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	Provedor de dados BJMBR (2) Autor Fernandes,A.A. (2) Ribeiro Junior,R.F. (2) Stefanon,I. (2) Vassallo,D.V. (2) Cade,J.R. (1) Fioresi,M. (1) Furieri,L.B. (1) Meira,E.F. (1) Mill,J.G. (1) Simões,M.R. (1) Targueta,G.P. (1) Mais... Palavra-chave Calcium handling (1) Heart failure (1) Lead (1) Myocardial contractility (1) Myocardial infarction (1) Na+-K+ ATPase (1) Ouabain (1) Ventricular pressure (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2013 (1) 2009 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Acute exposure to lead increases myocardial contractility independent of hypertension development BJMBR Fioresi,M.; Furieri,L.B.; Simões,M.R.; Ribeiro Junior,R.F.; Meira,E.F.; Fernandes,A.A.; Stefanon,I.; Vassallo,D.V.. We studied the effects of the acute administration of small doses of lead over time on hemodynamic parameters in anesthetized rats to determine if myocardial contractility changes are dependent or not on the development of hypertension. Male Wistar rats received 320 µg/kg lead acetateiv once, and their hemodynamic parameters were measured for 2 h. Cardiac contractility was evaluated in vitro using left ventricular papillary muscles as were Na+,K+-ATPase and myosin Ca2+-ATPase activities. Lead increased left- (control: 112 ± 3.7 vs lead: 129 ± 3.2 mmHg) and right-ventricular systolic pressures (control: 28 ± 1.2vs lead: 34 ± 1.2 mmHg) significantly without modifying heart rate. Papillary muscles were exposed to 8 µM lead acetate and evaluated 60 min later.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Lead; Myocardial contractility; Ventricular pressure. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200178 Ventricular performance and Na+-K+ ATPase activity are reduced early and late after myocardial infarction in rats BJMBR Stefanon,I.; Cade,J.R.; Fernandes,A.A.; Ribeiro Junior,R.F.; Targueta,G.P.; Mill,J.G.; Vassallo,D.V.. Myocardial infarction leads to compensatory ventricular remodeling. Disturbances in myocardial contractility depend on the active transport of Ca2+ and Na+, which are regulated by Na+-K+ ATPase. Inappropriate regulation of Na+-K+ ATPase activity leads to excessive loss of K+ and gain of Na+ by the cell. We determined the participation of Na+-K+ ATPase in ventricular performance early and late after myocardial infarction. Wistar rats (8-10 per group) underwent left coronary artery ligation (infarcted, Inf) or sham-operation (Sham). Ventricular performance was measured at 3 and 30 days after surgery using the Langendorff technique. Left ventricular systolic pressure was obtained under different ventricular diastolic pressures and increased extracellular Ca2+... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Ouabain; Na+-K+ ATPase; Myocardial infarction; Calcium handling. Ano: 2009 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001000005 Registros recuperados: 2 Primeira ... 1 ... Última

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