviral therapy; HIV.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000500363

Low frequency of hypersensitivity reactions to abacavir in HIV infected patients in a referral center in Bahia, Brazil
Provedor de dados: 55
Autores: Barreto,Raphael Gusmão; Brites,Carlos.
Abstract Abacavir can cause a multi-systemic hypersensitivity reaction (HSR) in 5-8% of the patients, which is related to HLA-B*57-01 allele. In Brazil, the HLA-B*57-01 screening test became available only in March 2018, several years after abacavir was in use. In this retrospective study we reviewed medical charts of all patients receiving an abacavir-containing regimen to evaluate the frequency of HSR in patients followed at a referral center in Salvador, Brazil. A total of 192 patients who received abacavir were identified, most male (67.1%), black or racially mixed (77.8%), and having diagnosis of a previous AIDS defining conditions (83.7%). Only one patient developed HSR (incidence: 0.52%). The main reasons for abacavir-containing antiretroviral...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Hypersensitivity; Antiretroviral; HIV; Abacavir.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000400268

Aging with HIV: an overview of an urban cohort in Rio de Janeiro (Brazil) across decades of life
Provedor de dados: 55
Autores: Torres,Thiago Silva; Cardoso,Sandra Wagner; Velasque,Luciane de Souza; Marins,Luana Monteiro Spindola; Oliveira,Marília Santini de; Veloso,Valdilea Gonçalves; Grinsztejn,Beatriz.
The introduction of highly active antiretroviral therapy during the 1990s was crucial to the decline in the rates of morbidity and death related to the acquired immunodeficiency syndrome (AIDS) and turned human immunodeficiency virus (HIV) infection into a chronic condition. Consequently, the HIV/AIDS population is becoming older. The aim of this study was to describe the immunological, clinical and comorbidity profile of an urban cohort of patients with HIV/AIDS followed up at Instituto de Pesquisa Clinica Evandro Chagas, Oswaldo Cruz Foundation in Rio de Janeiro, Brazil. Retrospective data from 2307 patients during January 1st, 2008 and December 31st, 2008 were collected. For continuous variables, Cuzick's non-parametric test was used. For categorical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Aging; Elderly; Brazil; Comorbidity; HAART.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000300004

Vaccination coverage and immunity against hepatitis B among HIV-infected patients in South Brazil
Provedor de dados: 55
Autores: Martins,Saulo; Livramento,Andréa do; Andrigueti,Michelle; Kretzer,Iara Fabricia; Machado,Marcos José; Spada,Celso; Treitinger,Arício.
Evidence-based strategies to improve the hepatitis B virus (HBV) vaccination coverage rates might help to reduce the burden caused by co-infection with HBV and human immuno-deﬁciency virus (HIV). In this study, the aim was to evaluate the vaccination coverage and immunity against HBV among HIV-infected individuals in South Brazil, and identify factors that are associated with compliance patterns and antibody reactivity. Three hundred HIV-infected men and women were included in this survey. The patients answered a standardized questionnaire, and vaccination cards were checked in order to assess hepatitis B vaccine status. A blood sample was collected for quantitative determination of antibody to hepatitis B virus surface antigen (anti-HBs). Participants...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Hepatitis B; HBV Vaccination; Immunity.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000200181

HLA-B*14 allele predicts HIV-1 mother-to-child-transmission, in Salvador, Brazil
Provedor de dados: 55
Autores: Angulo,Juan Manuel Cubillos; Cuesta,Taryn Ariadna Castro; Menezes,Eliane Pereira; Pedroso,Celia; Brites,Carlos.
ABSTRACT  Background: Class I human leukocyte antigens, especially the molecules encoded at the B locus (HLA-B), are associated with AIDS progression risk. Different groups of HLA-B alleles have been associated to a protective effect or increasing susceptibility to HIV infection and are expressed from the earliest stages of gestation.  Objective: The aim of this study was to evaluate which variants of HLA-B are associated with the risk of HIV vertical transmission in infected pregnant women and in their offspring, in a referral center in Salvador Bahia.  Methods: We performed HLA-B genotyping in 52 HIV-infected mothers and their children exposed to HIV-1 during pregnancy (N = 65) in Salvador, Brazil. We compared the HLA-B alleles frequency in mothers,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mother to child transmission; HIV; HLA-B.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200071

Prevalence of sexually transmitted infections among HIV-infected women in Brazil
Provedor de dados: 55
Autores: Travassos,Ana Gabriela Álvares; Brites,Carlos; Netto,Eduardo M.; Fernandes,Sheyla de Almeida; Rutherford,George W.; Queiroz,Conceição Maria.
This study aimed to evaluate the prevalence of sexually transmitted infections (STIs) and associated risk factors in HIV-infected pregnant women followed for prenatal care in Salvador, Bahia. This was a cross-sectional study of 63 women seeking prenatal care at a reference center. Participants were interviewed regarding socio-epidemiological and clinical history, and were tested for HBsAg, anti-HCV, anti HTLV I/II, VDRL, Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma hominis, Ureaplasma urealyticum, CD4 count, and HIV plasma viral load. The main outcome variable was the presence of any STI. The mean age of patients was 28.2 years (16-40 years). 23 (36.5%) were diagnosed with at least one STI. The frequency of diagnoses was: HBV, 3.2%; HCV, 8.1%;...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Sexually transmitted infections; Pregnancy; Prevalence.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600014

Metabolic syndrome in HIV-infected middle-aged women on antiretroviral therapy: prevalence and associated factors
Provedor de dados: 55
Autores: Akl,Lívia D.; Valadares,Ana L.R.; Moraes,Monica Jacques de; Pinto-Neto,Aarão M.; Lagrutta,Bianca; Costa-Paiva,Lúcia.
ABSTRACT  Objectives: To determine the prevalence of metabolic syndrome (MetS) and its associated factors in a group of HIV-infected middle-aged women.  Methods: Cross-sectional study including 273 HIV-infected climacteric women of 40-60 years of age under care in two HIV outpatient reference centers in Brazil. Metabolic syndrome diagnosis was based on 2006 International Diabetes Federation criteria. Sociodemographic, clinical and behavioral factors were evaluated as well as HIV infection-related parameters.  Results: Mean age was 47.7 years; 59.1% of women were premenopausal, 91% were on antiretroviral therapy. Current CD4 count was &gt;500 cells/mm3 in 61.7%, current viral load undetectable in 76.9% of women, and a quarter had previous diagnosis of aids....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Metabolic syndrome; Menopause; HIV; Protease inhibitors.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300263

Breast cancer in a cohort of human immunodeficiency virus (HIV)-infected women from Rio de Janeiro, Brazil: a cases series report and an incidence rate estimate
Provedor de dados: 55
Autores: Andrade,Angela Cristina Vasconcelos de; Luz,Paula Mendes; Veloso,Valdiléa Gonçalves; Cardoso,Sandra Wagner; Moreira,Ronaldo Ismerio; Grinsztejn,Beatriz; Friedman,Ruth Khalili.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Breast neoplasms; Case reports; Incidence.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000400016

Visceral Leishmaniasis/HIV co-infection in northeast Brazil: evaluation of outcome
Provedor de dados: 55
Autores: Távora,Lara Gurgel Fernandes; Nogueira,Marina Bizerril; Gomes,Sofia Teixeira.
ABSTRACT Since the beginning of the HIV burden, Visceral Leishmaniasis (VL)/HIV co-infection has been diagnosed not only in areas where VL is endemic (Latin America, India, Asia, Southern Europe), but also in North America, were it is considered an opportunistic disease. Clinical presentation, diagnostic tests sensitivity and treatment response in this population differs from VL alone.  OBJECTIVES:  To evaluate factors related to an unfavorable outcome in patients with VL/HIV diagnosis in a reference center in northeast Brazil.  METHODS:  Co-infected patients, diagnosed from 2010 to 2012, were included. Data from medical records were collected until one year after VL treatment completion.  RESULTS:  Forty-two HIV-infected patients were included in the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Visceral Leishmaniasis; HIV; AIDS.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600651

Evaluation of AIDS-related disability in a general hospital in southern, Brazil
Provedor de dados: 55
Autores: Zonta,Marise Bueno; Almeida,Sérgio Monteiro de; Carvalho,Mirian T Matsuno de; Werneck,Lineu César.
The increase in survival rates of patients affected by AIDS is associated with physical disabilities that can compromise their functional independence. We examined the degree and types of disabilities in hospitalized AIDS patients , as well the clinical and immunological parameters associated with disability. The lowered functional status was associated with increased time since AIDS had been diagnosed, with complaints of weakness, and with the involvement of more than one set of systems in the definition of AIDS. The inability to perform daily living activities was associated with higher viral loads (log) c/mL, lower CD4+/mL and CD4+/CD8+ ratios, and with involvement of the central nervous system, in the cause of hospitalization. Both the inability to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; HIV; Disability; Functional status; Functional assessment; Functional independence measure.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000600005

