Data/hora: 27/07/2024 01:43:12

Provedor de dados: 	55	
País: 	Brazil	
Título: 	Salmonella enterica serovar typhi: molecular analysis of strains with decreased susceptibility and resistant to ciprofloxacin in india from 2001-2003	
Autores: 	Capoor,Malini R.; Nair,Deepthi; Aggarwal,Pushpa; Mathys,Vanessa; Dehem,Marie; Bifani,Pablo Juan.	
Data: 	2007-08-01	
Ano: 	2007	
Palavras-chave: 	Salmonella enterica; S.Typhi; Ciprofloxacin; Resistance.	
Resumo: 	Chromosomally-mediated reduced susceptibility to ciprofloxacin narrows the therapeutic options in enteric fever. We made a molecular comparison of clinical isolates of fluoroquinolone-resistant strains of Salmonella enterica serotype Typhi from January 2001 to May 2003; 178 isolates were subjected to antimicrobial susceptibility testing by the Kirby-Bauer method of disk diffusion, and agar dilution was used to determine the minimum inhibitory concentration (MIC) to ciprofloxacin. Nalidixic-acid resistant strains (NARST) were observed in 51% of the isolates, of which 98.9% had decreased susceptibility (MIC&gt;0.125-1µg/mL) to ciprofloxacin. A single strain (4 µg/mL) was resistant to ciprofloxacin and double mutations were found in the gyrA gene (76 Asp-&gt;Asn, 44 leu-&gt;Ileu). Among seven NARST strains with reduced susceptibility, a single mutation was found in five strains, one of which had 76 Asp-&gt;Asn and two each had mutations at 87 Asp-&gt;Asn and 72 Phe-&gt;Tyr, respectively); no mutations could be detected in two isolates. Routine antimicrobial surveillance, coupled with molecular analysis of fluoroquinolone resistance, is crucial for revision of enteric fever therapeutics.	
Tipo: 	Info:eu-repo/semantics/article	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000400011	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702007000400011	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.11 n.4 2007	
Fonte: 	info:eu-repo/semantics/openAccess