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Development studies of captopril certified reference material BJPS
Nogueira,Raquel; Rego,Eliane Cristina Pires do; Sousa,Marcus Vinicius Barreto; Wollinger,Wagner; Silva,Thaís Elias da; Moreira,Gabriela Fernandes; Barin,Juliano Smanioto; Laporta,Luciane Varini; Mesko,Márcia Foster; Bittencourt,Celso Figueiredo; Rodrigues,Janaína Marques; Cunha,Valnei Smarçaro da.
This paper describes the studies performed with the candidate Certified Reference Material (CRM) of captopril, the first CRM of an active pharmaceutical ingredient (API) in Brazil, including determination of impurities (organic, inorganic and volatiles), homogeneity testing, short- and long-term stability studies, calculation of captopril content using the mass balance approach, and estimation of the associated measurement uncertainty.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Captopril/qualitative analysis; Medicines/Certified Reference Standards; Medicines/analytical quality control; High Pressure Liquid Chromatography (HPLC)/qualitative analysis; Medicines/contamination.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200015
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Validation of a liquid chromatographic method for determination of related substances in a candidate certified reference material of captopril BJPS
Nogueira,Raquel; Wollinger,Wagner; Silva,Thaís Elias da; Oliveira,Leonardo Mesquita de; Rego,Eliane Cristina Pires do; Moreira,Gabriela Fernandes; Barin,Juliano Smanioto; Laporta,Luciane Varini; Mesko,Márcia Foster; Bittencourt,Celso Figueiredo; Rodrigues,Janaína Marques; Cunha,Valnei Smarçaro da.
This paper describes the validation of a reversed-phase high performance liquid chromatography method (RP-HPLC) with diode array detection (DAD) for determination of related substances (impurities from organic synthesis and degradation products) of captopril according to the Brazilian Pharmacopeia IV. The aim of this study was to guarantee the method accuracy for quantification of related substances, an essential requisite to determine, using the mass balance approach, the captopril content in the first Brazilian certified reference material (CRM) of an active pharmaceutical ingredient (API), developed by Inmetro. The captopril instability in solution is discussed and the captopril content determined by mass balance is compared to the results from...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Captopril/qualitative analysis; Medicines/analysis; Medicines/method validation; Medicines/analytical quality control; High performance liquid chromatography/qualitative analysis; Medicines/contamination; Captopril/certified reference standards.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200016
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Investigation of glutathione peroxidase activity in chicken meat under different experimental conditions Ciênc. Tecnol. Aliment.
Cichoski,Alexandre José; Rotta,Renata Bezerra; Scheuermann,Gerson; Cunha Junior,Anildo; Barin,Juliano Smanioto.
Due to the fact that previous studies on the enzymatic activity of Glutathione peroxidase (GSH-Px) diverge widely in their methodology and results, this study aimed to investigate the influence of different analytical conditions on GSH-Px activity in chicken thighs from broilers that were fed different diets with different sources and concentrations of selenium. GSH-Px activity was evaluated six hours after slaughter and 120 days after frozen storage at -18 ºC. The different analytical conditions included time of pre-incubation (0, 10 and 30 minutes), reaction medium, types of substrate (H2O2 (0.72 mM, 7.2 mM, and 72 mM) and Terc-butil hydroperoxide 15 mM), and different buffer concentrations (buffer 1, potassium phosphate 50 mM pH 7.0 + EDTA 1 mM +...
Tipo: Info:eu-repo/semantics/article Palavras-chave: GSH-Px; Meat chicken; Enzymatic activity; Selenium; Buffers; Substrate.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612012000400004
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Extraction, characterization and microencapsulation of isoflavones from soybean molasses Ciência Rural
Batista,Vanessa Sabrina Fagundes; Nunes,Graciele Lorenzoni; Viegas,Gabriela Ilha; Lucas,Bruna Nichelle; Bochi,Vivian Caetano; Emanuelli,Tatiana; Barin,Juliano Smanioto; Menezes,Cristiano Ragagnin de; Rosa,Claudia Severo da.