Abacavir-induced liver toxicity
Provedor de dados: 55
Autores: Pezzani,Maria Diletta; Resnati,Chiara; Di Cristo,Valentina; Riva,Agostino; Gervasoni,Cristina.
Abstract Abacavir-induced liver toxicity is a rare event almost exclusively occurring in HLA B*5701-positive patients. Herein, we report one case of abnormal liver function tests occurring in a young HLA B*5701-negative woman on a stable nevirapine-based regimen with no history of liver problems or alcohol abuse after switching to abacavir from tenofovir. We also investigated the reasons for abacavir discontinuation in a cohort of patients treated with abacavir-lamivudine-nevirapine.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Abacavir; Liver toxicity.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500502

Anogenital infection by Chlamydia trachomatis and Neisseria gonorrhoeae in HIV-infected men and women in Salvador, Brazil
Provedor de dados: 55
Autores: Travassos,Ana Gabriela; Xavier-Souza,Eveline; Netto,Eduardo; Dantas,Eda Vinhaes; Timbó,Maiara; Nóbrega,Isabella; Haguihara,Tatiana; Neumayer,Júlia; Lisboa,Nathalia; Soidan,Maria Angela; Ferreira,Fábio; Brites,Carlos.
ABSTRACT  Background: Infections caused by Chlamydia trachomatis and Neisseria gonorrhoeae are the most common bacterial sexually transmitted infections throughout the world. These sexually transmitted infections are a growing problem in people living with HIV/AIDS. However, the presence of these agents in extra genital sites, remains poorly studied in our country. The objective of this study was to estimate the prevalence of Chlamydia trachomatis and Neisseria gonorrhoeae anal and genital infection in people living with HIV/AIDS followed in a reference center in Salvador, Brazil.  Methods: Cross-sectional study, from June 2013 to June 2015. Proven HIV-infected people attending this reference center were invited. Clinical and epidemiological data were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Chlamydia trachomatis; Neisseria gonorrhoeae; Sexually transmitted infections; Anogenital infections.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000600569

Effect of N-acetyl-L-cysteine on lymphocyte apoptosis, lymphocyte viability, TNF-alpha and IL-8 in HIV-infected patients undergoing anti-retroviral treatment
Provedor de dados: 55
Autores: Treitinger,Aricio; Spada,Celso; Masokawa,Ivete Yoshico; Verdi,Júlio César Vidal; Silveira,Mariette Van Der  Sander; Luis,Magali Chaves; Reis,Marcellus; Ferreira,Silvia Inês Alejandra Cordova de Pires; Abdalla,Dulcinéia Saes Parra.
N-acetyl-L-cysteine (NAC) has been proposed as an additional therapeutic agent for AIDS patients because it reduces human immunodeficiency virus type 1 (HIV-1) replication in stimulated CD4+ lymphocytes, and it ameliorates immunological reactivity. In a randomized, 180-day, double-blind, placebo-controlled trial performed with HIV-infected patients classified as A2 and A3 according to the criteria of the Center for Disease Control and Prevention, we investigated the effects of oral administration of NAC on HIV-infected patients undergoing their first anti-retroviral therapy; viral load, CD4+ lymphocyte, lymphocyte viability and apoptosis, and TNF-alpha and IL-8 levels were determined. Sixteen patients who received anti-retroviral therapy plus a placebo...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: N-acetylcysteine; Apoptosis; Viability; HIV; Glutathione; TNF-alpha; IL-8.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500005

Are traditional body fat equations and anthropometry valid to estimate body fat in children and adolescents living with HIV?
Provedor de dados: 55
Autores: Lima,Luiz Rodrigo Augustemak de; Martins,Priscila Custódio; Alves Junior,Carlos Alencar Souza; Castro,João Antônio Chula de; Silva,Diego Augusto Santos; Petroski,Edio Luiz.
Abstract The aim of this study was to assess the validity of traditional anthropometric equations and to develop predictive equations of total body and trunk fat for children and adolescents living with HIV based on anthropometric measurements. Forty-eight children and adolescents of both sexes (24 boys) aged 7-17 years, living in Santa Catarina, Brazil, participated in the study. Dual-energy X-ray absorptiometry was used as the reference method to evaluate total body and trunk fat. Height, body weight, circumferences and triceps, subscapular, abdominal and calf skinfolds were measured. The traditional equations of Lohman and Slaughter were used to estimate body fat. Multiple regression models were fitted to predict total body fat (Model 1) and trunk fat...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Body fat; HIV; Skinfold thickness; Anthropometry; DXA.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400448

Chronic skull osteomyelitis due to Cryptococcus neoformans: first case report in an HIV-infected patient
Provedor de dados: 55
Autores: Adiwardana,Natanael Sutikno; Morás,Juliana de Angelo; Bernardo,Leandro Lombo; Klautau,Giselle Burlamaqui; Queiroz,Wladimir; Vidal,Jose Ernesto.
ABSTRACT Osteomyelitis due to Cryptococcus neoformans are described in mostly 10% of patients with disseminated cryptococcosis, being direct inoculation even more uncommon. We report the case of an HIV-infected patient with history of recurring itching on his scalp and repetitive local trauma. For eighteen months, he noticed a painful and slow growing lump on his scalp. He was submitted to an excisional biopsy of the lesion but no etiological diagnosis was identified. After this procedure, the post-surgical wound never completely healed. At admission, the patient presented nausea and headache for three days and an open orifice into his skull. Investigations confirmed meningitis and skull osteomyelitis caused by Cryptococcus neoformans. He was treated with...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Cryptococcus neoformans; Osteomyelitis; Skull; HIV.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000600499

Incidence of congenital toxoplasmosis among infants born to HIV-coinfected mothers: case series and literature review
Provedor de dados: 55
Autores: Campos,Flávia Alves; Andrade,Gláucia Manzan Queiroz de; Lanna,Antônio de Pádua Santos; Lage,Bruno Freitas; Assumpção,Maria Vitória Mourão; Pinto,Jorge A.
Introduction:There is a paucity of data on the occurrence of congenital toxoplasmosis in children born to mothers dually infected with HIV and Toxoplasma gondii.Objective:To evaluate aspects of the mother–infant pairs associated with vertical transmission of toxoplasmosis in women co-infected with HIV in a referral center for perinatally acquired infections in Belo Horizonte, Brazil.Methods:Descriptive study of HIV vertically exposed children, with congenital toxoplasmosis, followed at a referral center (cohort/Belo Horizonte). Prenatal and post-natal variables for the mother–infant pairs were evaluated. A literature review with no filtering for time and language was performed to identify reports of congenital toxoplasmosis in HIV vertically exposed...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Congenital toxoplasmosis; HIV; Co-infection.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000600609

Infection of the lymphatic system by Aureobasidium pullulans in a patient with erythema nodosum leprosum
Provedor de dados: 55
Autores: Morais,Orlando Oliveira de; Porto,Cláudia; Coutinho,Anglya Samara Silva Leite; Reis,Carmélia Matos Santiago; Teixeira,Marcus de Melo; Gomes,Ciro Martins.
Aureobasidium pullulans is a causal agent of phaeohyphomycosis, occasionally found in men and animals. As an agent of different opportunistic fungal processes, it may cause fungemia, systemic infections and abscesses in different viscera. This paper aims to report a case of a patient with infection of the lymphatic system by A. pullulans. A 23-year-old patient being treated for erythema nodosum leprosum presented a 60-day complaint of daily fever, hoarseness, odynophagia and weight loss. Laboratory tests showed pancytopenia with severe neutropenia, cervical adenomegaly and solid contrast uptake lesion in the oropharyngeal region. Due to neutropenia and sepsis the patient was initially treated with cefepime and vancomycin, but there was no clinical...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: HIV; Pneumonia; Macrolides; Mortality.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000300019

Characterization of virologic failure after an initially successful 48-week course of antiretroviral therapy in HIV/AIDS outpatients treated in Santos, Brazil
Provedor de dados: 55
Autores: Caseiro,Marcos M.; Golegã,Alcino A.C.; Etzel,Arnaldo; Diaz,Ricardo Sobhie.
We characterized the virologic failure after an initially successful 48-week course of antiretroviral therapy among HIV/AIDS patients in a retrospective cohort study involving patients from Santos, Brazil. Patients with plasma HIV RNA below 500 copies/mL for 48 weeks were included. Variables analyzed included gender, age, level of education, marital status, mode of HIV acquisition, viral load, and CD4 cell count upon admission. There were 4,909 patients registered with the clinic, of which 669 patients met all the inclusion criteria (41.6% female and 58.4% male). Only 27.5% of the patients maintained undetectable viral loads during up to one year of follow-up. After 48 weeks, virologic failure occurred earlier in females and in patients first treated with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiretroviral therapy; Virologic failure; HIV; Brazil.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300001

