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Is the emergence of fungal resistance to medical triazoles related to their use in the agroecosystems? A mini review BJM
Ribas e Ribas,Aícha Daniela; Spolti,Pierri; Del Ponte,Emerson Medeiros; Donato,Katarzyna Zawada; Schrekker,Henri; Fuentefria,Alexandre Meneghello.
Abstract Triazole fungicides are used broadly for the control of infectious diseases of both humans and plants. The surge in resistance to triazoles among pathogenic populations is an emergent issue both in agriculture and medicine. The non-rational use of fungicides with site-specific modes of action, such as the triazoles, may increase the risk of antifungal resistance development. In the medical field, the surge of resistant fungal isolates has been related to the intensive and recurrent therapeutic use of a limited number of triazoles for the treatment and prophylaxis of many mycoses. Similarities in the mode of action of triazole fungicides used in these two fields may lead to cross-resistance, thus expanding the spectrum of resistance to multiple...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cross-resistance; Emerging fungal pathogens; Fungicide sensitivity; Agriculture; Medicine.
Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400793
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Antifungal activity against Cryptococcus neoformans strains and genotoxicity assessment in human leukocyte cells of Euphorbia tirucalli L. BJM
Oliveira,Luís Flávio Souza de; Fuentefria,Alexandre Meneghello; Klein,Fernanda da Silva; Machado,Michel Mansur.
In the last times, focus on plant research has increased all over the world. Euphorbia tirucalli L., a plant known popularly as Aveloz, and originally used in Africa, has been drawing attention for its use in the United States and Latin America, both for use as an ornamental plant and as a medicinal plant. E. tirucalli L. is a member of the family Euphorbiaceae and contains many diterpenoids and triterpenoids, in particular phorbol esters, apparently the main constituent of this plant, which are assumed to be responsible for their activities in vivo and in vitro. The in vitro antifungal activities of Euphorbia tirucalli (L.) against opportunistic yeasts were studied using microbroth dilution assay. The results showed that aqueous extract and latex...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Euphorbia tirucalli L.; Aveloz; Antifungal; Cryptococcus neoformans.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000400027
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Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans BJPS
Rocha,Letícia Fernandes da; Pippi,Bruna; Fuentefria,Alexandre Meneghello; Mezzari,Adelina.
The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were evaluated using checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cryptococcus neoformans; Ibuprofen; Itraconazole; Fluconazole; Synergism.
Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100577
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In Vitro additive effect on griseofulvin and terbinafine combinations against multidrug-resistant dermatophytes BJPS
Lana,Aline Jacobi Dalla; Pippi,Bruna; Carvalho,Anderson Ramos; Moraes,Renata Cougo; Kaiser,Samuel; Ortega,George Gonzalez; Fuentefria,Alexandre Meneghello; Silveira,Gustavo Pozza.
ABSTRACT Griseofulvin (GF) and terbinafine (TF) are commonly used drugs to treat dermatophytosis, a fungal infection of the skin. Today there is an increase in drug resistance to these antifungals which highlight the need for alternative synergistic therapies. Minimum Inhibitory Concentration (MIC) of GF and TF were determined against fungi clinical isolates from local hospitals with values ranging 0.03-2.0 µg mL-1 and 0.24-4.0 µg mL-1, respectively. A checkboard test was used to determine the combination of GF:TF which could induce an additive effect against the fungi isolates Multidrug-resistant isolates showed susceptibility after treatment with 16:2 µg mL-1 GF:TF. An MTT assay further verified that GF and TF combinations have greater additive effect...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Griseofulvin; Terbinafine; Dermatophyte; Multidrug-resistant fungi; Drug combination..
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000200623
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Assessment of the genotoxic impact of pesticides on farming communities in the countryside of Santa Catarina State, Brazil Genet. Mol. Biol.
Salvagni,Jaqueli; Ternus,Raquel Zeni; Fuentefria,Alexandre Meneghello.
The aim of this study was to assess the use of pesticides on farms located in the Lambedor River watershed in Guatambu, State of Santa Catarina, as well as to determine, by micronucleus testing, the risk of genotoxic impact. Samples from locally collected Cyprinus carpio, Hypostomus punctatus, Rhamdia quelen and Oreochromis niloticus gave evidence of a mean increase in micronuclei frequency from 6.21 to 13.78 in 1,000 erythrocytes, a clear indication of the genotoxic potenciality of pesticide residues in regional dams, and their significant contribution to local environmental contamination.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Pesticides; Environment; Micronucleus test.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100021
Registros recuperados: 5
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