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4-Hydroxy-pyran-2-one and 3-hydroxy-N-methyl-2-oxindole derivatives of Salinispora arenicola from Brazilian marine sediments. Repositório Alice
SILVA, A. B. DA; PINTO, F. DAS C. L.; LOTUFO, L. V. COSTA; COSTA, W. S.; AYALA, A. P.; CANUTO, K. M.; BARROS, A. B.; ARAÚJO, A. J.; FILHO, J. D. B. M.; PESSOA, O. D. L..
bitstream/item/209173/1/ART19131.pdf
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Antimicrobial activity; Salinispora arenicola; Análise; Enterococcus faecalis.
Ano: 2019 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1119005
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4-Nerolidylcatechol induces autophagy in human glioblastoma cells BJPS
Massaro,Renato Ramos; Brohem,Carla Abdo; Almeida,Rebeca Leite de; Rivelli,Diogo Pineda; Miyake,Juliano Andreoli; Colquhoun,Alison; Barros,Silvia Berlanga de Moraes; Maria-Engler,Silvya Stuchi.
ABSTRACT Gliomas account for the majority of primary malignant brain tumors and present invasive behavior into adjacent healthy tissue. While 4-NC had previously shown to induce apoptotic cell death in a melanoma model, for the glioma model described in this paper 4-NC is cytotoxic for the cells with the induction of the autophagic pathway. Trypan blue exclusion assay showed that 4-NC was cytotoxic in a dose-dependent manner for A172 and T98G cell lines. IC10 and IC50 values were at 32 µM and 41 µM for A172 and T98G respectively. Inhibition of cell proliferation was observed by total cell counts and by cell cycle analysis by flow cytometry, with cell cycle arrest of A172 and T98G cell lines respectively in the G1/G0 and S phases of the cell cycle. 4-NC...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 4-Nerolidylcatechol; Glioblastoma; Cytotoxicity; Autophagy.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300618
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4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents J. Venom. Anim. Toxins incl. Trop. Dis.
Rodrigues,Carina Agostinho; Santos,Paloma Freire dos; Costa,Marcela Oliveira Legramanti da; Pavani,Thais Fernanda Amorim; Xander,Patrícia; Geraldo,Mariana Marques; Mengarda,Ana; Moraes,Josué de; Rando,Daniela Gonçales Galasse.
Abstract Background: There is still a need for new alternatives in pharmacological therapy for neglected diseases, as the drugs available show high toxicity and parenteral administration. That is the case for the treatment of leishmaniasis, particularly to the cutaneous clinical form of the disease. In this study, we present the synthesis and biological screening of eight 4-phenyl-1,3-thiazol-2-amines assayed against Leishmania amazonensis. Herein we propose that these compounds are good starting points for the search of new antileishmanial drugs by demonstrating some of the structural aspects which could interfere with the observed activity, as well as suggesting potential macromolecular targets. Methods: The compounds were easily synthesized by the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: 2-aminothiazoles; Antikinetoplastids; Antileishmanial; Cutaneous; Target fishing.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992018000100317
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(4S)-4,8-dihydroxy-1-tetralone and other chemical constituents from Pestalotiopsis sp. EJC07, endophytic fromBauhinia guianensis Anais da ABC (AABC)
Souza,Eleane M.C. de; Silva,Ellon L. Da; Marinho,Andrey M.R.; Marinho,Patrícia S.B..
The present work reports the isolation of eight compounds fromPestalotiopsis sp. EJC07 isolated as endophytic fromBauhinia guianensis, a tipical plant of the Amazon. The compounds (4S)-4,8-dihydroxy-1-tetralone (1), uracil (2), uridin (3), p-hydroxybenzoic acid (4), ergosterol (5), ergosterol peroxide (6), cerevisterol (7) and ducitol (8) were isolated by chromatographic procedures and identified by spectral methods of 1D and 2D NMR and MS. The compound 1 is being reported for the first time in the genusPestalotiopsis.