Vaccination coverage in a cohort of HIV-infected patients receiving care at an AIDS outpatient clinic in Espírito Santo, Brazil
Provedor de dados: 55
Autores: Pinto Neto,Lauro Ferreira da Silva; Vieira,Julia Vescovi; Ronchi,Nathália Rossoni.
Abstract This cross-sectional study assessed the immunization status of human immune deficiency virus (HIV)-infected patients receiving care at an outpatient clinic in Brazil. The sociodemographic characteristics, CD4 count and HIV viral load of 281 out of 612 adult outpatients were analyzed. A total of 331 patients were excluded because of no availability of vaccination cards. Chi-square or Fisher's exact test were used. Immunization coverage was higher for diphtheria/tetanus (59.79%) and hepatitis B (56.7%), and lowest for hepatitis A (6.8%) and for meningococcal group C (6%). Only 11.74% of the patients had received the influenza virus vaccine yearly since their HIV-infection diagnosis. No vaccination against influenza (p &lt; 0.034) or hepatitis B (p...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Vaccination; Immunization coverage; Immunosuppressed.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000500515

Establishment of the serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy in the city of São Paulo, Brazil
Provedor de dados: 55
Autores: Kallas,Esper Georges; Bassichetto,Katia Cristina; Oliveira,Solange Maria; Goldenberg,Ieda; Bortoloto,Reginaldo; Moreno,Diva Maria Faleiros C.; Kanashiro,Cecilia; Chaves,Mariana Mellilo Sauer; Sucupira,Maria Cecilia A.; Diniz,Aparecido; Mesquita,Fabio C.
Several strategies aim at characterizing the AIDS epidemic in different parts of the world. Among these, the identification of recent HIV-1 infections using the recently described serologic testing algorithm for recent human immunodeficiency virus (HIV) seroconversion (STARHS) strategy was employed in four testing sites of the City of São Paulo Public Health Department (CSPPHD). Those identified as recently infected were invited to participate in a prospective clinical and laboratory evaluation study. We describe the establishment of the patient identification network and the success in enrolling the participants, as well as their clinical and laboratory characteristics. From May to December 2002, 6,443 persons were tested for HIV in the four participating...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Recent infection; Network; São Paulo.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000600003

Neonatal factors associated with HIV long term non-progressors in a cohort of vertically infected children in Rio de Janeiro, Brazil ("Peixe" Project)
Provedor de dados: 55
Autores: Hofer,Cristina B.; Oliveira,Ricardo Hugo; Machado,Elizabeth S.; Pala,Alessandra; Evangelista,Lúcia; Fernandes,Iraina; Abreu,Thalita F.
There are only scarce data on HIV progression in vertically infected children in developing countries. The aim of this study is to describe factors from neonatal period associated with long term non-progression (LTNP), in a Brazilian cohort. A cohort study, with data systematically collected from the "Peixe" Cohort (cohort study of children conducted at the main HIV Pediatric Center in Rio de Janeiro, from 1996 to 2005). The study included children who were vertically infected and started follow up at 5 years of age or younger. LTNP, defined as not reaching category C or severe immunosuppression before 5 years of age. Neonatal and demographic factors were studied. Variables with p-value&lt;0.15 were included in a logistic regression model. 213 patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Antiretroviral therapy; Long term non-progressors; Children; Brazil.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400007

The clinical utility of induced sputum for the diagnosis of bacterial community-acquired pneumonia in HIV-infected patients: a prospective cross-sectional study
Provedor de dados: 55
Autores: Silva,Rosemeri Maurici da; Teixeira,Paulo José Zimermann; Moreira,José da Silva.
BACKGROUND: Bacterial pneumonias have been overcoming pneumocytosis in frequency. Controversy still remains about how to manage immunocompromised patients and those with lung diseases. Sputum analysis is a noninvasive and simple method, and when interpreted according to specific criteria it may help with diagnosis. We conducted a study to evaluate sensitivity, specificity, positive and negative predicted values, and the accuracy of induced sputum (IS) for bacterial community-acquired pneumonia diagnosis in HIV-positive patients. MATERIAL AND METHODS: This cross sectional study evaluated a diagnostic procedure in a reference hospital for HIV patients in Florianópolis, SC, Brazil. From January 1, 2001 to September 30, 2002, 547 HIV-positive patients were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Induced sputum; HIV; Bacterial pneumonia.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200004

Factors related to HIV/tuberculosis coinfection in a Brazilian reference hospital
Provedor de dados: 55
Autores: Carvalho,Bráulio Matias de; Monteiro,André Jalles; Pires Neto,Roberto da Justa; Grangeiro,Thalles Barbosa; Frota,Cristiane Cunha.
Infection with both Human Immunodeficiency Virus (HIV) and Mycobacterium tuberculosis is currently the world's leading cause of death due to infectious agents. We evaluated factors related to the development of tuberculosis (TB) in HIV-infected patients who were being treated at an infectious diseases hospital in Fortaleza, Ceará, Brazil. From January 2004 to December 2005, we made an epidemiological study through the analysis of the medical records of 171 patients, who were diagnosed as having both HIV and tuberculosis. Among these co-infected patients, most (81%, p=0.0006) were male. Co-infection was more frequent (87.8%) among patients over 40 years of age and those with lower educational levels (less than eight years of schooling). Forty-one percent of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Mycobacterium tuberculosis; HIV/TB co-infection; Risk factors; AIDS.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000400005

Risk behavior score: a practical approach for assessing risk among men who have sex with men in Brazil
Provedor de dados: 55
Autores: Rocha,Gustavo Machado; Kerr,Lígia Regina Franco Sansigolo; Kendall,Carl; Guimarães,Mark Drew Crosland.
ABSTRACT HIV/AIDS epidemic is not well controlled, and multiple sexual behavior factors help explain high rates of HIV infection among men who have sex with men (MSM). This article proposes to exam the use of a potential risk behavior score for HIV infection, based on the type and number of sexual partners, and condom use, and their associated factors in a sample of MSM in Brazil. A cross sectional RDS (Respondent Driven Sampling) study was performed among 3738 MSM aged 18+ years old from ten Brazilian cities. The risk behavior score was composed by the number of male partners and anal condom use in the last year with steady, casual, and commercial partners. Most participants were 25+ years old (58.1%), non-white (83.1%), and single (84.9%). Final weighted...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Homosexuals; High-risk sex; Unsafe sex; HIV; AIDS.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200113

High HIV infection prevalence in a group of men who have sex with men
Provedor de dados: 55
Autores: Torres,Raquel Maria Cardoso; Cruz,Marly Marques da; Périssé,André Reynaldo Santos; Pires,Denise Ribeiro Franqueira.
ABSTRACT Brazil is characterized by a concentrated AIDS epidemic, it has a prevalence of less than 1% in the general population. However, there are higher rates in specific populations, especially in men who have sex with men. The study's aim was to analyze the association between sociodemographic characteristics, sexual practices, sexual behaviors and the HIV infection in a group of men who have sex with men. Secondary data was collected between June 2014 and September 2015 in a research of cross-sectional design in the city of Rio de Janeiro, Brazil. Volunteers answered an online computerized questionnaire and took HIV test. Chi-squared distribution and multiple logistic regression was used. There were 341 participants. Most of them were racially mixed,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Acquired Immunodeficiency Syndrome; Male homosexuality; Bisexuality; Sexual behavior; HIV serosorting.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600596

Prevalence, risk factors and genotypes of hepatitis B infection among HIV-infected patients in the State of MS, Central Brazil
Provedor de dados: 55
Autores: Freitas,Solange Zacalusni; Soares,Caroline Cordeiro; Tanaka,Tayana Serpa Ortiz; Lindenberg,Andréa Siqueira Campos; Teles,Sheila Araújo; Torres,Marina Sawada; Mello,Francisco Campello Amaral; Mendes-Corrêa,Maria Cássia; Savassi-Ribas,Flávia; Motta-Castro,Ana Rita Coimbra.
Objectives:A cross-sectional study on prevalence of HBV and HDV infection, risk factors and genotype distribution of HBV infection was conducted among 848 HIV-infected patients in Mato Grosso do Sul, Central Brazil.Methods:Serum samples of 848 participants were tested for hepatitis B surface antigen (HBsAg), hepatitis B core antibody (anti-HBc) and hepatitis surface antibody (anti-HBs). HBsAg positive samples were tested for anti-HBc IgM, HBeAg, anti-HBe, anti-HCV, and total anti-HDV. HBsAg and anti-HBc positive were subjected to DNA extraction. Viral DNA was amplified by semi-nested PCR for the regions pre-S/S and then purified and genotyped/subgenotyped by direct sequencing. Student's t-test, chi-square test and Fisher's exact test were used to compare...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Coinfection; HBV; HIV; Prevalence.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000500473

