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Kasahara,D.I.; Perini,A.; Lopes,F.D.T.Q.S.; Arantes-Costa,F.M.; Martins,M.A.; Nunes,M.P.T.. |
Beta-2-agonists have been widely used by asthmatic subjects to relieve their obstructive symptoms. However, there are reports that continuous use could lead to loss of bronchial protection and exacerbation of asthma symptoms. We evaluated the effect of two regimens of salbutamol administration (twice and five times a week) in a model of chronic airway inflammation in male Hartley guinea pigs (protocol starting weight: 286 ± 30 g) induced by repeated exposures to aerosols of ovalbumin (OVA). After sensitization, guinea pigs were exposed to aerosols of 0.1 mg/ml salbutamol solution twice a week (OVA + S2x, N = 7) or five times a week (OVA + S5x, N = 8). We studied allergen-specific (OVA inhalation time) and -nonspecific (response to methacholine) respiratory... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Salbutamol; Methacholine; Experimental asthma; Beta-agonist; Pulmonary responsiveness. |
Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000500009 |
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Bizeto,L.; Mazzolini,A.B.; Ribeiro,M.; Stelmach,R.; Cukier,A.; Nunes,M.P.T.. |
Little is known about airway inflammatory markers in chronic obstructive pulmonary disease (COPD). The objective of the present study was to identify and try to correlate pulmonary and peripheral blood inflammatory markers in COPD. In a cross-sectional study on patients with stable COPD, induced sputum and blood samples were collected for the determination of C-reactive protein, eosinophilic cationic protein, serum amyloid A protein, a-1 antitrypsin (a-1AT), and neutrophil elastase. Twenty-two patients were divided into two groups according to post-bronchodilator forced expiratory volume in the first second (%FEV1): group 1 (N = 12, FEV1 <40%) and group 2 (N = 10, FEV1 ³40%). An increase in serum elastase, eosinophilic cationic protein and a-1AT was... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronic obstructive pulmonary disease; C-reactive protein; Eosinophilic cationic protein; Serum amyloid A protein; A-1 antitrypsin; Neutrophil elastase. |
Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300003 |
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