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| Tlili,Mounira; Rouatbi,Sonia; Gandia,Fedoua; Hallegue,Dorsaf; Sriha,Badreddine; Yacoubi,Mohamed Taher; Krichah,Raja; Sakly,Mohsen; Rhouma,Khémais Ben; Vaudry,David; Wurtz,Olivier; Tebourbi,Olfa. |
| The aim of this study was to investigate both functionally and structurally bronchodilator effects of Pituitary adenylate cyclase activating peptide (PACAP38) and acetyl-[Ala15, Ala20] PACAP38-polyamide, a potent PACAP38 analog, in rats challenged by methacholine (MeCh). Male Wistar rats were divided randomly into five groups. Groups 1 and 2 inhaled respectively aerosols of saline or increasing doses of MeCh (0.5, 1, 2.12, 4.25, 8.5, 17, 34 and 68mg/L). The other groups received terbutaline (Terb) (250 µg/rat) (10-6 M), PACAP38 (50 µg/rat) (0.1 mM) or PACAP38 analog (50 µg/rat) associated to MeCh from the dose of 4.25 mg/L. Total lung resistances (RL) were recorded before and 2 min after MeCh administration by pneumomultitest equipment. MeCh administration... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pituitary adenylate cyclase activating peptide/effects/inflammatory lung diseases; Pituitary adenylate cyclase/analogs/effects in inflammatory lung diseases; Methacholine; Bronchodilators/effects; Inflammatory lung diseases/treatment. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000300681 |
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