GBV-C/HGV and HIV-1 coinfection
Provedor de dados: 55
Autores: Maidana,Maria Teresa; Sabino,Ester Cerdeira; Kallas,Esper Georges.
An interesting interaction pattern has been found between HIV-1 and GBV-C/HGV, resulting in protection against progression to AIDS. The mechanisms involved in this interaction remain to be clarified. We examined the current knowledge concerning this coinfection and developed hypotheses to explain its effects. A better understanding of this interaction could result in new concepts, which may lead to new strategies to control HIV-1 replication and progression to AIDS.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HGV; GBV-C; Pathogenesis; Review.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000200001

Extensive variation in drug-resistance mutational profile of Brazilian patients failing antiretroviral therapy in five large Brazilian cities
Provedor de dados: 55
Autores: Brites,Carlos; Pinto-Neto,Lauro; Medeiros,Melissa; Nunes,Estevão; Sprinz,Eduardo; Carvalho,Mariana.
Abstract  Background Development of drug-resistance mutations is the main cause of failure in antiretroviral therapy. In Brazil, there is scarce information on resistance pattern for patients failing antiretroviral therapy.  Objectives To define the HIV mutational profile associated with drug resistance in Brazilian patients from 5 large cities, after first, second or further failures to antiretroviral therapy.  Methods We reviewed genotyping results of 1520 patients failing therapy in five Brazilian cities. Frequency of mutations, mean number of active drugs, viral susceptibility to each antiretrovirals drug, and regional differences were assessed.  Results Mean time of antiretrovirals use was 22.7 ± 41.1 months. Mean pre-genotyping viral load was 4.2 ±...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Resistance; Brazil; Mutations.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000400323

Danger in the streets: exposures to bloodborne pathogens after community sharp injuries in Rio de Janeiro, Brazil
Provedor de dados: 55
Autores: Costa,Marcellus Dias; Rapparini,Cristiane; Schmaltz,Carolina Arana Stanis; Tuyama,Mari; Lauria,Lilian de Mello; Saraceni,Valeria; Barroso,Paulo Feijó.
ABSTRACT  Objective: Exposures to sharps injuries occurring in the community are relatively frequent. We describe characteristics of community sharp exposures reported in the city of Rio de Janeiro from 1997 to 2010.  Methods: A cross-sectional analysis of exposure reports to sharps in the community reported to a surveillance system, designed for health care workers, of the Municipal Health Department of Rio de Janeiro. The characteristics of exposed individuals analyzed included types of exposure, the circumstances of the accident, and the prophylaxis offered.  Results: 582 exposures were studied. Median age was 30 years and 83 (14%) involved children with less than 10 years of age. Two hundred and seventeen (37%) occurred with sharps found in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Needlestick; Bloodborne; HIV; Hepatitis; Medical waste; Sharp injuries; Postexposure prophylaxis.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300306

AIDS-associated diarrhea and wasting in northeast Brazil is associated with subtherapeutic plasma levels of antiretroviral medications and with both bovine and human subtypes of Cryptosporidium parvum
Provedor de dados: 55
Autores: Brantley,Richard K.; Williams,K. Robert; Silva,Terezinha M.J.; Sistrom,Maria; Thielman,Nathan M.; Ward,Honorine; Lima,Aldo A. M.; Guerrant,Richard L.
Advanced HIV infection is frequently complicated by diarrhea, disruption of bowel structure and function, and malnutrition. Resulting malabsorption of or pharmacokinetic changes in antiretroviral agents might lead to subtherapeutic drug dosing and treatment failure in individual patients, and could require dose adjustment and/or dietary supplements during periods of diarrheal illness. We determined the plasma levels of antiretroviral medications in patients that had already been started on medication by their physicians in an urban infectious diseases hospital in northeast Brazil. We also obtained blood samples from patients hospitalized for diarrhea or AIDS-associated wasting, and we found reduced stavudine and didanosine levels in comparison with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Malabsorption; DdI; D4T; Pharmacokinetics.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000100003

Recent HIV infection rates among HIV positive patients seeking voluntary counseling and testing centers in the metropolitan region of Recife - Pe, Brazil
Provedor de dados: 55
Autores: Cavalcanti,Ana Maria Salustiano; Brito,Ana Maria de; Salustiano,Daniela Medeiros; Lima,Kledoaldo Oliveira de; Silva,Sirleide Pereira da; Lacerda,Heloisa Ramos.
The BED capture enzyme immunoassay test makes it possible to determine whether individuals were recently infected with HIV. OBJECTIVE: In this study, the overall HIV and recent infections prevalences were determined at five Voluntary Counseling and Testing (VCT) centers, in the Metropolitan Region of Recife, Northeastern of Brazil. MATERIAL AND METHODS: A cross-sectional study was conducted among users of five VCTs in the metropolitan region of Recife between July 2007 and April 2009. Out of the individuals who tested positive for HIV, 169 were analyzed to assess the prevalence of recent infection by means of the BED-CEIA (BED-Calypte®). RESULTS: Out of 46,696 individuals tested 916 (1.96%) turned out positive for HIV infection The highest prevalence was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HIV seroprevalence; Seroepidemiologic studies; HIV infections.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200009

Hyponatremia, acute kidney injury, and mortality in HIV-related toxoplasmic encephalitis
Provedor de dados: 55
Autores: Libório,Alexandre B.; Silva Jr,Geraldo B.; Silva,Carolina G.C.H.; Lima Filho,Francisco J.C.; Studart Neto,Adalberto; Okoba,Willy; Bruin,Veralice M.S. de; Araújo,Sônia M.H.A.; Daher,Elizabeth F.
BACKGROUND: There are no reports on hyponatremia and acute kidney injury (AKI) involved in the course of HIV-related toxoplasmic encephalitis (TE). The main objective of this study was to describe the occurrence of hyponatremia and its relationship with AKI and mortality in HIV-related toxoplasmic encephalitis (TE). METHODS: This was a retrospective cohort study on patients with HIV-related TE. AKI was considered only when the RIFLE (risk, injury, failure, loss, end-stage) criterion was met, after the patient was admitted. RESULTS: A total of 92 patients were included, with a mean age of 36 ± 9 years. Hyponatremia at admission was observed in 43 patients (46.7%), with AKI developing in 25 (27.1%) patients during their hospitalization. Sulfadiazine was the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Toxoplasmosis; Encephalitis; Hyponatremia; Acute kidney injury; HIV; Mortality.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600010

Interleukin-10 gene polymorphism (-1082G/A) and allergy to efavirenz in patients infected with human immunodeficiency virus
Provedor de dados: 55
Autores: Rodrigues,Raphael de Oliveira; Carvalho,Paulo Germano de; Arruda,Érico Antônio Gomes de; Rabenhorst,Silvia Helena Barem; Silva,Silvia Fernandes Ribeiro da; Ribeiro,Ilana Farias; Lima,Denise Girão Limaverde; Nagao-Dias,Aparecida Tiemi.
The aim of the present study was to investigate the association between polymorphism in the interleukin-10 gene promoter at position -1082 in human immunodeficiency virus-infected patients who had presented allergic reaction due to efavirenz. The study included 63 patients treated at the Hospital São José de Doenças Infecciosas, Fortaleza, Ceará, Brazil. Twenty-one patients who had presented allergic reaction to efavirenz were compared to 42 patients with no allergic reaction following exposure to this drug. Blood samples were collected for DNA extraction and submitted to the restriction fragment length polymorphism - polymerase chain reaction technique. The -1082AA genotype was significantly more frequent in allergic patients as compared to non-allergic...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Drug allergy; Polymorphism; IL-10.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000400445

Incidence rate of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity during the first year of treatment stratified by age
Provedor de dados: 55
Autores: Torres,Thiago Silva; Cardoso,Sandra Wagner; Velasque,Luciane S.; Veloso,Valdilea G.; Grinsztejn,Beatriz.
Toxicity is the most frequently reported reason for modifying or discontinuing the first combined antiretroviral therapy regimens, and it can cause significant morbidity, poor quality of life and also can be an important barrier to adherence, ultimately resulting in treatment failure and viral resistance. Elderly patients with HIV/AIDS (≥50 years) may have a different profile in terms of treatment modification due to higher incidence of comorbidities and polypharmacy. The aim of this study was to describe the incidence of modifying or discontinuing first combined antiretroviral therapy regimen due to toxicity (TOX-MOD) during the first year of treatment at the IPEC – FIOCRUZ HIV/AIDS cohort, Rio de Janeiro, Brazil, stratified by age. Demographic, clinical...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Toxicity; Aging; Antiretroviral.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702014000100034