ABSTRACT: This study aimed to extract isoflavones from soybean molasses with different solvents, furthermore, the selected extract, which showed overall desirable characteristics was selected to evaluate the potentials of different encapsulating agents. The encapsulating agents employed for the study included 18% Maltodextrin DE20 (T1), 18% Hi-maize (T2), and a mixture of equal proportions of 9% Maltodextrin DE20 and 9% of Hi-maize (T3). Solvents such as 80% ethanol and methanol, and grain alcohol in varying different concentrations of 50 and 80% were used for the studies. The best solvent for the extraction of phenolics and total isoflavones was 50% cereal alcohol, this extract also presented higher antioxidant activity. Evaluation of the encapsulating...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Spray-drying; Antioxidant; Phenolics; Isoflavones.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782020000300751
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O ultrassom no amaciamento de carnes Ciência Rural
Alves,Larissa de Lima; Cichoski,Alexandre José; Barin,Juliano Smanioto; Rampelotto,Cristine; Durante,Edgar Cesar.
O ultrassom é uma das novas tecnologias limpas aplicadas a alimentos. Na ciência e tecnologia de carnes, é estudado principalmente quanto à sua capacidade de melhorar a maciez da carne, por mecanismos de cavitação. Alguns parâmetros acústicos como frequência, intensidade e tempo de exposição ao tratamento influenciam na tenderização da carne. Os primeiros estudos determinaram que o uso de altas frequências não apresentaram efeitos na textura, em função de não provocarem cavitação. A intensidade de ultrassom que atinge a matriz cárnea também é importante, sendo que, quando aplicada abaixo de 10W cm-2 ou muito acima desse valor, não se percebe o efeito. O tempo de exposição é dependente da frequência e intensidade utilizadas e influencia diretamente na...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Carne; Cavitação; Maciez; Tecnologia limpa.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782013000800029
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Development, characterization and viability study of probiotic microcapsules produced by complex coacervation followed by freeze-drying Ciência Rural
Silva,Thaiane Marques da; Barin,Juliano Smanioto; Lopes,Eduardo Jacob; Cichoski,Alexandre José; Flores,Erico Marlon de Moraes; Silva,Cristiane de Bona da; Menezes,Cristiano Ragagnin de.
ABSTRACT: Technique of complex coacervation was used to produce microcapsules of Lactobacillus acidophilus La-5 encapsulated in gelatin and gum arabic which were then freeze-drying. Microcapsules were characterized using scanning electron and optical microscopy, and resistance of probiotics was evaluated during release into a simulated gastrointestinal tract and storage at different temperatures. The complex coacervation process produced microcapsules with a high encapsulation efficiency (77.60% and 87.53%), ranging from 127.14-227.05 μm with uniform distribution. Microencapsulation was an efficient approach to achieve significant protection of probiotics against simulated gastrointestinal conditions compared with free cells. Encapsulation also improved...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Microencapsulation; Lactobacillus acidophilus; Gelatin; Gum Arabic.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000700752
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Determinação do teor de umidade em grãos empregando radiação micro-ondas Ciência Rural
Raschen,Matheus Rafael; Lucion,Fernanda Bortoluzzi; Cichoski,Alexandre José; Menezes,Cristiano Ragagnin de; Wagner,Roger; Lopes,Eduardo Jacob; Zepka,Leila Queiroz; Barin,Juliano Smanioto.
A determinação de umidade em grãos é um parâmetro de qualidade importante, uma vez que o teor de água presente no alimento tem influência tanto no armazenamento quanto na comercialização do produto. Os métodos usados como referência na determinação de umidade em grãos empregam a perda por dessecação em estufa (LOD). Apesar de ser de fácil execução, esse método dispende cerca de 24h de aquecimento, normalmente, em 105°C, para obtenção do resultado. No presente estudo, é proposta a determinação da perda por dessecação assistida por radiação micro-ondas (MALOD) para amostras de grãos moídos de arroz branco, arroz integral, ervilha, feijão branco, feijão carioca, feijão preto, grão-de-bico, lentilha e milho, buscando reduzir o tempo de análise. Parâmetros como...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Umidade; Micro-ondas; Grãos; Perda por dessecação; Determinação de água.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014000500026
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Ultrasonic assisted extraction to obtain bioactive, antioxidant and antimicrobial compounds from marcela Ciência Rural
Boeira,Caroline Pagnossim; Piovesan,Natiéli; Soquetta,Marcela Bromberger; Flores,Déborah Cristina Barcelos; Lucas,Bruna Nichelle; Barin,Juliano Smanioto; Rosa,Claudia Severo da; Terra,Nelcindo Nascimento.