Tipo: Info:eu-repo/semantics/article Palavras-chave: B. guianensis; Endophityc fungus; Pestalotiopsis; Tetralone.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000100029
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5 PASSOS para aumentar a produtividade do sorgo sacarino visando a produção de etanol. Infoteca-e
Época de semeadura; Uso de sementes com altos percentuais de vigor e de germinação; Espaçamento e densidade de semeadura; Fertilidade do solo; Controle de pragas, doenças e plantas daninhas.
Tipo: Fôlder / Folheto / Cartilha (INFOTECA-E) Palavras-chave: Sorghum bicolor; Rendimento.
Ano: 2012 URL: http://www.infoteca.cnptia.embrapa.br/handle/doc/937338
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50 Anos de informações meteorológicas de Bento Gonçalves, RS: análise descritiva. Infoteca-e
CZERMAINSKI, A. B. C.; ZAT, D. A..
2011
Tipo: Comunicado Técnico (INFOTECA-E) Palavras-chave: Estação meteorológica; Embrapa Uva e Vinho; Bento Gonçalves; História; Clima; Meteorologia; Agricultura; Temperatura; Chuva; Vento; Informação; Base de dados.
Ano: 2011 URL: http://www.infoteca.cnptia.embrapa.br/handle/doc/913632
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50 anos de P&D em citros no Nordeste brasileiro Repositório Alice
PASSOS, O. S..
A história da citricultura brasileira relaciona-se à própria história do País. Poucos anos depois do descobrimento, entre 1530 e 1540, os portugueses introduziram as primeiras sementes de laranja doce (Citrus sinensis) no Estado da Bahia. Fatos auspiciosos ocorreram no século XIX relacionados aos citros na região: o surgimento da laranja 'Bahia' (C. sinensis) no bairro do Cabula, em Salvador, contribuindo para o desenvolvimento da citricultura nos cinco continentes após sua introdução na Califórnia (EUA) e a exportação de laranjas doces do Ceará para Londres.
Tipo: Artigo em anais de congresso (ALICE) Palavras-chave: Citros.
Ano: 2012 URL: http://www.alice.cnptia.embrapa.br/handle/doc/941986
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50 anos de pesquisas em limnologia na Amazônia Acta Amazonica
Sioli,Harald.
Constitui-se o presente trabalho da transcrição integral da palestra realizada pelo Dr. Harald Sioli (1910-2004) no Seminário da Amazônia, em 10 de agosto de 1990, quando numa última viagem ao Amazonas, ao completar 80 anos de idade, foi homenageado pelos colegas e a convite do INPA falou sobre "50 anos de pesquisas em limnologia na Amazônia" que, segundo suas próprias palavras, foram "os dias mais decisivos de minha vida". O texto pode ser dividido em duas partes: a primeira se refere à história pessoal - da chegada ao Brasil, de como descobriu a Amazônia e sobreviveu, no interior do Amazonas e Pará, à 2.ª Guerra Mundial, até se tornar pesquisador do INPA e firmar o Convênio INPA/Max Planck. A segunda parte fala da sua pesquisa em limnologia, fazendo...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Amazônia; Limnologia; Clima equatorial; Quimismo.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672006000300001
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50 perguntas, 50 respostas sobre a Carne Carbono Neutro (CCN). Infoteca-e
ALVES, F. V.; ALMEIDA, R. G. de; LAURA, V. A.; PORFIRIO-DA-SILVA, V.; GOMES, R. da C.; MACEDO, M. C. M.; PEREIRA, M. de A.; FERREIRA, A. D.; BUNGENSTAB, D. J..
Este documento técnico busca trazer, de forma didática, respostas simples e em linguagem acessível às principais questões levantadas por produtores, técnicos, pesquisadores e público em geral, em relação à marca-conceito CCN. Foi elaborado por especialistas em sistemas de produção integrados e de produção de bovinos, entre eles os criadores da marca-conceito CCN. Desta forma, apresentamos o que há de mais qualificado e preciso em informações técnicas sobre o CCN. A forma escolhida, 50 perguntas e 50 respostas, tem como intuito trazer objetividade e clareza ao assunto e contribuir para o entendimento e difusão das premissas, elementos e requisitos do processo CCN, do sistema de produção ao produto final.