Comparison of the ACC/AHA and Framingham algorithms to assess cardiovascular risk in HIV-infected patients
Provedor de dados: 55
Autores: Pinto Neto,Lauro Ferreira da Silva; Dias,Fernanda Rezende; Bressan,Flavia Feres; Santos,Carolina Rocio Oliveira.
ABSTRACT The aim of this study was to compare the predictions of Framingham cardiovascular (CV) risk score (FRS) and the American College of Cardiology/American Heart Association (ACC/AHA) risk score in an HIV outpatient clinic in the city of Vitoria, Espirito Santo, Brazil. In a cross-sectional study 341 HIV infected patients over 40 years old consecutively recruited were interviewed. Cohen's kappa coefficient was used to assess agreement between the two algorithms. 61.3% were stratified as low risk by Framingham score, compared with 54% by ACC/AHA score (Spearman correlation 0.845; p &lt; 0.000). Only 26.1% were classified as cardiovascular high risk by Framingham compared to 46% by ACC/AHA score (Kappa = 0.745; p &lt; 0.039). Only one out of eight...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cardiovascular disease; HIV; Co-morbidities; Non-AIDS events.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000600577

HIV prevalence among blood donors in a blood bank in Curitiba (Brazil)
Provedor de dados: 55
Autores: Andrade Neto,José Luiz; Pintarelli,Vitor Last; Felchner,Paulo Cesar Zimmermann; Morais,Rodrigo Leite de; Nishimoto,Fabíola Lie.
There still is no cure for the acquired immunodeficiency syndrome (AIDS). Its etiologic agent is the human immunodeficiency virus (HIV), and transmission occurs through sexual relationships, contacts with blood, and vertically (mother to child). In this study, we sought to determine the prevalence of HIV among blood donors at a blood bank in Curitiba. We studied 213,666 blood donations made from March 1, 1992, to April 25, 1999. Each potential blood donor first answered a questionnaire, submitted to a clinical examination, and filled out a self-exclusion card. Blood was collected and analyzed only from the candidates approved by the first two criteria. Two tests were used to detect HIV: ELISA for screening, and Western-Blot for confirmation. The results...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Blood donor; HIV.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100003

Profile of patients diagnosed with AIDS at age 60 and above in Brazil, from 1980 until June 2009, compared to those diagnosed at age 18 to 59
Provedor de dados: 55
Autores: Fonseca,Marise Oliveira; Tupinambás,Unaí; Sousa,Artur Iuri Alves de; Baisley,Kathy; Greco,Dirceu Bartolomeu; Rodrigues,Laura.
OBJECTIVES: The aim of this study was to learn more about people diagnosed with acquired immunodeficiency syndrome (AIDS) at age 60 and above in Brazil, and to compare them with people diagnosed at a younger age. METHODS: This study was based on the analysis of secondary data from the Brazilian AIDS Program. The study population consisted of people diagnosed with AIDS at age 60 and above. The comparison group was comprised of a 20% random sample of people diagnosed at age 18 to 59, frequency-matched by year of diagnosis. RESULTS: 544,846 cases of AIDS were reported in Brazil from 1980 until June 2009. Over 90% of cases were diagnosed between 18 and 59 years of age, and 13,657 (2.5%) at age 60 and above. The first case of AIDS among the elderly was reported...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Elderly; Epidemiology; Brazil.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000600009

Previous use of quinolones: a surrogate marker for first line anti-tuberculosis drugs resistance in HIV-infected patients?
Provedor de dados: 55
Autores: Deutschendorf,Caroline; Goldani,Luciano Z.; Santos,Rodrigo Pires dos.
OBJECTIVES: Drug resistant Mycobacterium tuberculosis causes much higher rates of treatment toxicity, failure or relapse, and mortality. We determined the drug resistant profile of Mycobacterium tuberculosis strains isolated from a population of HIV-infected patients in southern Brazil and studied the potential factors associated with resistance. METHODS: We conducted a retrospective cohort study to determine the resistance profile of Mycobacterium tuberculosis isolated from HIV-infected patients and factors that could be associated with resistance from 2000 to 2005. RESULTS: 236 patients were included in the study. Resistance to at least one drug was observed in 32 (14.6%) isolates, and multi-drug resistance was observed in 4 (1.82%) isolates. On...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mycobacterium tuberculosis; HIV; Quinolones; Drug resistance.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702012000200006

Coinfection by HTLV-I/II is associated with an increased risk of strongyloidiasis and delay in starting antiretroviral therapy for AIDS patients
Provedor de dados: 55
Autores: Brites,C; Goyanna,F; França,LG; Pedroso,C; Netto,EM; Adriano,S; Sampaio,J; Harrington Jr,W.
OBJECTIVE: To compare the clinical characteristics and outcomes of HIV-1-HTLV-1 coinfected patients, in Bahia, Brazil. METHODS: Retrospective, comparative study. RESULTS: Among a total of 123 consecutive HIV infected patients, 20 men (20.6%) and 6 women (23.1%) had detectable antibodies against HTLV-I/II. The major risk factor associated with coinfection by HTLV was intravenous drug use (57.7% of coinfected patient versus 9.2% of HTLV seronegative patients, p &lt; 0.0001). Coinfected patients had higher absolute lymphocyte counts (1,921 + 762 versus 1,587 + 951, p = 0.03). Both groups of patients had similar means of CD4+ and CD8+ cell counts. However, among patients with AIDS CD4+ cell counts were significantly higher among those coinfected with HTLV-I/II...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HTLV-I/II; Coinfection Strongyloidiasis; CD4/CD8.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100002

Aging with HIV: a practical review
Provedor de dados: 55
Autores: Cardoso,Sandra Wagner; Torres,Thiago Silva; Santini-Oliveira,Marilia; Marins,Luana Monteiro Spindola; Veloso,Valdiléa Gonçalves; Grinsztejn,Beatriz.
The worldwide elderly population is expected to grow by an additional 694 million people by 2025. By that time, there will be approximately two billion elderly people in the world, most of whom (80%) will be living in developing countries. Based on recent estimates, this population will number over 40 million in 2030 in Brazil and a consequent increase in governmental spending for this population can be expected. Since highly active antiretroviral therapy became available in the mid-1990s, the life expectancy of people living with HIV has increased significantly. Approximately 12 million life years were added to the world between 1996 and 2008 as a consequence of wider access to highly active antiretroviral therapy. In Brazil, the incidence of AIDS among...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Aging; Elderly; Brazil; Comorbidity; HAART.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702013000400013

Seroprevalence of HIV among blood donors, antenatal women and other patients in a tertiary hospital in Nigeria
Provedor de dados: 55
Autores: Olajubu,F. A.; Osinupebi,O. A.; Deji-Agboola,M.; Jagun,E.O.
HIV/AIDS continues to remain a nightmare in the developing nations of the world especially in Nigeria, where about 2.9 million people are living with this problem. This study aimed at determining the sero-prevalence of HIV among both patients and blood donors at the Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria. Samples were collected between January 1st, 2005 and December, 31st 2006 and were screened using two rapid test kits, with two different principles (enzymatic and agglutination). Samples positive to the two methods were taken as truly sero-positive. The seropositive rate among blood donors, antenatal women, in- and out patients were, 3.2%, 6.9% and 17.5% respectively. There were five cases of positivity to both HIV I and II....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Blood donor; Antenatal; Sagamu; Nigeria.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000400008

Barriers to treatment of hepatitis C in HIV/HCV coinfected adults in Brazil
Provedor de dados: 55
Autores: Mendes-Corrêa,Maria Cássia; Martins,LG; Ferreira,PA; Tenore,S; Leite,OH; Leite,AG; Cavalcante,AJW; Shimose,M; Silva,MH; Uip,DE; Abrão Ferreira,PR.
The objective of this study was to assess the prevalence of barriers to interferon treatment in a population of HIV/HCV coinfected patients. A cross-sectional study was conducted at two AIDS Outpatient Clinics in Brazil. The study included all HIV infected patients followed at these institutions from January 2005 to November 2007. Medical records of 2,024 HIV-infected patients were evaluated. The prevalence of anti-HCV positive patients among them was 16.7%. Medical records of HCV/HIV coinfected patients were analyzed. 189 patients with the following characteristics were included in our study: mean age 43 years; male gender 65%; former IDUs (52%); HCV genotype 1 (66.4%); HCV genotype 3 (30.5%); median CD4+ T cell count was 340 cells/mm³. Among 189 patients...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Hepatitis C; HIV; Coinfected; Treatment.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300007