ABSTRACT: The aim of this study was to evaluate the effect of extraction conditions on bioactive compounds, as well as on antioxidant activity, and the antimicrobial activity of the extracts with the highest antioxidant characteristics. The extracts were obtained by conventional method and ultrasound-assisted extraction at various temperatures (20°C, 40°C and 60°C). Total phenolics, total flavonoids, antimicrobial activity and antioxidant activity were quantified by the methods of DPPH, FRAP, and ORAC, respectively. The conventional extraction method and ultrasound method influenced the phenolic content at all the tested temperatures. Flavonoids were not influenced by extraction methods. The antioxidant activity (DPPH) was highest in the ultrasonic method...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ultrasound; Bioactive compounds; Natural antioxidant; Achyrocline satureioides.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000600201
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Cytotoxicity and antioxidant activity of goldenberry extracts obtained with high intensity ultrasound Ciência Rural
Codevilla,Cristiane Franco; Tischer,Bruna; Gindri,Amanda Leitão; Nogueira-Librelotto,Daniele Rubert; Barin,Juliano Smanioto; Silva,Cristiane de Bona da; Rolim,Clarice Madalena Bueno; Zepka,Leila Queiroz; Menezes,Cristiano Ragagnin de.
ABSTRACT: The high intensity ultrasound-assisted extraction (HIU) is one of the most simple, quick and efficient techniques for the extraction of phenolic and other antioxidant compounds from plants. This is the first application of HIU for the extraction of these compounds from goldenberry fruit. The HIU and conventional extraction techniques showed similar results regarding to phenolic compounds and antioxidant capacity. However, the time required for HIU extraction (5min) was 24 times lower than conventional extraction (120min). Phenolic compounds reported were chlorogenic acid, caffeic acid and rutin. In vitro cytotoxicity assays were used for evaluation of extracts and the results showed that in a wide range of concentration, the extract maintains...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Goldenberry; Sonication; Antioxidant capacity; Cytotoxicity; High performance liquid chromatography.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782018000200752
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Microencapsulation of probiotics using sodium alginate Ciência Rural
Etchepare,Mariana de Araújo; Barin,Juliano Smanioto; Cichoski,Alexandre José; Jacob-Lopes,Eduardo; Wagner,Roger; Fries,Leadir Lucy Martins; Menezes,Cristiano Ragagnin de.
The consumption of probiotics is constantly growing due to the numerous benefits conferred on the health of consumers. In this context, Microencapsulation is a technology that favors the viability of probiotic cultures in food products, mainly by the properties of protection against adverse environmental conditions and controlled release. Currently there are different procedures for microencapsulation using polymers of various types of natural and synthetic origin. The use of sodium alginate polymers is one of the largest potential application in the encapsulation of probiotics because of their versatility, biocompatibility and toxicity exemption. The aim of this review is to present viable encapsulation techniques of probiotics with alginate, emphasizing...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Alginate; Controlled release; Microencapsulation; Probiotics..
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782015000701319
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Improvement of the viability of probiotics (Lactobacillus acidophilus) by multilayer encapsulation Ciência Rural
Menezes,Maria Fernanda da Silveira Cáceres de; Silva,Thaiane Marques da; Etchepare,Mariana de Araújo; Fonseca,Bruna de Souza; Sonza,Vandré Pinto; Codevilla,Cristiane Franco; Barin,Juliano Smanioto; Silva,Cristiane de Bona da; Menezes,Cristiano Ragagnin de.
ABSTRACT: This study produced pectin microcapsules containing Lactobacillus acidophilus by external ionic gelation, followed by the adsorption of whey protein and pectin to form multilayers. The viability of free and microencapsulated lactobacilli was evaluated after in vitro exposure to gastrointestinal conditions. They were also assessed by heat treatment, and stability was examined at -18 °C, 5 °C and 25 °C for 120 days. Exposure to different pHs, simulating passage through the gastrointestinal tract, showed that treatment of the microcapsules with only pectin (LA/P0) and with one and two layers of whey protein (treatments LA/P1 and LA/P3, respectively), were able to protect Lactobacillus acidophilus , with microcapsules increasing the release of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pectin; Whey protein concentrate; External ionic gelation.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000900751
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Composição química de folhas de oliveira (Olea europaea L.) da região de Caçapava do Sul, RS Ciência Rural
Cavalheiro,Caroline Viegas; Rosso,Vandrisa Dellinghausen; Paulus,Eloi; Cichoski,Alexandre José; Wagner,Roger; Menezes,Cristiano Ragagnin de; Barin,Juliano Smanioto.