Tipo: Documentos (INFOTECA-E) Palavras-chave: Certificação de Produto; Gado de Corte; Efeito Estufa; Impacto Ambiental.
Ano: 2018 URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/1093170
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5-Bromo-2’-deoxyuridine induces visible morphological alteration in the DNA puffs of the anterior salivary gland region of Bradysia hygida (Diptera, Sciaridae) BJMBR
de Almeida,J.C.; Sauaia,H.; Viana,J.C..
5-Bromo-2’-deoxyuridine (BrdUrd) has long been known to interfere with cell differentiation. We found that treatment ofBradysia hygida larvae with BrdUrd during DNA puff anlage formation in the polytene chromosomes of the salivary gland S1 region noticeably affects anlage morphology. However, it does not affect subsequent metamorphosis to the adult stage. The chromatin of the chromosomal sites that would normally form DNA puffs remains very compact and DNA puff expansion does not occur with administration of 4 to 8 mM BrdUrd. Injection of BrdUrd at different ages provoked a gradient of compaction of the DNA puff chromatin, leading to the formation of very small to almost normal puffs. By immunodetection, we show that the analogue is preferentially...
Tipo: Info:eu-repo/semantics/article Palavras-chave: DNA puffs; BrdUrd; Gene amplification; Polytene chromosomes; Salivary glands; Sciaridae.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200002
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5-HT1A autoreceptor modulation of locomotor activity induced by nitric oxide in the rat dorsal raphe nucleus BJMBR
Gualda,L.B.; Martins,G.G.; Müller,B.; Guimarães,F.S.; Oliveira,R.M.W..
The dorsal raphe nucleus (DRN) is the origin of ascending serotonergic projections and is considered to be an important component of the brain circuit that mediates anxiety- and depression-related behaviors. A large fraction of DRN serotonin-positive neurons contain nitric oxide (NO). Disruption of NO-mediated neurotransmission in the DRN by NO synthase inhibitors produces anxiolytic- and antidepressant-like effects in rats and also induces nonspecific interference with locomotor activity. We investigated the involvement of the 5-HT1A autoreceptor in the locomotor effects induced by NO in the DRN of male Wistar rats (280-310 g, N = 9-10 per group). The NO donor 3-morpholinosylnomine hydrochloride (SIN-1, 150, and 300 nmol) and the NO scavenger...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Dorsal raphe nucleus; Nitric oxide; Serotonin; 5-HT1A receptor; Locomotor activity.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000400010
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5-Methyltetrahydrofolate-homocysteine methyltransferase gene polymorphism (MTR) and risk of head and neck cancer BJMBR
Galbiatti,A.L.S.; Ruiz,M.T.; Biselli-Chicote,P.M.; Raposo,L.S.; Maniglia,J.V.; Pavarino-Bertelli,E.C.; Goloni-Bertollo,E.M..
The functional effect of the A>G transition at position 2756 on the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase), involved in folate metabolism, may be a risk factor for head and neck squamous cell carcinoma (HNSCC). The frequency of MTR A2756G (rs1805087) polymorphism was compared between HNSCC patients and individuals without history of neoplasias. The association of this polymorphism with clinical histopathological parameters was evaluated. A total of 705 individuals were included in the study. The polymerase chain reaction-restriction fragment length polymorphism technique was used to genotype the polymorphism. For statistical analysis, the chi-square test (univariate analysis) was used for comparisons between groups and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Head and neck cancer; Polymorphism; Folate metabolism; MTR gene.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500005
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5S rDNA characterization in twelve Sciaenidae fish species (Teleostei, Perciformes): depicting gene diversity and molecular markers Genet. Mol. Biol.
