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| Angelis,Daniela Souza Araújo de; Freire,Wilton Santos; Pannuti,Cláudio Sergio; Succi,Regina Célia de Menezes; Machado,Daisy Maria. |
| The CCR5 molecule, a chemokine receptor, is the most important co-receptor for macrophage-tropic HIV-1. A 32-bp deletion in the gene encoding CCR5 (CCR5-del32) confers nearly complete resistance to HIV-1 infection in homozygotes, and slows the rate of progression to AIDS in heterozygous adults. The aim of this study was to describe the CCR5 genotypes and the characteristics of HIV disease progression in perinatally infected children. From a total of 51 children analyzed for the CCR5-del32 mutation, 18 (35%) were considered to be rapid progressors, 28 (55%) were moderate progressors and 5 (10%) were slow progressors. A portion of the CCR5 gene was amplified by PCR from genomic DNA followed by agarose gel electrophoresis. Forty-nine children (96%) carried... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV-1; CCR5 co-receptor; HIV disease progression; Perinatally infected children. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000200004 |
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| Angelis,Daniela Souza Araújo de; Tateno,Adriana Fumie; Diaz,Ricardo Sobhie; Succi,Regina Célia de Menezes; Pannuti,Claudio Sergio; Gouvea,Aida de Fátima Barbosa; Machado,Daisy Maria. |
| Treatment of HIV-1 infection with highly active antiretroviral therapy has led to sustained viral suppression in the plasma in a large number of children. However, studies have suggested that the integrated provirus in resting CD4+ T lymphocytes could be a source of reactivatable virus and maintain drug-resistant virus. We evaluated the resistance-related mutations in children receiving antiretroviral therapy with prolonged viral suppression. Thirty-two peripheral blood mononuclear cell samples from 16 children with viral loads that had been below detection limits for at least 12 months were obtained at two different time points and the DNAs sequenced. The median CD4 cell count was 1,016 cells/mm³ (347-2,588) and 938 cells/mm³ (440-3,038) at the first and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Children; HIV-1; Prolonged viral suppression; Antiretroviral therapy; Antiretroviral resistance. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702011000100011 |
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| Carmo,Fabiana Bononi; Terreri,Maria Teresa; Succi,Regina Célia de Menezes; Beltrão,Suenia Vasconcelos; Gouvea,Aida de Fátima Tomé Barbosa; Paulino,Erica Regina Cruz; Machado,Daisy Maria. |
| ABSTRACT Background: The increase in life expectancy for patients living with human immunodeficiency virus (HIV) infection has resulted in health complications related to a chronic disease. Objectives: To evaluate the prevalence of bone mineral density (BMD) alterations and vitamin D concentrations in HIV-infected children and adolescents and to verify the variations in those parameters during a 12-month interval. Methods: A prospective cohort study with a dual period of evaluation was conducted in 57 patients perinatally HIV-infected and one patient with sexual abuse in early infancy. Demographic, anthropometric, pubertal stage, viral load, T CD4+ cell count and antiretroviral therapy were evaluated. Biochemical tests and total body (TB) and lumbar... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Antiretroviral; Infant; Diagnosis; Metabolism; Bone. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300270 |
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| Machado,Daisy Maria; Gouvêa,Aída de Fátima Barbosa; Cardoso,Maria Regina; Beltrão,Suênia Vasconcelos; Cunegundes,Kelly Simone; Bononi,Fabiana; Almeida,Fernanda; Cavalheiro,Kaline; Angelis,Daniela Souza Araújo de; Succi,Regina Célia de Menezes. |
| This study evaluates clinical, virological and immunological responses to antiretroviral (ARV) therapy based on Lopinavir/ritonovir (LPV/r) in previously protease -inhibitor-experienced children. The study included 29 Brazilian children (median age = 5.91 years) who had failed previous ARV therapy and had begun a regimen based on LPV/r. At 12 months follow-up, a good virological response to LPV/r therapy was defined as achieving an undetectable viral load or as a decrease in plasma HIV RNA levels to > 1 log. A good immunological response was defined as an increase in CD4+ cell count from baseline sufficient to attain a better CDC immune stage classification. The number of infectious episodes 12 months before and 12 months after beginning LPV/r was... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Children; HAART; Lopinavir/ritonavir. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702007000100006 |
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| Palchetti,Cecília Zanin; Szejnfeld,Vera Lúcia; Succi,Regina Célia de Menezes; Patin,Rose Vega; Teixeira,Patrícia Fonseca; Machado,Daisy Maria; Oliveira,Fernanda Luisa Ceragioli. |
| ABSTRACT OBJECTIVE: To evaluate bone mass accrual and determine the influence of clinical, anthropometric, dietary and biochemical parameters on bone mass. METHODS: A cohort study including 35 prepubertal HIV-infected children, between 7 and 12 years, attended at a referral center. At time 1 (T1) and time 2 (T2), patients were assessed according to clinical, anthropometric, dietary, biochemical parameters and bone mineral density (BMD). At T2, patients were divided into prepubertal and pubertal. RESULTS: Despite the increase in bone mass absolute values, there was no improvement in lumbar spine BMD (LSBMD) Z-score (p = 0.512) and worsening in total body BMD (TBMD) Z-score (p = 0.040). Pubertal patients (n = 19) showed higher bone mineral content... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: HIV; Child; Body composition; Bone mineral density. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702015000600623 |
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