A oliveira (Olea europaea L.) é uma planta característica da região Mediterrânea que teve seu cultivo disseminado para diversos países do mundo, devido ao grande interesse na produção de olivas e de seu azeite, ricos em ácidos graxos essenciais. As folhas da oliveira podem ser um importante subproduto gerado pela poda das árvores, pois apresentam quantidade significativa de compostos fenólicos e ácidos graxos benéficos à saúde. Tendo em vista a importância da constituição química das folhas de oliveira e o recente cultivo no sul do Brasil, este trabalho teve como objetivo fazer um estudo exploratório sobre a composição centesimal, compostos fenólicos totais, ácidos graxos e minerais presentes nas folhas da cultivar 'Arbequina', cultivada em Caçapava do...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Arbequina; Ácidos graxos; Minerais; Compostos fenólicos.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782014001001874
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Oxygen introduction during extraction and the improvement of antioxidant activity of essential oils of basil, lemon and lemongrass Ciência Rural
Ferreira,Daniele de Freitas; Nora,Flávia Michelon Dalla; Lucas,Bruna Nichelle; Menezes,Cristiano Ragagnin de; Cichoski,Alexandre José; Giacomelli,Sandro Rogério; Wagner,Roger; Barin,Juliano Smanioto.
ABSTRACT: Essential oil extraction is commonly carried out by using the hydrodistillation method, which is described in official compendia of food quality control and medicinal plants. Despite the widespread use of this method, few studies have evaluated the effect of the atmosphere change during extraction on the composition and antioxidant activity of essentials oils. Therefore, a study of oxygen introduction influence during the extraction of essential oils from basil, lemongrass and lemon by hydrodistillation was performed. Total amount of oxygenated compounds (e.g., linalool, camphor, α-terpineol, neral, geranial, eugenol and α-muurolol) increased for all essential oils extracted under oxygen flow. Antioxidant activity evaluated by using the ORAC...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antioxidant activity; Chromatography; ORAC; Volatile oil.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782017000800752
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Encapsulation of Lactobacillus acidophilus and different prebiotic agents by external ionic gelation followed by freeze-drying Ciência Rural
Poletto,Gabriela; Fonseca,Bruna de Souza; Raddatz,Greice Carine; Wagner,Roger; Lopes,Eduardo Jacob; Barin,Juliano Smanioto; Flores,Erico Marlon de Moraes; Menezes,Cristiano Ragagnin de.
ABSTRACT: The aim of this study was to investigate the influence of the addition of prebiotics rice bran, inulin and hi-maize, on the survival of Lactobacillus acidophilus in alginate microparticles obtained by external ionic gelation followed by freeze-drying. The microparticles size ranged from 127.5μm to 234.6μm. Microparticles added from the different prebiotics demonstrated an increase in the protection of the microorganism, which presented greater viability against the gastrointestinal simulation. As for storage under different conditions, rice bran treatment at 25ºC kept probiotics viable for 30 days. Under storage conditions -18°C and 7°C, treatments containing prebiotics hi-maize and rice bran maintained viable probiotic microorganisms for a...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Microencapsulation; Probiotics; Rice bran; Inulin; Hi-maize.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782019000200751
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Treatment of cattle-slaughterhouse wastewater and the reuse of sludge for biodiesel production by microalgal heterotrophic bioreactors Scientia Agricola
Maroneze,Mariana Manzoni; Barin,Juliano Smanioto; Menezes,Cristiano Ragagnin de; Queiroz,Maria Isabel; Zepka,Leila Queiroz; Jacob-Lopes,Eduardo.
Microalgal heterotrophic bioreactors are a potential technological development that can convert organic matter, nitrogen and phosphorus of wastewaters into a biomass suitable for energy production. The aim of this work was to evaluate the performance of microalgal heterotrophic bioreactors in the secondary treatment of cattle-slaughterhouse wastewater and the reuse of microalgal sludge for biodiesel production. The experiments were performed in a bubble column bioreactor using the microalgae Phormidium sp. Heterotrophic microalgal bioreactors removed 90 % of the chemical oxygen demand, 57 % of total nitrogen and 52 % of total phosphorus. Substantial microalgal sludge is produced in the process (substrate yield coefficient of 0.43 mg sludge mg chemical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bioreactor; Agro-industrial wastewater; Microalgae/cyanobacteria.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-90162014000600011
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