Alves-Costa,Fernanda A.; Martins,Cesar; Matos,Fernanda Del Campos de; Foresti,Fausto; Oliveira,Claudio; Wasko,Adriane P..
In order to extend the genetic data on the Sciaenidae fish family, the present study had the purpose to characterize PCR-generated 5S rDNA repeats of twelve species of this group through PAGE (Polyacrylamide Gel Electrophoresis) analysis. The results showed the occurrence of at least two different 5S rDNA size classes in all the species. Moreover, 5S rDNA repeats of one of the studied species - Isopisthus parvipinnis - were cloned and subjected to nucleotide sequencing and Southern blot membrane hybridization analyses, which permitted to confirm the existence of two major 5S rDNA classes. Phylogenetic analysis based on the nucleotide sequences of different 5S rDNA repeats of I. parvipinnis lead to their separation into two major clusters. These results may...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Sciaenidae; Fish; Isopisthus parvipinnis; 5S rDNA; Molecular markers.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000200025
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5th Food Safety and Security Symposium: food and health Ciênc. Tecnol. Aliment.
NITZKE,Julio Alberto; CLADERA,Florencia; THYS,Roberta; DA CRUZ,Fabiana Thomé; MARTINELLI,Sônia.
Abstract The 5º Simpósio de Segurança Alimentar (5th Food Safety and Security Symposium) was held in May, 2015, in Bento Gonçalves, RS, Brazil with the objective of discussing the interrelation between food and health, in various perspectives. This paper reviews the state of the art regarding all the issues discussed during the Symposium, connecting them with the lectures presented at the conference. As final remarks, it was perceived that the interrelation between food and health is growing stronger and cannot be discussed without involving the different areas involved.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Food safety; Food security; Food and health.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612016000500001
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6 weeks consumption of pure fresh coconut milk caused up-regulation of eNOS and CSE protein expression in middle-aged male rats BJPS
Jansakul,Chaweewan; Naphatthalung,Jomkarn; Pradab,Sakda; Yorsin,Somruedee; Kanokwiroon,Kanyanatt.
Coconut milk (CCM) has been an important cooking ingredient in the Asia-Pacific region since ancient time. Due to its high content of saturated fatty acids, it has been considered atherogenic. We have tested if chronic consumption of fresh coconut milk by middle-aged male rat affects vascular function, plasma glucose and lipid profiles. Compared to control, CCM caused lower maximal contraction to phenylephrine of thoracic aortic rings and increased relaxation to acetylcholine that was abolished by N G-nitro-L-arginine (L-NA) or disruption of the endothelium. DL-propargylglycine caused slight increase in baseline tension of L-NA treated aortic rings of CCM-treated rats and produced higher contractile response of the aortic rings to low concentrations of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Coconut milk; NO. H2S; Plasma glucose; Thoracic aorta.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300608
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60Co GAMMA RADIATION EFFECTS ON Apis mellifera VENOM: BIOCHEMICAL, PHARMACOLOGICAL, AND IMMUNOLOGICAL ASPECTS J. Venom. Anim. Toxins
Costa,H..
Tipo: Info:eu-repo/semantics/review
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000100016
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6-Benzilaminopurina e ácido indolbutírico na multiplicação in vitro da amoreira - preta (Rubus idaeus L.), cv. Tupy Ciência Rural
Erig,Alan Cristiano; De Rossi,Andrea; Fortes,Gerson Renan de Luces.
