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Mucoadhesive drug delivery systems 60
Carvalho,Flávia Chiva; Bruschi,Marcos Luciano; Evangelista,Raul Cesar; Gremião,Maria Palmira Daflon.
Drug actions can be improved by developing new drug delivery systems, such as the mucoadhesive system. These systems remain in close contact with the absorption tissue, the mucous membrane, releasing the drug at the action site leading to a bioavailability increase and both local and systemic effects. Mucoadhesion is currently explained by six theories: electronic, adsorption, wettability, diffusion, fracture and mechanical. Several in vitro and in vivo methodologies are proposed for studying its mechanisms. However, mucoadhesion is not yet well understood. The aim of this study was to review the mechanisms and theories involved in mucoadhesion, as well as to describe the most-used methodologies and polymers in mucoadhesive drug delivery systems.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mucoadhesion; Bioadhesion; Mucoadhesive systems; Drugs/delivery.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000100002
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Pharmaceutical films made from the waste material from the preparation of propolis extracts: development and characterization 60
Toledo,Lucas de Alcântara Sica de; Bavato,Maíra Isabeli; Rosseto,Hélen Cássia; Cortesi,Rita; Bruschi,Marcos Luciano.
abstract This study investigated the development and characterized the physicochemical properties of films obtained from by-products (BP) from the preparation of propolis extracts. Films were produced in the presence and absence of a polymeric adjuvant (gelatin or ethylcellulose) and propylene glycol by a solvent casting method. Density, surface topography by scanning electron microscopy, mechanical properties (folding endurance, tensile strength and percentage elongation), water vapour permeability (WVP), moisture uptake capacity, thermogravimetry, differential scanning calorimetry and Fourier transform infrared spectroscopy (FTIR) were determined. The films were a transparent, light greenish-yellow colour, with a uniform surface, and were flexible and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Propolis/byproducts; Propolis/use of waste material/films development; Films/propolis byproducts/physicochemical properties; Polymers; Ethylcellulose; Gelatin.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000400847
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