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	Provedor de dados BJMBR (8) Arq. Bras. Med. Vet. Zootec. (1) Autor Tucci,P.J.F. (9) Antonio,E.L. (5) Kanashiro,R.M. (3) Saraiva,R.M. (3) Campos,O. (2) Murad,N. (2) Portes,L.A. (2) Bonatto,R.C. (1) Bonilha,A.M.M. (1) Carvalho,A.C.C. (1) Cicogna,A.C. (1) Cravo,S.L.D. (1) Dos Santos,L. (1) Fioretto,J.R. (1) Flumignan,R.L.G. (1) Ishigai,M.M.S. (1) Kanashiro-Takeuchi,R.M. (1) Levy,R.F. (1) Mello,A.F.S. (1) Moises,V.A. (1) Mais... Palavra-chave Myocardial infarction size (3) Rats (3) Heart failure (2) Hemodynamics (2) Myocardial infarction (2) Afterload (1) Anesthesia (1) Bland-Altman test (1) Cardiac hypertrophy (1) Contractile function (1) Coronary flow (1) Coronary perfusion pressure (1) DP/dt (1) DT/dt (1) Developed pressure (1) Doppler echocardiography (1) Echocardiogram (1) Echocardiography (1) Echocardiography and triphenyltetrazolium comparison (1) Electrocardiogram (1) Mais... Tipo do documento Info:eu-repo/semantics/article (7) Info:eu-repo/semantics/other (2) Ano 2012 (1) 2008 (1) 2007 (1) 2006 (2) 2005 (1) 1999 (1) 1998 (1) 1997 (1) Mais... País Brazil (9) Idioma Inglês (9)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 9 Primeira ... 1 ... Última Hemodynamic and thermoregulatory effects of xylazine-ketamine mixture persist even after the anesthetic stage in rats Arq. Bras. Med. Vet. Zootec. Picollo,C.; Serra,A.J.; Levy,R.F.; Antonio,E.L.; Santos,L. dos; Tucci,P.J.F.. The xylazine-ketamine mixture (KX) is an anesthetic approach commonly administered to assess cardiovascular function in rodents. This study aimed to examine if the cardiovascular and thermoregulatory effects of KX could persist after the anesthetic state ceased in rats. Male Wistar rats were anesthetized with K (50mg/kg) X (10mg/kg) through the intra-peritoneal route. Hemodynamic and thermoregulatory repercussions were evaluated in animals in awake state, during an anesthetic depth and after complete recovery of anesthetized state. KX was efficient to significantly induce deep anesthesia in all rats after 10min. A complete recovery of anesthetized state was observed only after 210min. Compared with preanesthetic state and control animals that received no... Tipo: Info:eu-repo/semantics/article Palavras-chave: Anesthesia; Hypotension; Xylazine-ketamine; Hemodynamics; Thermoregulation. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000400011 Developed pressure data may provide misinformation when used alone to evaluate systolic function in isovolumetric left ventricle preparations BJMBR Murad,N.; Tucci,P.J.F.. We report data showing that developed pressure (DPmax) may lead to opposite conclusion with respect to maximal developed circumferential wall stress (<FONT FACE="Symbol">s</FONT>max) when used to assess contractile function in left ventricle isovolumic preparations. Isovolumetric left ventricle preparations of rats with cardiac hypertrophy (H; N = 10) induced by isoproterenol administration showed higher DPmax (174 ± 14 mmHg) than control (C; N = 8) animals (155 ± 12 mmHg) or rats with regression (R; N = 8) of hypertrophy (144 ± 11 mmHg). In contrast, the estimated <FONT FACE="Symbol">s</FONT>max for C (145 ± 26 kdynes/cm2) and R (133 ± 17 kdynes/cm2) was higher than for H (110 ± 13 kdynes/cm2). According to Laplace's law, the... Tipo: Info:eu-repo/semantics/other Palavras-chave: Contractile function; Developed pressure; Wall stress; Cardiac hypertrophy; Laplace's law. