Consulta: creatorFacets:"Barros,H.M.T."
Registros recuperados: 7
Data/hora: 26/07/2024 22:08:27

Acute effect of different antidepressants on glycemia in diabetic and non-diabetic rats
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Gomez,R.; Huber,J.; Tombini,G.; Barros,H.M.T.
Diabetic patients have a 20% higher risk of depression than the general population. Treatment with antidepressant drugs can directly interfere with blood glucose levels or may interact with hypoglycemic agents. The treatment of depression in diabetic patients must take into account variations of glycemic levels at different times and a comparison of the available antidepressant agents is important. In the present study we evaluated the interference of antidepressants with blood glucose levels of diabetic and non-diabetic rats. In a first experiment, male adult Wistar rats were fasted for 12 h. Imipramine (5 mg/kg), moclobemide (30 mg/kg), clonazepam (0.25 mg/kg), fluoxetine (20 mg/kg) sertraline (30 mg/kg) or vehicle was administered. After 30 min, fasting...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Depression; Antidepressants; Glucose tolerance; Diabetes; Glycemia.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000100007

Behavioral changes induced by cocaine in mice are modified by a hyperlipidic diet or recombinant leptin
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Erhardt,E.; Zibetti,L.C.E.; Godinho,J.M.; Bacchieri,B.; Barros,H.M.T.
The objective of the present study was to determine if the acute behavioral effects of cocaine acutely administered intraperitoneally (ip) at doses of 5, 10 and 20 mg/kg on white male CF1 mice, 90 days of age, would be influenced by leptin acutely administered ip (at doses of 5, 10 and 20 µg/kg) or by endogenous leptin production enhanced by a high-fat diet. The acute behavioral effects of cocaine were evaluated in open-field, elevated plus-maze and forced swimming tests. Results were compared between a group of 80 mice consuming a balanced diet and a high-fat diet, and a group of 80 mice fed a commercially available rodent chow formula (Ralston Purina) but receiving recombinant leptin (rLeptin) or saline ip. Both the high-fat-fed and rLeptin-treated mice...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Mice; Cocaine; Leptin; Hyperlipidic diet; Interaction.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001200014

Behavioral effects of endogenous or exogenous estradiol and progesterone on cocaine sensitization in female rats
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Souza,M.F.; Couto-Pereira,N.S.; Freese,L.; Costa,P.A.; Caletti,G.; Bisognin,K.M.; Nin,M.S.; Gomez,R.; Barros,H.M.T.
Cocaine sensitization is a marker for some facets of addiction, is greater in female rats, and may be influenced by their sex hormones. We compared the modulatory effects of endogenous or exogenous estradiol and progesterone on cocaine-induced behavioral sensitization in 106 female rats. Ovariectomized female rats received progesterone (0.5 mg/mL), estradiol (0.05 mg/mL), progesterone plus estradiol, or the oil vehicle. Sham-operated control females received oil. Control and acute subgroups received injections of saline, while the repeated group received cocaine (15 mg/kg, ip) for 8 days. After 10 days, the acute and repeated groups received a challenge dose of cocaine, after which locomotion and stereotypy were monitored. The estrous cycle phase was...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cocaine; Locomotor activity; Female rats; Estradiol; Progesterone; Stereotypic activity.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000600505

Effect of pilocarpine mouthwash on salivary flow
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Bernardi,R.; Perin,C.; Becker,F.L.; Ramos,G.Z.; Gheno,G.Z.; Lopes,L.R.; Pires,M.; Barros,H.M.T.
Pilocarpine is a cholinergic agonist that increases salivary flow and has been used to treat xerostomia. Oral intake is the most frequent route of administration. Adverse effects are dose-dependent and include sudoresis, facial blushing and increased urinary frequency. The objective of the present study was to evaluate the effects of topical pilocarpine solutions as mouthwashes on salivary flow and their adverse effects on healthy subjects. Forty volunteers received 10 ml 0.5, 1 and 2% pilocarpine solutions or 0.9% saline in a randomized, double-blind, placebo-controlled manner. Salivation was measured before and 45, 60 and 75 min after mouth rinsing for 1 min with 10 ml of saline or pilocarpine solutions. Vital signs were measured and ocular,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Pilocarpine; Mouth rinsing; Mouthwash; Xerostomia; Salivation.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100015

Influence of progesterone on GAD65 and GAD67 mRNA expression in the dorsolateral striatum and prefrontal cortex of female rats repeatedly treated with cocaine
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Souza,M.F.; Toniazo,V.M.; Frazzon,A.P.G.; Barros,H.M.T.
Female rats are intensely affected by cocaine, with estrogen probably playing an important role in this effect. Progesterone modulates the GABA system and attenuates the effects of cocaine; however, there is no information about its relevance in changing GABA synthesis pathways after cocaine administration to female rats. Our objective was to investigate the influence of progesterone on the effects of repeated cocaine administration on the isoenzymes of glutamic acid decarboxylase (GAD65 and GAD67) mRNA in brain areas involved in the addiction circuitry. Ovariectomized, intact and progesterone replacement-treated female rats received saline or cocaine (30 mg/kg, ip) acutely or repeatedly. GAD isoenzyme mRNA levels were determined in the dorsolateral...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cocaine; Progesterone; GAD mRNA; Dorsolateral striatum; Prefrontal cortex.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100011

Plasma insulin levels are increased by sertraline in rats under oral glucose overload
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Gomez,R.; Huber,J.; Lhullier,F.; Barros,H.M.T.
Recognition and control of depression symptoms are important to increase patient compliance with treatment and to improve the quality of life of diabetic patients. Clinical studies indicate that selective serotonin reuptake inhibitors (SSRI) are better antidepressants for diabetic patients than other drugs. However, preclinical trials have demonstrated that not all SSRI reduce plasma glucose levels. In fact, fluoxetine increases and sertraline decreases glycemia in diabetic and non-diabetic rats. In the present study we evaluated plasma insulin levels during fasting and after glucose overload after treatment with sertraline. Adult male Wistar rats were fasted and treated with saline or 30 mg/kg sertraline and submitted or not to glucose overload (N = 10)....
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Depression; Antidepressants; Diabetes; Insulinemia.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001001200009

Pup age and aggressive behavior in lactating rats
Provedor de dados: Brazilian Journal of Medical and Biological Research
Autores: Giovenardi,M.; Consiglio,A.R.; Barros,H.M.T.; Lucion,A.B.
High levels of aggressive behaviors against intruders in the nest area are displayed by female rats during the first 10 days after delivery, declining thereafter to very low levels, even though lactation continues. Cross-fostering experiments were undertaken to test the hypothesis that pup age may affect aggression in lactating rats. The behavior of females on the 8th day after delivery when raising fostered 8-day-old pups was compared to that of females on the 8th postpartum day raising older pups (18 days old) for the last 5 days, and females on the 18th day after delivery raising fostered 18-day-old pups were compared to females in the same postpartum period nursing younger pups (8 days of age at the time of the maternal aggression test) for 5 days. Pup...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Maternal aggression; Mother-infant interaction; Cross-fostering; Prolactin.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000900015