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	Provedor de dados BJMBR (2) Autor dos Santos,L. (2) Assis,A.L.E.M. (1) Baldo,M.P. (1) Coelho,P.M. (1) Cordeiro,J.P. (1) Leopoldo,A.S. (1) Lima-Leopoldo,A.P. (1) Luchi,T.C. (1) Lunz,W. (1) Marques,V.B. (1) Nogueira,B.V. (1) Stefanon,I. (1) Mais... Palavra-chave Aerobic exercise (1) Calcium (1) Cardiac remodeling (1) Cardiomyocyte (1) Collagen remodeling (1) Coronary occlusion (1) Heart failure (1) Inflammation (1) Mechanical dysfunction (1) Nitric oxide (1) Rats (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2020 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Remodeling in the ischemic heart: the stepwise progression for heart BJMBR Stefanon,I.; dos Santos,L.; Baldo,M.P.. Abstract Coronary artery disease is the leading cause of death in the developed world and in developing countries. Acute mortality from acute myocardial infarction (MI) has decreased in the last decades. However, the incidence of heart failure (HF) in patients with healed infarcted areas is increasing. Therefore, HF prevention is a major challenge to the health system in order to reduce healthcare costs and to provide a better quality of life. Animal models of ischemia and infarction have been essential in providing precise information regarding cardiac remodeling. Several of these changes are maladaptive, and they progressively lead to ventricular dilatation and predispose to the development of arrhythmias, HF and death. These events depend on cell death... Tipo: Info:eu-repo/semantics/article Palavras-chave: Coronary occlusion; Inflammation; Collagen remodeling; Mechanical dysfunction; Heart failure; Rats. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000900010 Chronic aerobic exercise associated to low-dose L-NAME improves contractility without changing calcium handling in rat cardiomyocytes BJMBR Luchi,T.C.; Coelho,P.M.; Cordeiro,J.P.; Assis,A.L.E.M.; Nogueira,B.V.; Marques,V.B.; dos Santos,L.; Lima-Leopoldo,A.P.; Lunz,W.; Leopoldo,A.S.. Nitric oxide (NO) inhibition by high-dose NG-nitro-L-arginine methyl ester (L-NAME) is associated with several detrimental effects on the cardiovascular system. However, low-dose L-NAME increases NO synthesis, which in turn induces physiological cardiovascular benefits, probably by activating a protective negative feedback mechanism. Aerobic exercise, likewise, improves several cardiovascular functions in healthy hearts, but its effects are not known when chronically associated with low-dose L-NAME. Thus, we tested whether the association between low-dose L-NAME administration and chronic aerobic exercise promotes beneficial effects to the cardiovascular system, evaluating the cardiac remodeling process. Male Wistar rats were randomly assigned to control... Tipo: Info:eu-repo/semantics/article Palavras-chave: Nitric oxide; Aerobic exercise; Cardiac remodeling; Cardiomyocyte; Calcium. Ano: 2020 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000300611 Registros recuperados: 2 Primeira ... 1 ... Última

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