Bilateral peripheral facial palsy secondary to lymphoma in a patient with HIV/AIDS: a case report and literature review
Provedor de dados: 55
Autores: Sasaki,Maria das Graças; Leite,Patrícia G. B.; Leite,Andréa G. B.; Almeida,Sérgio Monteiro de.
Neurological complications represent one of the most important causes of morbidity and mortality in patients with HIV/AIDS. However, peripheral neuropathy comprises only 5% to 20% of the total neurological complications and facial nerve palsy, especially when it is bilateral, is a less common manifestation. Peripheral facial palsy has been considered as a possible neurological complication of the early stage of HIV infection but the number of reported cases in the literature is limited. Histological findings of nervous tissue in peripheral facial palsy at an early stage of HIV infection include a degenerative and not suppurative inflammatory process, but its etiology remains obscure. Peripheral facial palsy in the late stage of HIV infection is...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Facial palsy; Lymphoma.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000100008

Is Visceral Leishmaniasis the same in HIV-coinfected adults?
Provedor de dados: 55
Autores: Henn,Guilherme Alves de Lima; Ramos Júnior,Alberto Novaes; Colares,Jeová Keny Baima; Mendes,Lorena Pinho; Silveira,João Gabriel Colares; Lima,Anderson Alberto Façanha; Aires,Bárbara Pontes; Façanha,Mônica Cardoso.
ABSTRACT  Introduction: Visceral Leishmaniasis is the most severe form of disease caused by the Leishmania donovani complex, with significant morbidity and mortality in developing countries. Worse outcomes occur among HIV-positive individuals coinfected with Leishmania. It is unclear, however, if there are significant differences on presentation between Visceral Leishmaniasis patients with or without HIV coinfection.  Methods: We reviewed medical records from adult patients with Visceral Leishmaniasis treated at a reference healthcare center in Fortaleza – Ceará, Brazil, from July 2010 to December 2013. Data from HIV-coinfected patients have been abstracted and compared to non-HIV controls diagnosed with Visceral Leishmaniasis in the same period.  Results:...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Leishmaniasis; HIV; Coinfection.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702018000200092

Case report of lymph nodal, hepatic and splenic tuberculosis in an HIV-positive patient
Provedor de dados: 55
Autores: Barone,Bianca; Kreuzig,Patrícia Lago; Gusmão,Patricia Medeiros; Chamié,Daniel; Bezerra,Sabrina; Pinheiro,Pedro; Coscarelli,Pedro; Paiva,Daurita; Fonseca,Leila; Marsico,Anna; Cirigliano,André; Perez,Mário.
We describe a case of a male patient, 38 years old, HIV-positive (most recent CD4 count about 259/mm³), with abdominal pain, nausea, vomiting, anorexia, weight loss, and vespertine high fever with chills. His hemogram showed normocytic and normochromic anemia, with a high erythrocyte sedimentation rate (ESR) and gross granulations in the neutrophils. Transaminases were normal. Bone marrow biopsy evidenced a chronic disease anemia pattern and a lack of infectious agents. Abdominal ultrasound examination showed a normal-size spleen, which exhibited heterogeneous parenchyma and multiple small hypoechoic images, together with small ascites, peripancreatic and para-aortic lymphadenopathy. These findings were confirmed by abdominal CT. The liver was normal in...
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Tuberculosis; HIV; Treatment.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000200014

Prevalence of selected sexually and blood-borne infections in Injecting drug abuser inmates of bandar abbas and roodan correction facilities, Iran, 2002
Provedor de dados: 55
Autores: Davoodian,Parivash; Dadvand,Habib; Mahoori,Khatereh; Amoozandeh,Alireza; Salavati,Alborz.
Human Immunodeficiency Virus (HIV) and other blood borne viral infections like hepatitis B virus (HBV) and hepatitis C virus (HCV) are major health issues especially in young and growing population of developing countries. All around the globe correctional facilities are known as potential source of spreading such disease. During summer 2002, HIV, HCV antibodies, hepatitis B surface (HBs) antigen and rapid plasma reagin (RPR) test were checked in venous blood samples of 252 injecting drug abuser prisoners from correctional facilities in southern Iran. Overall HIV, HCV and HBV infection rate was 15.1% (38/249), 64.8% (163/249), and 4.7% (12/249), respectively. HCV infection rate of HIV positive cases was 94% (35/38). All RPR results were negative. Duration...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Iran; Prisons; HBV; HCV.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702009000500008

Comparison of the effectiveness of initial combined antiretroviral therapy with nelfinavir or efavirenz at a university-based outpatient service in Brazil
Provedor de dados: 56
Autores: Vanni,T.; Morejón,K.M.; Santana,R.C.; Melo,L. de; Ferrão,S.B.R.L.; Amorim,A.P.; Gaspar,G.G.; Ponzi,C.C.; Golin,N.A.; Custódio,F.L.; Marangoni,A.T.D.; Campos Jr.,C.P.; Fonseca,B.A.L.
Since there are some concerns about the effectiveness of highly active antiretroviral therapy in developing countries, we compared the initial combination antiretroviral therapy with zidovudine and lamivudine plus either nelfinavir or efavirenz at a university-based outpatient service in Brazil. This was a retrospective comparative cohort study carried out in a tertiary level hospital. A total of 194 patients receiving either nelfinavir or efavirenz were identified through our electronic database search, but only 126 patients met the inclusion criteria. Patients were included if they were older than 18 years old, naive for antiretroviral therapy, and had at least 1 follow-up visit after starting the antiretroviral regimen. Fifty-one of the included...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; HIV; Antiretroviral treatment; Efavirenz; Nelfinavir; Highly active antiretroviral therapy.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700011

Factors associated with adherence to antiretroviral therapy in HIV/AIDS patients: a cross-sectional study in Southern Brazil
Provedor de dados: 56
Autores: Pinheiro,C.A.T.; de-Carvalho-Leite,J.C.; Drachler,M.L.; Silveira,V.L.
A cross-sectional study was conducted on HIV-infected adults being treated with antiretroviral drugs at a reference service in Southern Brazil. Participants answered a sociodemographic questionnaire and were tested by scales assessing sociocognitive variables. Adherence to treatment was assessed by a self-report inventory developed for the study. Clinical information was obtained from the patients' records. Significance tests were conducted using univariate logistic regressions followed by multivariate logistic regression analysis. A total of 195 patients participated in the study and 56.9% of them reported  &gt; or = 95% adherence on the previous two days. In univariate analysis, the odds of adherence increased with self-efficacy (a person's conviction...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Adherence; Antiretroviral therapy; Self-efficacy; HIV; AIDS.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001000010

Comparison of the quantitative competitive and semiquantitative RT-PCR methods for the determination of interferon-gamma mRNA levels in AIDS-free HIV-infected individuals
Provedor de dados: 56
Autores: Barabás,É.; Nagy,K.; Várkonyi,V.; Horváth,A.
IFN-gamma mRNA expression was evaluated in nonstimulated peripheral blood mononuclear cells (PBMC) of HIV-infected and seronegative individuals using quantitative competitive and semiquantitative RT-PCR and the sensitivity of these methods was compared. A significant correlation was found between quantitative competitive and semiquantitative RT-PCR in samples of both HIV-seronegative (P = 0.004) and HIV-infected individuals (P = 0.0004). PBMC from HIV-infected individuals presented a remarkable increase of IFN-gamma mRNA expression, as determined by both types of RT-PCR methods. Semiquantitative RT-PCR even without an internal standard is also acceptable for measuring cytokine mRNA expression, but less reliable if small amounts are quantified. Moreover, we...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Quantitative competitive RT-PCR; Semiquantitative RT-PCR; IFN-gamma mRNA; HIV.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001000006

Normal skin of HIV-infected individuals contains increased numbers of dermal CD8 T cells and normal numbers of Langerhans cells
Provedor de dados: 56
Autores: Galhardo,M.C.G.; Alvarenga,F.F.; Schueler,G.; Perez,M.; Morgado,M.G.; Ferreira,H.; Azevedo,L.M.S.; Sampaio,E.P.; Sarno,E.N.
Dysregulation of the skin immune system (SIS) could explain the high prevalence of skin disorders in HIV+ individuals. The present study was carried out to determine whether alterations in the cell population of SIS and epidermal immunoactivation occur in the normal skin of HIV+ individuals. Forty-five biopsies were taken from the normal upper arm skin of 45 HIV+ patients and of 15 healthy controls. HIV+ individuals were divided into three categories according to their CD4 cell blood count (&lt;200, 200-499 and ³500/µl). Hematoxylin-eosin was used to stain tissue sections for morphological analysis and immunohistochemistry was used for the evaluation of the frequency of macrophages, Langerhans cells, and CD lymphocyte subsets. In addition, semiquantitative...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Skin immune system; CD8 T cells; CD4-CD8 ratio; Langerhans cells.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500017

