Data/hora: 27/07/2024 03:06:31

Provedor de dados: 	Brazilian Journal of Infectious Diseases	
País: 	Brazil	
Título: 	Acute HIV infection with rapid progression to AIDS	
Autores: 	Silva,Marcio de Oliveira; Bastos,Milena; Martins Netto,Eduardo; Gouvea,Nancy Alves de Lima; Torres,Alex Jose Leite; Kallas,Esper; Watkins,David I; Altfeld,Marcus; Brites,Carlos.	
Data: 	2010-06-01	
Ano: 	2010	
Palavras-chave: 	HIV; Acute infection; Progression; AIDS.	
Resumo: 	Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.	
Tipo: 	Info:eu-repo/semantics/report	
Idioma: 	Inglês	
Identificador: 	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016	
Editor: 	Brazilian Society of Infectious Diseases	
Relação: 	10.1590/S1413-86702010000300016	
Formato: 	text/html	
Fonte: 	Brazilian Journal of Infectious Diseases  v.14 n.3 2010	
Fonte: 	info:eu-repo/semantics/openAccess