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Rabies infection and specific effect of vaccination in mice selected for high and low immunobiological parameters 56
Queiroz-da-Silva,L.H.; De-Franco,M.; Sant'Anna,O.A.
Innate and acquired resistance to rabies infection was investigated in mice genetically selected for high (H) or low (L) antibody responsiveness from selections I, III and IV and in mice selected for maximal (AIRmax) or minimal (AIRmin) acute inflammatory reaction. These mouse lines were infected intramuscularly with different virus dilutions and the LD50 was determined. The HIII and HIV mouse lines were more susceptible than the LIII and LIV lines and the HI line showed a discrete but higher resistance than the LI line. Analysis of the interline (H x L) F1 hybrids from selections III and IV indicated different dominance effects on the "resistant" and" susceptible" phenotypes when the route of vaccination was changed. No differences were observed between...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Rabies; Antibody; Vaccination; High and low antibody responder mice.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997001100008
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