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000600014 Incidence of heart failure in infarcted rats that die spontaneously BJMBR Flumignan,R.L.G.; Kanashiro,R.M.; Saraiva,R.M.; Portes,L.A.; Antonio,E.L.; Ishigai,M.M.S.; Tucci,P.J.F.. The present study reports for the first time the incidence of congestive heart failure (CHF) in previously infarcted rats that died spontaneously. Previously, pulmonary (PWC) and hepatic (HWC) water contents were determined in normal rats: 14 control animals were evaluated immediately after sacrifice, 8 placed in a refrigerator for 24 h, and 10 left at room temperature for 24 h. In the infarcted group, 9 rats died before (acute) and 28 died 48 h after (chronic) myocardial infarction. Thirteen chronic animals were submitted only to autopsy (N = 13), whereas PWC and HWC were also determined in the others (N = 15). Seven rats survived 48 h and died during anesthesia. Notably, PWC differed in normal rats: ambient (75.7 ± 1.3%) < control (77.5 ± 0.7%) <... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Myocardial infarction; Rats; Pulmonary congestion; Hepatic congestion. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001000008 The left ventricular contractility of the rat heart is modulated by changes in flow and a1-adrenoceptor stimulation BJMBR Vassallo,P.F.; Stefanon,I.; Rossoni,L.V.; Tucci,P.J.F.; Vassallo,D.V.. Myocardial contractility depends on several mechanisms such as coronary perfusion pressure (CPP) and flow as well as on <FONT FACE="Symbol">a</font>1-adrenoceptor stimulation. Both effects occur during the sympathetic stimulation mediated by norepinephrine. Norepinephrine increases force development in the heart and produces vasoconstriction increasing arterial pressure and, in turn, CPP. The contribution of each of these factors to the increase in myocardial performance needs to be clarified. Thus, in the present study we used two protocols: in the first we measured mean arterial pressure, left ventricular pressure and rate of rise of left ventricular pressure development in anesthetized rats (N = 10) submitted to phenylephrine (PE)... Tipo: Info:eu-repo/semantics/article Palavras-chave: Myocardial performance; Coronary perfusion pressure; Coronary flow; Phenylephrine. Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998001000019 A routine electrocardiogram cannot be used to determine the size of myocardial infarction in the rat BJMBR Bonilha,A.M.M.; Saraiva,R.M.; Kanashiro,R.M.; Portes,L.A.; Antonio,E.L.; Tucci,P.J.F.. Nine lead electrocardiograms of non-infarcted (N = 61) and infarcted (N = 71) female Wistar rats (200-250 g) were analyzed in order to distinguish left ventricle myocardial infarction (MI) larger than 40% (LMI) from MI smaller than 40% (SMI). MI larger than 40% clearly caused a deviation of ÂQRS and ÂT from normal values of 270-360 degrees to 90-270 degrees. Infarcted rats showed Q wave in D1 larger than 1 mm with 94% sensitivity and 100% specificity. The sum of QRS positivity in V1, V2 and V6 lower than 10 mm identified MI with 82% sensitivity and 100% specificity. The data showed that MI can be easily and reliably diagnosed by electrocardiogram in the rat. However, contradicting what is frequently believed, when specificity and sensitivity were analyzed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Myocardial infarction size; Rats; Electrocardiogram; Echocardiogram; ROC curve. Ano: 2005 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000400016 Determination of myocardial infarction size in rats by echocardiography and tetrazolium staining: correlation, agreements, and simplifications BJMBR Dos Santos,L.; Mello,A.F.S.; Antonio,E.L.; Tucci,P.J.F.. Triphenyltetrazolium chloride (TTC) staining and echocardiography (ECHO) are methods used to determine experimental myocardial infarction (MI) size, whose practical applicability should be expanded. Our objectives were to analyze the accuracy of ECHO in determining infarction size in rats during the first days following coronary occlusion and to test whether a simplified single measurement by TTC correctly indicates MI size, as determined by the average value for multiple slices. Infarction was induced in female Wistar rats by coronary artery occlusion and MI size analysis was performed after the acute (7th day) and chronic periods (after 4 weeks) by ECHO matched with TTC. ECHO and TTC showed similar values of MI size (% of left ventricle perimeter) in... Tipo: Info:eu-repo/semantics/other Palavras-chave: Myocardial infarction size; Echocardiography and triphenyltetrazolium comparison; Bland-Altman test. Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300004 The rate of force generation by the myocardium is not influenced by afterload BJMBR Fioretto,J.R.; Okoshi,M.P.; Okoshi,K.; Cicogna,A.C.; Bonatto,R.C.; Padovani,C.R.; Tucci,P.J.F.. The influence of afterload on the rate of force generation by the myocardium was investigated using two types of preparations: the in situ dog heart (dP/dt) and isolated papillary muscle of rats (dT/dt). Thirteen anesthetized, mechanically ventilated and thoracotomized dogs were submitted to pharmacological autonomic blockade (3.0 mg/kg oxprenolol plus 0.5 mg/kg atropine). A reservoir connected to the left atrium permitted the control of left ventricular end-diastolic pressure (LVEDP). A mechanical constriction of the descending thoracic aorta allowed to increase the systolic pressure in two steps of 20 mmHg (conditions H1 and H2) above control values (condition C). After arterial pressure elevations (systolic pressure C: 119 ± 8.1; H1: 142 ± 7.9; H2 166 ±... Tipo: Info:eu-repo/semantics/article Palavras-chave: Ventricular function; Afterload; DP/dt; DT/dt; Papillary muscle; Isometric contractions. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001200015 Rats with high left ventricular end-diastolic pressure can be identified by Doppler echocardiography one week after myocardial infarction BJMBR Saraiva,R.M.; Kanashiro-Takeuchi,R.M.; Antonio,E.L.; Campos,O.; Tucci,P.J.F.; Moisés,V.A.. The severity of left ventricular (LV) dysfunction in rats with myocardial infarction (MI) varies widely. Because homogeneity in baseline parameters is essential for experimental investigations, a study was conducted to establish whether Doppler echocardiography (DE) could accurately identify animals with high LV end-diastolic pressure as a marker of LV dysfunction soon after MI. Direct measurements of LV end-diastolic pressure were made and DE was performed simultaneously 1 week after surgically induced MI (N = 16) or sham-operation (N = 17) in female Wistar rats (200 to 250 g). The ratio of peak early (E) to late (A) diastolic LV filling velocities and the ratio of E velocity to peak early (Em) diastolic myocardial velocity were the best predictors of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Heart failure; Myocardial infarction; Echocardiography; Hemodynamics. Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100016 Performance of two-dimensional Doppler echocardiography for the assessment of infarct size and left ventricular function in rats BJMBR Nozawa,E.; Kanashiro,R.M.; Murad,N.; Carvalho,A.C.C.; Cravo,S.L.D.; Campos,O.; Tucci,P.J.F.; Moises,V.A.. Although echocardiography has been used in rats, few studies have determined its efficacy for estimating myocardial infarct size. Our objective was to estimate the myocardial infarct size, and to evaluate anatomic and functional variables of the left ventricle. Myocardial infarction was produced in 43 female Wistar rats by ligature of the left coronary artery. Echocardiography was performed 5 weeks later to measure left ventricular diameter and transverse area (mean of 3 transverse planes), infarct size (percentage of the arc with infarct on 3 transverse planes), systolic function by the change in fractional area, and diastolic function by mitral inflow parameters. The histologic measurement of myocardial infarction size was similar to the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rats; Myocardial infarction size; Systolic and diastolic function; Doppler echocardiography. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000500016 Registros recuperados: 9 Primeira ... 1 ... Última

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