Data/hora: 26/07/2024 23:07:07

Provedor de dados: 	Anais da Academia Brasileira de Ciências	
País: 	Brazil	
Título: 	Elastase-induced pulmonary emphysema: insights from experimental models	
Autores: 	Antunes,Mariana A.; Rocco,Patricia R.M.	
Data: 	2011-12-01	
Ano: 	2011	
Palavras-chave: 	Chronic obstructive pulonary disease; Elastase; Ephysea; Experiental odel; Soke.	
Resumo: 	Several distinct stimuli can be used to reproduce histological and functional features of human emphysema, a leading cause of disability and death. Since cigarette smoke is the main cause of emphysema in humans, experimental researches have attempted to reproduce this situation. However, this is an expensive and cumbersome method of emphysema induction, and simpler, more efficacious alternatives have been sought. Among these approaches, elastolytic enzymes have been widely used to reproduce some characteristics of human cigarette smoke-induced disease, such as: augmentation of airspaces, inflammatory cell influx into the lungs, and systemic inflammation. Nevertheless, the use of elastase-induced emphysema models is still controversial, since the disease pathways involved in elastase induction may differ from those occurring in smoke-induced emphysema. This indicates that the choice of an emphysema model may impact the results of new therapies or drugs being tested. The aim of this review is to compare the mechanisms of disease induction in smoke and elastase emphysema models, to describe the differences among various elastase models, and to establish the advantages and disadvantages of elastase-induced emphysema models. More studies are required to shed light on the mechanisms of elastase-induced emphysema.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000400025	
Editor: 	Academia Brasileira de Ciências	
Relação: 	10.1590/S0001-37652011005000039	
Formato: 	text/html	
Fonte: 	Anais da Academia Brasileira de Ciências  v.83 n.4 2011	
Fonte: 	info:eu-repo/semantics/openAccess