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Long non-coding RNA LINC00261 sensitizes human colon cancer cells to cisplatin therapy
Provedor de dados: 56
Autores: Wang,Z.K.; Yang,L.; Wu,L.L.; Mao,H.; Zhou,Y.H.; Zhang,P.F.; Dai,G.H.
Colon cancer is one of the most common digestive tumors. The present study aimed to explore the functional role, as well as the underlying mechanism of long non-coding RNA LINC00261 in colon cancer. Expression of LINC00261 was analyzed in colon cancer cell lines and human normal cell lines. Acquired resistance cell lines were then built and the acquired resistance efficiency was detected by evaluating cell viability. Thereafter, the effects of LINC00261 overexpression on cisplatin-resistant colon cancer cells were measured, as well as cell apoptosis, viability, migration, and invasion. Subsequently, we investigated the interaction of LINC00261 and β-catenin. The results showed that the LINC00261 gene was down-regulated in colon cancer cell lines and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Colon cancer; LINC00261; Β-catenin; Cisplatin resistance; Mechanism.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000200607