Consulta: creatorFacets:"Stransky,B."
Registros recuperados: 3
Data/hora: 27/07/2024 01:51:24

Aging and immunoglobulin isotype patterns in oral tolerance
Provedor de dados: 56
Autores: Faria,A.M.C.; Ficker,S.M.; Speziali,E.; Menezes,J.S.; Stransky,B.; Verdolin,B.A.; Lahmann,W.M.; Rodrigues,V.S.; Vaz,N.M.
In the present review we address oral tolerance as an important biological phenomenon and discuss how it is affected by aging. Other factors such as frequency of feeding and previous digestion of the antigen also seem to influence the establishment of oral tolerance. We also analyze immunoglobulin isotypes of specific antibodies formed by tolerant and immunized animals of different ages submitted to different conditions of oral antigen administration. Isotypic patterns were studied as a parameter for assessing the pathways of B and T cell interactions leading to antibody production
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Oral tolerance; Aging; Isotypes; Gut; Mucosa.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000100005

Interruption of recently induced immune responses by oral administration of antigen
Provedor de dados: 56
Autores: Conde,A.A.; Stransky,B.; Faria,A.M.C.; Vaz,N.M.
Interest in oral tolerance has been renewed in the last few years as a possibility of intervention in human autoimmune diseases. An obstacle in this direction is that, although easily induced in animals virgin of contact with the antigen, oral tolerance becomes hard to induce in previously immunized animals. The present results show that there is an early period after primary immunization in which prolonged oral exposure to the antigen may arrest ongoing immune responses. Beyond this period, oral exposures to the antigen become ineffective and may actually boost immune responses. The end of the susceptible period coincides with the emergence of free specific antibodies in serum. However, the previous administration of purified anti-ovalbumin antibodies (40...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Suppression; Antibody response; Oral tolerance; Ovalbumin.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000300008

Oral tolerance induction with altered forms of ovalbumin
Provedor de dados: 56
Autores: Stransky,B.; Faria,A.M.C.; Vaz,N.M.
As a T cell-dependent phenomenon, oral tolerance is not expected to depend necessarily on native configuration of antigens. We investigated the induction of oral tolerance with modified ovalbumin (Ova). Oral administration of heat-denatured (HD-Ova) and cyanogen bromide-degraded ovalbumin was less effective than native Ova in inducing oral tolerance in B6D2F1 mice. HD-Ova was effective in suppressing delayed-type hypersensitivity (DTH) reactions but did not suppress specific antibody formation. Injection of Ova directly into the stomach, but not into the ileum or cecum, suppressed subsequent immunization to DTH reactions. Gavage with protease inhibitors (aprotinin or ovomucoid) before gavage with Ova was ineffective in blocking tolerance induction....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antigen; Digestion; Oral tolerance; Mouse; Ovalbumin.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000300009