The vulnerability of Brazilian female prisoners to HIV infection
Provedor de dados: 56
Autores: Strazza,L.; Azevedo,R.S.; Carvalho,H.B.; Massad,E.
The purpose of the present study was to determine the vulnerability of women in prison to HIV infection. The study was carried out from August to October 2000 in a São Paulo State Penitentiary, where 299 female prisoners were serving time. We interviewed and obtained a blood sample from 290 females who agreed to enter the study. Sera were tested for the presence of antibodies to HIV, hepatitis C virus (HCV) and syphilis and the odds ratio (OR) was calculated for variables related to HIV positivity on the basis of a questionnaire. The overall prevalence data were: 13.9% for HIV (37 of 267), 22.8% for syphilis (66 of 290), and 16.2% for HCV (47 of 290). Sexual partnership variables were significantly related to HIV infection. These included HIV-positive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; HCV; Syphilis; Vulnerable populations; Women; Prisoners.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500020

Multiple facets of HIV-associated renal disease
Provedor de dados: 56
Autores: da Silva,D.R.; Gluz,I.C.; Kurz,J.; Thomé,G.G.; Zancan,R.; Bringhenti,R.N.; Schaefer,P.G.; dos Santos,M.; Barros,E.J.G.; Veronese,F.V.
HIV infection has a broad spectrum of renal manifestations. This study examined the clinical and histological manifestations of HIV-associated renal disease, and predictors of renal outcomes. Sixty-one (64% male, mean age 45 years) HIV patients were retrospectively evaluated. Clinical presentation and renal histopathology were assessed, as well as CD4 T-cell count and viral load. The predictive value of histological lesion, baseline CD4 cell count and viral load for end-stage renal disease (ESRD) or death were determined using the Cox regression model. The outcomes of chronic kidney disease (CKD) and ESRD or death were evaluated by baseline CD4 cell count. The percent distribution at initial clinical presentation was non-nephrotic proteinuria (54%), acute...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Renal disease; Proteinuria; Collapsing focal segmental glomerulosclerosis; CD4 cell count; Chronic kidney disease.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400709

Human group C rotavirus in children with diarrhea in the Federal District, Brazil
Provedor de dados: 56
Autores: Teixeira,J.M.S.; Camara,G.N.N.L.; Pimentel,P.F.V.; Ferreira,M.N.R.; Ferreira,M.S.R.; Alfieri,A.A.; Gentsch,J.R.; Leite,J.P.G.
Group C rotaviruses are fastidious in their in vitro cell culture requirements. Recent serosurveys indicate that antibody to group C rotavirus is present in 3-45% of the human population in certain geographic locations, suggesting that rotavirus group C infection is more prevalent than previously believed and that the low rate of detection of these agents is probably due to the lack of sensitive diagnostic assays. From March to December 1994, 406 fecal specimens were collected from children under five years of age who were outpatients at the emergency services of nine public hospitals in Brasília, Federal District, Brazil. In addition to the samples from children, one public outpatient unit requested virological investigation of a stool sample from an...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Group C rotavirus; Diarrhea; HIV; RT-PCR; Probe hybridization.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001100005

Urinary NO3 excretion and renal failure in indinavir-treated patients
Provedor de dados: 56
Autores: Eira,M.; Araujo,M.; Seguro,A.C.
Treatment with indinavir (IDV), a protease inhibitor, is frequently associated with renal abnormalities. We determined the incidence of renal failure (creatinine clearance &lt;80 mL min-1 1.73 (m²)-1) in HIV patients treated with highly active antiretroviral therapy, including IDV, and investigated the possible mechanisms and risk factors of IDV nephrotoxicity. Thirty-six patients receiving IDV were followed for 3 years. All were assessed for age, body weight, duration of infection, duration of IDV treatment, sulfur-derivative use, total cholesterol, triglycerides, magnesium, sodium, potassium, creatinine, and urinalysis. We also determined renal function in terms of creatinine clearance, urine osmolality and fractional excretion of sodium, potassium, and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; Indinavir; Nephrotoxicity; Nitric oxide.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000800009

Cardiovascular complications and increased levels of circulating modified low density lipoprotein in HIV patients and patients with lipodystrophy
Provedor de dados: 56
Autores: Ronchini,K.R.O.M.; Duarte,A.J.S.; Casseb,J.S.R.; Gidlund,M.
The introduction of highly active antiretroviral therapy (HAART) for patients infected with HIV has significantly prolonged the life expectancy and to some extent has restored a functional immune response. However, the premature introduction of HAART has led to a significant and alarming increase in cardiovascular complications, including myocardial infarction and the appearance of abnormal distribution of body fat seen as lipodystrophy. One key element in the development of ischemic coronary artery disease is the presence of circulating and tissue-fixed modified low density lipoprotein (mLDL) that contributes to the initiation and progression of arterial lesions and to the formation of foam cells. Even though not completely elucidated, the most likely...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Oxidized LDL; Modified low density lipoprotein; Lipodystrophy; Coronary artery disease.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000100016

Acute kidney injury in AIDS: frequency, RIFLE classification and outcome
Provedor de dados: 56
Autores: Libório,A.B.; Mota,R.M.S.; Abreu,K.L.S.; Silva,A.E.B.; Araújo,S.M.H.A.; Daher,E.F.
The objective of the present study was to evaluate the characteristics of acute kidney injury (AKI) in AIDS patients and the value of RIFLE classification for predicting outcome. The study was conducted on AIDS patients admitted to an infectious diseases hospital inBrazil. The patients with AKI were classified according to the RIFLE classification: R (risk), I (injury), F (failure), L (loss), and E (end-stage renal disease). Univariate and multivariate analyses were used to evaluate the factors associated with AKI. A total of 532 patients with a mean age of 35 ± 8.5 years were included in this study. AKI was observed in 37% of the cases. Patients were classified as "R" (18%), "I" (7.7%) and "F" (11%). Independent risk factors for AKI were thrombocytopenia...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Acute kidney injury; HIV; AIDS; Prognosis; Mortality; RIFLE.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001100013

Depression and diagnosis of neurocognitive impairment in HIV-positive patients
Provedor de dados: 56
Autores: Pinheiro,C.A.T.; Souza,L.D.M.; Motta,J.V.S.; Kelbert,E.F.; Souza,M.S.; Martins,C.S.R.; Coelho,F.M.C.; Pinheiro,K.A.T.; Pinheiro,R.T.
Neurocognitive impairment (NCI) is frequently observed in patients infected with human immunodeficiency virus (HIV) and results from the compromise of subcortical brain structures by the virus. The manifestations of NCI range from asymptomatic impairment to dementia. In addition to cognitive impairment resulting from HIV infection, other factors such as depression are associated with the loss of cognitive functions. The aim of this study was to estimate the prevalence of NCI in HIV-positive patients in a city in southern Brazil and to establish possible associations for the prevalence of NCI with HIV-related and other risk factors. This cross-sectional study of HIV-positive outpatients was conducted in a specialized care service in the city of Pelotas in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: AIDS; Depression; Neurocognitive; HIV; HAND; CD4.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016001000704

Two variants of HIV-1 B serotype are transmitted heterosexually in São Paulo, Brazil
Provedor de dados: 56
Autores: Casseb,J.; Hong,M.A.; Gonsalez,C.; Brígido,L.F.; Duarte,A.J.S.; Michael-Hendry,R.
HIV-1 variability may have an important impact on transmission and pathogenicity. Better characterization of the HIV epidemic in Brazil is necessary for the development of vaccine trials in this country. We analyzed sera from 108 HIV-1-infected volunteers from São Paulo City to determine serotype and reactivity for V3 motifs of HIV in this population, and the relationship to transmission mode. We concluded that the HIV-1 B serotype is frequent among heterosexually infected women, even in the absence of anal sex, and that two major V3 motifs, GPGR and GWGR, had similar prevalence among women (48% and 52%, respectively) and men (56% and 44%, respectively). We also observed an equal distribution of these strains regardless of their CD4+ T cell counts,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Serotyping; Gp 120 V3 loop; Synthetic peptides; Sexual transmission.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001000002

