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| Hales,Dana; Dumitrașcu,Dan Lucian; Tomuță,Ioan; Briciu,Corina; Muntean,Dana-Maria; Tefas,Lucia Ruxandra; Iurian,Sonia; Iovanov,Rareș Iuliu; Achim,Marcela; Vlase,Laurian. |
| ABSTRACT The aim of this study was to formulate and prepare compression-coated tablets for colonic release (CR-tablets), and to evaluate the bioavailability of ketoprofen following the administration of a single dose from mini-tablets with immediate release (IR-tablets) compared to CR-tablets. CR-tablets were prepared based on time-controlled hydroxypropylmethylcellulose K100M inner compression-coating and pH-sensitive Eudragit® L 30D-55 outer film-coating. The clinical bioavailability study consisted of two periods, in which two formulations were administered to 6 volunteers, according to a randomized cross-over design. The apparent cumulative absorption amount of ketoprofen was estimated by plasma profile deconvolution. CR-tablets were able to delay... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Colonic delivery; Compression-coated tablets; PH-Dependent release; Time-dependent release; In vitro-in vivo comparison. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400609 |
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