O presente trabalho avaliou o efeito de diferentes níveis de BAP (0; 2; 4; 6; 8 e 10miM) e de AIB (0; 0,5 e 1miM) na multiplicação in vitro da amoreira-preta cv. Tupy. O meio utilizado foi o MS suplementado com 100mg.<IMG SRC="http:/img/fbpe/cr/v32n5/11864s1.gif">-1 de mio-inositol, 30g.<IMG SRC="http:/img/fbpe/cr/v32n5/11864s1.gif">-1 de sacarose e 6g.<IMG SRC="http:/img/fbpe/cr/v32n5/11864s1.gif">-1 de ágar. Após a inoculação, as culturas foram mantidas em sala de cultura com 16 horas de fotoperíodo, temperatura de 25 ± 2ºC e radiação de 25µmoles.m-2.s-1. O número de gemas e o número de brotações foram avaliados com intervalo semanal, num total de quatro avaliações, e, na última avaliação, considerou-se a altura da brotação, bem como...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Reguladores de crescimento; Micropropagação; Cultura de tecidos.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782002000500005
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6-Bromoindirubin-3’-oxime promotes osteogenic differentiation of canine BMSCs through inhibition of GSK3β activity and activation of the Wnt/β-catenin signaling pathway Anais da ABC (AABC)
ZHAO,XIAO-E; YANG,ZHENSHAN; GAO,ZHEN; GE,JUNBANG; WEI,QIANG; MA,BAOHUA.
This study aimed to investigate how 6-bromoindirubin-3’-oxime (BIO) increases the osteogenic differentiation of canine bone mesenchymal stem cells (BMSCs) and the role of the Wnt/β-catenin signaling pathway in this process. We mimicked the effect of Wnt by adding BIO to the culture medium of BMSCs and examined whether canonical Wnt signaling positively affects the differentiation of these cells into osteoblasts. Canine BMSCs were cultured with 0.5 and 1.0 μM BIO under osteogenic conditions and then differentiation markers were investigated. It was found that BIO significantly increased the activity of alkaline phosphatase (ALP), the number of ALP-positive cells, the mineralization level and calcium deposits. Moreover, cells cultured with 0.5 and 1.0 μM...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bone mesenchymal stem cells; Bromoindirubin oxime; Osteogenetic differentiation; Canine.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100610
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6-Gingerol inhibits hair cycle via induction of MMP2 and MMP9 expression Anais da ABC (AABC)
HOU,CHUN; MIAO,YONG; JI,HANG; WANG,SUSHENG; LIANG,GANG; ZHANG,ZHIHUA; HONG,WEIJIN.
ABSTRACT 6-Gingerol is the major active constituent of ginger. In the current study, we aimed to investigate the mechanisms underlying the effects of 6-Gingerol on hair growth. Mice were randomly divided into five groups; after hair depilation (day 0), mice were treated with saline, or different concentrations of 6-Gingerol for 11 days. The histomorphological characteristics of the growing hair follicles were examined after hematoxylin and eosin staining. The results indicated that 6-Gingerol significantly suppressed hair growth compared with that in the control group. And choose the concentration of 6-Gingerol at 1 mg/mL to treated with mice. Moreover, 6-Gingerol (1 mg/mL) significantly reduced hair re-growth ratio, hair follicle number, and hair follicle...
Tipo: Info:eu-repo/semantics/article Palavras-chave: MMP2; MMP9; 6-Gingerol; Hair growth.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652017000602707
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6-n-propyltiouracil (PROP) taster status in Brazilian adults Ciênc. Tecnol. Aliment.
Von Atzingen,Maria Carolina Batista Campos; Silva,Maria Elisabeth Machado Pinto e.
The objective of this study was to determine PROP (6-n-propyltiouracil) taster status in adults and its relationship with anthropometric variables and pleasantness of sugar, salt, and fat. A total of 123 subjects rated the intensity of PROP and sodium cloride (NaCl) solutions using the labeled magnitude scale. For pleasantness evaluation, it was used concentrated orange juice (sugar) and mashed potato (salt and fat). The subjects were classified as non-tasters (n = 35), medium-tasters (n = 33) and super-tasters (n = 55). In this study, no relationship was found between PROP taster status and age, sex, weight, body mass index, and pleasantness. Although genetic markers may influence the degree of liking of certain foods, one must consider that the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Propylthiouracil; Body mass index; Pleasantness.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612012000400006
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