Target-directed catalytic metallodrugs
Provedor de dados: 56
Autores: Joyner,J.C.; Cowan,J.A.
Most drugs function by binding reversibly to specific biological targets, and therapeutic effects generally require saturation of these targets. One means of decreasing required drug concentrations is incorporation of reactive metal centers that elicit irreversible modification of targets. A common approach has been the design of artificial proteases/nucleases containing metal centers capable of hydrolyzing targeted proteins or nucleic acids. However, these hydrolytic catalysts typically provide relatively low rate constants for target inactivation. Recently, various catalysts were synthesized that use oxidative mechanisms to selectively cleave/inactivate therapeutic targets, including HIV RRE RNA or angiotensin converting enzyme (ACE). These oxidative...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Catalytic metallodrug; Artificial nuclease; Ribonuclease mimic; Artificial protease; HIV; Angiotensin converting enzyme.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000600465

Is arterial stiffness in HIV-infected individuals associated with HIV-related factors?
Provedor de dados: 56
Autores: Monteiro,P.; Miranda-Filho,D.B.; Bandeira,F.; Lacerda,H.R.; Chaves,H.; Albuquerque,M.F.P.M.; Montarroyos,U.R.; Ximenes,R.A.A.
We investigated the association between pulse wave velocity (PWV) and HIV infection, antiretroviral treatment-related characteristics, viral load, immune status, and metabolic changes in a cross-sectional study nested in a cohort of HIV/AIDS patients who have been followed for metabolic and cardiovascular changes since 2007. The study included patients recruited from the cohort (N = 261) and a comparison group (N = 82) of uninfected individuals, all enrolled from April to November 2009. Aortic stiffness was estimated using the carotid-femoral PWV (Complior-Artech, Paris, France). The groups were similar with respect to age, metabolic syndrome, diabetes mellitus, Framingham score, and use of antihypertensive and hypolipidemic medications. Hypertension was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: HIV; AIDS; Antiretroviral therapy; Arterial stiffness; Pulse wave velocity.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900005

Antiretroviral agents and acid-base balance at delivery of the neonate
Provedor de dados: 56
Autores: El-Beitune,P.; Duarte,G.; Morais,E.N. de; Campbell,O.; Spara-Gadelha,P.; Mauad-Filho,F.; Quintana,S.M.; Rodrigues,L.C.
Limited evidence is available regarding antiretroviral (ARV) safety for uninfected infants exposed to these drugs in utero. Our objective was to determine if ARV administered to pregnant women is associated with decreasing umbilical arterial pH and base excess in uninfected infants. A prospective study was conducted on 57 neonates divided into three groups: ZDV group, born to mothers taking zidovudine (N = 20), triple therapy (TT) group, born to mothers taking zidovudine + lamivudine + nelfinavir (N = 25), and control group (N = 12), born to uninfected mothers. Umbilical cord blood was used to determine umbilical artery gases. A test was performed to calculate the sample by comparing means by the unpaired one-tailed t-test, with a = 0.05 and ß = 20%,...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: HIV; Infant toxicity; Pregnancy; Umbilical arterial pH; Apgar scores.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700010

Diagnosis of the pulmonary tuberculosis by polymerase chain reaction: a comparative study between HIV - positive and - negative individuals
Provedor de dados: 58
Autores: Silva,Rosemeri Maurici da; Machado,Tairone; Bazzo,Maria Luiza.
This study was performed to assess the efficiency of polymerase chain reaction (PCR) directly from sputum for the diagnosis of pulmonary tuberculosis by comparison between HIV-positive and HIV-negative individuals. Sputum samples were collected from hospitalized patients admitted with a clinical diagnosis of pulmonary tuberculosis, and subjected to smear microscopy, culture on LJ medium and detection of M. tuberculosis by PCR. Sensitivity, specificity, and predictive values (positive and negative) were calculated using smear and/or culture at day 42 as the gold standard, by comparing the yield in HIV-positive and HIV-negative individuals. Regardless of serostatus, the technique's yield had 62% sensitivity, 70% specificity, 79% positive predictive value,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Tuberculosis; HIV; PCR; Sputum.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822012000100030

Association between soluble biomarkers - microbial translocation, inflammation and cardiovascular risk in HIV- infected individuals: a systematic review
Provedor de dados: 60
Autores: Borato,Danielle Cristyane Kalva; Vellosa,José Carlos Rebuglio.
Microbial translocation is associated with the increased risk of cardiovascular disease in HIV-infected individuals. There is scarce information regarding the possible associations between the biomarkers of microbial translocation, inflammation and cardiovascular risk that can be evaluated in clinical laboratories using plasma or serum samples. This systematic review was conducted according to the PRISMA protocol in order to verify the most used soluble biomarkers of microbial translocation, inflammation and cardiovascular risk, as well as possible associations between them, in HIV-infected individuals. A search was performed using the Medline, Scopus and Web of Science databases to identify existing studies regarding the relationship between microbial...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Microbial translocation; Inflammation; Cardiovascular risk; HIV; Biomarkers.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100614

Widespread use of anti-retroviral therapy elevated the prevalence of dyslipidemia in HIV-infected Chinese patients
Provedor de dados: 60
Autores: Ye,He; Hong,Yu Min; Jing,Song Xiao; Hui,Yang; Juan,Zhang Xiao; Wei,Zhao Yan.
With the widespread use of high-efficiency antiretroviral therapy (HAART), the life expectancy of HIV-infected patients has been significantly extended. However, the metabolic complications among HIV-infected patients treated with HAART have become the most common problem in the world. It is very important to explore the incidence of dyslipidaemia and studies on the role of potential risk factors in HIV-infected Chinese patients treated with HAART are sparse. Therefore, we designed current study, to investigate the effects of therapeutic intervention and continuous information support on the lifestyle of HIV/AIDS patients with dyslipidaemia. Three hundred and six HIV/AIDS patients admitted to the AIDS clinic in Beijing from January 2016 to January 2017...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Metabolic Complications; Lipid; Dyslipidaemia; HIV; HAART.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100636

Pharmaceutical care to pregnant women carrying human immunodeficiency virus
Provedor de dados: 60
Autores: Romeu,Geysa Aguiar; Paiva,Larissa Varela de; Fé,Mariana Mota Moura.
The purpose of this present study was to know the pharmacoepidemiological profile of pregnant women carrying HIV, the prevention actions against vertical transmission, and evaluate the service respecting the patients' level of satisfaction. It was developed a quali-quantitative longitudinal study, with the sample being composed by pregnant women carrying HIV attended at the Pharmaceutical Care Service of a public hospital of Fortaleza - state of Ceará, during the period between January and September, 2007. The data were collected by means of follow-up cards, patients' medical history and, finally, interviews to verify the users' level of satisfaction related to the service. Twenty seven pregnant and parturient women have participated in the study. The mean...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pharmacoepidemiology; Pharmaceutical Care; HIV; Pregnant women/pharmacoepidemiological profile.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000300026

Glycodendritic structures: tools to interact with DC-SIGN
Provedor de dados: 60
Autores: Reina,Jose J.; Rojo,Javier.
The key role of carbohydrates in many biological events has attracted the interest of the scientific community. This fact has demanded the access to new tools necessary to understand this role and the interaction of carbohydrates with their corresponding receptors, lectins. Glycodendrimers and glycodendritic structures in general, have demonstrated to be very efficient and interesting tools to intervene in those processes where carbohydrates participate. In this review, we discuss the different glycodendritic structures that have been used to interfere with DC-SIGN, a very attractive lectin involved in infection processes and in the regulation of the immune response.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: DC-SIGN; Ebola; Glycodendrimers; Glycofullerenes; HIV; Mannose.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000700009

Viviendo con VIH muriendo con SIDA
Provedor de dados: 122
Autores: Bustamante Salamanca, Mónica.
Se presenta la relación entre el discurso, la praxis y la emocionalidad en la construcción y significación de la infección del virus VIH, así como moralismos y relacionamientos que giran en torno a la infección y la muerte en la conciencia de un grupo de personas que viven con VIH/SIDA, sus familias y/o parejas, de quien se colecto información y testimonios.  Se analiza, las múltiples paradojas de la experiencia de vivir y morir con VIH/SIDA, cómo se percibe, las disociaciones y la persistencia de distintas construcciones conceptuales y representaciones mentales circundante a la infección, tanto de las organizaciones internacionales, de las instituciones hospitalarias como de las personas afectadas por el virus.
Tipo: Tesis
Palavras-chave: VIRUS DE INMUNODEFICIENCIA HUMANA; VIH; SÍNDROME DE INMUNO DEFICIENCIA ADQUIRIDA; SIDA; HOMOSEXUALIDAD; MUERTE INMORAL; HUMAN IMMUNODEFICIENCY VIRUS; HIV; ACQUIRED IMMUNE DEFICIENCY SYNDROME; AIDS; HOMOSEXUALITY; IMMORAL DEATH.
Ano: 2010
URL: http://hdl.handle.net/10469/3379