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Inhibition of in vitro CO2 production and lipid synthesis by 2-hydroxybutyric acid in rat brain BJMBR
Silva,A.R.; Ruschel,C.; Helegda,C.; Wyse,A.T.S.; Wannmacher,C.M.D.; Wajner,M.; Dutra-Filho,C.S..
2-Hydroxybutyric acid appears at high concentrations in situations related to deficient energy metabolism (e.g., birth asphyxia) and also in inherited metabolic diseases affecting the central nervous system during neonatal development, such as "cerebral" lactic acidosis, glutaric aciduria type II, dihydrolipoyl dehydrogenase (E3) deficiency, and propionic acidemia. The present study was carried out to determine the effect of 2-hydroxybutyric acid at various concentrations (1-10 mM) on CO2 production and lipid synthesis from labeled substrates in cerebral cortex of 30-day-old Wistar rats in vitro. CO2 production was significantly inhibited (30-70%) by 2-hydroxybutyric acid in cerebral cortex prisms, in total homogenates and in the mitochondrial fraction. We...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Lipid synthesis; Energy metabolism; Cerebral cortex; 2-hydroxybutyric acid.
Ano: 2001 URL:
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