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| Courtois, Anthony; Berthou, Christian; Guezennec, Jean; Boisset, Claire; Bordron, Anne. |
| The complement system is involved in the defence against bacterial infection, or in the elimination of tumour cells. However, disturbances in this system contributes to the pathogenesis of various inflammatory diseases. The efficiency of therapeutic anti-tumour antibodies is enhanced when the complement system is stimulated. In contrast, cancer cells are able to inhibit the complement system and thus proliferate. Some marine molecules are currently being developed as new drugs for use in humans. Among them, known exopolyssacharides (EPSs) generally originate from fungi, but few studies have been performed on bacterial EPSs and even fewer on EPSs extracted from deep-sea hydrothermal vent microbes. For use in humans, these high molecular weight EPSs must be... |
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| Ano: 2014 |
URL: http://archimer.ifremer.fr/doc/00198/30963/29337.pdf |
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| Courtois, Anthony; Simon-colin, Christelle; Boisset, Claire; Berthou, Christian; Deslandes, Eric; Guezennec, Jean; Bordron, Anne. |
| Many biological properties of algae have been found to have useful applications in human health, particularly in the fields of oncology and immunology. Floridoside, extracted from the red alga Mastocarpus stellatus, has a structure similar to the xenoantigen Gal alpha 1-3 Gal. This xenoantigen has been described to induce a high immune response in human xenografts and is mediated by natural anti-gal antibodies that activate the classical complement pathway. Based on this property, we analyzed the potential activities of floridoside on the immune system. We demonstrated that floridoside activates a complement cascade via the classical complement pathway, through the recruitment and activation of natural IgM. This algal molecule could represent an important... |
| Tipo: Text |
Palavras-chave: Complement system; Immunomodulation; Marine algae; Alpha galactosyl glycerol. |
| Ano: 2008 |
URL: http://archimer.ifremer.fr/doc/2008/publication-6248.pdf |
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| Maillet, A; Congy Jolivet, N; Le Guellec, S; Vecellio, L; Hamard, S; Courty, Y; Courtois, Anthony; Gauthier, F; Diot, P; Thibault, G; Lemarie, E; Heuze Vourc' H, N. |
| Purpose. Despite an increasing interest in the use of inhalation for local delivery of molecules for respiratory diseases and systemic disorders, methods to deliver therapy through air-ways has received little attention for lung cancer treatment. However, inhalation of anticancer drugs is an attractive alternative route to systemic administration which results in limited concentration of the medication in the lungs, and triggers whole-body toxicity. In this study, we investigated the feasibility of nebulization for therapeutic antibodies, a new class of fully-approved anticancer drugs in oncology medicine. Materials and methods. Cetuximab, a chimeric IgG1 targeting the epidermal growth factor receptor (EGER), was nebulized using three types of delivery... |
| Tipo: Text |
Palavras-chave: Nebulizer; Lung cancer; Cetuximab; Anticancer antibody; Aggregation; Aerosol. |
| Ano: 2008 |
URL: http://archimer.ifremer.fr/doc/2008/publication-4201.pdf |
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| Moppert, Xavier; Le Costaouec, Tinaig; Raguenes, Gerard; Courtois, Anthony; Simon-colin, Christelle; Crassous, Philippe; Costa, Bernard; Guezennec, Jean. |
| A bacterium isolated from microbial mats located on a polynesian atoll produced a high molecular weight (3,000 kDa) and highly sulphated exopolysaccharide. Previous studies showed that the chemical structure of this EPS consisted of neutral sugars, uronic acids, and high proportions of acetate and sulphate groups. The copper- and iron-binding ability of the purified pre-treated native EPS was investigated. Results showed that this EPS had a very high affinity for both copper (9.84 mmol g(-1) EPS) and ferrous iron (6.9 mmol g(-1) EPS). Amazingly, this EPS did not show any affinity for either ferric ions or selenium salts. This finding is one of the first steps in assessing the biotechnological potential of this polysaccharide. |
| Tipo: Text |
Palavras-chave: Sulphated exopolysaccharide; Microbial mats; Iron; Copper; Binding capacity. |
| Ano: 2009 |
URL: http://archimer.ifremer.fr/doc/2009/publication-6397.pdf |
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